{"id":"https://openalex.org/W2136376827","doi":null,"title":"New treatment strategies for Alzheimer's disease: is there a hope?","display_name":"New treatment strategies for Alzheimer's disease: is there a hope?","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2136376827","mag":"2136376827","pmid":"https://pubmed.ncbi.nlm.nih.gov/24434253","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868059"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2857445","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868059","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868059","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055247763","display_name":"Iv\u00e1n Aprahamian","orcid":"https://orcid.org/0000-0003-3806-7895","observed_orcids":["https://orcid.org/0000-0003-3806-7895"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan Aprahamian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003780479","display_name":"Florindo Stella","orcid":"https://orcid.org/0000-0001-6052-7312","observed_orcids":["https://orcid.org/0000-0001-6052-7312"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florindo Stella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046924742","display_name":"Orestes Vicente Forlenza","orcid":"https://orcid.org/0000-0002-6962-5899","observed_orcids":["https://orcid.org/0000-0002-6962-5899"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Orestes V Forlenza","raw_affiliation_strings":["Laboratory of Neuroscience (LIM 27) Department & Institute of Psychiatry, Faculty of Medicine,University of S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience (LIM 27) Department & Institute of Psychiatry, Faculty of Medicine,University of S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4058,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.88373612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"138","issue":"4","first_page":"449","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8090000152587891},{"id":"https://openalex.org/keywords/amyloid-hypothesis","display_name":"amyloid hypothesis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7710000276565552},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9200000166893005},{"id":"https://openalex.org/keywords/neuritic-plaques","display_name":"neuritic plaques","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":1.0},{"id":"https://openalex.org/keywords/anti-amyloid-drugs","display_name":"anti-amyloid drugs","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.8610121011734009},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.7397998571395874},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6746232509613037},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6169556379318237},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5954739451408386},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5887097120285034},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.5818106532096863},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5506203174591064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5220817923545837},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.47753608226776123},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4530389904975891},{"id":"https://openalex.org/C2779056891","wikidata":"https://www.wikidata.org/wiki/Q412690","display_name":"Galantamine","level":5,"score":0.44936150312423706},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.44625693559646606},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.4170716106891632},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3589925169944763},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2889200448989868},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28075268864631653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19344684481620789},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008559","descriptor_name":"Memantine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"pmh:oai:europepmc.org:2857445","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868059","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3868059","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868059","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Med Res","raw_type":"Text"},{"id":"pmid:24434253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24434253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Indian journal of medical research","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.unesp.br:11449/111277","doi":null,"is_oa":true,"landing_page_url":"http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2013;volume=138;issue=4;spage=449;epage=460;aulast=Aprahamian;type=0","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:americanae.aecid.es:1740229","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/111277","pdf_url":"http://hdl.handle.net/11449/111277","source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNESP","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.904.1306","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.904.1306","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://repositorio.unesp.br/bitstream/handle/11449/111277/WOS000330872300004.pdf%3Bjsessionid%3D445B341DD78EAD35F24A30B4550C276E?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:acervodigital.unesp.br:11449/111277","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/111277","pdf_url":null,"source":{"id":"https://openalex.org/S4306400256","display_name":"Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115194","host_organization_name":"Funda\u00e7\u00e3o para o Desenvolvimento da UNESP","host_organization_lineage":["https://openalex.org/I4210115194"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"outro"},{"id":"mag:2136376827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24434253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2857445","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868059","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136376827.pdf","grobid_xml":"https://content.openalex.org/works/W2136376827.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W50326776","https://openalex.org/W1492327929","https://openalex.org/W1551854265","https://openalex.org/W1567624342","https://openalex.org/W1573707492","https://openalex.org/W1577837690","https://openalex.org/W1582623884","https://openalex.org/W1596429639","https://openalex.org/W1621971853","https://openalex.org/W1693283493","https://openalex.org/W1905168637","https://openalex.org/W1946583083","https://openalex.org/W1965598001","https://openalex.org/W1966295452","https://openalex.org/W1969278735","https://openalex.org/W1969744825","https://openalex.org/W1972485487","https://openalex.org/W1980632974","https://openalex.org/W1983814429","https://openalex.org/W1983829653","https://openalex.org/W1985491014","https://openalex.org/W1986512401","https://openalex.org/W1986822172","https://openalex.org/W1989820287","https://openalex.org/W1991224402","https://openalex.org/W1993571512","https://openalex.org/W1994085255","https://openalex.org/W2000917982","https://openalex.org/W2002079745","https://openalex.org/W2004213355","https://openalex.org/W2015389516","https://openalex.org/W2018317802","https://openalex.org/W2019790095","https://openalex.org/W2021198371","https://openalex.org/W2026892832","https://openalex.org/W2030847210","https://openalex.org/W2031864556","https://openalex.org/W2037053607","https://openalex.org/W2042282383","https://openalex.org/W2046182783","https://openalex.org/W2048810707","https://openalex.org/W2049146362","https://openalex.org/W2050252476","https://openalex.org/W2055928970","https://openalex.org/W2058085247","https://openalex.org/W2059163911","https://openalex.org/W2062527635","https://openalex.org/W2063472038","https://openalex.org/W2065013480","https://openalex.org/W2067859842","https://openalex.org/W2069168024","https://openalex.org/W2082429191","https://openalex.org/W2086572083","https://openalex.org/W2088448500","https://openalex.org/W2090867290","https://openalex.org/W2096410114","https://openalex.org/W2100610042","https://openalex.org/W2101209575","https://openalex.org/W2101595685","https://openalex.org/W2102782858","https://openalex.org/W2103261758","https://openalex.org/W2103708669","https://openalex.org/W2107522606","https://openalex.org/W2108216694","https://openalex.org/W2112136536","https://openalex.org/W2113312452","https://openalex.org/W2122843800","https://openalex.org/W2127313444","https://openalex.org/W2129267808","https://openalex.org/W2129497119","https://openalex.org/W2131063537","https://openalex.org/W2131819352","https://openalex.org/W2133719476","https://openalex.org/W2138904731","https://openalex.org/W2154297075","https://openalex.org/W2157110881","https://openalex.org/W2158854213","https://openalex.org/W2167242702","https://openalex.org/W2167818155","https://openalex.org/W2171776741","https://openalex.org/W2409275772","https://openalex.org/W2565199879","https://openalex.org/W2603308917","https://openalex.org/W2921671520","https://openalex.org/W3023013291","https://openalex.org/W4322703303"],"related_works":["https://openalex.org/W1044733850","https://openalex.org/W3014691728","https://openalex.org/W3085706776","https://openalex.org/W2005216867","https://openalex.org/W2168436199","https://openalex.org/W1973600862","https://openalex.org/W2050954120","https://openalex.org/W2166727252","https://openalex.org/W3196802186","https://openalex.org/W3106951507"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3,28,134],"a":[4,97],"progressive":[5],"and":[6,10,40,64,90,103,112,120,172,184],"irreversible":[7],"neurodegenerative":[8],"disease,":[9],"corresponds":[11],"to":[12,45,58,96,101,117,147],"the":[13,24,32,37,46,59,69,73,78,107,118,156,161,165],"most":[14],"common":[15],"cause":[16],"of":[17,26,48,61,72,77,122,131],"dementia":[18],"worldwide.":[19],"Although":[20],"not":[21],"fully":[22],"understood,":[23],"pathophysiology":[25],"AD":[27,83,142],"largely":[29],"represented":[30],"by":[31,36,41,136],"neurotoxic":[33],"events":[34],"triggered":[35],"beta-amyloid":[38],"cascade":[39],"cytoskeletal":[42],"abnormalities":[43],"subsequent":[44],"hyperphosphorylation":[47],"microtubule-associated":[49],"Tau":[50,173],"protein":[51],"in":[52,141,175],"neurons.":[53],"These":[54],"processes":[55,140],"lead":[56],"respectively":[57],"formation":[60],"neuritic":[62],"plaques":[63],"neurofibrillary":[65],"tangles,":[66],"which":[67],"are":[68,92],"pathological":[70,139],"hallmarks":[71],"disease.":[74],"Clinical":[75],"benefits":[76],"available":[79,162],"pharmacological":[80],"treatment":[81],"for":[82],"with":[84,126],"antidementia":[85],"drugs":[86],"(namely":[87],"cholinesterase":[88],"inhibitors":[89],"memantine)":[91],"unquestionable,":[93],"although":[94],"limited":[95],"temporary,":[98],"symptomatic":[99],"support":[100],"cognitive":[102],"related":[104],"functions.":[105],"Over":[106],"past":[108],"decade,":[109],"substantial":[110],"funding":[111],"research":[113],"have":[114],"been":[115],"dedicated":[116],"search":[119],"development":[121],"new":[123,166],"pharmaceutical":[124,179],"compounds":[125,180],"disease-modifying":[127],"properties.":[128],"The":[129],"rationale":[130],"such":[132],"approach":[133],"that":[135,169],"tackling":[137],"key":[138],"it":[143],"may":[144],"be":[145],"possible":[146],"attenuate":[148],"or":[149],"even":[150],"change":[151],"its":[152],"natural":[153],"history.":[154],"In":[155],"present":[157],"review,":[158],"we":[159],"summarize":[160],"evidence":[163],"on":[164,178],"therapeutic":[167],"approaches":[168],"target":[170],"amyloid":[171],"pathology":[174],"AD,":[176],"focusing":[177],"undergoing":[181],"phase":[182,185],"2":[183],"3":[186],"randomized":[187],"controlled":[188],"trials.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
