{"id":"https://openalex.org/W2136278733","doi":"https://doi.org/10.1146/annurev.immunol.23.021704.115821","title":"REGULATION OF TH2 DIFFERENTIATION AND Il4 LOCUS ACCESSIBILITY","display_name":"REGULATION OF TH2 DIFFERENTIATION AND Il4 LOCUS ACCESSIBILITY","publication_year":2006,"publication_date":"2006-01-24","ids":{"openalex":"https://openalex.org/W2136278733","doi":"https://doi.org/10.1146/annurev.immunol.23.021704.115821","mag":"2136278733","pmid":"https://pubmed.ncbi.nlm.nih.gov/16551261"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.immunol.23.021704.115821","doi":"https://doi.org/10.1146/annurev.immunol.23.021704.115821","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.immunol.23.021704.115821","pdf_url":null,"source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051361479","display_name":"Karl Mark Ansel","orcid":"https://orcid.org/0000-0003-4840-9879","observed_orcids":["https://orcid.org/0000-0003-4840-9879"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Mark Ansel","raw_affiliation_strings":["Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115;,","Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA. ansel@cbr.med.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115;,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA. ansel@cbr.med.harvard.edu","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015404967","display_name":"Ivana M. Djuretic","orcid":"https://orcid.org/0009-0007-1094-3247","observed_orcids":["https://orcid.org/0009-0007-1094-3247"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivana Djuretic","raw_affiliation_strings":["Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115;,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018574547","display_name":"Bogdan Tanas\u0103","orcid":"https://orcid.org/0000-0002-3797-8171","observed_orcids":["https://orcid.org/0000-0002-3797-8171"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bogdan Tanasa","raw_affiliation_strings":["Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115;,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080472610","display_name":"Anjana Rao","orcid":"https://orcid.org/0000-0002-1870-1775","observed_orcids":["https://orcid.org/0000-0002-1870-1775"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjana Rao","raw_affiliation_strings":["Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115;,","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":4.3954,"has_fulltext":false,"cited_by_count":652,"citation_normalized_percentile":{"value":0.96997207,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"24","issue":"1","first_page":"607","last_page":"656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/th2-differentiation","display_name":"Th2 differentiation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.722000002861023},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transcriptional-regulatory-networks","display_name":"transcriptional regulatory networks","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.9819999933242798},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8307482600212097},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7074583768844604},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.7033926844596863},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5776051878929138},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.56150221824646},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.545581042766571},{"id":"https://openalex.org/C2781136212","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"T helper cell","level":4,"score":0.486803263425827},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4758327007293701},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47447043657302856},{"id":"https://openalex.org/C32046619","wikidata":"https://www.wikidata.org/wiki/Q14878303","display_name":"Interleukin 13","level":4,"score":0.42935532331466675},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.42874813079833984},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4232000708580017},{"id":"https://openalex.org/C145430368","wikidata":"https://www.wikidata.org/wiki/Q14914613","display_name":"STAT6","level":4,"score":0.42308345437049866},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37694695591926575},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.37178680300712585},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3586847186088562}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev.immunol.23.021704.115821","doi":"https://doi.org/10.1146/annurev.immunol.23.021704.115821","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.immunol.23.021704.115821","pdf_url":null,"source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},{"id":"pmid:16551261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16551261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":262,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1511991731","https://openalex.org/W1525912444","https://openalex.org/W1528180394","https://openalex.org/W1543604048","https://openalex.org/W1555985183","https://openalex.org/W1569503463","https://openalex.org/W1573775897","https://openalex.org/W1576057220","https://openalex.org/W1578776025","https://openalex.org/W1582610555","https://openalex.org/W1593596752","https://openalex.org/W1598861242","https://openalex.org/W1602470456","https://openalex.org/W1603793127","https://openalex.org/W1607528816","https://openalex.org/W1657409241","https://openalex.org/W1717188360","https://openalex.org/W1777054565","https://openalex.org/W1821797507","https://openalex.org/W1918737925","https://openalex.org/W1945784030","https://openalex.org/W1963506471","https://openalex.org/W1963512312","https://openalex.org/W1963996414","https://openalex.org/W1964318436","https://openalex.org/W1964329283","https://openalex.org/W1964614292","https://openalex.org/W1964631913","https://openalex.org/W1965490529","https://openalex.org/W1967261754","https://openalex.org/W1969331670","https://openalex.org/W1971290231","https://openalex.org/W1971459266","https://openalex.org/W1971615450","https://openalex.org/W1971723950","https://openalex.org/W1972087187","https://openalex.org/W1973548013","https://openalex.org/W1973904936","https://openalex.org/W1974595624","https://openalex.org/W1976365653","https://openalex.org/W1976427656","https://openalex.org/W1977093117","https://openalex.org/W1977118826","https://openalex.org/W1977701102","https://openalex.org/W1978287692","https://openalex.org/W1981262066","https://openalex.org/W1981301540","https://openalex.org/W1982295124","https://openalex.org/W1983715014","https://openalex.org/W1984208534","https://openalex.org/W1984654995","https://openalex.org/W1985677612","https://openalex.org/W1986396604","https://openalex.org/W1987286138","https://openalex.org/W1988290255","https://openalex.org/W1988298044","https://openalex.org/W1988369300","https://openalex.org/W1988707760","https://openalex.org/W1989092936","https://openalex.org/W1989454102","https://openalex.org/W1989753542","https://openalex.org/W1990735381","https://openalex.org/W1993068868","https://openalex.org/W1993426597","https://openalex.org/W1994894837","https://openalex.org/W1996065891","https://openalex.org/W1997569373","https://openalex.org/W1997832617","https://openalex.org/W1999349706","https://openalex.org/W1999909705","https://openalex.org/W1999944301","https://openalex.org/W2000904576","https://openalex.org/W2002654245","https://openalex.org/W2002745689","https://openalex.org/W2004499293","https://openalex.org/W2005824067","https://openalex.org/W2006101694","https://openalex.org/W2006610332","https://openalex.org/W2007684630","https://openalex.org/W2007888464","https://openalex.org/W2011405307","https://openalex.org/W2011480379","https://openalex.org/W2013433197","https://openalex.org/W2013495037","https://openalex.org/W2014256751","https://openalex.org/W2014946489","https://openalex.org/W2015132841","https://openalex.org/W2015949567","https://openalex.org/W2017340736","https://openalex.org/W2019468853","https://openalex.org/W2019573495","https://openalex.org/W2019666363","https://openalex.org/W2020096790","https://openalex.org/W2020775355","https://openalex.org/W2020977773","https://openalex.org/W2021759001","https://openalex.org/W2021919933","https://openalex.org/W2022447132","https://openalex.org/W2023482280","https://openalex.org/W2023488690","https://openalex.org/W2023879176","https://openalex.org/W2023942616","https://openalex.org/W2024156097","https://openalex.org/W2026082697","https://openalex.org/W2026177649","https://openalex.org/W2026501344","https://openalex.org/W2027699993","https://openalex.org/W2028050458","https://openalex.org/W2029531273","https://openalex.org/W2029819700","https://openalex.org/W2030013621","https://openalex.org/W2030120875","https://openalex.org/W2030980795","https://openalex.org/W2031087599","https://openalex.org/W2032736838","https://openalex.org/W2032917789","https://openalex.org/W2036813260","https://openalex.org/W2037541952","https://openalex.org/W2038271225","https://openalex.org/W2040191060","https://openalex.org/W2040234712","https://openalex.org/W2040665695","https://openalex.org/W2044306159","https://openalex.org/W2045402423","https://openalex.org/W2046443974","https://openalex.org/W2047820200","https://openalex.org/W2049118388","https://openalex.org/W2049734691","https://openalex.org/W2050869737","https://openalex.org/W2051152566","https://openalex.org/W2051304739","https://openalex.org/W2052312685","https://openalex.org/W2052997401","https://openalex.org/W2053513948","https://openalex.org/W2053633405","https://openalex.org/W2053833990","https://openalex.org/W2055739087","https://openalex.org/W2057972783","https://openalex.org/W2058593261","https://openalex.org/W2058607217","https://openalex.org/W2059180978","https://openalex.org/W2059189469","https://openalex.org/W2059382687","https://openalex.org/W2060711522","https://openalex.org/W2062754747","https://openalex.org/W2067500883","https://openalex.org/W2069302758","https://openalex.org/W2070359888","https://openalex.org/W2073089436","https://openalex.org/W2073340777","https://openalex.org/W2074140050","https://openalex.org/W2074915514","https://openalex.org/W2075087486","https://openalex.org/W2076956056","https://openalex.org/W2079231292","https://openalex.org/W2080322382","https://openalex.org/W2081091627","https://openalex.org/W2083073946","https://openalex.org/W2083103029","https://openalex.org/W2083381199","https://openalex.org/W2084104947","https://openalex.org/W2085932408","https://openalex.org/W2086350426","https://openalex.org/W2086368962","https://openalex.org/W2088609136","https://openalex.org/W2088928744","https://openalex.org/W2089894746","https://openalex.org/W2091301099","https://openalex.org/W2092263607","https://openalex.org/W2092599690","https://openalex.org/W2092809155","https://openalex.org/W2093648203","https://openalex.org/W2094176758","https://openalex.org/W2094786733","https://openalex.org/W2095002834","https://openalex.org/W2095111919","https://openalex.org/W2095935180","https://openalex.org/W2098084214","https://openalex.org/W2098319164","https://openalex.org/W2099067892","https://openalex.org/W2099845842","https://openalex.org/W2100796404","https://openalex.org/W2102651905","https://openalex.org/W2105259534","https://openalex.org/W2107653794","https://openalex.org/W2107723355","https://openalex.org/W2107773259","https://openalex.org/W2110107454","https://openalex.org/W2112167962","https://openalex.org/W2112495824","https://openalex.org/W2113759302","https://openalex.org/W2113773748","https://openalex.org/W2115785513","https://openalex.org/W2116287477","https://openalex.org/W2116322544","https://openalex.org/W2117391818","https://openalex.org/W2118033101","https://openalex.org/W2118681186","https://openalex.org/W2119767265","https://openalex.org/W2122774961","https://openalex.org/W2124268899","https://openalex.org/W2124595934","https://openalex.org/W2125338577","https://openalex.org/W2127600861","https://openalex.org/W2128741634","https://openalex.org/W2130253814","https://openalex.org/W2130794319","https://openalex.org/W2133157965","https://openalex.org/W2133654601","https://openalex.org/W2135806909","https://openalex.org/W2135837360","https://openalex.org/W2136093435","https://openalex.org/W2136991248","https://openalex.org/W2137257434","https://openalex.org/W2139013709","https://openalex.org/W2139633538","https://openalex.org/W2140707292","https://openalex.org/W2141171810","https://openalex.org/W2143658931","https://openalex.org/W2145042499","https://openalex.org/W2145499731","https://openalex.org/W2148044949","https://openalex.org/W2148077170","https://openalex.org/W2148993123","https://openalex.org/W2150111516","https://openalex.org/W2150560990","https://openalex.org/W2151627258","https://openalex.org/W2151762007","https://openalex.org/W2152244674","https://openalex.org/W2154284135","https://openalex.org/W2155083106","https://openalex.org/W2155227864","https://openalex.org/W2155908077","https://openalex.org/W2156446023","https://openalex.org/W2157973267","https://openalex.org/W2158156090","https://openalex.org/W2158630345","https://openalex.org/W2159907278","https://openalex.org/W2162102331","https://openalex.org/W2162309399","https://openalex.org/W2165764599","https://openalex.org/W2166647372","https://openalex.org/W2167132998","https://openalex.org/W2168331489","https://openalex.org/W2168476212","https://openalex.org/W2170240282","https://openalex.org/W2171760349","https://openalex.org/W2171972944","https://openalex.org/W2184153587","https://openalex.org/W2187960172","https://openalex.org/W2189453901","https://openalex.org/W2247766769","https://openalex.org/W2886978647","https://openalex.org/W4212766227","https://openalex.org/W4233036449","https://openalex.org/W4250405902","https://openalex.org/W4313331945","https://openalex.org/W4321429568","https://openalex.org/W6992757371","https://openalex.org/W7067741617","https://openalex.org/W7100923047"],"related_works":["https://openalex.org/W2080322382","https://openalex.org/W1573032931","https://openalex.org/W2091301099","https://openalex.org/W2150287216","https://openalex.org/W7099694711","https://openalex.org/W1985364817","https://openalex.org/W2068172687","https://openalex.org/W2053137959","https://openalex.org/W2092263607","https://openalex.org/W2046317156"],"abstract_inverted_index":{"Helper":[0],"T":[1,91,139],"cells":[2,12,70,92],"coordinate":[3],"immune":[4],"responses":[5],"through":[6],"the":[7,14,30,43,79,85,102,111,129],"production":[8],"of":[9,45,58,84,98,110,136],"cytokines.":[10],"Th2":[11,60],"express":[13],"closely":[15],"linked":[16],"Il4,":[17],"Il13,":[18],"and":[19,48,54,64,71,113,121,132],"Il5":[20],"cytokine":[21],"genes,":[22],"whereas":[23],"these":[24],"same":[25],"genes":[26],"are":[27],"silenced":[28],"in":[29,88],"Th1":[31],"lineage.":[32],"The":[33],"Th1/Th2":[34],"lineage":[35,130],"choice":[36],"has":[37],"become":[38],"a":[39,95],"textbook":[40],"example":[41],"for":[42],"regulation":[44],"cell":[46],"differentiation,":[47],"recent":[49,99],"discoveries":[50],"have":[51,93],"further":[52],"refined":[53],"expanded":[55],"our":[56],"understanding":[57],"how":[59],"differentiation":[61],"is":[62,104],"initiated":[63],"reinforced":[65],"by":[66],"signals":[67],"from":[68],"antigen-presenting":[69],"cytokine-driven":[72],"feedback":[73],"loops.":[74],"Epigenetic":[75],"changes":[76],"that":[77,125],"stabilize":[78],"active":[80],"or":[81],"silent":[82],"state":[83],"Il4":[86],"locus":[87],"differentiating":[89,137],"helper":[90,138],"been":[94],"major":[96],"focus":[97],"research.":[100],"Overall,":[101],"field":[103],"progressing":[105],"toward":[106],"an":[107],"integrated":[108],"model":[109],"signaling":[112],"transcription":[114],"factor":[115],"networks,":[116],"cis-regulatory":[117],"elements,":[118],"epigenetic":[119],"modifications,":[120],"RNA":[122],"interference":[123],"mechanisms":[124],"converge":[126],"to":[127],"determine":[128],"fate":[131],"gene":[133],"expression":[134],"patterns":[135],"cells.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":34},{"year":2015,"cited_by_count":37},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":46},{"year":2012,"cited_by_count":40}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
