{"id":"https://openalex.org/W2136559579","doi":"https://doi.org/10.1128/iai.73.1.287-297.2005","title":"The Clinical-Grade 42-Kilodalton Fragment of Merozoite Surface Protein 1 ofPlasmodium falciparumStrain FVO Expressed inEscherichia coliProtectsAotus nancymaiagainst Challenge with Homologous Erythrocytic-Stage Parasites","display_name":"The Clinical-Grade 42-Kilodalton Fragment of Merozoite Surface Protein 1 ofPlasmodium falciparumStrain FVO Expressed inEscherichia coliProtectsAotus nancymaiagainst Challenge with Homologous Erythrocytic-Stage Parasites","publication_year":2004,"publication_date":"2004-12-23","ids":{"openalex":"https://openalex.org/W2136559579","doi":"https://doi.org/10.1128/iai.73.1.287-297.2005","mag":"2136559579","pmid":"https://pubmed.ncbi.nlm.nih.gov/15618165","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/538964"},"language":"en","primary_location":{"id":"doi:10.1128/iai.73.1.287-297.2005","doi":"https://doi.org/10.1128/iai.73.1.287-297.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.73.1.287-297.2005","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/538964","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017445482","display_name":"Christian A. Darko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian A. Darko","raw_affiliation_strings":["Department of Immunology, Walter Reed Army Institute of Research, Silver Spring","Department of Immunology, Walter Reed Army Institute of Research, 503 Robert Grant Ave., Silver Spring, MD 20910, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Walter Reed Army Institute of Research, Silver Spring","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"Department of Immunology, Walter Reed Army Institute of Research, 503 Robert Grant Ave., Silver Spring, MD 20910, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084564556","display_name":"Evelina Angov","orcid":"https://orcid.org/0000-0001-9186-4098","observed_orcids":["https://orcid.org/0000-0001-9186-4098"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Evelina Angov","raw_affiliation_strings":["Department of Immunology, Walter Reed Army Institute of Research, Silver Spring"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Walter Reed Army Institute of Research, Silver Spring","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103513838","display_name":"William E. Collins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Collins","raw_affiliation_strings":["Division of Parasitic Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Parasitic Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090960821","display_name":"Elke S. Bergmann\u2010Leitner","orcid":"https://orcid.org/0000-0002-8571-8956","observed_orcids":["https://orcid.org/0000-0002-8571-8956"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elke S. Bergmann-Leitner","raw_affiliation_strings":["Department of Immunology, Walter Reed Army Institute of Research, Silver Spring"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Walter Reed Army Institute of Research, Silver Spring","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065783040","display_name":"Autumn S. Girouard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Autumn S. Girouard","raw_affiliation_strings":["Department of Immunology, Walter Reed Army Institute of Research, Silver Spring"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Walter Reed Army Institute of Research, Silver Spring","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038615975","display_name":"Stacy L. Hitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacy L. Hitt","raw_affiliation_strings":["Department of Immunology, Walter Reed Army Institute of Research, Silver Spring"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Walter Reed Army Institute of Research, Silver Spring","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111557809","display_name":"Jana S. McBride","orcid":"https://orcid.org/0009-0002-7651-7957","observed_orcids":["https://orcid.org/0009-0002-7651-7957"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jana S. McBride","raw_affiliation_strings":["School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113639232","display_name":"Carter L. Diggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801582665","display_name":"United States Agency for International Development","ror":"https://ror.org/01n6e6j62","country_code":"US","type":"government","lineage":["https://openalex.org/I2801582665"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carter L. Diggs","raw_affiliation_strings":["USAID Malaria Vaccine Development Program, U.S. Agency for International Development, Washington, D.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USAID Malaria Vaccine Development Program, U.S. Agency for International Development, Washington, D.C","institution_ids":["https://openalex.org/I2801582665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076699881","display_name":"Anthony A. Holder","orcid":"https://orcid.org/0000-0002-8490-6058","observed_orcids":["https://orcid.org/0000-0002-8490-6058"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony A. Holder","raw_affiliation_strings":["Division of Parasitology, National Institute for Medical Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Parasitology, National Institute for Medical Research, London, United Kingdom","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028156362","display_name":"Carole A. Long","orcid":"https://orcid.org/0000-0002-3835-5443","observed_orcids":["https://orcid.org/0000-0002-3835-5443"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carole A. Long","raw_affiliation_strings":["Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107825853","display_name":"John W. Barnwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Barnwell","raw_affiliation_strings":["Division of Parasitic Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Parasitic Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113543256","display_name":"Jeffrey A. Lyon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Lyon","raw_affiliation_strings":["Department of Immunology, Walter Reed Army Institute of Research, Silver Spring"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Walter Reed Army Institute of Research, Silver Spring","institution_ids":["https://openalex.org/I92664306"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5084564556"],"corresponding_institution_ids":["https://openalex.org/I92664306"],"apc_list":null,"apc_paid":null,"fwci":6.4522,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.96559131,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"73","issue":"1","first_page":"287","last_page":"297"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/merozoite-surface-protein-1","display_name":"merozoite surface protein 1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9850000143051147},{"id":"https://openalex.org/keywords/malaria-vaccine","display_name":"malaria vaccine","score":0.7020000219345093},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.6349999904632568},{"id":"https://openalex.org/keywords/egf-like-domain","display_name":"EGF-like domain","score":0.7379999756813049},{"id":"https://openalex.org/keywords/protective-immunity","display_name":"protective immunity","score":0.6200000047683716},{"id":"https://openalex.org/keywords/homologous-challenge","display_name":"homologous challenge","score":0.6499999761581421},{"id":"https://openalex.org/keywords/monoclonal-antibody-reactivity","display_name":"monoclonal antibody reactivity","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8883936405181885},{"id":"https://openalex.org/C2781034427","wikidata":"https://www.wikidata.org/wiki/Q6741353","display_name":"Malaria vaccine","level":4,"score":0.6563518047332764},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.6481682062149048},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6223456859588623},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6132338047027588},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5582839250564575},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.504953920841217},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.49371203780174255},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4878106415271759},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4730493128299713},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.4476291239261627},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4352726936340332},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.2288288176059723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14819759130477905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13629955053329468},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07879498600959778}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016645","descriptor_name":"Aotidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020066","descriptor_name":"Merozoite Surface Protein 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020066","descriptor_name":"Merozoite Surface Protein 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.73.1.287-297.2005","doi":"https://doi.org/10.1128/iai.73.1.287-297.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.73.1.287-297.2005","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2001258","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/538964","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:538964","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/538964","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:15618165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15618165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2001258","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/538964","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1300443776","display_name":null,"funder_award_id":"YIAI-0438-03","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1646733304","display_name":null,"funder_award_id":"CDC C100-042","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306115","display_name":"United States Agency for International Development","ror":"https://ror.org/01n6e6j62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338280","display_name":"Medical Research and Materiel Command","ror":"https://ror.org/03cd02q50"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1482401645","https://openalex.org/W1502040156","https://openalex.org/W1534267102","https://openalex.org/W1813288331","https://openalex.org/W1841669337","https://openalex.org/W1945802668","https://openalex.org/W1962127316","https://openalex.org/W1965543649","https://openalex.org/W1969251343","https://openalex.org/W1981774682","https://openalex.org/W1984303903","https://openalex.org/W1989672476","https://openalex.org/W1991449344","https://openalex.org/W2005843225","https://openalex.org/W2036875255","https://openalex.org/W2038322646","https://openalex.org/W2050101049","https://openalex.org/W2053643682","https://openalex.org/W2062972555","https://openalex.org/W2065262834","https://openalex.org/W2067620951","https://openalex.org/W2069448387","https://openalex.org/W2083971605","https://openalex.org/W2089035318","https://openalex.org/W2097448853","https://openalex.org/W2104936846","https://openalex.org/W2105920586","https://openalex.org/W2110134485","https://openalex.org/W2119234385","https://openalex.org/W2156461736","https://openalex.org/W2161149598","https://openalex.org/W2162134485","https://openalex.org/W2164209355","https://openalex.org/W2171988175","https://openalex.org/W2394668152","https://openalex.org/W2404802722","https://openalex.org/W2414578611"],"related_works":["https://openalex.org/W1984303903","https://openalex.org/W2129316783","https://openalex.org/W1813288331","https://openalex.org/W2474633587","https://openalex.org/W2166746681","https://openalex.org/W2105920586","https://openalex.org/W2171988175","https://openalex.org/W7099594195","https://openalex.org/W2097448853","https://openalex.org/W2164209355"],"abstract_inverted_index":{"A":[0],"42-kDa":[1],"fragment":[2,32,226,235],"from":[3,33],"the":[4,16,34,143,155,184,189,196,219,224,228,240,245],"C":[5],"terminus":[6],"of":[7,39,66,146,188,236,263],"major":[8],"merozoite":[9],"surface":[10],"protein":[11,47,61,242],"1":[12,248],"(MSP1)":[13],"is":[14],"among":[15],"leading":[17],"malaria":[18,27,83,132],"vaccine":[19,265],"candidates":[20],"that":[21,89,192],"target":[22],"infection":[23],"by":[24,118,173,183],"asexual":[25],"erythrocytic-stage":[26,131,267],"parasites.":[28,133],"The":[29,112,134],"MSP1(42)":[30,160,176,199,241,251],"gene":[31],"Vietnam-Oak":[35],"Knoll":[36],"(FVO)":[37,161,252],"strain":[38],"Plasmodium":[40,147],"falciparum":[41,82,129,268],"was":[42,71,115],"expressed":[43,253],"as":[44,69,150,162,260],"a":[45,151,163,261,264],"soluble":[46],"in":[48,94,107,214,254],"Escherichia":[49],"coli":[50,175,198,256],"and":[51,98,103,123,154,227],"purified":[52],"according":[53],"to":[54,92],"good":[55],"manufacturing":[56],"practices.":[57],"This":[58],"clinical-grade":[59],"recombinant":[60],"retained":[62],"some":[63],"important":[64],"elements":[65],"correct":[67],"structure,":[68],"it":[70,85,99],"reactive":[72,91],"with":[73,126,142,158,195,218],"several":[74],"functional,":[75],"conformation-dependent":[76],"monoclonal":[77],"antibodies":[78,87],"raised":[79],"against":[80,223,266],"P.":[81,128],"parasites,":[84],"induced":[86,100,172,182],"(Abs)":[88],"were":[90,177,193],"parasites":[93],"immunofluorescent":[95],"Ab":[96,170,221],"tests,":[97],"strong":[101],"growth":[102,230],"invasion":[104],"inhibitory":[105],"antisera":[106],"New":[108],"Zealand":[109],"White":[110],"rabbits.":[111],"antigen":[113,145,200],"quality":[114],"further":[116],"evaluated":[117],"vaccinating":[119],"Aotus":[120],"nancymai":[121],"monkeys":[122,191,216],"challenging":[124],"them":[125],"homologous":[127],"FVO":[130],"trial":[135],"included":[136],"two":[137,207],"control":[138],"groups,":[139],"one":[140],"vaccinated":[141,157,194],"sexual-stage-specific":[144],"vivax,":[148],"Pvs25,":[149],"negative":[152],"control,":[153],"other":[156],"baculovirus-expressed":[159,185],"positive":[164],"control.":[165],"Enzyme-linked":[166],"immunosorbent":[167],"assay":[168],"(ELISA)":[169],"titers":[171],"E.":[174,197,255],"significantly":[178],"higher":[179],"than":[180],"those":[181],"antigen.":[186],"None":[187],"six":[190],"required":[201,208],"treatment":[202,209],"for":[203,210],"uncontrolled":[204],"parasitemia,":[205],"but":[206,238],"anemia.":[211],"Protective":[212],"immunity":[213],"these":[215],"correlated":[217],"ELISA":[220],"titer":[222],"p19":[225],"epidermal":[229],"factor":[231],"(EGF)-like":[232],"domain":[233,247],"2":[234],"MSP1(42),":[237],"not":[239],"itself":[243],"or":[244],"EGF-like":[246],"fragment.":[249],"Soluble":[250],"offers":[257],"excellent":[258],"promise":[259],"component":[262],"malaria.":[269]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}