{"id":"https://openalex.org/W2136391236","doi":"https://doi.org/10.1681/asn.2009030271","title":"Conditional Mutation of Pkd2 Causes Cystogenesis and Upregulates \u03b2-Catenin","display_name":"Conditional Mutation of Pkd2 Causes Cystogenesis and Upregulates \u03b2-Catenin","publication_year":2009,"publication_date":"2009-11-26","ids":{"openalex":"https://openalex.org/W2136391236","doi":"https://doi.org/10.1681/asn.2009030271","mag":"2136391236","pmid":"https://pubmed.ncbi.nlm.nih.gov/19939939","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2794231"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2009030271","doi":"https://doi.org/10.1681/asn.2009030271","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2009030271","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2794231","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063902072","display_name":"Ingyu Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ingyu Kim","raw_affiliation_strings":["Division of Genetic Medicine, Department of Medicine and Cell and Developmental Biology, Vanderbilt University, 2215 Garland Avenue, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genetic Medicine, Department of Medicine and Cell and Developmental Biology, Vanderbilt University, 2215 Garland Avenue, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109313290","display_name":"Tianbing Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tianbing Ding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067900039","display_name":"Yulong Fu","orcid":"https://orcid.org/0000-0001-7991-9965","observed_orcids":["https://orcid.org/0000-0001-7991-9965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yulong Fu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055801372","display_name":"Cunxi Li","orcid":"https://orcid.org/0000-0003-1264-042X","observed_orcids":["https://orcid.org/0000-0003-1264-042X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cunxi Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032560362","display_name":"Lan WangChengbo FuYingbin Cui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lan Cui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359727","display_name":"Ao Li","orcid":"https://orcid.org/0000-0001-7861-6313","observed_orcids":["https://orcid.org/0000-0001-7861-6313","https://orcid.org/0009-0005-6842-2132","https://orcid.org/0009-0007-5698-8037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ao Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112532328","display_name":"Peiwen Lian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peiwen Lian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Dan Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014137444","display_name":"Dao Wen Wang","orcid":"https://orcid.org/0000-0002-9774-3980","observed_orcids":["https://orcid.org/0000-0002-9774-3980","https://orcid.org/0000-0002-1903-6180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dao W. Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113835530","display_name":"Caiying Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caiying Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101865262","display_name":"Jie Ma","orcid":"https://orcid.org/0000-0002-7419-136X","observed_orcids":["https://orcid.org/0000-0002-7419-136X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101770100","display_name":"Ping Zhao","orcid":"https://orcid.org/0000-0003-1255-6754","observed_orcids":["https://orcid.org/0000-0003-1255-6754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046249010","display_name":"Robert J. Coffey","orcid":"https://orcid.org/0000-0002-2180-3844","observed_orcids":["https://orcid.org/0000-0002-2180-3844"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert J. Coffey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100664083","display_name":"Qimin Zhan","orcid":"https://orcid.org/0000-0002-1731-938X","observed_orcids":["https://orcid.org/0000-0002-1731-938X","https://orcid.org/0000-0002-8964-2506","https://orcid.org/0009-0002-7646-4795","https://orcid.org/0000-0003-0542-3531","https://orcid.org/0000-0003-0087-0156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qimin Zhan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110546869","display_name":"Guanqing Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guanqing Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9973,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.91896949,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"20","issue":"12","first_page":"2556","last_page":"2569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystin-2","display_name":"polycystin-2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pkd2","display_name":"PKD2","score":0.9620000123977661},{"id":"https://openalex.org/keywords/autosomal-dominant-polycystic-kidney-disease","display_name":"autosomal dominant polycystic kidney disease","score":0.7009999752044678},{"id":"https://openalex.org/keywords/cyst-formation","display_name":"cyst formation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/beta-catenin-signaling","display_name":"\u03b2-catenin signaling","score":0.9399999976158142},{"id":"https://openalex.org/keywords/conditional-knockout","display_name":"conditional knockout","score":0.5109999775886536},{"id":"https://openalex.org/keywords/ciliogenesis","display_name":"ciliogenesis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/axin2","display_name":"Axin2","score":0.8600000143051147},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8299999833106995},{"id":"https://openalex.org/keywords/renal-cysts","display_name":"renal cysts","score":0.6579999923706055},{"id":"https://openalex.org/keywords/pancreatic-cysts","display_name":"pancreatic cysts","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C195267511","wikidata":"https://www.wikidata.org/wiki/Q5119969","display_name":"Ciliogenesis","level":3,"score":0.6475081443786621},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5887801647186279},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5746245980262756},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5293776988983154},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5176308751106262},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48657000064849854},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.46580109000205994},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4367421567440033},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4314955174922943},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.4187612235546112},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33879202604293823},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2794235348701477},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1708379089832306},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010182","descriptor_name":"Pancreatic Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010182","descriptor_name":"Pancreatic Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020297","descriptor_name":"Mice, Congenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050396","descriptor_name":"TRPP Cation Channels","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D050396","descriptor_name":"TRPP Cation Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050396","descriptor_name":"TRPP Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1681/asn.2009030271","doi":"https://doi.org/10.1681/asn.2009030271","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2009030271","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2794231","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2794231","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Soc Nephrol","raw_type":"Text"},{"id":"pmid:19939939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19939939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology : JASN","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2794231","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2794231","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Soc Nephrol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1125182491","display_name":"Molecular Genetics and Pathogenesis of ARPKD","funder_award_id":"R01DK071090","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2672503723","display_name":"Genetic Mechanisms of Polycystic Kidney Disease","funder_award_id":"R01DK062373","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4841106333","display_name":"SPORE in GI Cancer","funder_award_id":"P50CA095103","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1546107754","https://openalex.org/W1782336782","https://openalex.org/W1783360620","https://openalex.org/W1919420085","https://openalex.org/W1959400241","https://openalex.org/W1968179754","https://openalex.org/W1971075145","https://openalex.org/W1980350823","https://openalex.org/W1986340915","https://openalex.org/W1988435915","https://openalex.org/W1999560996","https://openalex.org/W2005026678","https://openalex.org/W2005938853","https://openalex.org/W2011505059","https://openalex.org/W2013002334","https://openalex.org/W2014604277","https://openalex.org/W2016499189","https://openalex.org/W2017086844","https://openalex.org/W2024254525","https://openalex.org/W2028097749","https://openalex.org/W2029085436","https://openalex.org/W2031943544","https://openalex.org/W2038567992","https://openalex.org/W2041546338","https://openalex.org/W2045985868","https://openalex.org/W2050717638","https://openalex.org/W2053521290","https://openalex.org/W2058172887","https://openalex.org/W2064104813","https://openalex.org/W2065603011","https://openalex.org/W2068642486","https://openalex.org/W2071233660","https://openalex.org/W2080853555","https://openalex.org/W2095869636","https://openalex.org/W2096141807","https://openalex.org/W2103146019","https://openalex.org/W2106182995","https://openalex.org/W2107211482","https://openalex.org/W2108552531","https://openalex.org/W2111436561","https://openalex.org/W2112900504","https://openalex.org/W2113588019","https://openalex.org/W2118697060","https://openalex.org/W2121032266","https://openalex.org/W2125720034","https://openalex.org/W2134914006","https://openalex.org/W2135030130","https://openalex.org/W2135100794","https://openalex.org/W2136451773","https://openalex.org/W2136582251","https://openalex.org/W2136875701","https://openalex.org/W2141838148","https://openalex.org/W2147014496","https://openalex.org/W2148078342","https://openalex.org/W2148538867","https://openalex.org/W2152653845","https://openalex.org/W2153155610","https://openalex.org/W2164020057","https://openalex.org/W2164628127","https://openalex.org/W2165148994","https://openalex.org/W2165251675","https://openalex.org/W2166003718","https://openalex.org/W2168609240","https://openalex.org/W2169832556","https://openalex.org/W2171774082","https://openalex.org/W2330545449","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2894426551","https://openalex.org/W1783360620","https://openalex.org/W2790033552","https://openalex.org/W4391144333","https://openalex.org/W2080853555","https://openalex.org/W2148478198","https://openalex.org/W4397025127","https://openalex.org/W2023131100","https://openalex.org/W4397047802","https://openalex.org/W2149159973"],"abstract_inverted_index":{"Loss":[0],"of":[1,33,56,85,127,132,138],"polycystin-2":[2],"(PC2)":[3],"in":[4,8,149],"mice":[5,64],"(Pkd2(-/-))":[6],"results":[7,123],"total":[9],"body":[10],"edema,":[11],"focal":[12],"hemorrhage,":[13],"structural":[14],"cardiac":[15],"defects,":[16],"abnormal":[17],"left-right":[18],"axis,":[19],"hepatorenal":[20],"and":[21,24,69,112,120],"pancreatic":[22],"cysts,":[23],"embryonic":[25],"lethality.":[26,71],"The":[27],"molecular":[28],"mechanisms":[29],"by":[30],"which":[31],"loss":[32,126],"PC2":[34,67,128],"leads":[35],"to":[36,45,62,88],"these":[37,105],"phenotypes":[38],"remain":[39],"unknown.":[40],"We":[41],"generated":[42],"a":[43,59,142],"model":[44],"allow":[46],"targeted":[47],"Pkd2":[48,57,86],"inactivation":[49,55],"using":[50],"the":[51],"Cre-loxP":[52],"system.":[53],"Global":[54],"produced":[58],"phenotype":[60],"identical":[61],"Pkd2(-/-)":[63],"with":[65,102],"undetectable":[66],"protein":[68],"perinatal":[70],"Using":[72],"various":[73],"Cre":[74],"mouse":[75],"lines,":[76],"we":[77,93],"found":[78],"that":[79,125],"kidney,":[80],"pancreas,":[81],"or":[82],"time-specific":[83],"deletion":[84],"led":[87],"cyst":[89],"formation.":[90],"In":[91],"addition,":[92],"developed":[94],"an":[95],"immortalized":[96],"renal":[97,133],"collecting":[98],"duct":[99],"cell":[100],"line":[101],"inactive":[103],"Pkd2;":[104],"cells":[106,135],"had":[107],"aberrant":[108],"cell-cell":[109],"contact,":[110],"ciliogenesis,":[111],"tubulomorphogenesis.":[113],"They":[114],"also":[115],"significantly":[116],"upregulated":[117],"beta-catenin,":[118],"axin2,":[119],"cMyc.":[121],"Our":[122],"suggest":[124],"disrupts":[129],"normal":[130],"behavior":[131],"epithelial":[134],"through":[136],"dysregulation":[137],"beta-catenin-dependent":[139],"signaling,":[140],"revealing":[141],"potential":[143],"role":[144],"for":[145],"this":[146],"signaling":[147],"pathway":[148],"PC2-associated":[150],"ADPKD.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
