{"id":"https://openalex.org/W2136337955","doi":"https://doi.org/10.1016/s0022-2275(20)38328-0","title":"CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption.","display_name":"CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption.","publication_year":1989,"publication_date":"1989-05-01","ids":{"openalex":"https://openalex.org/W2136337955","doi":"https://doi.org/10.1016/s0022-2275(20)38328-0","mag":"2136337955","pmid":"https://pubmed.ncbi.nlm.nih.gov/2760542"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2275(20)38328-0","doi":"https://doi.org/10.1016/s0022-2275(20)38328-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)38328-0","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0022-2275(20)38328-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049529862","display_name":"Elwood E. Largis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E E Largis","raw_affiliation_strings":["American Cyanamid Company, Medical Research Division, Metabolic Disease Research Section, Pearl River, NY 10965","Cholestech, 3100 Diablo Ave., Hayward, CA 94545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Cyanamid Company, Medical Research Division, Metabolic Disease Research Section, Pearl River, NY 10965","institution_ids":[]},{"raw_affiliation_string":"Cholestech, 3100 Diablo Ave., Hayward, CA 94545","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063486038","display_name":"Chao-Hsiung Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C H Wang","raw_affiliation_strings":["American Cyanamid Company, Medical Research Division, Metabolic Disease Research Section, Pearl River, NY 10965","Cholestech, 3100 Diablo Ave., Hayward, CA 94545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Cyanamid Company, Medical Research Division, Metabolic Disease Research Section, Pearl River, NY 10965","institution_ids":[]},{"raw_affiliation_string":"Cholestech, 3100 Diablo Ave., Hayward, CA 94545","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050703126","display_name":"Vern G. DeVries","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V G DeVries","raw_affiliation_strings":["American Cyanamid Company, Medical Research Division, Metabolic Disease Research Section, Pearl River, NY 10965","Cholestech, 3100 Diablo Ave., Hayward, CA 94545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Cyanamid Company, Medical Research Division, Metabolic Disease Research Section, Pearl River, NY 10965","institution_ids":[]},{"raw_affiliation_string":"Cholestech, 3100 Diablo Ave., Hayward, CA 94545","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014987704","display_name":"Sheldon A. Schaffer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Schaffer","raw_affiliation_strings":["American Cyanamid Company, Medical Research Division, Metabolic Disease Research Section, Pearl River, NY 10965","Cholestech, 3100 Diablo Ave., Hayward, CA 94545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Cyanamid Company, Medical Research Division, Metabolic Disease Research Section, Pearl River, NY 10965","institution_ids":[]},{"raw_affiliation_string":"Cholestech, 3100 Diablo Ave., Hayward, CA 94545","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.3303,"has_fulltext":false,"cited_by_count":125,"citation_normalized_percentile":{"value":0.88438715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"5","first_page":"681","last_page":"690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acat-inhibitors","display_name":"ACAT inhibitors","score":0.843999981880188},{"id":"https://openalex.org/keywords/acyl-coa-cholesterol-acyltransferase","display_name":"acyl-CoA:cholesterol acyltransferase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cholesterol-esterification","display_name":"cholesterol esterification","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cholesterol-absorption","display_name":"cholesterol absorption","score":0.8730000257492065},{"id":"https://openalex.org/keywords/intestinal-microsomes","display_name":"intestinal microsomes","score":0.8420000076293945},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.8379999995231628},{"id":"https://openalex.org/keywords/lcat","display_name":"lecithin:cholesterol acyltransferase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.5699999928474426},{"id":"https://openalex.org/keywords/fecal-sterol-excretion","display_name":"fecal sterol excretion","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6941109299659729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5989421010017395},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5466705560684204},{"id":"https://openalex.org/C37002583","wikidata":"https://www.wikidata.org/wiki/Q418755","display_name":"Sterol O-acyltransferase","level":4,"score":0.43592873215675354},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.42241692543029785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32253265380859375},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11467882990837097},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.08050447702407837},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002785","descriptor_name":"Sterol O-Acyltransferase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D002788","descriptor_name":"Cholesterol Esters","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002791","descriptor_name":"Cholesterol, Dietary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-2275(20)38328-0","doi":"https://doi.org/10.1016/s0022-2275(20)38328-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)38328-0","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:2760542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2760542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f2c77325ffa74ed1b6d1a84ef2965cc6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f2c77325ffa74ed1b6d1a84ef2965cc6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 30, Iss 5, Pp 681-690 (1989)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s0022-2275(20)38328-0","doi":"https://doi.org/10.1016/s0022-2275(20)38328-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)38328-0","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1528094737","https://openalex.org/W1576143677","https://openalex.org/W1690989171","https://openalex.org/W1762207328","https://openalex.org/W1885778179","https://openalex.org/W1940775645","https://openalex.org/W1978026006","https://openalex.org/W1982052627","https://openalex.org/W1984596488","https://openalex.org/W1987119044","https://openalex.org/W1988277618","https://openalex.org/W1995571665","https://openalex.org/W2004819234","https://openalex.org/W2009693687","https://openalex.org/W2011364994","https://openalex.org/W2015816429","https://openalex.org/W2019868922","https://openalex.org/W2026310716","https://openalex.org/W2030212131","https://openalex.org/W2044103346","https://openalex.org/W2046006081","https://openalex.org/W2052985926","https://openalex.org/W2054309139","https://openalex.org/W2070683471","https://openalex.org/W2074958815","https://openalex.org/W2078387276","https://openalex.org/W2081614838","https://openalex.org/W2085710489","https://openalex.org/W2090743131","https://openalex.org/W2093893855","https://openalex.org/W2112607815","https://openalex.org/W2120626817","https://openalex.org/W2135503869","https://openalex.org/W2158979977","https://openalex.org/W2168526937","https://openalex.org/W2169502881","https://openalex.org/W2173237738","https://openalex.org/W2186320764","https://openalex.org/W2187146142","https://openalex.org/W2188814922","https://openalex.org/W2189179707","https://openalex.org/W2315123766","https://openalex.org/W2317339985","https://openalex.org/W2345976769","https://openalex.org/W2398346263","https://openalex.org/W2414786835","https://openalex.org/W2431905133","https://openalex.org/W2950005186","https://openalex.org/W4249299501","https://openalex.org/W4253480285"],"related_works":["https://openalex.org/W2038896211","https://openalex.org/W2011792759","https://openalex.org/W2186320764","https://openalex.org/W1970997914","https://openalex.org/W2088096116","https://openalex.org/W2009471331","https://openalex.org/W2038918536","https://openalex.org/W1967115865","https://openalex.org/W2294824851","https://openalex.org/W1967189075"],"abstract_inverted_index":{"CL":[0],"277,082":[1],"(I)":[2],"was":[3,45,61,102,117],"found":[4,62],"to":[5,48,63],"be":[6,64],"a":[7,20,118],"potent":[8,119],"inhibitor":[9,120],"of":[10,22,27,104,121,147],"acyl":[11,107],"CoA:cholesterol":[12],"acyltransferase":[13,90,109],"(ACAT,":[14],"EC":[15],"2.3.1.26)":[16],"in":[17,51,66,124,131,151],"microsomes":[18,114],"from":[19,111],"variety":[21],"tissues":[23],"with":[24],"IC50":[25],"values":[26],"0.14":[28],"microM":[29,35,40],"for":[30,36,41],"intestinal":[31,112],"mucosal":[32,113],"microsomes,":[33],"0.74":[34],"liver,":[37],"and":[38,60,92,133],"1.18":[39],"rat":[42],"adrenal.":[43],"I":[44,116],"also":[46],"shown":[47],"inhibit":[49,74],"ACAT":[50],"cultured":[52],"smooth":[53],"muscle":[54],"cells":[55],"(IC50":[56],"=":[57,138],"0.8":[58],"microM)":[59],"specific":[65],"inhibiting":[67,129],"cholesterol":[68,84,94,122,135],"esterification":[69,103],"since":[70],"it":[71],"did":[72],"not":[73,97],"fatty":[75],"acid":[76],"incorporation":[77],"into":[78],"triglycerides":[79],"or":[80],"phospholipids.":[81],"Also,":[82],"other":[83],"esterifying":[85],"enzymes":[86],"such":[87],"as":[88],"lecithin:cholesterol":[89],"(LCAT)":[91],"pancreatic":[93],"esterase":[95],"were":[96],"inhibited":[98],"by":[99,106,127],"I,":[100],"nor":[101],"retinol":[105],"CoA:retinol":[108],"(ARAT)":[110],"inhibited.":[115],"absorption":[123],"cholesterol-fed":[125],"rats":[126],"markedly":[128],"increases":[130],"liver":[132],"serum":[134],"concentration":[136],"(ED50":[137],"5.2":[139],"mg/kg":[140],"per":[141],"day)":[142],"while":[143],"increasing":[144],"the":[145,152],"excretion":[146],"neutral":[148],"14C-labeled":[149],"sterol":[150],"feces.":[153]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}