{"id":"https://openalex.org/W2136523955","doi":null,"title":"Role of nonhistone chromosomal proteins in the regulation of histone gene expression.","display_name":"Role of nonhistone chromosomal proteins in the regulation of histone gene expression.","publication_year":1976,"publication_date":"1976-11-01","ids":{"openalex":"https://openalex.org/W2136523955","mag":"2136523955","pmid":"https://pubmed.ncbi.nlm.nih.gov/975064"},"language":"en","primary_location":{"id":"pmid:975064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/975064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110642660","display_name":"Gary Stephen Stein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G S Stein","raw_affiliation_strings":["[University of Florida]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of Florida]","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081119848","display_name":"Janet Lee Stein","orcid":"https://orcid.org/0000-0002-2474-6822","observed_orcids":["https://orcid.org/0000-0002-2474-6822"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Stein","raw_affiliation_strings":["[University of Florida]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of Florida]","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043733403","display_name":"Lewis J. Kleinsmith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L J Kleinsmith","raw_affiliation_strings":["[University of Florida]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of Florida]","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075916745","display_name":"Judith A. Thomson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Thomson","raw_affiliation_strings":["Restorative Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Restorative Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085776374","display_name":"W D Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W D Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064259066","display_name":"Robert L. Jansing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R L Jansing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3735,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.54848789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"11 Pt. 2","first_page":"4307","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-gene-expression","display_name":"histone gene expression","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nonhistone-chromosomal-proteins","display_name":"non-histone proteins","score":0.9679999947547913},{"id":"https://openalex.org/keywords/histone-mrna","display_name":"histone mRNA","score":0.9340000152587891},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.9449999928474426},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/polysomes","display_name":"polysomes","score":0.7770000100135803},{"id":"https://openalex.org/keywords/chromatin-reconstitution","display_name":"chromatin reconstitution","score":0.890999972820282},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/sv40-transformed-fibroblasts","display_name":"SV40-transformed fibroblasts","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hela-s3-cells","display_name":"HeLa S3 cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/wi-38-fibroblasts","display_name":"WI-38 fibroblasts","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C56428682","wikidata":"https://www.wikidata.org/wiki/Q24785535","display_name":"Histone H2A","level":4,"score":0.7297729849815369},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6851776838302612},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6427960395812988},{"id":"https://openalex.org/C101152365","wikidata":"https://www.wikidata.org/wiki/Q838135","display_name":"Histone H1","level":4,"score":0.5998052358627319},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5584652423858643},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5458363890647888},{"id":"https://openalex.org/C10058791","wikidata":"https://www.wikidata.org/wiki/Q910897","display_name":"Histone code","level":5,"score":0.427114337682724},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42358189821243286},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.422819048166275},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.4225093126296997},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3757230341434479},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3575725555419922},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.25528183579444885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24514979124069214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.188899427652359},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.13355520367622375},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.05957403779029846},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011132","descriptor_name":"Polyribosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:975064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/975064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:stein-1192","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/stein/193","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stein, Stein, Lian, vanWijnen Lab Publications","raw_type":"text"},{"id":"mag:2136523955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/975064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W84643335","https://openalex.org/W2959967048","https://openalex.org/W2027419536","https://openalex.org/W2037285029","https://openalex.org/W2107246811","https://openalex.org/W1976873624","https://openalex.org/W3023216090","https://openalex.org/W2023792283","https://openalex.org/W2075044084","https://openalex.org/W1999973020"],"abstract_inverted_index":{"Histone":[0],"gene":[1,116,144,176],"expression":[2,117],"was":[3,35],"studied":[4],"during":[5,63,68,146],"the":[6,57,112,124,147,150,161,172],"cell":[7,151],"cycle":[8,152],"of":[9,17,20,29,71,80,90,98,114,142,149,174,192,196],"continuously":[10],"dividing":[11],"HeLa":[12,49],"S3-cells":[13],"and":[14,59,96,188],"following":[15],"stimulation":[16],"confluent":[18],"monolayers":[19],"WI-38":[21,87,179],"human":[22,180],"diploid":[23,181],"fibroblasts":[24,182],"to":[25,39,45,167],"proliferate.":[26],"The":[27],"presence":[28],"histone":[30,46,51,75,91,99,115,143,175,197],"messenger":[31],"RNA":[32],"(mRNA)":[33],"sequences":[34,53,77,93,101,199],"assayed":[36],"by":[37,184],"hybridization":[38],"a":[40,137],"3H-labeled":[41],"single-stranded":[42],"DNA":[43,105,154],"complementary":[44],"mRNA's.":[47],"In":[48],"S3-cells,":[50],"mRNA":[52,76,92,100,198],"were":[54],"found":[55],"in":[56,86,121,140,171],"nucleus":[58],"associated":[60,159],"with":[61,94,160],"polyribosomes":[62,95],"S":[64],"phase":[65],"but":[66,78],"not":[67],"G1.":[69],"Transcripts":[70],"S-phase":[72,162],"chromatin":[73,82,103],"contained":[74],"those":[79],"G1":[81],"did":[83],"not.":[84],"Similarly,":[85],"cells":[88],"association":[89],"transcription":[97,145,195],"from":[102],"parallel":[104],"replication.":[106],"Together":[107],"these":[108],"results":[109],"suggest":[110],"that":[111,132],"regulation":[113],"resides,":[118],"at":[119,123],"least":[120],"part,":[122],"transcriptional":[125],"level.":[126],"Chromatin":[127],"reconstitution":[128],"studies":[129],"provide":[130],"evidence":[131],"nonhistone":[133,163],"chromosomal":[134,164],"proteins":[135,165],"play":[136],"key":[138],"role":[139],"activation":[141],"period":[148],"when":[153],"is":[155],"replicated.":[156],"Phosphate":[157],"groups":[158],"appear":[166],"be":[168],"functionally":[169],"involved":[170],"control":[173],"readout.":[177],"Although":[178],"transformed":[183],"SV40":[185],"exhibit":[186],"morphological":[187],"biochemical":[189],"modifications":[190],"characteristic":[191],"neoplastic":[193],"cells,":[194],"remains":[200],"unaltered.":[201]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
