{"id":"https://openalex.org/W2136286249","doi":null,"title":"Screening for eukaryotic signal transduction and Mycobacterium isocitrate lyase inhibitor from actinomycetes and fungi of dipterocarp rain forests at Imbak Valley, Sabah, Malaysia","display_name":"Screening for eukaryotic signal transduction and Mycobacterium isocitrate lyase inhibitor from actinomycetes and fungi of dipterocarp rain forests at Imbak Valley, Sabah, Malaysia","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2136286249","mag":"2136286249"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ums.edu.my:32259","doi":null,"is_oa":true,"landing_page_url":"https://eprints.ums.edu.my/id/eprint/32259/1/Screening%20for%20eukaryotic%20signal%20transduction%20and%20Mycobacterium%20isocitrate%20lyase%20inhibitor%20from%20actinomycetes%20and%20fungi%20of%20dipterocarp%20rain%20forests%20at%20Imabak%20Valey%2C%20Sabah%2C%20Malaysia.pdf","pdf_url":"https://eprints.ums.edu.my/id/eprint/32259/3/Screening%20for%20eukaryotic%20signal%20transduction%20and%20Mycobacterium%20isocitrate%20lyase%20inhibitor%20from%20actinomycetes%20and%20fungi%20of%20dipterocarp%20rain%20forests%20at%20Imabak%20Valey%2C%20Sabah%2C%20Malaysia_ABSTRACT.pdf","source":{"id":"https://openalex.org/S4306400331","display_name":"UMS Institutional Repository (Universiti Malaysia Sabah)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161371597","host_organization_name":"Universiti of Malaysia Sabah","host_organization_lineage":["https://openalex.org/I161371597"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://eprints.ums.edu.my/id/eprint/32259/3/Screening%20for%20eukaryotic%20signal%20transduction%20and%20Mycobacterium%20isocitrate%20lyase%20inhibitor%20from%20actinomycetes%20and%20fungi%20of%20dipterocarp%20rain%20forests%20at%20Imabak%20Valey%2C%20Sabah%2C%20Malaysia_ABSTRACT.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108879123","display_name":"Coy Choke Ho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ho Coy Choke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014609694","display_name":"Justin Janim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin Janim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041308178","display_name":"Jagdish Kaur Chahil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jagdish Kaur Chahil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050844973","display_name":"Low Ai Ching","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Low Ai Ching","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025873151","display_name":"Lee Bee Koon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lee Bee Koon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081047541","display_name":"Kee Cheng Ling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kee Cheng Ling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055050943","display_name":"Lo Chor Wai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lo Chor Wai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033740241","display_name":"Sylvia Jerome Daim","orcid":"https://orcid.org/0000-0003-0065-5712","observed_orcids":["https://orcid.org/0000-0003-0065-5712"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvia Daim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0065-5712","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021095881","display_name":"Christopher Voo Lok Yung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Voo Lok Yung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061925078","display_name":"Lai Ngit Shin","orcid":"https://orcid.org/0000-0002-6831-5493","observed_orcids":["https://orcid.org/0000-0002-6831-5493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lai Ngit Shin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/actinomycetes","display_name":"actinomycetes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/fungi","display_name":"fungi","score":0.8090000152587891},{"id":"https://openalex.org/keywords/soil-microorganisms","display_name":"soil microbes","score":0.7239999771118164},{"id":"https://openalex.org/keywords/streptomyces","display_name":"Streptomyces","score":0.8880000114440918},{"id":"https://openalex.org/keywords/map-kinase-kinase","display_name":"MAP kinase kinase","score":0.5709999799728394},{"id":"https://openalex.org/keywords/map-kinase-phosphatase","display_name":"MAP kinase phosphatase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ras-raf-interaction","display_name":"Ras-Raf interaction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/isocitrate-lyase","display_name":"isocitrate lyase","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6784247756004333},{"id":"https://openalex.org/C133479454","wikidata":"https://www.wikidata.org/wiki/Q326228","display_name":"Mycelium","level":2,"score":0.6342989206314087},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5542252063751221},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5145725607872009},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.5123354196548462},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4641374945640564},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4576394557952881},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.45138105750083923},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.37805068492889404},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2120477557182312},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.18571621179580688},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08264163136482239}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ums.edu.my:32259","doi":null,"is_oa":true,"landing_page_url":"https://eprints.ums.edu.my/id/eprint/32259/1/Screening%20for%20eukaryotic%20signal%20transduction%20and%20Mycobacterium%20isocitrate%20lyase%20inhibitor%20from%20actinomycetes%20and%20fungi%20of%20dipterocarp%20rain%20forests%20at%20Imabak%20Valey%2C%20Sabah%2C%20Malaysia.pdf","pdf_url":"https://eprints.ums.edu.my/id/eprint/32259/3/Screening%20for%20eukaryotic%20signal%20transduction%20and%20Mycobacterium%20isocitrate%20lyase%20inhibitor%20from%20actinomycetes%20and%20fungi%20of%20dipterocarp%20rain%20forests%20at%20Imabak%20Valey%2C%20Sabah%2C%20Malaysia_ABSTRACT.pdf","source":{"id":"https://openalex.org/S4306400331","display_name":"UMS Institutional Repository (Universiti Malaysia Sabah)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161371597","host_organization_name":"Universiti of Malaysia Sabah","host_organization_lineage":["https://openalex.org/I161371597"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"mag:2136286249","doi":null,"is_oa":false,"landing_page_url":"https://www.ums.edu.my/ibtpv2/images/publication/JTBC/JTBC-VOL-5/10-lai%203%20jan%202010.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:eprints.ums.edu.my:32259","doi":null,"is_oa":true,"landing_page_url":"https://eprints.ums.edu.my/id/eprint/32259/1/Screening%20for%20eukaryotic%20signal%20transduction%20and%20Mycobacterium%20isocitrate%20lyase%20inhibitor%20from%20actinomycetes%20and%20fungi%20of%20dipterocarp%20rain%20forests%20at%20Imabak%20Valey%2C%20Sabah%2C%20Malaysia.pdf","pdf_url":"https://eprints.ums.edu.my/id/eprint/32259/3/Screening%20for%20eukaryotic%20signal%20transduction%20and%20Mycobacterium%20isocitrate%20lyase%20inhibitor%20from%20actinomycetes%20and%20fungi%20of%20dipterocarp%20rain%20forests%20at%20Imabak%20Valey%2C%20Sabah%2C%20Malaysia_ABSTRACT.pdf","source":{"id":"https://openalex.org/S4306400331","display_name":"UMS Institutional Repository (Universiti Malaysia Sabah)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161371597","host_organization_name":"Universiti of Malaysia Sabah","host_organization_lineage":["https://openalex.org/I161371597"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136286249.pdf","grobid_xml":"https://content.openalex.org/works/W2136286249.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W10925699","https://openalex.org/W243593085","https://openalex.org/W307353604","https://openalex.org/W1045435039","https://openalex.org/W1525951918","https://openalex.org/W1538422738","https://openalex.org/W1794035661","https://openalex.org/W1857242751","https://openalex.org/W1864461701","https://openalex.org/W1992020799","https://openalex.org/W2035151362","https://openalex.org/W2053867514","https://openalex.org/W2054696920","https://openalex.org/W2066696278","https://openalex.org/W2085197965","https://openalex.org/W2136623592","https://openalex.org/W2138778824","https://openalex.org/W2153811680","https://openalex.org/W2181380647","https://openalex.org/W2310583287","https://openalex.org/W4235743258"],"related_works":["https://openalex.org/W7043075994","https://openalex.org/W2982041252","https://openalex.org/W189603859","https://openalex.org/W2599810468","https://openalex.org/W183907315","https://openalex.org/W2992990099","https://openalex.org/W7097898733","https://openalex.org/W2325257914","https://openalex.org/W2606243284","https://openalex.org/W65003847"],"abstract_inverted_index":{"A":[0,18],"diversity":[1],"of":[2,20,52,76,100,147,218,273,287,304,328,330,338],"actinomycetes":[3,56,79,114,263],"and":[4,54,60,91,124,128,141,156,171,212],"fungi":[5,101],"was":[6,80,204,215,234],"isolated":[7,78,103],"from":[8,70,104],"various":[9],"sites":[10],"during":[11],"the":[12,77,105,148,177,188,219,228,237,243,288,299,318,322,326,339],"Imbak":[13,37],"Valley":[14,38],"Scientific":[15],"Expedition":[16],"2000.":[17],"total":[19],"144":[21],"soil":[22,72,107],"samples":[23,108],"were":[24,102,116,145,160,190,261],"collected":[25],"under":[26,118],"trees":[27],"that":[28,265,295],"have":[29,173],"been":[30],"identified":[31],"to":[32,162,206,250,280,334],"species":[33,294],"or":[34],"genus":[35],"level.":[36],"is":[39,45,282,309,332],"a":[40,277,292],"lowland":[41],"dipterocarp":[42],"forest,":[43],"which":[44,248,308,325],"interestingly":[46],"dominated":[47],"by":[48],"Dryobalanops":[49],"beccarii.":[50],"Isolation":[51],"Streptomyces":[53,293],"non-Streptomyces":[55,66],"on":[57,84,95,110],"HV":[58],"medium":[59],"other":[61],"specific":[62],"isolation":[63],"media":[64],"for":[65,130,164,252,285,302],"yielded":[67],"203":[68],"isolates":[69,115],"89":[71],"samples.":[73],"Morphological":[74],"characterisation":[75],"carried":[81],"out":[82],"based":[83],"aerial":[85],"mycelium":[86,89],"colour,":[87],"substrate":[88],"colour":[90],"diffusible":[92],"pigment":[93],"production":[94],"oatmeal":[96],"medium.":[97,112],"Nine":[98],"strains":[99],"six":[106],"plated":[109],"PDA":[111],"All":[113],"grown":[117],"aerobic":[119],"condition":[120],"in":[121,152,176,183,187,192,202,226,236,238,298,324],"liquid":[122],"culture":[123],"extracted":[125],"with":[126,242],"acetone,":[127],"used":[129,151,161,205,249],"screening":[131,229,246],"against":[132,209,254,268],"proteins":[133,150,175],"involved":[134],"eukaryotic":[135],"signal":[136,180],"transduction.":[137],"Yeast":[138],"MAPK":[139],"kinase":[140,143,170,179],"MAP":[142,178],"phosphatase":[144,172,200],"some":[146],"targeted":[149],"this":[153],"research.":[154],"MKK1P386":[155],"MKK1P386-MSG5":[157],"mutant":[158],"yeasts":[159],"screen":[163,207,251,301],"these":[165,168,193],"inhibitors,":[166],"as":[167],"yeast":[169,203,244,269,281],"homologous":[174],"transduction":[181],"pathway":[182],"human.":[184],"No":[185,231],"inhibitors":[186,208,211,286],"extracts":[189,221,264],"found":[191,235],"screenings.":[194],"Type":[195],"1":[196],"protein":[197,257],"serine/":[198],"threonine":[199],"(GLC7)":[201],"PP1":[210],"no":[213],"inhibitor":[214,233,253,303],"found.":[216],"None":[217],"fungal":[220],"showed":[222,266,296,317],"any":[223],"inhibitory":[224],"activities":[225],"all":[227],"systems.":[230],"Ras/Raf":[232,240],"vivo":[239],"interaction":[241,258],"two-hybrid":[245],"system,":[247],"Ras/":[255,274],"Raf":[256],"inhibitor.":[259],"There":[260],"11":[262],"toxicity":[267],"strain":[270],"LZ":[271],"(transformant":[272],"Raf).":[275],"H7667,":[276],"Streptomycete":[278],"toxic":[279],"further":[283],"screened":[284],"GSK3-beta":[289],"pathway.":[290],"H7763,":[291],"positive":[297],"primary":[300],"isocitrate":[305],"lyase":[306],"(ICL)":[307],"not":[310],"itaconic":[311],"acid":[312],"(known":[313],"ICL":[314],"inhibitor).":[315],"H7240":[316],"strongest":[319],"susceptibility":[320],"towards":[321],"resin":[323,331],"concentration":[327],"5g/l":[329],"sufficient":[333],"produce":[335],"growth":[336],"inhibition":[337],"bacteria.":[340]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}