{"id":"https://openalex.org/W2136353305","doi":"https://doi.org/10.1161/01.atv.18.9.1440","title":"Transcriptional Activation of Scavenger Receptor Expression in Human Smooth Muscle Cells Requires AP-1/c-Jun and C/EBP\u03b2","display_name":"Transcriptional Activation of Scavenger Receptor Expression in Human Smooth Muscle Cells Requires AP-1/c-Jun and C/EBP\u03b2","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2136353305","doi":"https://doi.org/10.1161/01.atv.18.9.1440","mag":"2136353305","pmid":"https://pubmed.ncbi.nlm.nih.gov/9743233"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.18.9.1440","doi":"https://doi.org/10.1161/01.atv.18.9.1440","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.18.9.1440","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030646475","display_name":"Michele Mietus\u2010Snyder","orcid":"https://orcid.org/0000-0003-2791-9896","observed_orcids":["https://orcid.org/0000-0003-2791-9896"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele Mietus-Snyder","raw_affiliation_strings":["From the Gladstone Institute of Cardiovascular Disease and Cardiovascular Research Institute (M.M., R.E.P.), and the Departments of Pediatrics (M.M.) and Pathology (R.E.P.), University of California, San Francisco, and the Department of Medicine (C.K.G.), University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Gladstone Institute of Cardiovascular Disease and Cardiovascular Research Institute (M.M., R.E.P.), and the Departments of Pediatrics (M.M.) and Pathology (R.E.P.), University of California, San Francisco, and the Department of Medicine (C.K.G.), University of California, San Diego","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039839135","display_name":"Christopher K. Glass","orcid":"https://orcid.org/0000-0003-4344-3592","observed_orcids":["https://orcid.org/0000-0003-4344-3592"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher K. Glass","raw_affiliation_strings":["From the Gladstone Institute of Cardiovascular Disease and Cardiovascular Research Institute (M.M., R.E.P.), and the Departments of Pediatrics (M.M.) and Pathology (R.E.P.), University of California, San Francisco, and the Department of Medicine (C.K.G.), University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Gladstone Institute of Cardiovascular Disease and Cardiovascular Research Institute (M.M., R.E.P.), and the Departments of Pediatrics (M.M.) and Pathology (R.E.P.), University of California, San Francisco, and the Department of Medicine (C.K.G.), University of California, San Diego","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063890834","display_name":"Robert E. Pitas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Pitas","raw_affiliation_strings":["From the Gladstone Institute of Cardiovascular Disease and Cardiovascular Research Institute (M.M., R.E.P.), and the Departments of Pediatrics (M.M.) and Pathology (R.E.P.), University of California, San Francisco, and the Department of Medicine (C.K.G.), University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Gladstone Institute of Cardiovascular Disease and Cardiovascular Research Institute (M.M., R.E.P.), and the Departments of Pediatrics (M.M.) and Pathology (R.E.P.), University of California, San Francisco, and the Department of Medicine (C.K.G.), University of California, San Diego","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2914,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.79060847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"9","first_page":"1440","last_page":"1449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.31540000438690186,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.31540000438690186,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.3122999966144562,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scavenger-receptor-a","display_name":"scavenger receptor A","score":0.8679999709129333},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.8130000233650208},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.9810000061988831},{"id":"https://openalex.org/keywords/c-ebpbeta","display_name":"C/EBP\u03b2","score":0.8830000162124634},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.902999997138977},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/promoter-cis-acting-elements","display_name":"promoter cis-acting elements","score":0.6930000185966492},{"id":"https://openalex.org/keywords/macrophage-differentiation","display_name":"macrophage differentiation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/foam-cells","display_name":"foam cells","score":0.7689999938011169},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/oxidized-ldl-uptake","display_name":"oxidized LDL uptake","score":0.7940000295639038},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9110000133514404},{"id":"https://openalex.org/keywords/vanadate","display_name":"vanadate","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7919999957084656},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.742153525352478},{"id":"https://openalex.org/C183978625","wikidata":"https://www.wikidata.org/wiki/Q903596","display_name":"Electrophoretic mobility shift assay","level":4,"score":0.5946744680404663},{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.5648632645606995},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5491622686386108},{"id":"https://openalex.org/C149240914","wikidata":"https://www.wikidata.org/wiki/Q907967","display_name":"Ccaat-enhancer-binding proteins","level":5,"score":0.5349932909011841},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.5049322247505188},{"id":"https://openalex.org/C2781116636","wikidata":"https://www.wikidata.org/wiki/Q426228","display_name":"Vanadate","level":2,"score":0.502769947052002},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.5025177001953125},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4742664098739624},{"id":"https://openalex.org/C132376346","wikidata":"https://www.wikidata.org/wiki/Q7315962","display_name":"Response element","level":5,"score":0.4550415873527527},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.4449394643306732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43440765142440796},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41550347208976746},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.40281257033348083},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.38238829374313354},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29739582538604736},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2828673720359802},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25806260108947754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25506487488746643},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.21076980233192444},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016755","descriptor_name":"Proto-Oncogene Proteins c-jun","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018110","descriptor_name":"Receptors, Lipoprotein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022762","descriptor_name":"CCAAT-Enhancer-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051116","descriptor_name":"Receptors, Scavenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051117","descriptor_name":"Scavenger Receptors, Class A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051122","descriptor_name":"Scavenger Receptors, Class B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.atv.18.9.1440","doi":"https://doi.org/10.1161/01.atv.18.9.1440","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.18.9.1440","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:9743233","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9743233","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6538273531","display_name":"GENETIC ALTERATIONS ON LIPOPROTEINS AND ATHEROSCLEROSIS","funder_award_id":"P01HL047660","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W74408211","https://openalex.org/W129757728","https://openalex.org/W207547976","https://openalex.org/W317487423","https://openalex.org/W1489079707","https://openalex.org/W1528630840","https://openalex.org/W1534501747","https://openalex.org/W1547367445","https://openalex.org/W1574193072","https://openalex.org/W1638074023","https://openalex.org/W1659855560","https://openalex.org/W1663535755","https://openalex.org/W1833545182","https://openalex.org/W1880220804","https://openalex.org/W1962586152","https://openalex.org/W1966582616","https://openalex.org/W1966714249","https://openalex.org/W1967004332","https://openalex.org/W1984903682","https://openalex.org/W1985096908","https://openalex.org/W1987453246","https://openalex.org/W1988059168","https://openalex.org/W1991464867","https://openalex.org/W1993002482","https://openalex.org/W1994975139","https://openalex.org/W1995138033","https://openalex.org/W1996078764","https://openalex.org/W1997296254","https://openalex.org/W1997739078","https://openalex.org/W2003962192","https://openalex.org/W2010409226","https://openalex.org/W2010701664","https://openalex.org/W2016730049","https://openalex.org/W2023208656","https://openalex.org/W2026951979","https://openalex.org/W2032038465","https://openalex.org/W2032731208","https://openalex.org/W2037599912","https://openalex.org/W2038484123","https://openalex.org/W2040179925","https://openalex.org/W2042260090","https://openalex.org/W2048435568","https://openalex.org/W2048569323","https://openalex.org/W2063329261","https://openalex.org/W2072569572","https://openalex.org/W2077309544","https://openalex.org/W2077880395","https://openalex.org/W2090554202","https://openalex.org/W2095623345","https://openalex.org/W2107611361","https://openalex.org/W2118897660","https://openalex.org/W2120626817","https://openalex.org/W2125008479","https://openalex.org/W2126440278","https://openalex.org/W2130066440","https://openalex.org/W2134605118","https://openalex.org/W2135633069","https://openalex.org/W2142100523","https://openalex.org/W2143314312","https://openalex.org/W2143837695","https://openalex.org/W2149870206","https://openalex.org/W2155512285","https://openalex.org/W2165235458","https://openalex.org/W2166513754","https://openalex.org/W2170005346","https://openalex.org/W2184891169","https://openalex.org/W2318787693","https://openalex.org/W2462837542"],"related_works":["https://openalex.org/W1974273062","https://openalex.org/W2110606487","https://openalex.org/W1962586152","https://openalex.org/W2113905128","https://openalex.org/W2071395953","https://openalex.org/W2108833026","https://openalex.org/W1976533104","https://openalex.org/W2025083945","https://openalex.org/W2139284406","https://openalex.org/W2017047609"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1,236],"species":[2,237],"generated":[3],"by":[4,141,167,186,301],"treatment":[5],"of":[6,20,27,46,93,101,111,136,202,251,260,287,295],"smooth":[7],"muscle":[8],"cells":[9,309],"(SMCs)":[10],"with":[11,17,257],"either":[12,94],"phorbol":[13,195],"12-myristate":[14,196],"13-acetate":[15],"or":[16,97,199],"the":[18,28,36,42,47,82,95,98,133,137,162,177,187,200,219,239,246,285,293],"combination":[19,201,259],"H2O2":[21,203],"and":[22,65,77,118,161,204,243,264,272,290,304],"vanadate":[23,263],"strongly":[24],"induce":[25],"expression":[26,56,289],"class":[29],"A":[30,67],"scavenger":[31],"receptor":[32],"(SR-A)":[33],"gene.":[34],"In":[35],"current":[37],"studies,":[38],"cis-acting":[39],"elements":[40],"in":[41,57,62,108,139,184,227,245,254,310],"proximal":[43],"245":[44],"bp":[45,79],"SR-A":[48,90,163,192,247,288],"promoter":[49,106,138,164],"were":[50,165],"shown":[51,223],"to":[52,59,81,179,224,284,306],"direct":[53],"luciferase":[54],"reporter":[55],"response":[58],"oxidative":[60,252,280],"stress":[61,253,281],"both":[63,302],"SMCs":[64,140,185,305],"macrophages.":[66],"composite":[68],"activating":[69],"protein-1":[70],"(AP-1)/ets":[71],"binding":[72,128,173,212],"element":[73],"located":[74,115],"between":[75,116,147,157,241],"-67":[76],"-50":[78],"relative":[80],"transcriptional":[83],"start":[84],"site":[85,103,114,221],"is":[86],"critical":[87],"for":[88,152,176,218],"macrophage":[89,269,303],"activity.":[91,274],"Mutation":[92,110],"AP-1":[96],"ets":[99],"component":[100],"this":[102],"also":[104],"prevented":[105],"activity":[107,135,213],"SMCs.":[109,228],"a":[112,126,258],"second":[113],"-44":[117],"-21":[119],"bp,":[120],"which":[121],"we":[122],"have":[123],"identified":[124],"as":[125],"CCAAT/enhancer":[127],"protein":[129],"(C/EBP)":[130],"element,":[131],"reduced":[132],"inducible":[134],"50%,":[142],"suggesting":[143],"that":[144,190,234,278],"combinatorial":[145],"interactions":[146,240],"these":[148,231],"sites":[149],"are":[150],"necessary":[151],"optimal":[153],"gene":[154],"induction.":[155],"Interactions":[156],"SMC":[158,215],"nuclear":[159],"extracts":[160,216],"analyzed":[166],"electrophoretic":[168],"mobility":[169],"shift":[170],"assay.":[171],"c-Jun/AP-1":[172,242],"activity,":[174],"specific":[175,217],"-67-":[178],"-50-bp":[180],"site,":[181],"was":[182,222],"induced":[183,268],"same":[188],"conditions":[189],"increased":[191],"expression.":[193],"Moreover,":[194],"13-acetate,":[197],"H2O2,":[198,267],"sodium":[205],"orthovanadate":[206],"(vanadate)":[207],"activated":[208],"c-Jun-activating":[209],"kinase.":[210],"The":[211],"within":[214],"C/EBP":[220],"be":[225],"C/EBPbeta":[226,244],"Taken":[229],"together,":[230],"findings":[232],"demonstrate":[233],"reactive":[235],"regulate":[238],"promoter.":[248],"Furthermore,":[249],"induction":[250,286],"THP-1":[255],"cells,":[256],"10":[261],"micromol/L":[262,266],"100":[265],"differentiation,":[270],"adhesion,":[271],"SR":[273],"These":[275],"data":[276],"suggest":[277],"vascular":[279],"may":[282],"contribute":[283],"thereby":[291],"promote":[292],"uptake":[294],"oxidatively":[296],"modified":[297],"low":[298],"density":[299],"lipoprotein":[300],"produce":[307],"foam":[308],"atherosclerotic":[311],"lesions.":[312]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}