{"id":"https://openalex.org/W2136706606","doi":"https://doi.org/10.1158/1078-0432.ccr-08-2494","title":"Chromosomal Instability and Copy Number Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma","display_name":"Chromosomal Instability and Copy Number Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma","publication_year":2009,"publication_date":"2009-05-05","ids":{"openalex":"https://openalex.org/W2136706606","doi":"https://doi.org/10.1158/1078-0432.ccr-08-2494","mag":"2136706606","pmid":"https://pubmed.ncbi.nlm.nih.gov/19417022","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2684570"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-08-2494","doi":"https://doi.org/10.1158/1078-0432.ccr-08-2494","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-08-2494","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2684570","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064063128","display_name":"Thomas G. Paulson","orcid":"https://orcid.org/0000-0002-3857-2683","observed_orcids":["https://orcid.org/0000-0002-3857-2683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas G. Paulson","raw_affiliation_strings":["1Divisions of Human Biology,","2Public Health Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Divisions of Human Biology,","institution_ids":[]},{"raw_affiliation_string":"2Public Health Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062132898","display_name":"Carlo C. Maley","orcid":"https://orcid.org/0000-0002-0745-7076","observed_orcids":["https://orcid.org/0000-0002-0745-7076"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo C. Maley","raw_affiliation_strings":["4Molecular and Cellular Oncogenesis Program, Systems Biology Division, The Wistar Institute, Philadelphia, Pennsylvania;","5Genomics and Computational Biology Graduate Program and Cellular and Molecular Biology Graduate Program, University of Pennsylvania, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Molecular and Cellular Oncogenesis Program, Systems Biology Division, The Wistar Institute, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"5Genomics and Computational Biology Graduate Program and Cellular and Molecular Biology Graduate Program, University of Pennsylvania, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaohong Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaohong Li","raw_affiliation_strings":["2Public Health Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Public Health Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082318113","display_name":"Hongzhe Li","orcid":"https://orcid.org/0000-0003-3662-3907","observed_orcids":["https://orcid.org/0000-0003-3662-3907","https://orcid.org/0009-0005-7695-0533"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongzhe Li","raw_affiliation_strings":["6Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046153450","display_name":"Carissa A. Sanchez","orcid":"https://orcid.org/0000-0003-3861-1432","observed_orcids":["https://orcid.org/0000-0003-3861-1432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carissa A. Sanchez","raw_affiliation_strings":["1Divisions of Human Biology,","2Public Health Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Divisions of Human Biology,","institution_ids":[]},{"raw_affiliation_string":"2Public Health Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048216017","display_name":"Dennis L. Chao","orcid":"https://orcid.org/0000-0002-8253-6321","observed_orcids":["https://orcid.org/0000-0002-8253-6321"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis L. Chao","raw_affiliation_strings":["3The Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington;","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061079739","display_name":"Robert Daniel Odze","orcid":"https://orcid.org/0000-0001-7910-8273","observed_orcids":["https://orcid.org/0000-0001-7910-8273"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Odze","raw_affiliation_strings":["7Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; and","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011306393","display_name":"Thomas L. Vaughan","orcid":"https://orcid.org/0000-0003-1537-0242","observed_orcids":["https://orcid.org/0000-0003-1537-0242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas L. Vaughan","raw_affiliation_strings":["2Public Health Sciences, and","8Departments of Epidemiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Public Health Sciences, and","institution_ids":[]},{"raw_affiliation_string":"8Departments of Epidemiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057244007","display_name":"Patricia L. Blount","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia L. Blount","raw_affiliation_strings":["10Medicine, University of Washington, Seattle, Washington","1Divisions of Human Biology,","2Public Health Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"1Divisions of Human Biology,","institution_ids":[]},{"raw_affiliation_string":"2Public Health Sciences, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025406097","display_name":"Brian J. Reid","orcid":"https://orcid.org/0000-0002-5352-1067","observed_orcids":["https://orcid.org/0000-0002-5352-1067"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. Reid","raw_affiliation_strings":["10Medicine, University of Washington, Seattle, Washington","1Divisions of Human Biology,","2Public Health Sciences, and","9Genome Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"1Divisions of Human Biology,","institution_ids":[]},{"raw_affiliation_string":"2Public Health Sciences, and","institution_ids":[]},{"raw_affiliation_string":"9Genome Sciences, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.3631,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.98919153,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"15","issue":"10","first_page":"3305","last_page":"3314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9459999799728394},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.9990000128746033},{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":1.0},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4819999933242798},{"id":"https://openalex.org/keywords/high-grade-dysplasia","display_name":"high-grade dysplasia","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cancer-risk-biomarkers","display_name":"cancer risk biomarkers","score":0.6290000081062317},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.7801728248596191},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.7801270484924316},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.7667090892791748},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.7336297035217285},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.6449910998344421},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.627342939376831},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.5851520895957947},{"id":"https://openalex.org/C2778589982","wikidata":"https://www.wikidata.org/wiki/Q808892","display_name":"Barrett's esophagus","level":4,"score":0.5289124250411987},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5263587236404419},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.4602929353713989},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4448120594024658},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4335612654685974},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4309194087982178},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.4122482240200043},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3953489065170288},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3650330603122711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19137874245643616},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18183046579360962},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.12381339073181152},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.12126564979553223},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.08143350481987},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-08-2494","doi":"https://doi.org/10.1158/1078-0432.ccr-08-2494","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-08-2494","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:19417022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19417022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:authors.fhcrc.org:227","doi":null,"is_oa":false,"landing_page_url":"http://authors.fhcrc.org/227/1/PaulsonTManuscript031609.pdf","pdf_url":"http://authors.fhcrc.org/227/1/PaulsonTManuscript031609.pdf","source":{"id":"https://openalex.org/S4306402156","display_name":"authors@Fred Hutch (Fred Hutchinson Cancer Research Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089486","host_organization_name":"Fred Hutch Cancer Center","host_organization_lineage":["https://openalex.org/I4210089486"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article or Abstract"},{"id":"pmh:oai:pubmedcentral.nih.gov:2684570","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2684570","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2684570","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2684570","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2062169749","display_name":"CHROMOSOME ALTERATIONS IN BARRETT'S ESOPHAGUS","funder_award_id":"K07CA089147","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6125780952","display_name":"Barrett's Esophagus: Predictors of Progression","funder_award_id":"P01CA091955","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G940333781","display_name":"Interdisciplinary Training in Cancer Research","funder_award_id":"T32CA080416","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W145604346","https://openalex.org/W1509930884","https://openalex.org/W1576726818","https://openalex.org/W1649167417","https://openalex.org/W1965560988","https://openalex.org/W1970984844","https://openalex.org/W1972955523","https://openalex.org/W1979821364","https://openalex.org/W1984252693","https://openalex.org/W1986927287","https://openalex.org/W1987447127","https://openalex.org/W1992965559","https://openalex.org/W1998927054","https://openalex.org/W2000771104","https://openalex.org/W2002777462","https://openalex.org/W2005422079","https://openalex.org/W2017535462","https://openalex.org/W2023583823","https://openalex.org/W2025343608","https://openalex.org/W2032400212","https://openalex.org/W2038373909","https://openalex.org/W2044368607","https://openalex.org/W2045012271","https://openalex.org/W2053818271","https://openalex.org/W2059997545","https://openalex.org/W2073172834","https://openalex.org/W2079288043","https://openalex.org/W2084422956","https://openalex.org/W2084819007","https://openalex.org/W2087015500","https://openalex.org/W2097149362","https://openalex.org/W2097407589","https://openalex.org/W2098750893","https://openalex.org/W2102482497","https://openalex.org/W2103429101","https://openalex.org/W2106088192","https://openalex.org/W2114442699","https://openalex.org/W2116753165","https://openalex.org/W2119317141","https://openalex.org/W2122380766","https://openalex.org/W2122576282","https://openalex.org/W2125849814","https://openalex.org/W2131738928","https://openalex.org/W2134537028","https://openalex.org/W2135160082","https://openalex.org/W2150027485","https://openalex.org/W2155306883","https://openalex.org/W2155707112","https://openalex.org/W2161638580","https://openalex.org/W2166095372","https://openalex.org/W2170339479","https://openalex.org/W2170659347","https://openalex.org/W2170818799","https://openalex.org/W4231845372","https://openalex.org/W4300037956"],"related_works":["https://openalex.org/W2134537028","https://openalex.org/W6950258191","https://openalex.org/W4387330087","https://openalex.org/W2308089754","https://openalex.org/W4391447024","https://openalex.org/W2936372780","https://openalex.org/W7223103008","https://openalex.org/W1979821364","https://openalex.org/W2125233650","https://openalex.org/W3047077718"],"abstract_inverted_index":{"PURPOSE:":[0],"Chromosomal":[1],"instability,":[2],"as":[3,108,222,248,250],"assessed":[4],"by":[5],"many":[6],"techniques,":[7],"including":[8,40,175],"DNA":[9,45,185,203],"content":[10,186,204],"aneuploidy,":[11],"loss":[12,41],"of":[13,36,42,58,81,110,141,180,200,224,232,241,254,257],"heterozygosity,":[14],"and":[15,28,44,55,79,166,173,218],"comparative":[16,132],"genomic":[17,133],"hybridization,":[18],"has":[19,47],"consistently":[20],"been":[21,48,85,100],"reported":[22,49],"to":[23,50,64,135,147,202],"be":[24,261],"common":[25,236,255],"in":[26,30,87,95,105,118,154,168],"cancer":[27,111,245],"rare":[29,153],"normal":[31],"tissues.":[32],"Recently,":[33],"a":[34,235],"panel":[35],"chromosome":[37,82,242],"instability":[38,76,243],"biomarkers,":[39],"heterozygosity":[43],"content,":[46],"identify":[51],"patients":[52,120],"at":[53,138,197],"high":[54],"low":[56],"risk":[57,199,220,246],"progression":[59,142,201],"from":[60,144],"Barrett's":[61],"esophagus":[62],"(BE)":[63],"esophageal":[65],"adenocarcinoma":[66],"(EA),":[67],"but":[68,161],"required":[69],"multiple":[70],"platforms":[71],"for":[72,238,244,251,264],"implementation.":[73],"Although":[74],"chromosomal":[75],"involving":[77,193],"amplifications":[78],"deletions":[80],"regions":[83,256],"have":[84,98],"observed":[86],"nearly":[88],"all":[89],"cancers,":[90],"copy":[91],"number":[92,179],"alterations":[93],"(CNA)":[94],"premalignant":[96],"tissues":[97],"not":[99],"well":[101,249],"characterized":[102],"or":[103,124,206],"evaluated":[104],"cohort":[106],"studies":[107],"biomarkers":[109],"risk.":[112],"EXPERIMENTAL":[113],"DESIGN:":[114],"We":[115],"examined":[116],"CNAs":[117,137,151,181,192,233],"98":[119],"having":[121],"either":[122],"BE":[123,146],"EA":[125,207],"using":[126],"Bacterial":[127],"Artificial":[128],"Chromosome":[129],"(BAC)":[130],"array":[131],"hybridization":[134],"characterize":[136],"different":[139],"stages":[140,156,170],"ranging":[143],"early":[145,155],"advanced":[148],"EA.":[149],"RESULTS:":[150],"were":[152,162,196],"(less":[157],"than":[158],"high-grade":[159],"dysplasia)":[160],"progressively":[163],"more":[164,223],"frequent":[165],"larger":[167],"later":[169],"(high-grade":[171],"dysplasia":[172],"EA),":[174],"high-level":[176],"amplifications.":[177],"The":[178],"correlated":[182],"highly":[183],"with":[184],"aneuploidy.":[187],"Patients":[188],"whose":[189],"biopsies":[190],"contained":[191],">70":[194],"Mbp":[195],"increased":[198,221],"abnormalities":[205],"(hazards":[208],"ratio,":[209],"4.9;":[210],"95%":[211],"confidence":[212],"interval,":[213],"1.6-14.8;":[214],"P":[215],"=":[216],"0.0047),":[217],"the":[219,225,239,252],"genome":[226],"was":[227],"affected.":[228],"CONCLUSIONS:":[229],"Genome-wide":[230],"analysis":[231],"provides":[234],"platform":[237],"evaluation":[240],"assessment":[247],"identification":[253],"alteration":[258],"that":[259],"can":[260],"further":[262],"studied":[263],"biomarker":[265],"discovery.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
