{"id":"https://openalex.org/W2136289786","doi":"https://doi.org/10.1016/j.juro.2006.04.038","title":"Age Related Changes in the Functional, Biochemical and Molecular Properties of \u03b1 1 -Adrenoceptors in the Rat Genitourinary Tract","display_name":"Age Related Changes in the Functional, Biochemical and Molecular Properties of \u03b1 1 -Adrenoceptors in the Rat Genitourinary Tract","publication_year":2006,"publication_date":"2006-08-09","ids":{"openalex":"https://openalex.org/W2136289786","doi":"https://doi.org/10.1016/j.juro.2006.04.038","mag":"2136289786","pmid":"https://pubmed.ncbi.nlm.nih.gov/16890728"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2006.04.038","doi":"https://doi.org/10.1016/j.juro.2006.04.038","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2006.04.038","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033748764","display_name":"Makoto Yono","orcid":"https://orcid.org/0000-0002-5239-1395","observed_orcids":["https://orcid.org/0000-0002-5239-1395"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Makoto Yono","raw_affiliation_strings":["Section of Urology, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Urology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111686671","display_name":"Harris E. Foster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harris E. Foster","raw_affiliation_strings":["Section of Urology, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Urology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert M. Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Weiss","raw_affiliation_strings":["Section of Urology, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Urology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041631443","display_name":"Jamshid Latifpour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamshid Latifpour","raw_affiliation_strings":["Section of Urology, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Urology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":2.4482,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.88027778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"176","issue":"3","first_page":"1214","last_page":"1219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.030400000512599945,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.9589999914169312},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9549999833106995},{"id":"https://openalex.org/keywords/urogenital-tract","display_name":"urogenital tract","score":0.7649999856948853},{"id":"https://openalex.org/keywords/prostate","display_name":"prostate","score":0.5839999914169312},{"id":"https://openalex.org/keywords/bladder","display_name":"urinary bladder","score":0.9210000038146973},{"id":"https://openalex.org/keywords/receptor-density","display_name":"receptor density","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.7720000147819519},{"id":"https://openalex.org/keywords/lower-urinary-tract-symptoms","display_name":"lower urinary tract symptoms","score":0.9039999842643738},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alpha1-adrenoceptor-antagonists","display_name":"alpha1-adrenoceptor antagonists","score":0.9869999885559082},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.593999981880188},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C133507102","wikidata":"https://www.wikidata.org/wiki/Q4712977","display_name":"Genitourinary system","level":2,"score":0.7968826293945312},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6871439218521118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6689814329147339},{"id":"https://openalex.org/C2779478474","wikidata":"https://www.wikidata.org/wiki/Q446372","display_name":"Lower urinary tract symptoms","level":4,"score":0.6255247592926025},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.5147943496704102},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4680459499359131},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.46473053097724915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44706302881240845},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42967426776885986},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.41974225640296936},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07802727818489075}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018340","descriptor_name":"Receptors, Adrenergic, alpha-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.juro.2006.04.038","doi":"https://doi.org/10.1016/j.juro.2006.04.038","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2006.04.038","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:16890728","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16890728","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G176483288","display_name":null,"funder_award_id":"DK 38311","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G439106616","display_name":null,"funder_award_id":"DK 42530","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W140697957","https://openalex.org/W206138987","https://openalex.org/W255223806","https://openalex.org/W1524454035","https://openalex.org/W1596759229","https://openalex.org/W1956994924","https://openalex.org/W1976448914","https://openalex.org/W1984935646","https://openalex.org/W1985407755","https://openalex.org/W2004131441","https://openalex.org/W2008071770","https://openalex.org/W2020696219","https://openalex.org/W2023268665","https://openalex.org/W2034493393","https://openalex.org/W2062413481","https://openalex.org/W2066966887","https://openalex.org/W2072422046","https://openalex.org/W2091388190","https://openalex.org/W2111165009","https://openalex.org/W2321246816","https://openalex.org/W2418697569"],"related_works":["https://openalex.org/W3177088287","https://openalex.org/W1971331628","https://openalex.org/W2379873816","https://openalex.org/W206138987","https://openalex.org/W46525031","https://openalex.org/W2001163993","https://openalex.org/W2039316245","https://openalex.org/W2034463933","https://openalex.org/W1977072423","https://openalex.org/W2042833340"],"abstract_inverted_index":{"PURPOSE:":[0],"Because":[1],"age":[2,34,118],"related":[3,35,169],"changes":[4,36],"occur":[5],"in":[6,11,37,46,58,121,126,156,171,180,189,200,204,209],"the":[7,38,47,59,122,127,147,157,172,181,190,201,210],"properties":[8,43,123,177],"of":[9,44,56,69,124,137,162,178],"alpha(1)-adrenoceptor":[10,16,45,57,125,133,140,193,213],"several":[12],"mammalian":[13],"tissues":[14],"and":[15,41,61,64,67,71,84,105,130,144,146,159,175],"antagonists":[17,194,214],"are":[18],"extensively":[19],"used":[20,216],"to":[21,28,151,192,212,217,224],"treat":[22,218],"lower":[23,99,155,219],"urinary":[24,220],"tract":[25,184,221],"symptoms":[26,222],"secondary":[27,223],"benign":[29,225],"prostatic":[30,226],"hyperplasia,":[31],"we":[32],"investigated":[33],"functional,":[39],"biochemical":[40,174],"molecular":[42],"rat":[48,182],"genitourinary":[49,183],"tract.":[50],"MATERIALS":[51],"AND":[52],"METHODS:":[53],"The":[54],"characteristics":[55],"ventral":[60,103,158],"dorsolateral":[62,160],"prostate,":[63],"bladder":[65,108,128],"base":[66,129],"dome":[68,109],"3":[70,139],"22-month-old":[72],"rats":[73,93,208],"were":[74,153],"determined":[75],"using":[76],"an":[77],"isolated":[78],"muscle":[79],"bath,":[80],"radioligand":[81],"receptor":[82],"binding":[83],"real-time":[85],"reverse":[86],"transcriptase-polymerase":[87],"chain":[88],"reaction":[89],"techniques.":[90],"RESULTS:":[91],"Old":[92],"had":[94],"significantly":[95,154],"higher":[96],"body":[97],"weight,":[98],"testosterone,":[100],"a":[101,106,198],"smaller":[102],"prostate":[104,161],"larger":[107],"than":[110],"young":[111,207],"rats.":[112,166],"Although":[113],"there":[114],"was":[115],"no":[116],"significant":[117],"dependent":[119],"difference":[120],"dome,":[131],"total":[132],"density,":[134],"mRNA":[135],"expression":[136],"all":[138],"subtypes":[141],"(alpha(1A),":[142],"alpha(1B)":[143],"alpha(1D))":[145],"maximum":[148],"contractile":[149],"responses":[150],"phenylephrine":[152],"22":[163],"vs":[164,206],"3-month-old":[165],"CONCLUSIONS:":[167],"Age":[168],"differences":[170,188],"molecular,":[173],"functional":[176],"alpha(1)-adrenoceptors":[179],"may":[185],"indicate":[186],"potential":[187],"response":[191,203,211],"with":[195],"aging,":[196],"ie":[197],"decrease":[199],"therapeutic":[202],"old":[205],"when":[215],"hyperplasia.":[227]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}