{"id":"https://openalex.org/W2136469366","doi":"https://doi.org/10.1074/jbc.273.25.15758","title":"Versican V2 Is a Major Extracellular Matrix Component of the Mature Bovine Brain","display_name":"Versican V2 Is a Major Extracellular Matrix Component of the Mature Bovine Brain","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2136469366","doi":"https://doi.org/10.1074/jbc.273.25.15758","mag":"2136469366","pmid":"https://pubmed.ncbi.nlm.nih.gov/9624174"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.273.25.15758","doi":"https://doi.org/10.1074/jbc.273.25.15758","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.25.15758","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.273.25.15758","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065745227","display_name":"Michael Schmalfeldt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michael Schmalfeldt","raw_affiliation_strings":["Institute of Clinical Pathology, Department of Pathology, University of Z\u00fcrich, 8091 Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Pathology, Department of Pathology, University of Z\u00fcrich, 8091 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108215508","display_name":"Mar\u0131\u0301a T. Dours-Zimmermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mar\u0131\u0301a T. Dours-Zimmermann","raw_affiliation_strings":["Institute of Clinical Pathology, Department of Pathology, University of Zu\u0308rich, 8091 Zu\u0308rich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Pathology, Department of Pathology, University of Zu\u0308rich, 8091 Zu\u0308rich","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022202339","display_name":"Kaspar H. Winterhalter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405254385","display_name":"Institute of Biochemistry","ror":"https://ror.org/01rd8n845","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405254385"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Kaspar H. Winterhalter","raw_affiliation_strings":["Laboratory of Biochemistry I, Federal Institute of Technology, 8092 Zu\u0308rich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry I, Federal Institute of Technology, 8092 Zu\u0308rich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405254385"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110160266","display_name":"Dieter R. Zimmermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Dieter R. Zimmermann","raw_affiliation_strings":["Institute of Clinical Pathology, Department of Pathology, University of Zu\u0308rich, 8091 Zu\u0308rich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Pathology, Department of Pathology, University of Zu\u0308rich, 8091 Zu\u0308rich","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110160266"],"corresponding_institution_ids":["https://openalex.org/I202697423"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.1317,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.75904592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"273","issue":"25","first_page":"15758","last_page":"15764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brevican","display_name":"brevican","score":0.7870000004768372},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7889999747276306},{"id":"https://openalex.org/keywords/bovine-brain","display_name":"bovine brain","score":0.9520000219345093},{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.9269999861717224},{"id":"https://openalex.org/keywords/chondroitinase-abc","display_name":"chondroitinase ABC","score":0.824999988079071},{"id":"https://openalex.org/keywords/neuronal-cell-adhesion","display_name":"neuronal adhesion","score":0.8529999852180481},{"id":"https://openalex.org/keywords/axon-growth","display_name":"axon growth","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C159470946","wikidata":"https://www.wikidata.org/wiki/Q14888030","display_name":"Versican","level":4,"score":0.9945119619369507},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.7327264547348022},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6071312427520752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49181440472602844},{"id":"https://openalex.org/C2775895372","wikidata":"https://www.wikidata.org/wiki/Q5104536","display_name":"Chondroitin sulfate proteoglycan","level":4,"score":0.4808814823627472},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.46626076102256775},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41442710161209106},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.35049867630004883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28332841396331787},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07142531871795654}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002852","descriptor_name":"Chromatography, Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011508","descriptor_name":"Chondroitin Sulfate Proteoglycans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011508","descriptor_name":"Chondroitin Sulfate Proteoglycans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053675","descriptor_name":"Versicans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.273.25.15758","doi":"https://doi.org/10.1074/jbc.273.25.15758","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.25.15758","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9624174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9624174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.273.25.15758","doi":"https://doi.org/10.1074/jbc.273.25.15758","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.25.15758","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W121777809","https://openalex.org/W1484703368","https://openalex.org/W1492080952","https://openalex.org/W1515081605","https://openalex.org/W1520383980","https://openalex.org/W1521949639","https://openalex.org/W1531779321","https://openalex.org/W1544955002","https://openalex.org/W1564232667","https://openalex.org/W1575127176","https://openalex.org/W1579361735","https://openalex.org/W1581190406","https://openalex.org/W1581765874","https://openalex.org/W1598171890","https://openalex.org/W1605448867","https://openalex.org/W1656557885","https://openalex.org/W1821151201","https://openalex.org/W1839821620","https://openalex.org/W1966538134","https://openalex.org/W1975832582","https://openalex.org/W1978382337","https://openalex.org/W1978514720","https://openalex.org/W1988575276","https://openalex.org/W1997360121","https://openalex.org/W2001308076","https://openalex.org/W2002196437","https://openalex.org/W2019144255","https://openalex.org/W2021539651","https://openalex.org/W2038220785","https://openalex.org/W2053179599","https://openalex.org/W2066045232","https://openalex.org/W2067037382","https://openalex.org/W2067538834","https://openalex.org/W2069235575","https://openalex.org/W2071806738","https://openalex.org/W2077787084","https://openalex.org/W2082277421","https://openalex.org/W2110114807","https://openalex.org/W2120186017","https://openalex.org/W2120347833","https://openalex.org/W2166086027","https://openalex.org/W2168876033","https://openalex.org/W2325060126","https://openalex.org/W2402974134"],"related_works":["https://openalex.org/W7212052123","https://openalex.org/W1544955002","https://openalex.org/W2472075263","https://openalex.org/W2060431203","https://openalex.org/W2156763800","https://openalex.org/W3086777726","https://openalex.org/W2029894061","https://openalex.org/W2035816752","https://openalex.org/W1575127176","https://openalex.org/W4400938976"],"abstract_inverted_index":{"We":[0],"have":[1],"isolated":[2],"and":[3,20,46,62,66,73,100,148,152,190],"characterized":[4],"the":[5,23,29,93,134,145],"proteoglycan":[6],"isoforms":[7,53],"of":[8,22,36,51,92,121,162,173],"versican":[9,31,40,52,83,174],"from":[10],"bovine":[11,30,39],"brain":[12,95],"extracts.":[13],"Our":[14,79,155],"approach":[15],"included":[16],"(i)":[17],"cDNA":[18],"cloning":[19],"sequencing":[21],"entire":[24],"open":[25],"reading":[26],"frame":[27],"encoding":[28],"splice":[32],"variants;":[33],"(ii)":[34],"preparation":[35],"antibodies":[37,143],"against":[38,144,149],"using":[41],"recombinant":[42],"core":[43],"protein":[44],"fragments":[45],"synthetic":[47,150],"peptides;":[48],"(iii)":[49],"isolation":[50],"by":[54,59,69,142],"ammonium":[55],"sulfate":[56],"precipitation":[57],"followed":[58],"anion":[60],"exchange":[61],"hyaluronan":[63],"affinity":[64],"chromatography;":[65],"(iv)":[67],"characterization":[68],"SDS-polyacrylamide":[70],"gel":[71,132],"electrophoresis":[72],"Coomassie":[74],"Blue":[75],"staining":[76],"or":[77,166],"immunoblotting.":[78],"results":[80],"demonstrate":[81],"that":[82],"V2":[84,110,175],"is,":[85],"together":[86],"with":[87,116],"brevican,":[88],"a":[89,129],"major":[90,159],"component":[91],"mature":[94],"extracellular":[96],"matrix.":[97],"Versicans":[98],"V0":[99],"V1":[101],"are":[102],"only":[103],"present":[104],"in":[105,186],"relatively":[106],"small":[107],"amounts.":[108],"Versican":[109],"migrates":[111],"after":[112],"chondroitinase":[113],"ABC":[114],"digestion":[115],"an":[117],"apparent":[118],"molecular":[119],"mass":[120],"about":[122],"400":[123],"kDa,":[124],"whereas":[125],"it":[126],"barely":[127],"enters":[128],"4-15%":[130],"polyacrylamide":[131],"without":[133],"enzyme":[135],"treatment.":[136],"The":[137],"400-kDa":[138],"product":[139],"is":[140],"recognized":[141],"glycosaminoglycan-alpha":[146],"domain":[147],"NH2-":[151],"COOH-terminal":[153],"peptides.":[154],"preparations":[156],"contain":[157],"no":[158],"proteolytic":[160],"products":[161],"versican,":[163],"e.g.":[164],"hyaluronectin":[165],"glial":[167],"hyaluronate-binding":[168],"protein.":[169],"Having":[170],"biochemical":[171],"quantities":[172],"available":[176],"will":[177],"allow":[178],"us":[179],"to":[180],"test":[181],"its":[182],"putative":[183],"modulatory":[184],"role":[185],"neuronal":[187],"cell":[188],"adhesion":[189],"axonal":[191],"growth.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
