{"id":"https://openalex.org/W2136397936","doi":"https://doi.org/10.2337/diab.44.8.954","title":"Insulin Sensitivity Accounts for Glucose and Lactate Kinetics After Intravenous Glucose Injection","display_name":"Insulin Sensitivity Accounts for Glucose and Lactate Kinetics After Intravenous Glucose Injection","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W2136397936","doi":"https://doi.org/10.2337/diab.44.8.954","mag":"2136397936","pmid":"https://pubmed.ncbi.nlm.nih.gov/7622002"},"language":"en","primary_location":{"id":"doi:10.2337/diab.44.8.954","doi":"https://doi.org/10.2337/diab.44.8.954","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.44.8.954","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042069971","display_name":"Richard M. Watanabe","orcid":"https://orcid.org/0000-0003-1015-0531","observed_orcids":["https://orcid.org/0000-0003-1015-0531"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M Watanabe","raw_affiliation_strings":["Department of Exercise Science, and the University of Southern California School of Medicine the Department of Physiology & Biophysics\u2008Los Angeles, California","University of Southern California\u2008Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, and the University of Southern California School of Medicine the Department of Physiology & Biophysics\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111479931","display_name":"Jennifer C. Lovejoy","orcid":"https://orcid.org/0009-0003-2334-077X","observed_orcids":["https://orcid.org/0009-0003-2334-077X"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Lovejoy","raw_affiliation_strings":["Pennington Biomedical Research Center, Louisiana State University\u2008Baton Rouge, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennington Biomedical Research Center, Louisiana State University\u2008Baton Rouge, Louisiana","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070771680","display_name":"Garry M. Steil","orcid":"https://orcid.org/0000-0001-5418-5256","observed_orcids":["https://orcid.org/0000-0001-5418-5256"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garry M Steil","raw_affiliation_strings":["Department of Exercise Science, and the University of Southern California School of Medicine the Department of Physiology & Biophysics\u2008Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, and the University of Southern California School of Medicine the Department of Physiology & Biophysics\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083678636","display_name":"Mario DiGirolamo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario DiGirolamo","raw_affiliation_strings":["Emory University School of Medicine, Department of Medicine, Division of Gerontology and Geriatric Medicine\u2008Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Department of Medicine, Division of Gerontology and Geriatric Medicine\u2008Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030791389","display_name":"Richard N. Bergman","orcid":"https://orcid.org/0000-0003-1539-4471","observed_orcids":["https://orcid.org/0000-0003-1539-4471"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard N Bergman","raw_affiliation_strings":["Department of Exercise Science, and the University of Southern California School of Medicine the Department of Physiology & Biophysics\u2008Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, and the University of Southern California School of Medicine the Department of Physiology & Biophysics\u2008Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2913,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82106831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"44","issue":"8","first_page":"954","last_page":"962"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.39989998936653137,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.39989998936653137,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.29910001158714294,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.2207999974489212,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/glucose-kinetics","display_name":"glucose kinetics","score":0.9520000219345093},{"id":"https://openalex.org/keywords/lactate-kinetics","display_name":"lactate kinetics","score":0.9980000257492065},{"id":"https://openalex.org/keywords/frequently-sampled-intravenous-glucose-tolerance-test","display_name":"frequently sampled intravenous glucose tolerance test","score":0.9409999847412109},{"id":"https://openalex.org/keywords/glucose-effectiveness","display_name":"glucose effectiveness","score":0.675000011920929},{"id":"https://openalex.org/keywords/parameter-precision","display_name":"parameter precision","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.783328652381897},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6065433025360107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49304911494255066},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4464433491230011},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.44327372312545776},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43101999163627625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3238556385040283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28299081325531006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20756414532661438},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diab.44.8.954","doi":"https://doi.org/10.2337/diab.44.8.954","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.44.8.954","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"doi:10.2337/diabetes.44.8.954","doi":"https://doi.org/10.2337/diabetes.44.8.954","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.44.8.954","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:7622002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7622002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1143685601","display_name":null,"funder_award_id":"RR00039","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2754049150","display_name":"OBESITY, LACTATE OVERPRODUCTION AND INSULIN RESISTANCE","funder_award_id":"5r01dk039326-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3524011918","display_name":null,"funder_award_id":"DK39326","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6775933354","display_name":"Quantitation of Factors Regulating Glucose Tolerance","funder_award_id":"R01DK029867","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8458361167","display_name":null,"funder_award_id":"DK29867","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320315254","display_name":"Innovative Research Group Project of the National Natural Science Foundation of China","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1595152290","https://openalex.org/W1771429046","https://openalex.org/W2362658856","https://openalex.org/W2100795674","https://openalex.org/W2103331109","https://openalex.org/W2125409908","https://openalex.org/W1991309804","https://openalex.org/W2621083019","https://openalex.org/W2683257443","https://openalex.org/W7096352241"],"abstract_inverted_index":{"Mathematical":[0],"modeling":[1],"was":[2,109,188,208,221],"used":[3],"to":[4,41,179],"explore":[5],"the":[6,14,43,57,61,64,112,175,189,201],"interaction":[7],"between":[8],"glucose,":[9],"insulin,":[10],"and":[11,30,50,85,95,98,164],"lactate":[12,51,77,86,102,107,129,160,186],"during":[13,174],"frequently":[15],"sampled":[16],"intravenous":[17],"glucose":[18,38,49,68,84,96,115,172],"tolerance":[19],"test":[20],"(FSIGTT).":[21],"Insulin-modified":[22],"FSIGTs":[23,36],"were":[24],"performed":[25],"in":[26,192,194,213,218],"25":[27],"lean":[28],"volunteers,":[29],"an":[31],"additional":[32,182],"5":[33],"volunteers":[34],"underwent":[35],"with":[37,117],"injection":[39],"alone":[40],"illustrate":[42],"effect":[44,134,207],"of":[45,60,67,76,92,101,114,120,123,128,170,184],"insulin":[46,93,124],"on":[47,125,135],"both":[48,83],"kinetics.":[52,78,103],"The":[53,79],"model":[54,66,75,80,161],"chosen":[55],"as":[56,198],"best":[58],"representation":[59],"system":[62],"extended":[63],"minimal":[65],"kinetics":[69,130,187],"(MM)":[70],"by":[71,111,200],"including":[72,185],"a":[73,215],"two-compartment":[74],"accounted":[81],"for":[82,211],"kinetics,":[87],"provided":[88],"traditional":[89],"MM":[90,136,195],"parameters":[91,100,137],"sensitivity":[94],"effectiveness,":[97],"descriptive":[99],"Modeling":[104],"suggested":[105],"that":[106,166],"production":[108],"limited":[110],"rate":[113],"disappearance,":[116],"no":[118,132],"indication":[119],"direct":[121],"effects":[122],"lactate.":[126,180],"Inclusion":[127],"had":[131],"adverse":[133],"(SG:":[138],"0.023":[139,143],"+/-":[140,144,149,153,225,229,232],"0.009":[141],"vs.":[142,151,162,227],"0.010":[145],"min-1,":[146],"SI:":[147],"1.01":[148],"0.70":[150],"1.03":[152],"0.71":[154],"x":[155],"10(4).min-1.pmol-1.1;":[156],"P":[157],">":[158],"0.50,":[159],"MM),":[163],"indicated":[165],"approximately":[167],"1.2%":[168],"min-1":[169],"total":[171],"disappearance":[173],"FSIGT":[176],"is":[177],"converted":[178],"An":[181],"benefit":[183],"significant":[190],"improvement":[191,217],"precision":[193,220],"parameter":[196,219],"estimates":[197],"reflected":[199],"fractional":[202],"standard":[203],"deviations":[204],"(FSDs).":[205],"This":[206],"most":[209],"prominent":[210],"SG,":[212],"which":[214],"threefold":[216],"observed":[222],"(FSD:":[223],"13.5":[224],"3.1":[226],"42.5":[228],"48.5;":[230],"means":[231],"SD).(ABSTRACT":[233],"TRUNCATED":[234],"AT":[235],"250":[236],"WORDS)":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}