{"id":"https://openalex.org/W2136264833","doi":null,"title":"Biophysical and electropharmacological properties of single mitoKATP channel in rat brain mitochondrial inner membrane","display_name":"Biophysical and electropharmacological properties of single mitoKATP channel in rat brain mitochondrial inner membrane","publication_year":2012,"publication_date":"2012-10-10","ids":{"openalex":"https://openalex.org/W2136264833","mag":"2136264833"},"language":"en","primary_location":{"id":"mag:2136264833","doi":null,"is_oa":false,"landing_page_url":"http://www.phypha.ir/ppj/article-1-812-en.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Physiology and Pharmacology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040654715","display_name":"Javad Fahanik\u2010Babaei","orcid":"https://orcid.org/0000-0001-6707-132X","observed_orcids":["https://orcid.org/0000-0001-6707-132X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javad Fahanik\u2010Babaei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018240929","display_name":"Afsaneh Eliassi","orcid":"https://orcid.org/0000-0002-4899-3430","observed_orcids":["https://orcid.org/0000-0002-4899-3430"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Afsaneh Eliassi","raw_affiliation_strings":["Shahid Beheshti University of Medical Sciences"],"raw_orcid":"https://orcid.org/0000-0002-4899-3430","affiliations":[{"raw_affiliation_string":"Shahid Beheshti University of Medical Sciences","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061195566","display_name":"Reza Saghiri","orcid":"https://orcid.org/0000-0002-5402-453X","observed_orcids":["https://orcid.org/0000-0002-5402-453X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reza Saghiri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.13089375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"3","first_page":"283","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-atp-sensitive-potassium-channel","display_name":"mitochondrial ATP-sensitive potassium channel","score":0.8980000019073486},{"id":"https://openalex.org/keywords/brain-mitochondria","display_name":"brain mitochondria","score":0.7699999809265137},{"id":"https://openalex.org/keywords/inner-mitochondrial-membrane","display_name":"inner mitochondrial membrane","score":0.9649999737739563},{"id":"https://openalex.org/keywords/single-channel-properties","display_name":"single-channel properties","score":0.6420000195503235},{"id":"https://openalex.org/keywords/slope-conductance","display_name":"slope conductance","score":0.6629999876022339},{"id":"https://openalex.org/keywords/dwell-time-distribution","display_name":"dwell time distribution","score":0.6890000104904175},{"id":"https://openalex.org/keywords/4-aminopyridine","display_name":"4-aminopyridine","score":0.824999988079071},{"id":"https://openalex.org/keywords/tetraethylammonium","display_name":"tetraethylammonium","score":0.9929999709129333},{"id":"https://openalex.org/keywords/kir6-1","display_name":"Kir6.1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/sur2b","display_name":"SUR2B","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mitochondrial-homeostasis","display_name":"mitochondrial homeostasis","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.6711646318435669},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6606305241584778},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.6152892112731934},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.6020928621292114},{"id":"https://openalex.org/C2778920010","wikidata":"https://www.wikidata.org/wiki/Q410968","display_name":"Digitonin","level":3,"score":0.6014842987060547},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5918844938278198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.559947669506073},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.476086288690567},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.47526806592941284},{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.4530371129512787},{"id":"https://openalex.org/C2776309818","wikidata":"https://www.wikidata.org/wiki/Q4654794","display_name":"ATP-sensitive potassium channel","level":4,"score":0.44440793991088867},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.374098002910614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2780972719192505},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08670976758003235},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2136264833","doi":null,"is_oa":false,"landing_page_url":"http://www.phypha.ir/ppj/article-1-812-en.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Physiology and Pharmacology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W796312054","https://openalex.org/W1508200059","https://openalex.org/W1548755019","https://openalex.org/W1583101702","https://openalex.org/W1597339748","https://openalex.org/W1963866525","https://openalex.org/W1972246035","https://openalex.org/W1972319192","https://openalex.org/W1974210120","https://openalex.org/W1977221331","https://openalex.org/W1977843417","https://openalex.org/W1978385489","https://openalex.org/W1978474161","https://openalex.org/W1981319412","https://openalex.org/W1981886269","https://openalex.org/W1988722898","https://openalex.org/W1989348863","https://openalex.org/W1990179610","https://openalex.org/W1990299268","https://openalex.org/W1993034869","https://openalex.org/W1994968070","https://openalex.org/W1998665484","https://openalex.org/W1999257888","https://openalex.org/W2000588392","https://openalex.org/W2014376812","https://openalex.org/W2017212706","https://openalex.org/W2017515163","https://openalex.org/W2021667794","https://openalex.org/W2026945507","https://openalex.org/W2029070759","https://openalex.org/W2031429867","https://openalex.org/W2033349405","https://openalex.org/W2036861927","https://openalex.org/W2039976537","https://openalex.org/W2045201746","https://openalex.org/W2045342846","https://openalex.org/W2045849165","https://openalex.org/W2049386888","https://openalex.org/W2052394509","https://openalex.org/W2060974177","https://openalex.org/W2061988480","https://openalex.org/W2062875140","https://openalex.org/W2062991442","https://openalex.org/W2064769717","https://openalex.org/W2064837843","https://openalex.org/W2065966626","https://openalex.org/W2068118359","https://openalex.org/W2068861883","https://openalex.org/W2074196316","https://openalex.org/W2081510474","https://openalex.org/W2084341511","https://openalex.org/W2085381747","https://openalex.org/W2088394572","https://openalex.org/W2088658333","https://openalex.org/W2090298199","https://openalex.org/W2094904158","https://openalex.org/W2094923138","https://openalex.org/W2098368476","https://openalex.org/W2101204196","https://openalex.org/W2102589963","https://openalex.org/W2108589033","https://openalex.org/W2113208711","https://openalex.org/W2123416020","https://openalex.org/W2126544267","https://openalex.org/W2127849030","https://openalex.org/W2129987455","https://openalex.org/W2132687960","https://openalex.org/W2133020052","https://openalex.org/W2133838366","https://openalex.org/W2139514626","https://openalex.org/W2150116795","https://openalex.org/W2158350888","https://openalex.org/W2400385027","https://openalex.org/W2403522517"],"related_works":["https://openalex.org/W2081510474","https://openalex.org/W2029070759","https://openalex.org/W1988722898","https://openalex.org/W2300773238","https://openalex.org/W2528660670","https://openalex.org/W7125806381","https://openalex.org/W1977843417","https://openalex.org/W1596194642","https://openalex.org/W1530529896","https://openalex.org/W2088394572"],"abstract_inverted_index":{"Introduction:":[0],"Different":[1],"ATP-sensitive":[2,214],"potassium":[3,215],"channels":[4],"have":[5],"been":[6],"detected":[7],"in":[8,21,39,58,71,88,130,247,251],"the":[9,30,40,50,53,180,191],"mitochondrial":[10,42,65,213],"inner":[11,43,66],"membrane":[12,67],"of":[13,35,107,126,196,212,234],"cells.":[14],"They":[15],"are":[16],"suggested":[17],"to":[18,166,244],"be":[19,245],"involved":[20,246],"cell":[22,25,255],"processes":[23],"including":[24],"protection.":[26],"Here,":[27],"we":[28],"characterized":[29,176],"biophysical":[31],"and":[32,48,62,64,101,147,155,174,188,207,224,236,254],"electropharmacological":[33],"properties":[34],"a":[36,89,104,120,123,203,228,231],"KATP":[37,181],"channel":[38,117,121,178,192,197,205,241],"brain":[41,252],"membranes.":[44],"Methods:":[45],"After":[46],"removing":[47],"homogenizing":[49],"rat":[51],"brain,":[52],"supernatant":[54],"was":[55,77,198],"separately":[56],"centrifuged":[57],"MSE":[59,72],"digitonin,":[60],"H2O":[61],"Na2CO3":[63],"vesicles":[68],"were":[69,86,96,164],"obtained":[70],"solution.":[73],"L-\u03b1Phosphatidylcholine":[74],"(membrane":[75],"lipid)":[76],"extracted":[78],"from":[79],"fresh":[80],"egg":[81],"yolk.":[82],"Bilayer":[83],"lipid":[84],"membranes":[85],"formed":[87],"150":[90],"\u03bcm":[91],"diameter":[92],"hole.":[93],"All":[94],"recordings":[95,118],"filtered":[97],"at":[98,103,148,153],"1":[99],"kHz":[100,109],"stored":[102],"sampling":[105],"rate":[106],"10":[108],"for":[110],"offline":[111],"analysis":[112],"by":[113,172,201],"PClamp10.":[114],"Results:":[115],"Single":[116],"revealed":[119],"with":[122,219,230],"slope":[124],"conductance":[125],"143":[127],"\u00b1":[128],"7pS":[129],"voltage":[131],"dependent":[132],"200":[133],"mM":[134,137],"KCl":[135,138],"cis/50":[136],"trans.":[139],"The":[140,159,170,194],"closed":[141],"dwell":[142,161],"time":[143,162],"distributions":[144],"indicated":[145],"one":[146],"least":[149],"two":[150,167],"exponential":[151,168],"components":[152],"positive":[154],"negative":[156],"potentials,":[157],"respectively.":[158,238],"open":[160],"events":[163],"fitted":[165],"functions.":[169],"block":[171],"ATP":[173],"glibenclamide":[175],"this":[177],"as":[179],"channel.":[182],"We":[183],"also":[184],"showed":[185],"that":[186],"4AP":[187],"TEA":[189],"inhibited":[190],"activities.":[193],"activity":[195],"not":[199],"influenced":[200],"iberiotoxin,":[202],"BK":[204],"blocker,":[206],"5-hydroxydecanoic":[208],"acid,":[209],"an":[210],"inhibitor":[211],"channels.":[216],"Western":[217],"blotting":[218],"antibodies":[220],"directed":[221],"against":[222],"Kir6.1":[223],"SUR2B":[225],"subunits":[226],"recognized":[227],"blocking-peptide-sensitive":[229],"molecular":[232],"mass":[233],"~55-64kDa":[235],"~120kDa,":[237],"Conclusion:":[239],"This":[240],"is":[242],"likely":[243],"maintaining":[248],"proper":[249],"homeostasis":[250],"mitochondria":[253],"processes.":[256]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}