{"id":"https://openalex.org/W2136456087","doi":"https://doi.org/10.2174/15748847113089990047","title":"The Role of Sympathetic Nervous System in the Progression of Chronic Kidney Disease in the Era of Catheter Based Sympathetic Renal Denervation","display_name":"The Role of Sympathetic Nervous System in the Progression of Chronic Kidney Disease in the Era of Catheter Based Sympathetic Renal Denervation","publication_year":2013,"publication_date":"2013-06-30","ids":{"openalex":"https://openalex.org/W2136456087","doi":"https://doi.org/10.2174/15748847113089990047","mag":"2136456087","pmid":"https://pubmed.ncbi.nlm.nih.gov/23173962"},"language":"en","primary_location":{"id":"doi:10.2174/15748847113089990047","doi":"https://doi.org/10.2174/15748847113089990047","is_oa":false,"landing_page_url":"https://doi.org/10.2174/15748847113089990047","pdf_url":null,"source":{"id":"https://openalex.org/S165219199","display_name":"Current Clinical Pharmacology","issn_l":"1574-8847","issn":["1574-8847","2212-3938","2772-4328","2772-4336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113210846","display_name":"Dimitrios I. Petras","orcid":"https://orcid.org/0000-0003-4469-094X","observed_orcids":["https://orcid.org/0000-0003-4469-094X"]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Petras","raw_affiliation_strings":["Nephrology Department, Hippokrateio Hospital, Athens, Greece. petrasdim@hotmail.com","Nephrology Department, Hippokrateio Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department, Hippokrateio Hospital, Athens, Greece. petrasdim@hotmail.com","institution_ids":["https://openalex.org/I4210165841"]},{"raw_affiliation_string":"Nephrology Department, Hippokrateio Hospital, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083767785","display_name":"Konstantinos Koutroutsos","orcid":"https://orcid.org/0000-0002-2103-9823","observed_orcids":["https://orcid.org/0000-0002-2103-9823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantinos Koutroutsos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080650197","display_name":"Athanasios Kordalis","orcid":"https://orcid.org/0000-0003-4093-4601","observed_orcids":["https://orcid.org/0000-0003-4093-4601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Athanasios Kordalis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107877457","display_name":"Costas P. Tsioufis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Costas Tsioufis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005228083","display_name":"Christodoulos Stefanadis","orcid":"https://orcid.org/0000-0001-5974-6454","observed_orcids":["https://orcid.org/0000-0001-5974-6454","https://orcid.org/0000-0002-5388-2735"]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Christodoulos Stefanadis","raw_affiliation_strings":["Nephrology Department, Hippokrateio Hospital, 26 Alkiviadou Street, 19009 Rafina, Athens, Greece.,Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Department, Hippokrateio Hospital, 26 Alkiviadou Street, 19009 Rafina, Athens, Greece.,Greece","institution_ids":["https://openalex.org/I4210165841"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005228083"],"corresponding_institution_ids":["https://openalex.org/I4210165841"],"apc_list":null,"apc_paid":null,"fwci":1.0505,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.78150509,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"3","first_page":"197","last_page":"205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.12449999898672104,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.8679999709129333},{"id":"https://openalex.org/keywords/chronic-kidney-disease-progression","display_name":"chronic kidney disease progression","score":0.9879999756813049},{"id":"https://openalex.org/keywords/catheter-based-renal-denervation","display_name":"catheter-based renal denervation","score":0.878000020980835},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.7269999980926514},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nitric-oxide-system","display_name":"nitric oxide system","score":0.8859999775886536},{"id":"https://openalex.org/keywords/renal-ischemia","display_name":"renal ischemia","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.879035234451294},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.695576548576355},{"id":"https://openalex.org/C2780177628","wikidata":"https://www.wikidata.org/wiki/Q2186707","display_name":"Renal sympathetic denervation","level":4,"score":0.6923389434814453},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.6331241130828857},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6285149455070496},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6170347332954407},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.505915105342865},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4687611758708954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.455645889043808},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34459203481674194},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3412851095199585},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.09736958146095276},{"id":"https://openalex.org/C3019558611","wikidata":"https://www.wikidata.org/wiki/Q41861","display_name":"Resistant hypertension","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013562","descriptor_name":"Sympathectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/15748847113089990047","doi":"https://doi.org/10.2174/15748847113089990047","is_oa":false,"landing_page_url":"https://doi.org/10.2174/15748847113089990047","pdf_url":null,"source":{"id":"https://openalex.org/S165219199","display_name":"Current Clinical Pharmacology","issn_l":"1574-8847","issn":["1574-8847","2212-3938","2772-4328","2772-4336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:23173962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23173962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995670113","https://openalex.org/W2066763870","https://openalex.org/W2025719390","https://openalex.org/W242434088","https://openalex.org/W2559458754","https://openalex.org/W3009840602","https://openalex.org/W1970647993","https://openalex.org/W2991295270","https://openalex.org/W2022207771","https://openalex.org/W4391132937"],"abstract_inverted_index":{"The":[0,95],"kidney":[1,70,74,124,160],"has":[2,84],"been":[3,41,85],"shown":[4],"to":[5,69,87,174],"be":[6],"critically":[7],"involved":[8],"as":[9],"both":[10,20,114],"trigger":[11],"and":[12,22,27,34,59,65,72,116,120,132,162,165],"target":[13],"of":[14,30,36,51,79,98,141,153,159,171],"sympathetic":[15,55,80,144,154],"nervous":[16,81],"system":[17,33,39,82],"overactivity":[18,155],"in":[19,43,62,129,134,156],"experimental":[21,135],"clinical":[23,130],"studies.":[24],"Renal":[25],"injury":[26,71,161],"ischemia,":[28],"activation":[29,45],"renin":[31],"angiotensin":[32],"dysfunction":[35],"nitric":[37],"oxide":[38],"have":[40,88],"implicated":[42],"adrenergic":[44],"from":[46],"kidney.":[47],"Conversely,":[48],"several":[49],"lines":[50],"evidence":[52],"suggest":[53],"that":[54],"overactivity,":[56],"through":[57],"functional":[58],"morphological":[60],"alterations":[61],"renal":[63,110,118,143,172],"physiology":[64],"structure,":[66],"may":[67],"contribute":[68],"chronic":[73],"disease":[75],"progression.":[76],"Pharmacologic":[77],"modulation":[78],"activity":[83],"found":[86],"a":[89],"blood":[90,126],"pressure":[91,127],"independent":[92],"renoprotective":[93],"effect.":[94],"inadequate":[96],"normalization":[97],"sympathoexcitation":[99],"by":[100,137],"pharmacologic":[101],"treatment":[102,106],"asks":[103],"for":[104],"novel":[105],"options.":[107],"Catheter":[108],"based":[109],"denervation":[111,173],"targets":[112],"selectively":[113],"efferent":[115],"afferent":[117],"nerves":[119],"functionally":[121],"denervates":[122],"the":[123,139,151,157,169],"providing":[125],"reduction":[128],"trials":[131],"renoprotection":[133],"models":[136],"ameliorating":[138],"effects":[140],"excessive":[142],"drive.":[145],"This":[146],"review":[147],"will":[148,166],"focus":[149],"on":[150,168],"role":[152],"pathogenesis":[158],"CKD":[163],"progression":[164],"speculate":[167],"effect":[170],"these":[175],"conditions.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
