{"id":"https://openalex.org/W2136237921","doi":null,"title":"Humoral Immunity to the Opportunistic Pathogen, Pneumocystis, in a Simian Model of HIV Infection.","display_name":"Humoral Immunity to the Opportunistic Pathogen, Pneumocystis, in a Simian Model of HIV Infection.","publication_year":2010,"publication_date":"2010-04-30","ids":{"openalex":"https://openalex.org/W2136237921","mag":"2136237921"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:7729","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/7729/1/KlingHM_ETD2010.pdf","pdf_url":"http://d-scholarship.pitt.edu/7729/1/KlingHM_ETD2010.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/7729/1/KlingHM_ETD2010.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002529868","display_name":"Heather M. Kling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Heather M. Kling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002529868"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19239771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pneumocystis-jirovecii","display_name":"Pneumocystis jirovecii","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pneumocystis-jirovecii-pneumonia","display_name":"Pneumocystis carinii pneumonia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.7080000042915344},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.8550000190734863},{"id":"https://openalex.org/keywords/shiv","display_name":"SHIV","score":0.6399999856948853},{"id":"https://openalex.org/keywords/macaque","display_name":"macaque","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pneumocystis-colonization","display_name":"Pneumocystis colonization","score":0.8949999809265137},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.9139999747276306},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/b-cell-dysfunction","display_name":"B cell dysfunction","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hypergammaglobulinemia","display_name":"hypergammaglobulinemia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6809999942779541},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.7059999704360962},{"id":"https://openalex.org/keywords/pulmonary-obstruction","display_name":"pulmonary obstruction","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7316386699676514},{"id":"https://openalex.org/C2993443204","wikidata":"https://www.wikidata.org/wiki/Q134478","display_name":"Pneumocystis carinii","level":4,"score":0.64009690284729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.578474223613739},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5509185791015625},{"id":"https://openalex.org/C2777160144","wikidata":"https://www.wikidata.org/wiki/Q15401586","display_name":"Pneumocystis pneumonia","level":4,"score":0.5363895297050476},{"id":"https://openalex.org/C2777995582","wikidata":"https://www.wikidata.org/wiki/Q1890246","display_name":"Simian immunodeficiency virus","level":3,"score":0.5345892906188965},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.5254891514778137},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.4844772517681122},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.4766579270362854},{"id":"https://openalex.org/C2779196057","wikidata":"https://www.wikidata.org/wiki/Q835718","display_name":"Opportunistic infection","level":4,"score":0.468908429145813},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.46505674719810486},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.44982805848121643},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.43518081307411194},{"id":"https://openalex.org/C2777559004","wikidata":"https://www.wikidata.org/wiki/Q134478","display_name":"Pneumocystis jirovecii","level":3,"score":0.4291520416736603},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.377465158700943},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.268535315990448},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2539025545120239},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.07766774296760559},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06286269426345825},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:7729","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/7729/1/KlingHM_ETD2010.pdf","pdf_url":"http://d-scholarship.pitt.edu/7729/1/KlingHM_ETD2010.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:2136237921","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/7729/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:7729","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/7729/1/KlingHM_ETD2010.pdf","pdf_url":"http://d-scholarship.pitt.edu/7729/1/KlingHM_ETD2010.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136237921.pdf","grobid_xml":"https://content.openalex.org/works/W2136237921.grobid-xml"},"referenced_works_count":216,"referenced_works":["https://openalex.org/W36696615","https://openalex.org/W114176068","https://openalex.org/W190297698","https://openalex.org/W196856055","https://openalex.org/W229319184","https://openalex.org/W1514614300","https://openalex.org/W1536211762","https://openalex.org/W1551782598","https://openalex.org/W1563776614","https://openalex.org/W1573020564","https://openalex.org/W1575555729","https://openalex.org/W1586476245","https://openalex.org/W1750732865","https://openalex.org/W1753094669","https://openalex.org/W1781015672","https://openalex.org/W1785971308","https://openalex.org/W1792035729","https://openalex.org/W1882489999","https://openalex.org/W1927412796","https://openalex.org/W1945182745","https://openalex.org/W1966196211","https://openalex.org/W1966382332","https://openalex.org/W1967178390","https://openalex.org/W1968272735","https://openalex.org/W1969952390","https://openalex.org/W1971315902","https://openalex.org/W1971631973","https://openalex.org/W1971710289","https://openalex.org/W1972318575","https://openalex.org/W1973530626","https://openalex.org/W1978209921","https://openalex.org/W1978924494","https://openalex.org/W1979495197","https://openalex.org/W1982368830","https://openalex.org/W1984409141","https://openalex.org/W1987039284","https://openalex.org/W1987069525","https://openalex.org/W1988897396","https://openalex.org/W1988938349","https://openalex.org/W1989525908","https://openalex.org/W1990674750","https://openalex.org/W1992993866","https://openalex.org/W1994556678","https://openalex.org/W1995671912","https://openalex.org/W1996486288","https://openalex.org/W1998520243","https://openalex.org/W2000210076","https://openalex.org/W2000378367","https://openalex.org/W2000737064","https://openalex.org/W2001163557","https://openalex.org/W2001710332","https://openalex.org/W2002793477","https://openalex.org/W2005284010","https://openalex.org/W2005511960","https://openalex.org/W2007334511","https://openalex.org/W2011945649","https://openalex.org/W2013703920","https://openalex.org/W2014022546","https://openalex.org/W2015218371","https://openalex.org/W2016186295","https://openalex.org/W2017915940","https://openalex.org/W2018080378","https://openalex.org/W2019303462","https://openalex.org/W2019722722","https://openalex.org/W2021239480","https://openalex.org/W2024345386","https://openalex.org/W2024745920","https://openalex.org/W2026686867","https://openalex.org/W2027205878","https://openalex.org/W2027947833","https://openalex.org/W2027990333","https://openalex.org/W2030547360","https://openalex.org/W2031033693","https://openalex.org/W2033803014","https://openalex.org/W2036135759","https://openalex.org/W2036327819","https://openalex.org/W2040690041","https://openalex.org/W2042569077","https://openalex.org/W2046590268","https://openalex.org/W2047219499","https://openalex.org/W2047981850","https://openalex.org/W2049102964","https://openalex.org/W2049219987","https://openalex.org/W2049483717","https://openalex.org/W2049947898","https://openalex.org/W2050080302","https://openalex.org/W2053809644","https://openalex.org/W2054069744","https://openalex.org/W2058229221","https://openalex.org/W2061575742","https://openalex.org/W2062171241","https://openalex.org/W2063708305","https://openalex.org/W2064071539","https://openalex.org/W2064917619","https://openalex.org/W2066030558","https://openalex.org/W2066948397","https://openalex.org/W2067675669","https://openalex.org/W2068813963","https://openalex.org/W2070412644","https://openalex.org/W2070870274","https://openalex.org/W2071475769","https://openalex.org/W2074214128","https://openalex.org/W2076272086","https://openalex.org/W2076777112","https://openalex.org/W2077344672","https://openalex.org/W2077636984","https://openalex.org/W2078748988","https://openalex.org/W2079427948","https://openalex.org/W2080800299","https://openalex.org/W2081618939","https://openalex.org/W2082659485","https://openalex.org/W2085748050","https://openalex.org/W2090946141","https://openalex.org/W2095826652","https://openalex.org/W2099193721","https://openalex.org/W2100664832","https://openalex.org/W2101286028","https://openalex.org/W2104518947","https://openalex.org/W2104520807","https://openalex.org/W2105760854","https://openalex.org/W2106087109","https://openalex.org/W2108357566","https://openalex.org/W2109909586","https://openalex.org/W2112578422","https://openalex.org/W2115101818","https://openalex.org/W2115515139","https://openalex.org/W2116649409","https://openalex.org/W2116692576","https://openalex.org/W2117268277","https://openalex.org/W2117333847","https://openalex.org/W2117845590","https://openalex.org/W2118425309","https://openalex.org/W2118879181","https://openalex.org/W2119063189","https://openalex.org/W2119583493","https://openalex.org/W2119615572","https://openalex.org/W2120679663","https://openalex.org/W2121233545","https://openalex.org/W2122126625","https://openalex.org/W2122686366","https://openalex.org/W2124077127","https://openalex.org/W2125078269","https://openalex.org/W2125553744","https://openalex.org/W2126581959","https://openalex.org/W2127094219","https://openalex.org/W2127159607","https://openalex.org/W2127327473","https://openalex.org/W2127365188","https://openalex.org/W2128012958","https://openalex.org/W2128483742","https://openalex.org/W2129707656","https://openalex.org/W2131884217","https://openalex.org/W2133856149","https://openalex.org/W2135016101","https://openalex.org/W2135082908","https://openalex.org/W2135360588","https://openalex.org/W2136110161","https://openalex.org/W2136458828","https://openalex.org/W2137089903","https://openalex.org/W2137329158","https://openalex.org/W2138449937","https://openalex.org/W2139188399","https://openalex.org/W2140067613","https://openalex.org/W2140929540","https://openalex.org/W2142777498","https://openalex.org/W2144117671","https://openalex.org/W2144305264","https://openalex.org/W2145843306","https://openalex.org/W2146533975","https://openalex.org/W2146628582","https://openalex.org/W2146747881","https://openalex.org/W2146997008","https://openalex.org/W2148468307","https://openalex.org/W2148890968","https://openalex.org/W2148937423","https://openalex.org/W2150264495","https://openalex.org/W2150858055","https://openalex.org/W2151217507","https://openalex.org/W2151304962","https://openalex.org/W2152542026","https://openalex.org/W2152668642","https://openalex.org/W2152858989","https://openalex.org/W2153407838","https://openalex.org/W2153408607","https://openalex.org/W2154082517","https://openalex.org/W2155315822","https://openalex.org/W2155647946","https://openalex.org/W2156602998","https://openalex.org/W2156816514","https://openalex.org/W2157096777","https://openalex.org/W2157423084","https://openalex.org/W2158351251","https://openalex.org/W2158855166","https://openalex.org/W2159225279","https://openalex.org/W2160490440","https://openalex.org/W2161135832","https://openalex.org/W2162633432","https://openalex.org/W2163206714","https://openalex.org/W2166559731","https://openalex.org/W2166717288","https://openalex.org/W2170452931","https://openalex.org/W2286580524","https://openalex.org/W2316750734","https://openalex.org/W2317107786","https://openalex.org/W2319153630","https://openalex.org/W2325624902","https://openalex.org/W2330826215","https://openalex.org/W2334860476","https://openalex.org/W2412222676","https://openalex.org/W2412483042","https://openalex.org/W2416333338","https://openalex.org/W2475120062","https://openalex.org/W2607650379","https://openalex.org/W3021671064","https://openalex.org/W4205258978","https://openalex.org/W4313347866"],"related_works":["https://openalex.org/W2114865585","https://openalex.org/W7095369755","https://openalex.org/W2137089903","https://openalex.org/W2256765887","https://openalex.org/W4311705982","https://openalex.org/W2092960278","https://openalex.org/W4313373864","https://openalex.org/W4313386453","https://openalex.org/W2965237601","https://openalex.org/W2104520807"],"abstract_inverted_index":{"The":[0,68],"fungal":[1],"opportunistic":[2,347],"pathogen,":[3],"Pneumocystis":[4,7,18],"jirovecii":[5],"(formerly":[6],"carinii":[8],"f.":[9],"sp.":[10],"hominis)":[11],"(Pc)":[12],"is":[13,55],"the":[14,42,61,96,127,242],"causative":[15],"agent":[16],"of":[17,44,53,64,72,98,111,118,177,222,244,282,300,307,320],"Pneumonia":[19],"(PcP)":[20],"in":[21,26,37,46,57,75,95,155,165,193,203,209,229,261,297,325],"immunocompromised":[22,38,178],"persons.":[23],"Despite":[24],"improvements":[25],"anti-retroviral":[27],"treatments":[28],"and":[29,189,214,227,330],"Pc":[30,32,40,45,73,92,109,137,164,253,292,328],"prophylaxis,":[31],"remains":[33],"an":[34],"important":[35],"pathogen":[36],"populations.":[39,265],"colonization,":[41,138],"presence":[43],"subjects":[47],"without":[48],"clinical":[49,62],"signs":[50],"or":[51,80],"symptoms":[52],"PcP,":[54],"common":[56],"HIV+":[58,194,239],"subjects;":[59],"however,":[60],"consequences":[63],"colonization":[65,93,110,254,329],"are":[66,191],"undefined.":[67],"non-human":[69],"primate":[70],"model":[71,246],"infection":[74],"simian":[76],"immunodeficiency":[77,83],"virus":[78,84],"(SIV)-":[79],"chimeric":[81],"simian-human":[82],"(SHIV)-infected":[85],"macaques":[86,112,145,156],"has":[87,235],"been":[88,236],"developed":[89],"to":[90,115,122,126,233,291,294,305,341],"study":[91],"pathogenesis":[94],"context":[97],"AIDS":[99],"immunosuppression.":[100,315],"Using":[101],"this":[102,245,346],"model,":[103],"immunologic":[104],"parameters":[105],"associated":[106,271],"with":[107,133,259,272],"natural":[108],"were":[113,149],"evaluated":[114],"gain":[116],"understanding":[117],"protective":[119],"immune":[120],"responses":[121],"Pc.":[123],"Humoral":[124],"immunity":[125],"recombinant":[128],"Pc-antigen,":[129],"kexin":[130],"(KEX1),":[131],"correlated":[132],"protection":[134,176,267,326],"from":[135,180,268,327],"subsequent":[136],"despite":[139,279],"declining":[140],"CD4+":[141],"T":[142],"cells.":[143,286],"Furthermore,":[144],"that":[146,157],"remained":[147],"Pc-negative":[148],"protected":[150],"against":[151,345],"lung":[152],"injury":[153],"observed":[154],"became":[158],"Pc-colonized,":[159],"supporting":[160],"a":[161,273,308,321,335],"role":[162],"for":[163,238,247,337],"pulmonary":[166,183,331],"obstruction":[167],"development.":[168],"These":[169,287,316],"experiments":[170],"suggest":[171,289],"KEX1-specific":[172,274],"antibodies":[173],"may":[174],"provide":[175],"individuals":[179],"developing":[181],"obstructive":[182],"disease.":[184],"Because":[185],"B":[186,200,217,225,250,263,276,285,311],"cell":[187,201,218,251,264,277,312],"deficits":[188,260],"dysfunctions":[190],"reported":[192,237],"subjects,":[195],"we":[196],"examined":[197],"peripheral":[198],"blood":[199],"populations":[202,344],"SHIV-infected":[204,230],"macaques.":[205],"We":[206],"report":[207],"declines":[208],"total":[210,262,283],"(CD20+),":[211],"memory":[212,216,275,310],"(CD20+CD27+)":[213],"IgM+":[215],"numbers,":[219],"increased":[220],"percentages":[221],"activated":[223],"(CD95+)":[224],"cells,":[226,303],"hypergammaglobulinemia":[228],"macaques,":[231],"similar":[232],"what":[234],"patients,":[240],"suggesting":[241],"relevance":[243],"studying":[248],"HIV-related":[249],"dysfunctions.":[252],"status":[255],"did":[256],"not":[257],"correlate":[258],"Rather,":[266],"Pc-colonization":[269],"appears":[270],"pool,":[278],"early":[280],"loss":[281],"CD27+":[284],"results":[288,317],"exposure":[290],"prior":[293],"immunosuppression,":[295],"resulting":[296],"high":[298],"levels":[299],"circulating":[301],"antibodies/plasma":[302],"contributes":[304],"maintenance":[306],"Pc-specific":[309,322],"pool":[313],"following":[314],"demonstrate":[318],"importance":[319],"humoral":[323],"response":[324],"damage,":[332],"thereby":[333],"providing":[334],"rationale":[336],"Pc-KEX1":[338],"vaccine":[339],"development":[340],"protect":[342],"at-risk":[343],"pathogen.":[348]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
