{"id":"https://openalex.org/W2136559526","doi":"https://doi.org/10.1093/rheumatology/keg449","title":"Decreased levels of serum soluble complement receptor-II (CR2/CD21) in patients with rheumatoid arthritis","display_name":"Decreased levels of serum soluble complement receptor-II (CR2/CD21) in patients with rheumatoid arthritis","publication_year":2003,"publication_date":"2003-09-16","ids":{"openalex":"https://openalex.org/W2136559526","doi":"https://doi.org/10.1093/rheumatology/keg449","mag":"2136559526","pmid":"https://pubmed.ncbi.nlm.nih.gov/12867574"},"language":"en","primary_location":{"id":"doi:10.1093/rheumatology/keg449","doi":"https://doi.org/10.1093/rheumatology/keg449","is_oa":false,"landing_page_url":"https://doi.org/10.1093/rheumatology/keg449","pdf_url":null,"source":{"id":"https://openalex.org/S4210231286","display_name":"British journal of rheumatology","issn_l":"0263-7103","issn":["0263-7103","1460-2172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003802328","display_name":"Madhan Masilamani","orcid":"https://orcid.org/0000-0001-8181-8848","observed_orcids":["https://orcid.org/0000-0001-8181-8848"]},"institutions":[{"id":"https://openalex.org/I189712700","display_name":"University of Konstanz","ror":"https://ror.org/0546hnb39","country_code":"DE","type":"education","lineage":["https://openalex.org/I189712700"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"M. Masilamani","raw_affiliation_strings":["Department of Biology, Immunology, Faculty of Sciences, University of Konstanz, Konstanz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Immunology, Faculty of Sciences, University of Konstanz, Konstanz, Germany","institution_ids":["https://openalex.org/I189712700"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003802328"],"corresponding_institution_ids":["https://openalex.org/I189712700"],"apc_list":null,"apc_paid":null,"fwci":1.2214,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.77406532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"43","issue":"2","first_page":"186","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7900000214576721},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7099999785423279},{"id":"https://openalex.org/keywords/age-specific-reference-values","display_name":"age-related reference values","score":0.5630000233650208},{"id":"https://openalex.org/keywords/rheumatoid-factor","display_name":"rheumatoid factor","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8566299676895142},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6031292676925659},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5876662731170654},{"id":"https://openalex.org/C34814297","wikidata":"https://www.wikidata.org/wiki/Q4845302","display_name":"CD23","level":4,"score":0.5361993312835693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4610997140407562},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4554159641265869},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32275527715682983},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3113681674003601},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017464","descriptor_name":"Receptors, Complement 3d","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/rheumatology/keg449","doi":"https://doi.org/10.1093/rheumatology/keg449","is_oa":false,"landing_page_url":"https://doi.org/10.1093/rheumatology/keg449","pdf_url":null,"source":{"id":"https://openalex.org/S4210231286","display_name":"British journal of rheumatology","issn_l":"0263-7103","issn":["0263-7103","1460-2172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},{"id":"pmid:12867574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12867574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:doc.rero.ch:290974","doi":null,"is_oa":false,"landing_page_url":"http://doc.rero.ch/record/290974/files/keg449.pdf","pdf_url":"http://doc.rero.ch/record/290974/files/keg449.pdf","source":{"id":"https://openalex.org/S4306400148","display_name":"reroDoc Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:pub.h-brs.de:3797","doi":null,"is_oa":false,"landing_page_url":"https://pub.h-brs.de/frontdoor/index/index/docId/3797","pdf_url":null,"source":{"id":"https://openalex.org/S4306400385","display_name":"Publication Server of Bonn-Rhein-Sieg University of Applied Sciences (Bonn-Rhein-Sieg University of Applied Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135140700","host_organization_name":"University of Bonn","host_organization_lineage":["https://openalex.org/I135140700"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN 1462-0324","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6057834384","display_name":"Verbundprojekt: Verbund Proteom-Analyse: Charakterisierung stadienspezifischer Gen- und Proteinexpression in einem k\u00fcnstlichen in vitro Pannusgewebe","funder_award_id":"01GG9834/1","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1943277847","https://openalex.org/W1990158052","https://openalex.org/W2003743580","https://openalex.org/W2015873999","https://openalex.org/W2019724467","https://openalex.org/W2050587051","https://openalex.org/W2054322014","https://openalex.org/W2063389584","https://openalex.org/W2065419533","https://openalex.org/W2083268627","https://openalex.org/W2101882317","https://openalex.org/W2144058261","https://openalex.org/W2149103649","https://openalex.org/W2152294634","https://openalex.org/W2152348310","https://openalex.org/W2187375650","https://openalex.org/W6651185533"],"related_works":["https://openalex.org/W2063048253","https://openalex.org/W7135249817","https://openalex.org/W2052883175","https://openalex.org/W2490575616","https://openalex.org/W2373724028","https://openalex.org/W2029605535","https://openalex.org/W6976859797","https://openalex.org/W4337941","https://openalex.org/W1976847502","https://openalex.org/W2029736603"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,56,122],"soluble":[2],"cluster":[3],"of":[4,12,41,64,91,125,136,178,200,203,215,220,227],"differentiation":[5],"21":[6],"(sCD21)":[7],"represents":[8],"the":[9,13,89,201,204,228],"extracellular":[10],"portion":[11],"CD21":[14,27,119,216],"glycoprotein":[15],"and":[16,31,52,100,108,112,114,133,175,225],"is":[17],"released":[18,213],"by":[19],"shedding":[20],"from":[21,82,105,139,162,209],"cell":[22],"surfaces":[23],"into":[24],"plasma.":[25],"Soluble":[26],"binds":[28],"complement":[29],"fragments":[30],"activates":[32],"monocytes":[33],"through":[34],"binding":[35],"to":[36,61,80,141,164,184],"membrane":[37],"CD23.":[38],"Elevated":[39],"levels":[40,63,160,195],"sCD21":[42,65,92,127,159,194],"are":[43,230],"found":[44],"during":[45],"Epstein-Barr":[46],"virus":[47],"EBV":[48],"infections,":[49],"B-cell":[50],"lymphoma":[51],"other":[53],"lymphoblastoid":[54],"tumours.":[55],"present":[57],"study":[58],"was":[59,74],"undertaken":[60],"investigate":[62],"in":[66,94,128],"rheumatoid":[67,109,156,179,189,210],"arthritis.":[68],"METHODS:":[69],"A":[70],"specific":[71],"enzyme-linked":[72],"immunoassay":[73],"developed":[75],"using":[76],"sCD21,":[77],"biochemically":[78],"purified":[79],"homogeneity":[81],"human":[83],"plasma":[84],"as":[85],"a":[86],"standard":[87],"for":[88,118],"determination":[90],"concentration":[93],"patient":[95],"sera.":[96],"Peripheral":[97],"blood":[98],"B":[99,207],"T":[101],"lymphocytes":[102],"were":[103,116,176],"isolated":[104],"healthy":[106,129,185],"donors":[107],"arthritis":[110,157,190,211],"patients":[111,187,212],"cultured,":[113],"supernatants":[115],"analysed":[117],"shedding.":[120],"RESULTS:":[121],"normal":[123,221],"values":[124],"serum":[126],"individuals":[130],"between":[131],"20":[132],"40":[134],"yr":[135],"age":[137,149,174,202],"ranged":[138,161],"100":[140],"477":[142],"ng/ml":[143,166],"(median":[144,167],"292":[145],"ng/ml),":[146,169],"decreasing":[147],"with":[148,153,173,188,218],"but":[150],"not":[151,171],"differing":[152],"gender.":[154],"In":[155,182],"patients,":[158],"50":[163],"300":[165],"182":[168],"did":[170],"differ":[172],"independent":[177],"factor.":[180],"CONCLUSIONS:":[181],"contrast":[183],"donors,":[186],"have":[191],"significantly":[192],"lower":[193],"(P":[196],"<":[197],"0.0001),":[198],"independently":[199],"patients.":[205],"Sorted":[206],"cells":[208],"amounts":[214],"comparable":[217],"those":[219],"controls.":[222],"Possible":[223],"causes":[224],"consequences":[226],"findings":[229],"discussed.":[231]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}