{"id":"https://openalex.org/W2136451654","doi":"https://doi.org/10.1002/prca.200780046","title":"Towards a comprehensive proteome of normal and malignant human colon tissue by 2\u2010D\u2010LC\u2010ESI\u2010MS and 2\u2010DE proteomics and identification of S100A12 as potential cancer biomarker","display_name":"Towards a comprehensive proteome of normal and malignant human colon tissue by 2\u2010D\u2010LC\u2010ESI\u2010MS and 2\u2010DE proteomics and identification of S100A12 as potential cancer biomarker","publication_year":2007,"publication_date":"2007-12-11","ids":{"openalex":"https://openalex.org/W2136451654","doi":"https://doi.org/10.1002/prca.200780046","mag":"2136451654","pmid":"https://pubmed.ncbi.nlm.nih.gov/21136775"},"language":"en","primary_location":{"id":"doi:10.1002/prca.200780046","doi":"https://doi.org/10.1002/prca.200780046","is_oa":false,"landing_page_url":"https://doi.org/10.1002/prca.200780046","pdf_url":null,"source":{"id":"https://openalex.org/S118886446","display_name":"PROTEOMICS - CLINICAL APPLICATIONS","issn_l":"1862-8346","issn":["1862-8346","1862-8354"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS \u2013 Clinical Applications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009950158","display_name":"Michael Thierolf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Thierolf","raw_affiliation_strings":["Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030766795","display_name":"Marie\u2010Luise Hagmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie\u2010Luise Hagmann","raw_affiliation_strings":["Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032308820","display_name":"Michael Pfeffer","orcid":"https://orcid.org/0000-0002-1758-5442","observed_orcids":["https://orcid.org/0000-0002-1758-5442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Pfeffer","raw_affiliation_strings":["Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024374106","display_name":"Nikolaos Berntenis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nikolaos Berntenis","raw_affiliation_strings":["Hoffmann-La Roche Ltd., Roche Center of Medical Genomics, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoffmann-La Roche Ltd., Roche Center of Medical Genomics, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070457458","display_name":"Norbert Wild","orcid":"https://orcid.org/0000-0001-8828-2513","observed_orcids":["https://orcid.org/0000-0001-8828-2513"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norbert Wild","raw_affiliation_strings":["Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Markus Roe\u00dfler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Roe\u00dfler","raw_affiliation_strings":["Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905040","display_name":"Stefan Palme","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Palme","raw_affiliation_strings":["Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110160","display_name":"Johann Karl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johann Karl","raw_affiliation_strings":["Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091746085","display_name":"Heinz Bodenm\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heinz Bodenm\u00fcller","raw_affiliation_strings":["Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028984477","display_name":"Josef R\u00fcschoff","orcid":"https://orcid.org/0000-0003-1467-8149","observed_orcids":["https://orcid.org/0000-0003-1467-8149"]},"institutions":[{"id":"https://openalex.org/I4210150299","display_name":"Klinikum Kassel","ror":"https://ror.org/048ycfv73","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210150299"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Josef R\u00fcschoff","raw_affiliation_strings":["Klinikum Kassel GmbH, Institute of Pathology and Biomedical Research, Kassel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum Kassel GmbH, Institute of Pathology and Biomedical Research, Kassel, Germany","institution_ids":["https://openalex.org/I4210150299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048982888","display_name":"S. Rossol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134834","display_name":"Krankenhaus Nordwest","ror":"https://ror.org/02rppq041","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134834"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Siegbert Rossol","raw_affiliation_strings":["Medizinische Klinik, Krankenhaus Nordwest, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik, Krankenhaus Nordwest, Frankfurt, Germany","institution_ids":["https://openalex.org/I4210134834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011028993","display_name":"G. Rohr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerhard Rohr","raw_affiliation_strings":["Medizinische Klinik II, Hochtaunuskliniken, Bad Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik II, Hochtaunuskliniken, Bad Homburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075806643","display_name":"Wolfgang H R\u00f6sch","orcid":"https://orcid.org/0000-0002-3809-3471","observed_orcids":["https://orcid.org/0000-0002-3809-3471"]},"institutions":[{"id":"https://openalex.org/I4210134834","display_name":"Krankenhaus Nordwest","ror":"https://ror.org/02rppq041","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134834"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang R\u00f6sch","raw_affiliation_strings":["Medizinische Klinik, Krankenhaus Nordwest, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik, Krankenhaus Nordwest, Frankfurt, Germany","institution_ids":["https://openalex.org/I4210134834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110132975","display_name":"Helmut Friess","orcid":"https://orcid.org/0000-0001-6029-5857","observed_orcids":["https://orcid.org/0000-0001-6029-5857"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helmut Friess","raw_affiliation_strings":["Department of General Surgery, University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111673782","display_name":"Axel Eickhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130435","display_name":"Klinikum Ludwigshafen","ror":"https://ror.org/037wq4b75","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210130435"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel Eickhoff","raw_affiliation_strings":["Klinikum, Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum, Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210130435"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110403764","display_name":"Karl\u2010Walter Jauch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl\u2010Walter Jauch","raw_affiliation_strings":["Klinikum der Universita\u0308t, Mu\u0308nchen, Germany","Klinikum der Universit\u00e4t M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum der Universita\u0308t, Mu\u0308nchen, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Klinikum der Universit\u00e4t M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111373717","display_name":"Hanno Langen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hanno Langen","raw_affiliation_strings":["Hoffmann-La Roche Ltd., Roche Center of Medical Genomics, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoffmann-La Roche Ltd., Roche Center of Medical Genomics, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079733224","display_name":"Werner Zolg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Werner Zolg","raw_affiliation_strings":["Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002959839","display_name":"Michael Tacke","orcid":"https://orcid.org/0009-0009-4199-3292","observed_orcids":["https://orcid.org/0009-0009-4199-3292"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Tacke","raw_affiliation_strings":["Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Diagnostics GmbH, Roche Professional Diagnostics, Penzberg, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5002959839"],"corresponding_institution_ids":[],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":1.3335,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.75763606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"1","first_page":"11","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8690000176429749},{"id":"https://openalex.org/keywords/s100a12","display_name":"S100A12","score":0.972000002861023},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.8259999752044678},{"id":"https://openalex.org/keywords/protein-overexpression","display_name":"protein overexpression","score":0.6520000100135803},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9869999885559082},{"id":"https://openalex.org/keywords/calnexin","display_name":"calnexin","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7879910469055176},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.7506657838821411},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.669305682182312},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5833366513252258},{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.533847451210022},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4984447956085205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4142642021179199},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40031155943870544},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32807058095932007},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23486220836639404},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.196512371301651},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09973594546318054},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/prca.200780046","doi":"https://doi.org/10.1002/prca.200780046","is_oa":false,"landing_page_url":"https://doi.org/10.1002/prca.200780046","pdf_url":null,"source":{"id":"https://openalex.org/S118886446","display_name":"PROTEOMICS - CLINICAL APPLICATIONS","issn_l":"1862-8346","issn":["1862-8346","1862-8354"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS \u2013 Clinical Applications","raw_type":"journal-article"},{"id":"pmid:21136775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21136775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteomics. Clinical applications","raw_type":"Journal Article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/736859","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/736859","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1480754351","https://openalex.org/W1525575010","https://openalex.org/W1536690700","https://openalex.org/W1544269671","https://openalex.org/W1955382134","https://openalex.org/W1966792579","https://openalex.org/W1970761334","https://openalex.org/W1977151767","https://openalex.org/W1993406037","https://openalex.org/W1996299434","https://openalex.org/W1997504014","https://openalex.org/W2001263691","https://openalex.org/W2001313488","https://openalex.org/W2026465178","https://openalex.org/W2035833877","https://openalex.org/W2039635363","https://openalex.org/W2046511786","https://openalex.org/W2050284687","https://openalex.org/W2052508124","https://openalex.org/W2058680827","https://openalex.org/W2063543381","https://openalex.org/W2065282473","https://openalex.org/W2072942230","https://openalex.org/W2077565457","https://openalex.org/W2080205650","https://openalex.org/W2084898158","https://openalex.org/W2088923388","https://openalex.org/W2089279054","https://openalex.org/W2089813874","https://openalex.org/W2095331480","https://openalex.org/W2095518569","https://openalex.org/W2097786984","https://openalex.org/W2102103993","https://openalex.org/W2104960492","https://openalex.org/W2108787198","https://openalex.org/W2112078820","https://openalex.org/W2118835794","https://openalex.org/W2120745365","https://openalex.org/W2123964933","https://openalex.org/W2133123321","https://openalex.org/W2142430067","https://openalex.org/W2145602937","https://openalex.org/W2145802889","https://openalex.org/W2152510426","https://openalex.org/W2152712415","https://openalex.org/W2158714788","https://openalex.org/W2160110467","https://openalex.org/W2168042083","https://openalex.org/W2188078935","https://openalex.org/W2312288626","https://openalex.org/W3159164887","https://openalex.org/W4234660912"],"related_works":["https://openalex.org/W2358608499","https://openalex.org/W2366474185","https://openalex.org/W1972751834","https://openalex.org/W4241992081","https://openalex.org/W2358730266","https://openalex.org/W2022586110","https://openalex.org/W2092773050","https://openalex.org/W2033710359","https://openalex.org/W4245454588","https://openalex.org/W2247000188"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"aim":[2],"of":[3,11,52,60,108,136,145,180],"this":[4],"study":[5],"was":[6,139],"to":[7,92,154,163,174,187,194],"characterize":[8],"the":[9,20,50,57,84,93,116,192],"proteome":[10,22],"normal":[12,102],"and":[13,25,27,101,133,151,176,190],"malignant":[14],"colonic":[15],"tissue.":[16],"We":[17,166],"previously":[18],"studied":[19],"colon":[21,54,103],"using":[23,63],"2\u2010DE":[24],"MALDI\u2010MS":[26],"identified":[28,73,82],"734":[29],"proteins":[30,55,71,89,110,138],"(Roe\u00dfler,":[31],"M.,":[32],"Rollinger,":[33],"W.,":[34],"Palme":[35],"S.,":[36],"Hagmann,":[37],"M.\u2010L.,":[38],"et":[39],"al..,":[40],"Clin.":[41],"Cancer":[42],"Res.":[43],"2005,":[44],"11,":[45],"6550\u20136557).":[46],"Here":[47],"we":[48],"report":[49],"identification":[51],"additional":[53],"from":[56],"same":[58],"set":[59],"tissue":[61,104,181],"samples":[62],"a":[64,171],"complementary":[65,186],"nano\u2010flow":[66],"2\u2010D\u2010LC\u2010ESI\u2010MS.":[67],"In":[68],"total,":[69],"484":[70],"were":[72,90,147,152],"in":[74,99,111,158],"colon.":[75],"Of":[76],"these,":[77],"252":[78],"had":[79],"also":[80],"been":[81],"by":[83,141,149],"2\u2010DE/MALDI\u2010MS":[85,188],"approach,":[86],"whereas":[87],"232":[88],"unique":[91],"2\u2010D\u2010LC\u2010ESI\u2010MS":[94,169],"analysis.":[95],"Comparing":[96],"protein":[97,129,178],"expression":[98,107],"neoplastic":[100],"indicated":[105],"elevated":[106,157],"several":[109],"colorectal":[112,159],"cancer,":[113],"among":[114],"them":[115],"well":[117,124],"established":[118],"tumor":[119],"marker":[120],"carcinoembryonic":[121],"antigen,":[122],"as":[123,125],"calnexin,":[126],"40S":[127],"ribosomal":[128],"S15a,":[130],"serpin":[131],"H1,":[132],"S100A12.":[134],"Overexpression":[135],"these":[137],"confirmed":[140],"immunoblotting.":[142],"Serum":[143],"levels":[144],"S100A12":[146],"determined":[148],"ELISA":[150],"found":[153],"be":[155],"strongly":[156],"cancer":[160],"patients":[161],"compared":[162],"healthy":[164],"individuals.":[165],"conclude,":[167],"that":[168,183],"is":[170,185],"powerful":[172],"approach":[173],"identify":[175,195],"compare":[177],"profiles":[179],"samples,":[182],"it":[184],"approaches":[189],"has":[191],"potential":[193],"novel":[196],"biomarkers.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}