{"id":"https://openalex.org/W2136569697","doi":null,"title":"Suppression of T-lymphoma cell apoptosis by monoclonal antibodies raised against cell surface adhesion molecules.","display_name":"Suppression of T-lymphoma cell apoptosis by monoclonal antibodies raised against cell surface adhesion molecules.","publication_year":1993,"publication_date":"1993-10-15","ids":{"openalex":"https://openalex.org/W2136569697","mag":"2136569697","pmid":"https://pubmed.ncbi.nlm.nih.gov/8402694"},"language":"en","primary_location":{"id":"pmid:8402694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8402694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000523070","display_name":"Naoya Fujita","orcid":"https://orcid.org/0000-0002-9631-9264","observed_orcids":["https://orcid.org/0000-0002-9631-9264"]},"institutions":[{"id":"https://openalex.org/I4405286657","display_name":"Institute for Quantitative Biosciences, The University of Tokyo","ror":"https://ror.org/02qwvne14","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286657","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Fujita","raw_affiliation_strings":["Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan","institution_ids":["https://openalex.org/I4405286657","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055461062","display_name":"Shinichi Kataoka","orcid":"https://orcid.org/0000-0003-3292-4139","observed_orcids":["https://orcid.org/0000-0003-3292-4139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Kataoka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111468908","display_name":"Mikihiko Naito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Naito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043935267","display_name":"Yuji Heike","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Heike","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010090426","display_name":"Narikazu Boku","orcid":"https://orcid.org/0000-0002-1438-707X","observed_orcids":["https://orcid.org/0000-0002-1438-707X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Boku","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021593247","display_name":"Motowo Nakajima","orcid":"https://orcid.org/0000-0001-7687-6365","observed_orcids":["https://orcid.org/0000-0001-7687-6365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Nakajima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112158124","display_name":"Takashi TSURUO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Tsuruo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8135,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.67850736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"53","issue":"20","first_page":"5022","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.3375999927520752,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.3375999927520752,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.23250000178813934,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.23100000619888306,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-lymphoma","display_name":"T-cell lymphoma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.8519999980926514},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9869999885559082},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/paracrine-growth-factors","display_name":"paracrine growth factors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/cell-surface-receptors","display_name":"cell surface receptors","score":0.42100000381469727},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7933011651039124},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5732710957527161},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5148800611495972},{"id":"https://openalex.org/C125864771","wikidata":"https://www.wikidata.org/wiki/Q13360240","display_name":"Lymph node stromal cell","level":3,"score":0.5133273005485535},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.47027093172073364},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45297566056251526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4526238441467285},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4226633310317993},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4206797778606415},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3929058313369751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35647597908973694},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3503870964050293},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.334303081035614},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26250553131103516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10195425152778625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8402694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8402694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2136569697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8402694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W29671035","https://openalex.org/W1517746878","https://openalex.org/W1541355533","https://openalex.org/W1985572665","https://openalex.org/W2000036320","https://openalex.org/W2010215050","https://openalex.org/W2013381560","https://openalex.org/W2015028428","https://openalex.org/W2020653496","https://openalex.org/W2031209863","https://openalex.org/W2037067921","https://openalex.org/W2040232267","https://openalex.org/W2043825701","https://openalex.org/W2057091891","https://openalex.org/W2074114480","https://openalex.org/W2074278764","https://openalex.org/W2079420925","https://openalex.org/W2088023845","https://openalex.org/W2096428903","https://openalex.org/W2100837269","https://openalex.org/W2104947013","https://openalex.org/W2122079287","https://openalex.org/W2143937597","https://openalex.org/W2153520135","https://openalex.org/W2345226429","https://openalex.org/W2398323541","https://openalex.org/W2402326353","https://openalex.org/W2409258959","https://openalex.org/W2418391690","https://openalex.org/W2439832548"],"related_works":["https://openalex.org/W2410775317","https://openalex.org/W4243018003","https://openalex.org/W2020653496","https://openalex.org/W2229062730","https://openalex.org/W1979845451","https://openalex.org/W1517949169","https://openalex.org/W2036762513","https://openalex.org/W2419473781","https://openalex.org/W2407461647","https://openalex.org/W2046125843"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"established":[3],"a":[4,65,106,119,128],"mouse":[5],"malignant":[6],"T-lymphoma":[7],"CS-21":[8,24,43,61,72,92,103,114,140,151,174,204,229,236],"cell":[9,51,73,77,82,93,109,122,141,152,206,224,237],"line":[10],"that":[11,197,231],"preferentially":[12],"metastasizes":[13],"to":[14,64,105,134,138,158,234],"lymph":[15,40,199],"nodes":[16],"after":[17],"s.c.":[18],"inoculation":[19],"into":[20],"BALB/c":[21],"mice.":[22],"The":[23],"lymphoma":[25,175,205],"cells":[26,37,44,62,70,104,149,176,202,230],"were":[27,45,132,155],"grown":[28],"in":[29,31,184],"vitro":[30],"the":[32,58,81,100,162,185,218],"presence":[33,163],"of":[34,60,67,102,164,192,228],"CA-12":[35,68,107,147,188,198],"stromal":[36,69,108,148,166,189,201],"isolated":[38],"from":[39,146],"nodes.":[41],"When":[42],"cultured":[46],"alone,":[47],"they":[48],"underwent":[49],"apoptotic":[50],"death":[52],"with":[53,187],"DNA":[54],"fragmentation.":[55],"In":[56,161],"contrast,":[57],"culture":[59],"attached":[63],"monolayer":[66],"prevented":[71],"apoptosis":[74,136,178],"and":[75,125,137,169,179,213,221],"enhanced":[76,150],"proliferation.":[78],"To":[79],"identify":[80],"adhesion":[83,226],"molecules,":[84],"we":[85,195],"developed":[86],"monoclonal":[87],"antibodies":[88],"(mAbs)":[89],"directed":[90,117],"against":[91,113,118,127],"surface":[94,225],"proteins.":[95],"Fourteen":[96],"mAbs":[97,170],"partially":[98],"inhibited":[99],"binding":[101],"monolayer.":[110],"MCS-5":[111,171],"(mAb":[112],"No.":[115],"5)":[116],"M(r)":[120,129,219,222],"168,000":[121,220],"membrane":[123],"protein":[124,131],"MCS-19":[126],"23,000":[130,223],"found":[133],"suppress":[135],"stimulate":[139],"growth.":[142],"Soluble":[143],"factors":[144,168,212],"secreted":[145],"growth":[153,207,211],"but":[154],"not":[156],"sufficient":[157],"prevent":[159,235],"apoptosis.":[160,238],"both":[165],"cell-secreted":[167],"or":[172],"MCS-19,":[173],"evaded":[177],"grew":[180],"as":[181,183],"fast":[182],"coculture":[186],"cells.":[190],"Because":[191],"these":[193],"results,":[194],"conclude":[196],"node":[200],"support":[203],"by":[208,214],"secreting":[209],"paracrine":[210],"presenting":[215],"receptors":[216],"for":[217],"molecules":[227],"transmit":[232],"signals":[233]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}