{"id":"https://openalex.org/W2136367179","doi":null,"title":"Evaluation of Melatonin for Prevention of Radiation Myelopathy in Irradiated Cervical Spinal Cord","display_name":"Evaluation of Melatonin for Prevention of Radiation Myelopathy in Irradiated Cervical Spinal Cord","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2136367179","mag":"2136367179"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:76fca923797547b1b157f5dcc141c8ca","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/76fca923797547b1b157f5dcc141c8ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Journal, Vol 11, Iss 1, Pp 43-48 (2009)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101993938","display_name":"Alireza Shirazi","orcid":"https://orcid.org/0000-0002-7579-1797","observed_orcids":["https://orcid.org/0000-0002-7579-1797"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alireza Shirazi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7579-1797","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013240849","display_name":"Gholamhassan Haddadi","orcid":"https://orcid.org/0000-0002-1401-4951","observed_orcids":["https://orcid.org/0000-0002-1401-4951"]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hadadi Gh.H.","raw_affiliation_strings":["Tehran University of Medical Sciences ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tehran University of Medical Sciences ,","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003219872","display_name":"Mahmoud Ghazi\u2010Khansari","orcid":"https://orcid.org/0000-0001-9844-7529","observed_orcids":["https://orcid.org/0000-0001-9844-7529"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahmoud Ghazi\u2010Khansari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9844-7529","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040646084","display_name":"Abou Alhasani Farid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abou Alhasani Farid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012690210","display_name":"Seied Rabi Mahdavi","orcid":"https://orcid.org/0000-0003-1973-2140","observed_orcids":["https://orcid.org/0000-0003-1973-2140"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seied Rabi Mahdavi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1973-2140","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110197233","display_name":"M R Eshraghian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Eshraghian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7139,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.81968078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"141","first_page":"43","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/radiation-myelopathy","display_name":"radiation myelopathy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cervical-spinal-cord","display_name":"cervical spinal cord","score":0.859000027179718},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.6539999842643738},{"id":"https://openalex.org/keywords/head-and-neck-radiotherapy-complications","display_name":"head and neck radiotherapy complications","score":0.7369999885559082},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8320000171661377},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9810000061988831},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":1.0},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cobalt-60-gamma-irradiation","display_name":"cobalt-60 gamma irradiation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9458245038986206},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.7847837805747986},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6398753523826599},{"id":"https://openalex.org/C2777604421","wikidata":"https://www.wikidata.org/wiki/Q2303951","display_name":"Myelopathy","level":3,"score":0.5686219334602356},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5259278416633606},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4900299310684204},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.4166603684425354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3982471525669098},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.39314883947372437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3560289144515991},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3546098470687866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2903116047382355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06301024556159973},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.04973098635673523},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:76fca923797547b1b157f5dcc141c8ca","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/76fca923797547b1b157f5dcc141c8ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Journal, Vol 11, Iss 1, Pp 43-48 (2009)","raw_type":"article"},{"id":"mag:2136367179","doi":null,"is_oa":false,"landing_page_url":"https://www.sid.ir/en/VEWSSID/J_pdf/82320094109.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cell","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W35745764","https://openalex.org/W174629306","https://openalex.org/W969915667","https://openalex.org/W1220639384","https://openalex.org/W1914572002","https://openalex.org/W1987684601","https://openalex.org/W1992544569","https://openalex.org/W1996482313","https://openalex.org/W1998091373","https://openalex.org/W2002510503","https://openalex.org/W2030966861","https://openalex.org/W2038118231","https://openalex.org/W2054643117","https://openalex.org/W2064746056","https://openalex.org/W2069308124","https://openalex.org/W2074267977","https://openalex.org/W2082352153","https://openalex.org/W2085484338","https://openalex.org/W2088682528","https://openalex.org/W2093663895","https://openalex.org/W2101529296","https://openalex.org/W2122010571","https://openalex.org/W2128635872","https://openalex.org/W2130725042","https://openalex.org/W2137034584","https://openalex.org/W2167647381","https://openalex.org/W2170330790","https://openalex.org/W2185866075","https://openalex.org/W2473055077"],"related_works":["https://openalex.org/W2050001481","https://openalex.org/W2169889456","https://openalex.org/W7099699373","https://openalex.org/W2916052844","https://openalex.org/W4303650698","https://openalex.org/W7098899653","https://openalex.org/W2000847452","https://openalex.org/W2109893952","https://openalex.org/W3110690028","https://openalex.org/W2902326214"],"abstract_inverted_index":{"Objective:":[0],"Radiation":[1],"myelopathy":[2,195],"(RM)":[3],"is":[4],"known":[5],"as":[6,60,221,223],"a":[7],"serious":[8],"complication":[9],"of":[10,19,28,37,45,56,134,170,178,194,215],"head":[11],"andneck":[12],"radiation":[13],"therapy.":[14],"Furthermore,":[15,159],"the":[16,34,47,148,156,160,173,199,206,212,230],"radioprotective":[17,213],"roles":[18],"melatonin":[20,38,101,179,200,216],"have":[21],"beeninvestigated":[22],"on":[23,39],"different":[24],"tissues.":[25],"The":[26,62,68,79,93,144],"aim":[27],"this":[29,164,189],"study":[30,210],"was":[31,64,73,110],"to":[32,205],"assess":[33],"radio":[35],"protectiveeffects":[36],"biochemical,":[40,220],"histopathological":[41,142],"and":[42,52,103,127,136,140,183,226],"clinical":[43,192,227],"manifestations":[44],"RMin":[46],"rat":[48],"cervical":[49,83],"spinal":[50,84,231],"cord.Materials":[51],"Methods:":[53],"Four":[54],"groups":[55],"rats":[57],"were":[58,151,166,196],"investigated":[59],"follows:":[61],"controlgroup":[63,157],"treated":[65],"with":[66,75,88,112],"vehicle.":[67],"second":[69],"group":[70,95,121,150,165,175,203],"(melatonin":[71,96],"only)":[72],"intraperitoneallyinjected":[74],"100":[76,99],"mg/kg":[77,100],"melatonin.":[78],"third":[80],"group's":[81],"(radiation)":[82],"cord":[85],"areawas":[86],"irradiated":[87,111,207],"22":[89,113,128],"Gy":[90,114],"cobalt-60":[91],"gamma-rays.":[92],"fourth":[94],"plus":[97,201],"irradiation)received":[98],"intraperitoneally,":[102],"after":[104,130],"30":[105],"minutes":[106],"their":[107],"spinalcord":[108],"area":[109],"gamma":[115],"radiation.":[116],"Five":[117],"animals":[118],"from":[119],"each":[120],"wererandomly":[122],"selected.":[123],"72":[124],"hours,":[125],"8":[126],"weeks":[129],"irradiation":[131,149,202],"for":[132],"analysis":[133],"malondialdehyde(MDA)":[135],"glutathione":[137],"(GSH)":[138],"levels,":[139],"underwent":[141],"studies.Results:":[143],"MDA":[145,181],"levels":[146,162,187],"in":[147,155,163,172,188,198,229],"significantly":[152,167],"higher":[153],"than":[154],"(p<0.001).":[158,176],"GSH":[161,185],"lowerthan":[168],"that":[169],"those":[171],"control":[174],"Administration":[177],"markedlyreduced":[180],"(p<0.001)":[182],"increased":[184],"(p<0.05)":[186],"group.":[190],"Demyelinationand":[191],"signs":[193],"decreased":[197],"incomparison":[204],"group.Conclusion:":[208],"Our":[209],"confirms":[211],"effects":[214],"at":[217],"early":[218],"stagesof":[219],"well":[222],"late":[224],"histological":[225],"changes":[228],"cord.":[232]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}