{"id":"https://openalex.org/W2136555176","doi":null,"title":"Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display.","display_name":"Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display.","publication_year":2001,"publication_date":"2001-12-15","ids":{"openalex":"https://openalex.org/W2136555176","mag":"2136555176","pmid":"https://pubmed.ncbi.nlm.nih.gov/11751411"},"language":"en","primary_location":{"id":"pmid:11751411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11751411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087091914","display_name":"Jing\u2010Gung Chung","orcid":"https://orcid.org/0000-0002-7303-2287","observed_orcids":["https://orcid.org/0000-0002-7303-2287"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"J G Chung","raw_affiliation_strings":["Department of Microbiology, School of Medicine, Institute of Associated Chinese and Western Medicine, China Medical College, Taichung 40421, Taiwan, Rebublic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, School of Medicine, Institute of Associated Chinese and Western Medicine, China Medical College, Taichung 40421, Taiwan, Rebublic of China","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045333057","display_name":"Kun\u2010Tu Yeh","orcid":"https://orcid.org/0000-0003-0665-8586","observed_orcids":["https://orcid.org/0000-0003-0665-8586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K T Yeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076376944","display_name":"Shenglong Wu","orcid":"https://orcid.org/0000-0003-3876-9483","observed_orcids":["https://orcid.org/0000-0003-3876-9483","https://orcid.org/0009-0004-9807-3300","https://orcid.org/0000-0002-0954-6312"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S L Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110397143","display_name":"N. Y. Hsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Y Hsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056929833","display_name":"Guang\u2010Wu Chen","orcid":"https://orcid.org/0000-0002-5322-4839","observed_orcids":["https://orcid.org/0000-0002-5322-4839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G W Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039235123","display_name":"Y W Yeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y W Yeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"H C Ho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H C Ho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5775,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.58465817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"61","issue":"24","first_page":"8873","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.09860000014305115,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mitofusin-1","display_name":"mitofusin 1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.953000009059906},{"id":"https://openalex.org/keywords/exon-deletion","display_name":"exon deletion","score":0.5759999752044678},{"id":"https://openalex.org/keywords/protein-isoforms","display_name":"protein isoforms","score":0.5529999732971191},{"id":"https://openalex.org/keywords/plasma-membrane-localization","display_name":"plasma membrane localization","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7679761648178101},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7495133876800537},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.7342175841331482},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6858929395675659},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5883621573448181},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4977472126483917},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.4392828941345215},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.4374348521232605},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4356377124786377},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.41805338859558105},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4177708327770233},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4054625332355499},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11751411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11751411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2136555176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11751411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W44035196","https://openalex.org/W1501296331","https://openalex.org/W1601987151","https://openalex.org/W1627698625","https://openalex.org/W1716367672","https://openalex.org/W1898862743","https://openalex.org/W1969931302","https://openalex.org/W1971438777","https://openalex.org/W1974234931","https://openalex.org/W1978368163","https://openalex.org/W1983251909","https://openalex.org/W1997349466","https://openalex.org/W2014229034","https://openalex.org/W2014781571","https://openalex.org/W2056496184","https://openalex.org/W2060844515","https://openalex.org/W2065018956","https://openalex.org/W2065717811","https://openalex.org/W2073969754","https://openalex.org/W2103224845","https://openalex.org/W2115780677","https://openalex.org/W2127265303","https://openalex.org/W2133498336","https://openalex.org/W2144846851","https://openalex.org/W2145485258","https://openalex.org/W2147207574","https://openalex.org/W2147694156","https://openalex.org/W2149401899","https://openalex.org/W2153330273","https://openalex.org/W2163403085","https://openalex.org/W2164249947"],"related_works":["https://openalex.org/W2033475930","https://openalex.org/W2898383530","https://openalex.org/W1579307773","https://openalex.org/W2077949933","https://openalex.org/W4237723904","https://openalex.org/W2168833294","https://openalex.org/W3208223596","https://openalex.org/W2362718634","https://openalex.org/W4255889608","https://openalex.org/W2039292788"],"abstract_inverted_index":{"The":[0,55,82,151,171,259],"technique":[1],"of":[2,14,36,58,68,77,106,120,138,141,146,174,187,213,231,255,264,308],"differential":[3],"display":[4],"was":[5,61,114,160,177,199,235,247,282,314],"used":[6],"previously":[7],"to":[8,47,63,132,163,218],"profile":[9],"the":[10,75,89,93,104,117,121,125,133,143,211,214,219,229,239,253,265,285,299,306],"gene":[11,56],"expression":[12,173,260],"patterns":[13],"non-small":[15,189],"cell":[16,158,190,203],"lung":[17,156,191],"cancer,":[18],"and":[19,92,206,250,261,268,298],"several":[20],"genes":[21],"differentially":[22],"expressed":[23],"were":[24,130,272],"thus":[25],"identified.":[26],"In":[27],"this":[28],"report,":[29],"we":[30],"demonstrate":[31],"that":[32,88,127,284],"a":[33,52,65,111,195],"DNA":[34],"fragment":[35],"347-bp":[37],"length,":[38],"up-regulated":[39,172],"in":[40,116,154,166,180,202,311],"tumor":[41,181,312],"tissues,":[42],"showed":[43],"100%":[44],"sequence":[45,80,84,123,208,221],"similarity":[46],"human":[48,97],"cDNA":[49,59,90,94],"FLJ20693":[50,60,91],"for":[51,79,95],"370-residue":[53],"protein.":[54],"product":[57,198,246],"postulated":[62],"be":[64],"shorter":[66,270,300],"isoform":[67],"transmembrane":[69,175,309],"GTPase,":[70],"termed":[71],"TG370,":[72],"based":[73],"upon":[74],"results":[76],"searching":[78],"homology.":[81],"nucleotide":[83],"alignment":[85],"also":[86,161],"indicated":[87],"741-residue":[96],"mitofusin":[98],"1":[99],"(TG741)":[100],"possibly":[101],"resulted":[102],"from":[103,109,183],"event":[105],"alternative":[107,152],"splicing":[108,153],"which":[110,142],"127-bp":[112,144],"region":[113,145,216],"retained":[115,302],"latter.":[118],"Analysis":[119],"genome":[122,220],"confirmed":[124],"speculation":[126],"both":[128],"cDNAs":[129],"mapped":[131,217],"same":[134],"chromosomal":[135],"position":[136],"composing":[137],"18":[139],"exons,":[140],"TG741":[147,267,287],"constituted":[148],"exon":[149,225,256],"11.":[150],"all":[155,167],"cancer":[157,192],"lines":[159],"observed":[162,249],"occur":[164],"nearly":[165],"tissue":[168],"specimens":[169],"examined.":[170],"GTPase":[176,310],"subsequently":[178],"found":[179,236],"tissues":[182,313],"at":[184,289,303],"least":[185],"five":[186],"seven":[188],"patients.":[193],"Also,":[194],"distinct":[196],"PCR":[197],"initially":[200],"detected":[201,273],"line":[204],"H520,":[205],"further":[207,315],"analysis":[209],"identified":[210,251],"presence":[212],"86-bp":[215,232],"immediately":[222],"followed":[223],"by":[224,274],"10.":[226],"To":[227],"evaluate":[228],"retention":[230],"region,":[233],"it":[234],"that,":[237],"besides":[238],"predicted":[240],"486-bp":[241],"product,":[242],"an":[243],"unexpected":[244],"332-bp":[245],"concomitantly":[248],"as":[252],"result":[254],"8":[257],"deletion.":[258],"subcellular":[262],"localization":[263],"full-length":[266,286],"other":[269],"isoforms":[271,301],"flow":[275],"cytometry":[276],"using":[277,317],"three":[278],"polyclonal":[279],"antibodies.":[280],"It":[281],"concluded":[283],"located":[288],"plasma":[290],"membrane":[291],"with":[292],"its":[293],"NH(2)-terminal":[294],"domain":[295],"exposed":[296],"extracellularly":[297],"cytosol.":[304],"Finally,":[305],"up-regulation":[307],"illustrated":[316],"immunohistochemical":[318],"staining.":[319]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}