{"id":"https://openalex.org/W2136304667","doi":"https://doi.org/10.1085/jgp.79.1.1","title":"The T-SR junction in contracting single skeletal muscle fibers.","display_name":"The T-SR junction in contracting single skeletal muscle fibers.","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2136304667","doi":"https://doi.org/10.1085/jgp.79.1.1","mag":"2136304667","pmid":"https://pubmed.ncbi.nlm.nih.gov/7061983","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2215487"},"language":"en","primary_location":{"id":"doi:10.1085/jgp.79.1.1","doi":"https://doi.org/10.1085/jgp.79.1.1","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.79.1.1","pdf_url":"https://rupress.org/jgp/article-pdf/79/1/1/1248088/1.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jgp/article-pdf/79/1/1/1248088/1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103432135","display_name":"Brenda Russell Eisenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B R Eisenberg","raw_affiliation_strings":["From the Department of Physiology, Rush Medical College, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Physiology, Rush Medical College, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091003144","display_name":"Bob Eisenberg","orcid":"https://orcid.org/0000-0002-4860-5434","observed_orcids":["https://orcid.org/0000-0002-4860-5434"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R S Eisenberg","raw_affiliation_strings":["From the Department of Physiology, Rush Medical College, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Physiology, Rush Medical College, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1168,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.95552101,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"79","issue":"1","first_page":"1","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-tubules","display_name":"T-tubules","score":0.6759999990463257},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum","display_name":"sarcoplasmic reticulum","score":0.9929999709129333},{"id":"https://openalex.org/keywords/skeletal-muscle-fibers","display_name":"skeletal muscle fibers","score":0.5600000023841858},{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/pillar-formation","display_name":"pillar formation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/caffeine-induced-contraction","display_name":"caffeine-induced contraction","score":0.6549999713897705},{"id":"https://openalex.org/keywords/potassium-activation","display_name":"potassium activation","score":0.5379999876022339},{"id":"https://openalex.org/keywords/frog-skeletal-muscle","display_name":"frog skeletal muscle","score":0.6710000038146973},{"id":"https://openalex.org/keywords/ultrastructure","display_name":"ultrastructure","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.6732785105705261},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5880029201507568},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5685402750968933},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5321136116981506},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48798245191574097},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.48408806324005127},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.42221078276634216},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.37230971455574036},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.33242830634117126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19303131103515625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17509198188781738},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1085/jgp.79.1.1","doi":"https://doi.org/10.1085/jgp.79.1.1","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.79.1.1","pdf_url":"https://rupress.org/jgp/article-pdf/79/1/1/1248088/1.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2215487","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2215487","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Physiol","raw_type":"Text"},{"id":"pmid:7061983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7061983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.7088","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.7088","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a2/48/J_Gen_Physiol_1982_Jan_1_79(1)_1-19.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1085/jgp.79.1.1","doi":"https://doi.org/10.1085/jgp.79.1.1","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.79.1.1","pdf_url":"https://rupress.org/jgp/article-pdf/79/1/1/1248088/1.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320308306","display_name":"Muscular Dystrophy Association","ror":"https://ror.org/01frxsf98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136304667.pdf","grobid_xml":"https://content.openalex.org/works/W2136304667.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W26395903","https://openalex.org/W174161117","https://openalex.org/W397537768","https://openalex.org/W1965027362","https://openalex.org/W1973150566","https://openalex.org/W1973154482","https://openalex.org/W1981176514","https://openalex.org/W1986969419","https://openalex.org/W1990901750","https://openalex.org/W1993237652","https://openalex.org/W1995507555","https://openalex.org/W1997974802","https://openalex.org/W2007062222","https://openalex.org/W2010143584","https://openalex.org/W2014778788","https://openalex.org/W2015154923","https://openalex.org/W2026362533","https://openalex.org/W2028006365","https://openalex.org/W2056741720","https://openalex.org/W2059871021","https://openalex.org/W2071724691","https://openalex.org/W2074969278","https://openalex.org/W2077879270","https://openalex.org/W2082311802","https://openalex.org/W2083810536","https://openalex.org/W2116695922","https://openalex.org/W2127911529","https://openalex.org/W2155528622","https://openalex.org/W2233670410","https://openalex.org/W2328578416","https://openalex.org/W2338373073","https://openalex.org/W2415547617","https://openalex.org/W2417378968","https://openalex.org/W4235612371","https://openalex.org/W4241048159","https://openalex.org/W4241181537","https://openalex.org/W6632683237","https://openalex.org/W6647685823","https://openalex.org/W6652076402"],"related_works":["https://openalex.org/W7097594270","https://openalex.org/W2013682104","https://openalex.org/W2043890114","https://openalex.org/W2231314130","https://openalex.org/W4415467518","https://openalex.org/W2156022181","https://openalex.org/W2957608798","https://openalex.org/W2135356042","https://openalex.org/W7171811121","https://openalex.org/W4242475783"],"abstract_inverted_index":{"The":[0],"junction":[1],"between":[2,37,73],"the":[3,35,61,71,79,89,97,173],"T":[4,38,74],"system":[5],"and":[6,18,40,55,76,175],"sarcoplasmic":[7],"reticulum":[8],"(SR)":[9],"of":[10,25,47,119],"frog":[11],"skeletal":[12],"muscle":[13],"was":[14,67],"examined":[15],"in":[16,45,70,144,185],"resting":[17],"contracting":[19,143],"muscles.":[20],"Pillars,":[21],"defined":[22,43],"as":[23,56,83],"pairs":[24],"electron-opaque":[26,53],"lines":[27],"bounding":[28],"an":[29],"electron-lucent":[30],"interior,":[31],"were":[32],"seen":[33],"spanning":[34],"gap":[36,72],"membrane":[39,75],"SR.":[41,77],"Feet,":[42],"previously":[44],"images":[46],"heavily":[48],"stained":[49],"preparations,":[50],"appear":[51],"with":[52],"interiors":[54],"such":[57],"are":[58,162],"distinct":[59],"from":[60,172],"pillars":[62],"studied":[63],"here.":[64],"Amorphous":[65],"material":[66,81],"often":[68],"present":[69],"Sometimes":[78],"amorphous":[80],"appeared":[82],"a":[84,126,183],"thin":[85],"line":[86],"parallel":[87],"to":[88,146],"membranes;":[90],"sometimes":[91],"it":[92],"seemed":[93],"loosely":[94],"organized":[95],"at":[96,129],"sites":[98],"where":[99],"feet":[100],"have":[101],"been":[102],"reported.":[103],"Resting":[104],"single":[105],"fibers":[106,142,161],"contained":[107,133,150],"39":[108],"+/-":[109,112,135,152],"14.3":[110],"(mean":[111],"SD;":[113],"n":[114],"=":[115,139,155],"9":[116],"fibers)":[117],"pillars/micrometer2":[118,137],"tubule":[120],"membrane.":[121],"Single":[122],"fibers,":[123],"activated":[124,163],"by":[125],"potassium-rich":[127],"solution":[128],"4":[130],"degrees":[131],"C,":[132],"66":[134],"12.9":[136],"(n":[138,154],"8)":[140],"but":[141,165],"response":[145],"2":[147],"mM":[148],"caffeine":[149],"33":[151],"8.6/micrometer2":[153],"5).":[156],"Pillar":[157],"formation":[158,181],"occurs":[159],"when":[160,167],"electrically,":[164],"not":[166],"calcium":[168],"is":[169,182],"released":[170],"directly":[171],"SR;":[174],"so":[176],"we":[177],"postulate":[178],"that":[179],"pillar":[180],"step":[184],"excitation-contraction":[186],"coupling.":[187]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}