{"id":"https://openalex.org/W2136680679","doi":null,"title":"Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial.","display_name":"Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial.","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W2136680679","mag":"2136680679","pmid":"https://pubmed.ncbi.nlm.nih.gov/21744744"},"language":"en","primary_location":{"id":"pmid:21744744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21744744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112147744","display_name":"Lilliana Ciotta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Ciotta","raw_affiliation_strings":["Microbiological and Gynecological Science Department, Gynecology Section Santo Bambino Hospital (Catania), University of Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiological and Gynecological Science Department, Gynecology Section Santo Bambino Hospital (Catania), University of Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003768838","display_name":"Mariagrazia Stracquadanio","orcid":"https://orcid.org/0000-0003-3467-0734","observed_orcids":["https://orcid.org/0000-0003-3467-0734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Stracquadanio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"I Pagano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Pagano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042677000","display_name":"Adriana Carbonaro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Carbonaro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085183433","display_name":"Marco Antonio Palumbo","orcid":"https://orcid.org/0000-0002-0467-4892","observed_orcids":["https://orcid.org/0000-0002-0467-4892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Palumbo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072433952","display_name":"Ferdinando Antonio Gulino","orcid":"https://orcid.org/0000-0001-7910-0386","observed_orcids":["https://orcid.org/0000-0001-7910-0386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Gulino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8257,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.95146958,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"15","issue":"5","first_page":"509","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myo-inositol","display_name":"myo-inositol","score":0.9800000190734863},{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oocyte-quality","display_name":"oocyte quality","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ovulation-induction","display_name":"ovulation induction","score":0.9110000133514404},{"id":"https://openalex.org/keywords/folic-acid-supplementation","display_name":"folic acid supplementation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/oocyte-maturation","display_name":"oocyte maturation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/immature-oocytes","display_name":"immature oocytes","score":0.6949999928474426},{"id":"https://openalex.org/keywords/ovarian-follicle-development","display_name":"ovarian follicle development","score":0.4869999885559082},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.8135393857955933},{"id":"https://openalex.org/C2780853582","wikidata":"https://www.wikidata.org/wiki/Q25556","display_name":"Anovulation","level":5,"score":0.7710330486297607},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.6245652437210083},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.5678900480270386},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.517676830291748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5074052214622498},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5014474391937256},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.496202290058136},{"id":"https://openalex.org/C2776537878","wikidata":"https://www.wikidata.org/wiki/Q7239894","display_name":"Pregnancy rate","level":3,"score":0.4836364984512329},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.45702052116394043},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.42691460251808167},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.39230525493621826},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3865630626678467},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3706005811691284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.342284619808197},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.31292909383773804},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.2795338034629822},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.2192651927471161},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06925386190414429},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007294","descriptor_name":"Inositol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010062","descriptor_name":"Ovulation Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21744744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21744744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2136680679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21744744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1969062482","https://openalex.org/W2006699482","https://openalex.org/W2053450620","https://openalex.org/W2056411420","https://openalex.org/W2063463279","https://openalex.org/W2084588222","https://openalex.org/W2095365589","https://openalex.org/W2118600958","https://openalex.org/W2144741181","https://openalex.org/W2145984551","https://openalex.org/W2156121263","https://openalex.org/W2156191286","https://openalex.org/W2163069137","https://openalex.org/W2164412438","https://openalex.org/W2165846997","https://openalex.org/W2171177397","https://openalex.org/W2171389484","https://openalex.org/W2414963813"],"related_works":["https://openalex.org/W66436175","https://openalex.org/W2734721797","https://openalex.org/W2517684199","https://openalex.org/W2118600958","https://openalex.org/W4417533654","https://openalex.org/W2323967404","https://openalex.org/W4205175877","https://openalex.org/W2925323220","https://openalex.org/W2796797549","https://openalex.org/W3024558750"],"abstract_inverted_index":{"BACKGROUND:":[0],"Polycystic":[1],"ovary":[2,116],"syndrome":[3],"is":[4,99],"the":[5,64,68,73,78,102,160,171,175,190,196,207,214,227,249],"most":[6],"common":[7],"cause":[8],"of":[9,25,31,42,63,70,80,96,104,112,129,135,140,154,173,177,179,192,198,217,230,251],"chronic":[10],"anovulation":[11],"infertility":[12],"in":[13,15,86,206,248,265],"women":[14,55,113],"fertile":[16],"period,":[17],"and":[18,27,45,76,189,220,235,262],"it's":[19],"characterized":[20],"by":[21],"an":[22],"increased":[23],"production":[24],"androgens":[26],"estrogens.":[28],"The":[29,94,121],"administration":[30],"myo-inositol,":[32,211],"a":[33,40,60,110,163],"B":[34,150],"complex":[35],"vitamin,":[36],"was":[37,226],"associated":[38],"with":[39,114,210],"decreased":[41],"serum":[43],"testosterone":[44],"simultaneously,":[46],"due":[47],"to":[48,51,100,202],"its":[49,259,263],"ability":[50],"increase":[52,77],"insulin":[53],"sensitivity,":[54],"who":[56],"received":[57],"myo-inositol":[58,105,136],"showed":[59],"great":[61],"improvement":[62],"ovulary":[65],"function.":[66],"Besides,":[67],"supplementation":[69],"inositol":[71],"improves":[72],"oocytes'":[74],"quality":[75,108],"number":[79,176,191,216,229],"oocytes":[81,193,232],"collected":[82],"after":[83],"ovarian":[84],"stimulation":[85],"patients":[87,122,128,253],"undergoing":[88,254],"IVF":[89],"(in":[90],"vitro":[91],"fertilization).":[92],"AIM:":[93],"aim":[95],"this":[97],"study":[98],"determine":[101],"effects":[103],"on":[106,109],"oocyte's":[107],"sample":[111],"polycystic":[115],"syndrome.":[117],"MATERIAL":[118],"AND":[119],"METHODS:":[120],"were":[123,200],"divided":[124],"into":[125],"two":[126],"groups:":[127],"Group":[130,149],"A":[131],"in-took":[132],"2":[133],"g":[134],"+":[137],"200":[138,152],"microg":[139,153],"folic":[141,155],"acid":[142],"(Inofolic,":[143],"LO.LI.":[144],"Pharma,":[145],"Rome,":[146],"Italy)":[147],"while":[148],"only":[151],"acid,":[156],"both":[157,257],"groups":[158],"took":[159],"treatment":[161,250],"twice":[162],"day,":[164],"continuously":[165],"for":[166,258],"3":[167],"months.":[168],"RESULTS:":[169],"At":[170],"end":[172],"treatment,":[174],"follicles":[178],"diameter":[180],">":[181],"15":[182],"mm,":[183],"visible":[184],"at":[185,195],"ultrasound":[186],"during":[187],"stimulation,":[188],"recovered":[194],"time":[197],"pick-ups":[199],"found":[201],"be":[203,246],"significantly":[204],"greater":[205],"group":[208],"treated":[209],"so":[212],"as":[213],"aver-age":[215],"embryos":[218],"transferred":[219],"embryo":[221],"Score":[222],"S1.":[223],"Significantly":[224],"reduced":[225],"average":[228],"immature":[231],"(vesicles":[233],"germ":[234],"degenerated":[236],"oocytes)":[237],"too.":[238],"CONCLUSIONS:":[239],"These":[240],"data":[241],"suggest":[242],"that":[243],"myoinositol":[244],"may":[245],"useful":[247],"PCOS":[252],"ovulation":[255],"induction,":[256],"insulin-sensitizing":[260],"activity,":[261],"role":[264],"oocyte":[266],"maturation.":[267]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}