{"id":"https://openalex.org/W2136700669","doi":null,"title":"Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk.","display_name":"Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk.","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W2136700669","mag":"2136700669","pmid":"https://pubmed.ncbi.nlm.nih.gov/7834625"},"language":"en","primary_location":{"id":"pmid:7834625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7834625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111981103","display_name":"Martin J Blaser","orcid":"https://orcid.org/0000-0003-2447-2443","observed_orcids":["https://orcid.org/0000-0003-2447-2443"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Blaser","raw_affiliation_strings":["Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112255686","display_name":"P.-H. Chyou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P H Chyou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113540009","display_name":"Abraham M. Y. Nomura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Nomura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":27.4668,"has_fulltext":false,"cited_by_count":398,"citation_normalized_percentile":{"value":0.99756645,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"55","issue":"3","first_page":"562","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori-infection","display_name":"Helicobacter pylori infection","score":0.9480000138282776},{"id":"https://openalex.org/keywords/age-at-infection","display_name":"age at infection","score":0.7009999752044678},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.7910000085830688},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/duodenal-ulcer","display_name":"duodenal ulcer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/number-of-siblings","display_name":"number of siblings","score":0.9620000123977661},{"id":"https://openalex.org/keywords/birth-order","display_name":"birth order","score":1.0},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5569999814033508},{"id":"https://openalex.org/keywords/japanese-american-men","display_name":"Japanese-American men","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.8446123600006104},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7594558000564575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7343361377716064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7189748883247375},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6804123520851135},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.648501992225647},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.6117775440216064},{"id":"https://openalex.org/C2779137044","wikidata":"https://www.wikidata.org/wiki/Q7577827","display_name":"Spirillaceae","level":4,"score":0.5393993258476257},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.45416906476020813},{"id":"https://openalex.org/C2779209633","wikidata":"https://www.wikidata.org/wiki/Q2914808","display_name":"Birth order","level":3,"score":0.4407428801059723},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.24872499704360962},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.18591228127479553},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001722","descriptor_name":"Birth Order","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004381","descriptor_name":"Duodenal Ulcer","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005190","descriptor_name":"Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008889","descriptor_name":"Military Personnel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7834625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7834625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},{"id":"mag:2136700669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7834625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1203296936","display_name":"EPIDEMIOLOGY OF GASTRIC CANCER--H PYLORI COFACTORS","funder_award_id":"R01CA058834","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4736972153","display_name":"CANCER SERO EPIDEMIOLOGY AMONG THE JAPANESE IN HAWAII","funder_award_id":"R01CA033644","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1528009881","https://openalex.org/W1561069887","https://openalex.org/W1589671693","https://openalex.org/W1636505675","https://openalex.org/W1877917243","https://openalex.org/W1967139816","https://openalex.org/W1976992230","https://openalex.org/W1989473327","https://openalex.org/W1991114930","https://openalex.org/W1996405559","https://openalex.org/W2003544098","https://openalex.org/W2003647849","https://openalex.org/W2028190840","https://openalex.org/W2029865847","https://openalex.org/W2034165112","https://openalex.org/W2035930633","https://openalex.org/W2049613823","https://openalex.org/W2057970541","https://openalex.org/W2076261293","https://openalex.org/W2079955663","https://openalex.org/W2082904836","https://openalex.org/W2086716942","https://openalex.org/W2093977176","https://openalex.org/W2117137288","https://openalex.org/W2160504871","https://openalex.org/W2255678518","https://openalex.org/W2265746432","https://openalex.org/W2313559777","https://openalex.org/W2320937221","https://openalex.org/W2327597225","https://openalex.org/W2329240046","https://openalex.org/W2340725464","https://openalex.org/W2411130816","https://openalex.org/W2416826340","https://openalex.org/W3085323863","https://openalex.org/W4298290178"],"related_works":["https://openalex.org/W2066913654","https://openalex.org/W2012630981","https://openalex.org/W1965653329","https://openalex.org/W162546671","https://openalex.org/W2069378448","https://openalex.org/W2079302368","https://openalex.org/W2321415533","https://openalex.org/W2077643591","https://openalex.org/W254746448","https://openalex.org/W4410890001"],"abstract_inverted_index":{"Helicobacter":[0],"pylori":[1,45,73,203],"is":[2,46],"an":[3],"important":[4],"risk":[5,48,130,161,180,206],"factor":[6,49],"for":[7,50,119,132,162],"gastric":[8,10,81,84,109,164,182,210,213],"cancer,":[9],"ulcer,":[11,14,110,113],"and":[12,32,99,111,115,123,150,212],"duodenal":[13,86,112,188,217],"yet":[15],"most":[16],"infected":[17,168],"persons":[18],"do":[19],"not":[20,140,171,187,216],"develop":[21],"disease.":[22],"We":[23],"examined":[24],"two":[25],"correlates":[26],"of":[27,43,53,61,64,71,80,105,134,151,181,201,207],"acquisition":[28,42,200],"age,":[29],"sibship":[30],"size":[31,122],"birth":[33,124,153,176],"order,":[34],"to":[35],"evaluate":[36],"the":[37,51,78,89,106,195,205],"hypothesis":[38,196],"that":[39,197],"early":[40,198],"life":[41,199],"H.":[44,72,137,141,166,202],"a":[47,62,116],"development":[52,79,133],"these":[54,135],"illnesses.":[55],"In":[56],"earlier":[57],"nested":[58],"case-control":[59],"studies":[60],"cohort":[63],"Japanese":[65],"American":[66],"men":[67,101,143,169,173],"in":[68],"Hawaii,":[69],"evidence":[70],"infection":[74],"was":[75],"associated":[76],"with":[77,194],"cancer":[82,211],"or":[83,85],"ulceration":[87],"during":[88],"subsequent":[90],"period,":[91],"1968-1989.":[92],"The":[93],"present":[94],"analysis":[95],"included":[96],"102,":[97],"147,":[98],"64":[100],"who":[102],"developed":[103],"adenocarcinoma":[104],"distal":[107],"stomach,":[108],"respectively,":[114],"matched":[117],"control":[118],"each.":[120],"Sibship":[121],"order":[125,154,177],"data":[126,191],"were":[127,158],"analyzed":[128],"as":[129],"factors":[131],"diseases.":[136],"pylori-infected":[138],"but":[139,170,186,215],"pylori-uninfected":[142],"from":[144],"larger":[145],"sibships":[146],"(odds":[147,155,183],"ratio,":[148,156,184],"2.06)":[149],"higher":[152,175],"1.67)":[157],"at":[159,174],"increased":[160,179],"developing":[163,208],"cancer.":[165],"pylori-":[167],"uninfected":[172],"had":[178],"1.64)":[185],"ulcers.":[189],"These":[190],"are":[192],"consistent":[193],"increases":[204],"both":[209],"ulcer":[214],"ulcer.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}