{"id":"https://openalex.org/W2136335306","doi":"https://doi.org/10.1111/adb.12264","title":"Lateral hypothalamic melanocortin receptor signaling modulates binge-like ethanol drinking in C57BL/6J mice","display_name":"Lateral hypothalamic melanocortin receptor signaling modulates binge-like ethanol drinking in C57BL/6J mice","publication_year":2015,"publication_date":"2015-05-15","ids":{"openalex":"https://openalex.org/W2136335306","doi":"https://doi.org/10.1111/adb.12264","mag":"2136335306","pmid":"https://pubmed.ncbi.nlm.nih.gov/25975524","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4644727"},"language":"en","primary_location":{"id":"doi:10.1111/adb.12264","doi":"https://doi.org/10.1111/adb.12264","is_oa":false,"landing_page_url":"https://doi.org/10.1111/adb.12264","pdf_url":null,"source":{"id":"https://openalex.org/S118332200","display_name":"Addiction Biology","issn_l":"1355-6215","issn":["1355-6215","1369-1600"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4644727","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062102945","display_name":"Gretchen M. Sprow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gretchen M. Sprow","raw_affiliation_strings":["Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071284614","display_name":"Jennifer A. Rinker","orcid":"https://orcid.org/0000-0003-3738-3693","observed_orcids":["https://orcid.org/0000-0003-3738-3693"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. Rinker","raw_affiliation_strings":["Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040290147","display_name":"Emily G. Lowery-Gointa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily G. Lowery-Gointa","raw_affiliation_strings":["Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040423103","display_name":"Angela M. Sparrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela M. Sparrow","raw_affiliation_strings":["Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055502018","display_name":"Montserrat Navarro","orcid":"https://orcid.org/0000-0002-6249-7425","observed_orcids":["https://orcid.org/0000-0002-6249-7425"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Montserrat Navarro","raw_affiliation_strings":["Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007599570","display_name":"Todd E. Thiele","orcid":"https://orcid.org/0000-0001-8908-9256","observed_orcids":["https://orcid.org/0000-0001-8908-9256"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Todd E. Thiele","raw_affiliation_strings":["Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007599570"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":null,"fwci":1.6634,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80991736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"21","issue":"4","first_page":"835","last_page":"846"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanocortin-system","display_name":"melanocortin system","score":0.9599999785423279},{"id":"https://openalex.org/keywords/lateral-hypothalamus","display_name":"lateral hypothalamus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alpha-msh","display_name":"alpha-melanocyte-stimulating hormone","score":0.9789999723434448},{"id":"https://openalex.org/keywords/agouti-related-protein","display_name":"agouti-related protein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melanotan-ii","display_name":"melanotan II","score":0.8930000066757202},{"id":"https://openalex.org/keywords/alcohol-abuse","display_name":"alcohol abuse","score":0.5950000286102295},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C43295716","wikidata":"https://www.wikidata.org/wiki/Q21118676","display_name":"Melanocortin 4 receptor","level":4,"score":0.7847484946250916},{"id":"https://openalex.org/C2779993316","wikidata":"https://www.wikidata.org/wiki/Q6591465","display_name":"Melanocortin","level":3,"score":0.7398611307144165},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6609832048416138},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6385658979415894},{"id":"https://openalex.org/C2776679223","wikidata":"https://www.wikidata.org/wiki/Q1521260","display_name":"Binge drinking","level":4,"score":0.6090044975280762},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.510822057723999},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4775962829589844},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.369997501373291},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33799564838409424},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.3179379105567932},{"id":"https://openalex.org/C3019635848","wikidata":"https://www.wikidata.org/wiki/Q154","display_name":"Alcohol consumption","level":3,"score":0.1656724512577057},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05286911129951477}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063425","descriptor_name":"Binge Drinking","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D063425","descriptor_name":"Binge Drinking","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D063425","descriptor_name":"Binge Drinking","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/adb.12264","doi":"https://doi.org/10.1111/adb.12264","is_oa":false,"landing_page_url":"https://doi.org/10.1111/adb.12264","pdf_url":null,"source":{"id":"https://openalex.org/S118332200","display_name":"Addiction Biology","issn_l":"1355-6215","issn":["1355-6215","1369-1600"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction Biology","raw_type":"journal-article"},{"id":"pmid:25975524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25975524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4644727","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4644727","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Addict Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4644727","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4644727","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Addict Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2151763855","display_name":"CFR signaling in stress- and dependence- induced ethanol consumption","funder_award_id":"F31AA017803","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G3126736605","display_name":"Melanocortin Neuropeptides & Ethanol Intake","funder_award_id":"R01AA015148","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G3197818700","display_name":"Histone Methylation: a role in excessive ethanol intake and self-administration","funder_award_id":"F32AA021611","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5608247939","display_name":"Stress-induced increases of ethanol intake: The role of neuropeptide Y (NPY)","funder_award_id":"F31AA017818","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5624462870","display_name":"Ethanol-Induced Locomotor Sensitization: NPY Signaling and Chromatin Remodeling","funder_award_id":"F31AA019839","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7216287058","display_name":"MELANCORTIN AND OPIOID PEPTIDE INTERACTIONS IN THE MODULATION OF BINGE ALCOHOL DRINKING","funder_award_id":"W81XWH0910293","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G7918766688","display_name":"Neuropeptide Y: Role in Ethanol Intake and Sensitivity","funder_award_id":"R01AA013573","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000884384","display_name":"Predoctoral Training in Addiction Science","funder_award_id":"T32DA007244","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000890683","display_name":"Neuropeptide Y: Role in Ethanol Intake and Sensitivity","funder_award_id":"R37AA013573","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000901846","display_name":"The role of corticotropin releasing factor in binge-like ethanol drinking","funder_award_id":"R01AA022048","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G990791623","display_name":"Adolescent binging augments adult alcohol intake: A role of histone methylation","funder_award_id":"R21AA022044","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W332043374","https://openalex.org/W1780379214","https://openalex.org/W1798179180","https://openalex.org/W1970953621","https://openalex.org/W1971951650","https://openalex.org/W1979914335","https://openalex.org/W1981784954","https://openalex.org/W1989084391","https://openalex.org/W1989416066","https://openalex.org/W1990618841","https://openalex.org/W1997127337","https://openalex.org/W2001164806","https://openalex.org/W2002190250","https://openalex.org/W2006102894","https://openalex.org/W2008360236","https://openalex.org/W2017911732","https://openalex.org/W2018571651","https://openalex.org/W2023058003","https://openalex.org/W2036723133","https://openalex.org/W2040982044","https://openalex.org/W2042124635","https://openalex.org/W2044655068","https://openalex.org/W2044786960","https://openalex.org/W2048812086","https://openalex.org/W2055917442","https://openalex.org/W2056359334","https://openalex.org/W2057279285","https://openalex.org/W2057361936","https://openalex.org/W2066169417","https://openalex.org/W2069091630","https://openalex.org/W2072483237","https://openalex.org/W2077266139","https://openalex.org/W2085199926","https://openalex.org/W2088174118","https://openalex.org/W2090974177","https://openalex.org/W2091496200","https://openalex.org/W2094640076","https://openalex.org/W2099440512","https://openalex.org/W2109645453","https://openalex.org/W2130481665","https://openalex.org/W2132417212","https://openalex.org/W2153867200","https://openalex.org/W2156744092","https://openalex.org/W2159646413","https://openalex.org/W2165413852","https://openalex.org/W2166737526","https://openalex.org/W2414963940","https://openalex.org/W2777548161"],"related_works":["https://openalex.org/W2006102894","https://openalex.org/W2023058003","https://openalex.org/W1979914335","https://openalex.org/W2954450282","https://openalex.org/W2040982044","https://openalex.org/W4248578975","https://openalex.org/W2165413852","https://openalex.org/W4301332452","https://openalex.org/W1990618841","https://openalex.org/W2751730470"],"abstract_inverted_index":{"Binge":[0],"ethanol":[1,30,58,86,151,192,232],"drinking":[2],"is":[3],"a":[4,43,209],"highly":[5],"pervasive":[6],"and":[7,28,32,75,126,234],"destructive":[8],"behavior":[9],"yet":[10],"the":[11,37,49,61,64,72,170,177,185,197,204,214,218,226],"underlying":[12],"neurobiological":[13,23],"mechanisms":[14,24,227],"remain":[15],"poorly":[16],"understood.":[17],"Recent":[18],"work":[19,51],"suggests":[20],"that":[21,36,132,176,208,228],"overlapping":[22],"modulate":[25,229],"feeding":[26],"disorders":[27],"excessive":[29,230],"intake,":[31],"converging":[33],"evidence":[34],"indicates":[35],"melanocortin":[38],"(MC)":[39],"system":[40,74],"may":[41,235],"be":[42],"promising":[44],"candidate.":[45],"The":[46],"aims":[47],"of":[48,79,99,117,213],"present":[50,205],"were":[52,91,202],"to":[53,93,164],"examine":[54],"how":[55],"repeated":[56,149],"binge-like":[57,85,100,150,191,231],"drinking,":[59,105],"using":[60],"'drinking":[62],"in":[63],"dark'":[65],"(DID)":[66],"protocol,":[67],"impacts":[68],"key":[69,118],"peptides":[70],"within":[71,144,169,217],"MC":[73,80,119,215],"if":[76],"site-specific":[77],"manipulation":[78],"receptor":[81],"(MCR)":[82],"signaling":[83],"modulates":[84],"drinking.":[87,152],"Male":[88],"C57BL/6J":[89],"mice":[90],"exposed":[92],"one,":[94],"three":[95],"or":[96,103,166],"six":[97],"cycles":[98],"ethanol,":[101],"sucrose":[102],"water":[104],"after":[106],"which":[107],"brain":[108],"tissue":[109],"was":[110,135,141],"processed":[111],"via":[112],"immunohistochemistry":[113],"(IHC)":[114],"for":[115],"analysis":[116],"peptides,":[120],"including":[121],"alpha-melanocyte":[122],"stimulating":[123],"hormone":[124],"(\u03b1-MSH)":[125],"agouti-related":[127],"protein":[128],"(AgRP).":[129],"Results":[130],"indicated":[131],"\u03b1-MSH":[133],"expression":[134,140],"selectively":[136,142],"decreased,":[137],"while":[138,184],"AgRP":[139,189],"increased,":[143],"specific":[145],"hypothalamic":[146],"subregions":[147],"following":[148],"To":[153],"further":[154],"explore":[155],"this":[156],"relationship,":[157],"we":[158],"used":[159],"site-directed":[160],"drug":[161],"delivery":[162],"techniques":[163],"agonize":[165],"antagonize":[167],"MCRs":[168],"lateral":[171],"hypothalamus":[172,219],"(LH).":[173],"We":[174],"found":[175],"nonselective":[178,186],"MCR":[179,187],"agonist":[180],"melanotan-II":[181],"(MTII)":[182],"blunted,":[183],"antagonist":[188],"augmented,":[190],"consumption":[193],"when":[194],"delivered":[195],"into":[196,225],"LH.":[198],"As":[199],"these":[200],"effects":[201],"region-specific,":[203],"results":[206],"suggest":[207],"more":[210],"thorough":[211],"understanding":[212],"neurocircuitry":[216],"will":[220],"help":[221,236],"provide":[222],"novel":[223],"insight":[224],"intake":[233],"uncover":[237],"new":[238],"therapeutic":[239],"targets":[240],"aimed":[241],"at":[242],"treating":[243],"alcohol":[244],"abuse":[245],"disorders.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}