{"id":"https://openalex.org/W2136596347","doi":"https://doi.org/10.1111/jsap.12354","title":"Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma","display_name":"Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2136596347","doi":"https://doi.org/10.1111/jsap.12354","mag":"2136596347","pmid":"https://pubmed.ncbi.nlm.nih.gov/25828786"},"language":"en","primary_location":{"id":"doi:10.1111/jsap.12354","doi":"https://doi.org/10.1111/jsap.12354","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jsap.12354","pdf_url":null,"source":{"id":"https://openalex.org/S79984219","display_name":"Journal of Small Animal Practice","issn_l":"0022-4510","issn":["0022-4510","1748-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Small Animal Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085046088","display_name":"Claire M. Cannon","orcid":"https://orcid.org/0000-0002-0656-6916","observed_orcids":["https://orcid.org/0000-0002-0656-6916"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Cannon","raw_affiliation_strings":["Veterinary Clinical Sciences Department University of Minnesota St Paul MN 55108 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Clinical Sciences Department University of Minnesota St Paul MN 55108 USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077140922","display_name":"Antonella Borgatti","orcid":"https://orcid.org/0000-0003-1939-0611","observed_orcids":["https://orcid.org/0000-0003-1939-0611"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Borgatti","raw_affiliation_strings":["Veterinary Clinical Sciences Department University of Minnesota St Paul MN 55108 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Clinical Sciences Department University of Minnesota St Paul MN 55108 USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Henson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Henson","raw_affiliation_strings":["Veterinary Clinical Sciences Department University of Minnesota St Paul MN 55108 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Clinical Sciences Department University of Minnesota St Paul MN 55108 USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056480233","display_name":"Brian D. Husbands","orcid":"https://orcid.org/0000-0003-0966-4439","observed_orcids":["https://orcid.org/0000-0003-0966-4439"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Husbands","raw_affiliation_strings":["Veterinary Clinical Sciences Department University of Minnesota St Paul MN 55108 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Clinical Sciences Department University of Minnesota St Paul MN 55108 USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":4520,"currency":"USD","value_usd":4520},"apc_paid":null,"fwci":3.9487,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.94146656,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"56","issue":"7","first_page":"425","last_page":"429"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canine-histiocytic-sarcoma","display_name":"canine histiocytic sarcoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lomustine","display_name":"lomustine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":1.0},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9789999723434448},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6349999904632568},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.8790000081062317},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.40700000524520874},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2779434656","wikidata":"https://www.wikidata.org/wiki/Q415378","display_name":"Lomustine","level":5,"score":0.9831492304801941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9497597813606262},{"id":"https://openalex.org/C2777578932","wikidata":"https://www.wikidata.org/wiki/Q5773034","display_name":"Histiocytic sarcoma","level":3,"score":0.9193819761276245},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6580632925033569},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5823419094085693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.534675657749176},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.513974130153656},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.4633297324180603},{"id":"https://openalex.org/C2908752941","wikidata":"https://www.wikidata.org/wiki/Q1710882","display_name":"Canine Lymphoma","level":3,"score":0.42343869805336},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4019165635108948},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38749951124191284},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38493767380714417},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33344346284866333},{"id":"https://openalex.org/C43100952","wikidata":"https://www.wikidata.org/wiki/Q654612","display_name":"Histiocyte","level":2,"score":0.30693691968917847},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.25387221574783325}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008130","descriptor_name":"Lomustine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054747","descriptor_name":"Histiocytic Sarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D054747","descriptor_name":"Histiocytic Sarcoma","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/jsap.12354","doi":"https://doi.org/10.1111/jsap.12354","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jsap.12354","pdf_url":null,"source":{"id":"https://openalex.org/S79984219","display_name":"Journal of Small Animal Practice","issn_l":"0022-4510","issn":["0022-4510","1748-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Small Animal Practice","raw_type":"journal-article"},{"id":"pmid:25828786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25828786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of small animal practice","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1549793505","https://openalex.org/W1624109424","https://openalex.org/W1702196088","https://openalex.org/W1989454836","https://openalex.org/W2004037456","https://openalex.org/W2007450618","https://openalex.org/W2009951980","https://openalex.org/W2037694273","https://openalex.org/W2071578867","https://openalex.org/W2097055773","https://openalex.org/W2108567554","https://openalex.org/W2119032282","https://openalex.org/W2140623005","https://openalex.org/W2157007561","https://openalex.org/W2213268081","https://openalex.org/W4205388838","https://openalex.org/W4246659857","https://openalex.org/W4256390741"],"related_works":["https://openalex.org/W4294073932","https://openalex.org/W2625414225","https://openalex.org/W4389315430","https://openalex.org/W2790075896","https://openalex.org/W2313797532","https://openalex.org/W1979724799","https://openalex.org/W1996269853","https://openalex.org/W6958553268","https://openalex.org/W3011332029","https://openalex.org/W2092523303"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"describe":[2],"a":[3,110],"chemotherapy":[4,76],"protocol":[5,145],"combining":[6],"lomustine":[7,33],"and":[8,16,34,59,159],"doxorubicin":[9,35],"in":[10,99,155],"canine":[11,152],"histiocytic":[12,29,153],"sarcoma,":[13],"including":[14],"outcomes":[15],"toxicity.":[17],"MATERIALS":[18],"AND":[19],"METHODS:":[20],"Retrospective":[21],"review":[22],"of":[23,51,75,80,101,116],"case":[24],"records":[25],"for":[26,123],"dogs":[27,87],"with":[28,32,109],"sarcoma":[30,154],"treated":[31],"(\u00b1":[36],"cyclophosphamide)":[37],"alternating":[38],"every":[39],"2":[40],"weeks.":[41],"Data":[42],"collected":[43],"included":[44],"signalment,":[45],"clinical":[46],"signs,":[47],"clinicopathological":[48],"abnormalities,":[49],"extent":[50],"disease,":[52],"response,":[53],"toxicity,":[54],"time":[55,112,129],"to":[56,91,113,120,133,166],"tumour":[57,114],"progression":[58,115],"survival":[60,128],"time.":[61],"RESULTS:":[62],"Of":[63],"17":[64],"dogs,":[65],"15":[66],"had":[67,148],"disseminated":[68],"or":[69,96],"metastatic":[70],"disease.":[71,93],"The":[72,103,125,144],"median":[73,111,127],"number":[74],"cycles":[77],"(one":[78],"dose":[79],"each":[81],"drug)":[82],"received":[83],"was":[84,107,130],"three;":[85],"most":[86],"discontinued":[88],"therapy":[89],"due":[90],"progressive":[92],"Dose":[94],"reductions":[95],"delays":[97],"occurred":[98],"18%":[100],"cycles.":[102],"overall":[104,126],"response":[105],"rate":[106],"58%,":[108],"185":[117,131],"(range,":[118],"59":[119],"268)":[121],"days":[122],"responders.":[124],"(18":[132],"402)":[134],"days.":[135],"No":[136],"significant":[137],"prognostic":[138],"factors":[139],"were":[140],"identified.":[141],"CLINICAL":[142],"SIGNIFICANCE:":[143],"appeared":[146],"well-tolerated,":[147],"some":[149],"efficacy":[150],"against":[151],"the":[156],"study":[157],"population":[158],"could":[160],"be":[161,172],"considered":[162],"as":[163],"an":[164],"alternative":[165],"single-agent":[167],"protocols;":[168],"prospective":[169],"comparison":[170],"may":[171],"warranted.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}