{"id":"https://openalex.org/W2136263973","doi":"https://doi.org/10.1084/jem.153.6.1391","title":"Chemotactic activity generated from the fifth component of complement by plasma kallikrein of the rabbit.","display_name":"Chemotactic activity generated from the fifth component of complement by plasma kallikrein of the rabbit.","publication_year":1981,"publication_date":"1981-06-01","ids":{"openalex":"https://openalex.org/W2136263973","doi":"https://doi.org/10.1084/jem.153.6.1391","mag":"2136263973","pmid":"https://pubmed.ncbi.nlm.nih.gov/6910482","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2186194"},"language":"en","primary_location":{"id":"doi:10.1084/jem.153.6.1391","doi":"https://doi.org/10.1084/jem.153.6.1391","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.153.6.1391","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2186194","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022290728","display_name":"Roger C. Wiggins","orcid":"https://orcid.org/0000-0002-1166-2849","observed_orcids":["https://orcid.org/0000-0002-1166-2849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R C Wiggins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045710915","display_name":"Patricia C. Giclas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P C Giclas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030906578","display_name":"Peter M. Henson","orcid":"https://orcid.org/0000-0003-1934-8405","observed_orcids":["https://orcid.org/0000-0003-1934-8405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M Henson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.7971,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.96770081,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"153","issue":"6","first_page":"1391","last_page":"1404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.4124000072479248,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-c5","display_name":"complement C5","score":0.7870000004768372},{"id":"https://openalex.org/keywords/plasma-kallikrein","display_name":"plasma kallikrein","score":0.9639999866485596},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.6940000057220459},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9440000057220459},{"id":"https://openalex.org/keywords/high-molecular-weight-kininogen","display_name":"high molecular weight kininogen","score":0.7979999780654907},{"id":"https://openalex.org/keywords/factor-xii","display_name":"factor XII","score":0.9710000157356262},{"id":"https://openalex.org/keywords/carboxypeptidase-n","display_name":"carboxypeptidase N","score":0.8259999752044678},{"id":"https://openalex.org/keywords/kinin-generation","display_name":"kinin generation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.42800000309944153},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.9078826904296875},{"id":"https://openalex.org/C2777902427","wikidata":"https://www.wikidata.org/wiki/Q6413860","display_name":"Kininogen","level":4,"score":0.84852135181427},{"id":"https://openalex.org/C2781317560","wikidata":"https://www.wikidata.org/wiki/Q24721273","display_name":"High-molecular-weight kininogen","level":5,"score":0.8199833631515503},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.5381447076797485},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.537225604057312},{"id":"https://openalex.org/C2776246183","wikidata":"https://www.wikidata.org/wiki/Q421924","display_name":"Kinin","level":4,"score":0.4942591190338135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4819912314414978},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4700295627117157},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46643948554992676},{"id":"https://openalex.org/C108477463","wikidata":"https://www.wikidata.org/wiki/Q426367","display_name":"Carboxypeptidase","level":3,"score":0.4157536029815674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34147292375564575},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29639267921447754},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.28310906887054443},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001121","descriptor_name":"Lysine Carboxypeptidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003182","descriptor_name":"Complement C5","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005174","descriptor_name":"Factor XII","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005966","descriptor_name":"Glucuronidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1084/jem.153.6.1391","doi":"https://doi.org/10.1084/jem.153.6.1391","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.153.6.1391","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2186194","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2186194","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:6910482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6910482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2186194","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2186194","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1482118367","https://openalex.org/W1523926729","https://openalex.org/W1558646336","https://openalex.org/W1775749144","https://openalex.org/W1906592865","https://openalex.org/W1921676257","https://openalex.org/W1961046981","https://openalex.org/W1964522162","https://openalex.org/W1975372670","https://openalex.org/W1985832243","https://openalex.org/W1990942696","https://openalex.org/W1995135269","https://openalex.org/W1996282461","https://openalex.org/W2011296570","https://openalex.org/W2039710770","https://openalex.org/W2045810087","https://openalex.org/W2047809554","https://openalex.org/W2053702349","https://openalex.org/W2055383193","https://openalex.org/W2075166342","https://openalex.org/W2109782036","https://openalex.org/W2120151544","https://openalex.org/W2144694645","https://openalex.org/W2170809792","https://openalex.org/W2316856711","https://openalex.org/W2330022989","https://openalex.org/W2335302374","https://openalex.org/W2405987214","https://openalex.org/W2415146532","https://openalex.org/W2494320093","https://openalex.org/W2945551756"],"related_works":["https://openalex.org/W4313310011","https://openalex.org/W2144694645","https://openalex.org/W1615364751","https://openalex.org/W7096850183","https://openalex.org/W7098910863","https://openalex.org/W2080526318","https://openalex.org/W1991000470","https://openalex.org/W2143465583","https://openalex.org/W2416144660","https://openalex.org/W1961046981"],"abstract_inverted_index":{"Rabbit":[0],"plasma":[1],"kallikrein":[2,28,59],"incubated":[3],"with":[4,71],"rabbit":[5,17],"C5":[6,22,79],"resulted":[7],"in":[8,144],"the":[9,50,53,57,72,81,94,145],"generation":[10,55,73,95,146],"of":[11,74,96,104,124,136,147],"chemotactic":[12,67,108,149],"and":[13,30,90,129],"secretagogue":[14],"activity":[15],"for":[16,112],"neutrophils.":[18],"This":[19],"effect":[20,82],"on":[21],"appeared":[23],"to":[24,27,32,49,93],"be":[25,39,84],"due":[26],"itself":[29],"not":[31,142],"a":[33,75,97],"contaminating":[34],"enzyme,":[35],"because":[36,80],"it":[37],"could":[38,83],"inhibited":[40,62,86],"by":[41,45,56,63,87],"anti-kallikrein":[42],"IgG":[43],"or":[44,120],"soybean":[46],"trypsin":[47],"inhibitor":[48],"same":[51,58],"extent":[52],"kinin":[54],"preparation":[60],"was":[61,69,91,110],"these":[64],"agents.":[65],"The":[66],"response":[68,109],"consistent":[70],"C5a-like":[76],"peptide":[77],"from":[78],"partially":[85],"carboxypeptidase":[88],"N":[89],"related":[92],"small":[98],"(approximately":[99],"14,000":[100],"mol":[101],"wt)":[102],"fragment":[103],"C5.":[105,122],"No":[106],"direct":[107],"detectable":[111,148],"kallikrein,":[113],"activated":[114],"Hageman":[115,130],"factor,":[116],"high-molecular":[117,126],"weight":[118,127],"kininogen,":[119,128],"intact":[121],"Incubation":[123],"Kallikrein,":[125],"factor":[131],"together,":[132],"so":[133],"that":[134],"activation":[135],"all":[137],"three":[138],"proteins":[139],"occurred,":[140],"did":[141],"results":[143],"activity.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
