{"id":"https://openalex.org/W2136347487","doi":null,"title":"The role of norepinephrine in learning: Cerebellar motor learning in rats","display_name":"The role of norepinephrine in learning: Cerebellar motor learning in rats","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2136347487","mag":"2136347487"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.usf.edu:etd-3314","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/etd/2315","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018874284","display_name":"Daniel Paredes","orcid":"https://orcid.org/0000-0002-9635-8001","observed_orcids":["https://orcid.org/0000-0002-9635-8001"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel Paredes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9635-8001","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018874284"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10982","display_name":"Motor Control and Adaptation","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":1.0},{"id":"https://openalex.org/keywords/cerebellar-motor-learning","display_name":"cerebellar motor learning","score":0.9110000133514404},{"id":"https://openalex.org/keywords/delay-eyeblink-conditioning","display_name":"delay eyeblink conditioning","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gaba-release","display_name":"GABA release","score":0.7319999933242798},{"id":"https://openalex.org/keywords/glutamate-release","display_name":"glutamate release","score":0.9990000128746033},{"id":"https://openalex.org/keywords/noradrenergic-modulation","display_name":"noradrenergic modulation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/gabaergic-modulation","display_name":"GABAergic modulation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/memory-consolidation","display_name":"memory consolidation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.8939999938011169},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9700000286102295},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.8939999938011169},{"id":"https://openalex.org/keywords/rp-camps","display_name":"Rp-cAMPS","score":0.9639999866485596},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9200000166893005},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.859000027179718},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/associative-learning","display_name":"associative learning","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C107690735","wikidata":"https://www.wikidata.org/wiki/Q852461","display_name":"Motor learning","level":2,"score":0.6585875153541565},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.6527351140975952},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6274495124816895},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.482523649930954},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39916762709617615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37756937742233276},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.16855737566947937}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.usf.edu:etd-3314","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/etd/2315","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},{"id":"pmh:oai:scholarcommons.usf.edu:etd-3314","doi":null,"is_oa":false,"landing_page_url":"https://scholarcommons.usf.edu/etd/2315","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},{"id":"mag:2136347487","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=3314&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":213,"referenced_works":["https://openalex.org/W59157286","https://openalex.org/W137814523","https://openalex.org/W203960507","https://openalex.org/W206496653","https://openalex.org/W328208477","https://openalex.org/W559973919","https://openalex.org/W1494607607","https://openalex.org/W1547412330","https://openalex.org/W1554606633","https://openalex.org/W1557671402","https://openalex.org/W1579779680","https://openalex.org/W1592924128","https://openalex.org/W1601794636","https://openalex.org/W1768037304","https://openalex.org/W1854590017","https://openalex.org/W1870077474","https://openalex.org/W1944942244","https://openalex.org/W1949031418","https://openalex.org/W1954301870","https://openalex.org/W1963867698","https://openalex.org/W1967441301","https://openalex.org/W1968023664","https://openalex.org/W1968064081","https://openalex.org/W1969378612","https://openalex.org/W1969930180","https://openalex.org/W1971301037","https://openalex.org/W1974036042","https://openalex.org/W1975908033","https://openalex.org/W1978006832","https://openalex.org/W1978232296","https://openalex.org/W1980284406","https://openalex.org/W1980919005","https://openalex.org/W1980933730","https://openalex.org/W1980964751","https://openalex.org/W1982357092","https://openalex.org/W1984510409","https://openalex.org/W1984696739","https://openalex.org/W1984994314","https://openalex.org/W1987013771","https://openalex.org/W1988756143","https://openalex.org/W1990043673","https://openalex.org/W1991221986","https://openalex.org/W1991413218","https://openalex.org/W1991463051","https://openalex.org/W1992084781","https://openalex.org/W1992799862","https://openalex.org/W1993665570","https://openalex.org/W1995627779","https://openalex.org/W1996354217","https://openalex.org/W1996516360","https://openalex.org/W1998107657","https://openalex.org/W1998747207","https://openalex.org/W2000644415","https://openalex.org/W2000684951","https://openalex.org/W2001301118","https://openalex.org/W2002008252","https://openalex.org/W2002062781","https://openalex.org/W2002637112","https://openalex.org/W2002853561","https://openalex.org/W2003106844","https://openalex.org/W2003609015","https://openalex.org/W2004678625","https://openalex.org/W2008792865","https://openalex.org/W2010343225","https://openalex.org/W2010487646","https://openalex.org/W2014428642","https://openalex.org/W2016144247","https://openalex.org/W2017742909","https://openalex.org/W2018222414","https://openalex.org/W2018761259","https://openalex.org/W2019267183","https://openalex.org/W2022746495","https://openalex.org/W2023307299","https://openalex.org/W2023347036","https://openalex.org/W2023677185","https://openalex.org/W2024328209","https://openalex.org/W2024651640","https://openalex.org/W2025518593","https://openalex.org/W2027178056","https://openalex.org/W2027801223","https://openalex.org/W2029055087","https://openalex.org/W2029410796","https://openalex.org/W2029700228","https://openalex.org/W2030854707","https://openalex.org/W2031402048","https://openalex.org/W2031576304","https://openalex.org/W2031753211","https://openalex.org/W2034486385","https://openalex.org/W2034991193","https://openalex.org/W2035322026","https://openalex.org/W2035475181","https://openalex.org/W2035767599","https://openalex.org/W2035853515","https://openalex.org/W2036075005","https://openalex.org/W2037161788","https://openalex.org/W2037647183","https://openalex.org/W2038405912","https://openalex.org/W2039129264","https://openalex.org/W2039246671","https://openalex.org/W2039430854","https://openalex.org/W2040957577","https://openalex.org/W2041091172","https://openalex.org/W2044584315","https://openalex.org/W2047433628","https://openalex.org/W2048699323","https://openalex.org/W2048993922","https://openalex.org/W2049356130","https://openalex.org/W2049564628","https://openalex.org/W2049722992","https://openalex.org/W2049761557","https://openalex.org/W2050180374","https://openalex.org/W2051473177","https://openalex.org/W2051663449","https://openalex.org/W2054511295","https://openalex.org/W2058107525","https://openalex.org/W2058481843","https://openalex.org/W2060685476","https://openalex.org/W2061642062","https://openalex.org/W2061845880","https://openalex.org/W2062657498","https://openalex.org/W2063416152","https://openalex.org/W2067839550","https://openalex.org/W2067945948","https://openalex.org/W2068232954","https://openalex.org/W2069132198","https://openalex.org/W2070110077","https://openalex.org/W2070201885","https://openalex.org/W2070750371","https://openalex.org/W2072704197","https://openalex.org/W2072965049","https://openalex.org/W2074486757","https://openalex.org/W2075895425","https://openalex.org/W2076075953","https://openalex.org/W2076425653","https://openalex.org/W2076436143","https://openalex.org/W2076765743","https://openalex.org/W2079668152","https://openalex.org/W2081634597","https://openalex.org/W2081655354","https://openalex.org/W2081743596","https://openalex.org/W2084727387","https://openalex.org/W2085644595","https://openalex.org/W2087432006","https://openalex.org/W2087685632","https://openalex.org/W2088801460","https://openalex.org/W2089118815","https://openalex.org/W2089240179","https://openalex.org/W2089587147","https://openalex.org/W2090648172","https://openalex.org/W2090707995","https://openalex.org/W2092745439","https://openalex.org/W2092867302","https://openalex.org/W2094404393","https://openalex.org/W2094768330","https://openalex.org/W2096766442","https://openalex.org/W2100787849","https://openalex.org/W2101172780","https://openalex.org/W2101540219","https://openalex.org/W2104341251","https://openalex.org/W2107458172","https://openalex.org/W2108556904","https://openalex.org/W2113377738","https://openalex.org/W2115204602","https://openalex.org/W2116447221","https://openalex.org/W2118303874","https://openalex.org/W2119588378","https://openalex.org/W2120003285","https://openalex.org/W2121609469","https://openalex.org/W2122400789","https://openalex.org/W2123179212","https://openalex.org/W2123567120","https://openalex.org/W2127863330","https://openalex.org/W2136965594","https://openalex.org/W2137800379","https://openalex.org/W2138141709","https://openalex.org/W2138728119","https://openalex.org/W2140505891","https://openalex.org/W2140804641","https://openalex.org/W2140954354","https://openalex.org/W2142520556","https://openalex.org/W2145661991","https://openalex.org/W2146392503","https://openalex.org/W2147084578","https://openalex.org/W2149028245","https://openalex.org/W2150666125","https://openalex.org/W2151416715","https://openalex.org/W2154054429","https://openalex.org/W2154653323","https://openalex.org/W2155051950","https://openalex.org/W2155551742","https://openalex.org/W2155834215","https://openalex.org/W2160425673","https://openalex.org/W2162177059","https://openalex.org/W2167160358","https://openalex.org/W2168367599","https://openalex.org/W2237071195","https://openalex.org/W2266790894","https://openalex.org/W2295352249","https://openalex.org/W2295917380","https://openalex.org/W2315512556","https://openalex.org/W2320347944","https://openalex.org/W2330767417","https://openalex.org/W2385528296","https://openalex.org/W2395552982","https://openalex.org/W2396368615","https://openalex.org/W2401750990","https://openalex.org/W2419209303","https://openalex.org/W2467292408","https://openalex.org/W2468401558","https://openalex.org/W4255512560","https://openalex.org/W4292340975","https://openalex.org/W4318444672","https://openalex.org/W4407042387"],"related_works":["https://openalex.org/W2093089228","https://openalex.org/W2149028245","https://openalex.org/W2140954354","https://openalex.org/W2121609469","https://openalex.org/W2072965049","https://openalex.org/W3213566126","https://openalex.org/W4385726989","https://openalex.org/W1995627779","https://openalex.org/W2104341251","https://openalex.org/W1497313133"],"abstract_inverted_index":{"Delay":[0],"classical":[1],"eyeblink":[2,134,197],"conditioning":[3,135,198],"is":[4,47,211],"an":[5],"important":[6],"model":[7],"of":[8,23,34,79,93,101,119,126,158,170,186,202,245],"associative,":[9],"cerebellar":[10,50],"dependent":[11],"learning.":[12,172,251],"Norepinephrine":[13],"(NE)":[14],"plays":[15],"a":[16,91,99,162,191],"significant":[17],"modulatory":[18],"role":[19],"in":[20,49,85,164,193,216,247],"the":[21,77,102,113,117,124,133,139,143,156,165,168,183,194,203,207,214,236],"acquisition":[22,169],"learning;":[24],"other":[25],"neurotransmitter":[26,108,204],"systems":[27],"are":[28,148],"also":[29,230],"at":[30],"play.":[31],"The":[32,74,227],"goal":[33],"this":[35,232],"dissertation":[36],"was":[37,61,177,188],"to":[38,70,107,179,196,221],"determine":[39],"whether":[40,58],"NE,":[41],"GABA":[42,97],"and":[43,57,66,81,96,121,142,182,199,240],"glutamate":[44],"(Glu)":[45],"release":[46,60,187],"observed":[48],"cortex":[51],"during":[52],"delay":[53,192],"eye":[54],"blink":[55],"conditioning,":[56],"such":[59],"selectively":[62],"associated":[63],"with":[64,88],"training":[65,131],"not":[67],"due":[68,220],"only":[69],"stimulatory":[71],"sensory":[72],"input.":[73],"data":[75],"support":[76,155],"hypothesis":[78,157],"noradrenergic":[80],"GABAergic":[82],"system":[83],"involvement":[84],"motor":[86,171],"learning":[87,127],"NE":[89,159],"as":[90,98,161],"modulator":[92],"early":[94],"responding":[95],"mediator":[100],"learned":[103],"response.":[104],"In":[105],"addition":[106],"levels,":[109],"we":[110,241],"found":[111,242],"that":[112,138,213,243],"local":[114],"administration":[115],"into":[116],"cerebellum":[118,166],"Rp-cAMP":[120],"propranolol":[122],"impair":[123],"consolidation":[125],"when":[128],"administered":[129],"post":[130],"on":[132],"task":[136],"indicating":[137],"B-adrenergic":[140],"receptor":[141],"cAMP":[144],"downstream":[145],"signaling":[146],"cascade":[147],"essential":[149],"for":[150,167],"memory":[151],"consolidation.":[152],"These":[153],"results":[154],"acting":[160],"neuromodulator":[163],"A":[173],"similar":[174],"experimental":[175],"design":[176],"applied":[178],"aged":[180,248],"animals":[181,249],"neurochemical":[184],"pattern":[185],"haracterized":[189],"by":[190,206,224,234],"response":[195],"smaller":[200],"amounts":[201],"evoked":[205],"paired":[208],"US-CS.":[209],"It":[210],"hypothesized":[212],"impairment":[215],"aging":[217],"could":[218],"be":[219],"excitotoxicity":[222],"caused":[223],"chronic":[225],"inflammation.":[226],"present":[228],"study":[229],"approached":[231],"issue":[233],"targeting":[235],"pro-inflammatory":[237],"cytokine":[238],"TNF-a":[239,246],"suppression":[244],"improved":[250]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}