{"id":"https://openalex.org/W2136208974","doi":"https://doi.org/10.1586/17512433.2015.1011125","title":"Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms","display_name":"Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms","publication_year":2015,"publication_date":"2015-02-06","ids":{"openalex":"https://openalex.org/W2136208974","doi":"https://doi.org/10.1586/17512433.2015.1011125","mag":"2136208974","pmid":"https://pubmed.ncbi.nlm.nih.gov/25655639"},"language":"en","primary_location":{"id":"doi:10.1586/17512433.2015.1011125","doi":"https://doi.org/10.1586/17512433.2015.1011125","is_oa":false,"landing_page_url":"https://doi.org/10.1586/17512433.2015.1011125","pdf_url":null,"source":{"id":"https://openalex.org/S102962966","display_name":"Expert Review of Clinical Pharmacology","issn_l":"1751-2433","issn":["1751-2433","1751-2441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070116875","display_name":"Harumi Okuyama","orcid":"https://orcid.org/0000-0003-3332-4565","observed_orcids":["https://orcid.org/0000-0003-3332-4565"]},"institutions":[{"id":"https://openalex.org/I158048120","display_name":"Kinjo Gakuin University","ror":"https://ror.org/0475w6974","country_code":"JP","type":"education","lineage":["https://openalex.org/I158048120"]},{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Harumi Okuyama","raw_affiliation_strings":["Nagoya City University and Institute for Consumer Science and Human Life, Kinjo Gakuin University, 2-1723 Omori, Moriyama, Nagoya 463-8521, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya City University and Institute for Consumer Science and Human Life, Kinjo Gakuin University, 2-1723 Omori, Moriyama, Nagoya 463-8521, Japan","institution_ids":["https://openalex.org/I158048120","https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065569536","display_name":"Peter H. Langsjoen","orcid":"https://orcid.org/0000-0002-3355-2114","observed_orcids":["https://orcid.org/0000-0002-3355-2114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter H Langsjoen","raw_affiliation_strings":["Clinical Cardiology Practice, 1107 Doctors Drive, Tyler, TX 75701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cardiology Practice, 1107 Doctors Drive, Tyler, TX 75701, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014965523","display_name":"Tomohito Hamazaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomohito Hamazaki","raw_affiliation_strings":["Toyama Onsen Daini Hospital, 1-13-6 Taromaru-Nishimachi, Toyama-city, Toyama 939-8271, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toyama Onsen Daini Hospital, 1-13-6 Taromaru-Nishimachi, Toyama-city, Toyama 939-8271, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110403989","display_name":"Yoichi Ogushi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoichi Ogushi","raw_affiliation_strings":["Ogushi Institute of Medical Informatics, 12-43-2, Daikancho, Hiratsuka, Kanagawa 254-0807, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ogushi Institute of Medical Informatics, 12-43-2, Daikancho, Hiratsuka, Kanagawa 254-0807, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109050333","display_name":"Rokuro Hama","orcid":"https://orcid.org/0000-0002-3802-6754","observed_orcids":["https://orcid.org/0000-0002-3802-6754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rokuro Hama","raw_affiliation_strings":["Non-Profit Organization Japan Institute of Pharmacovigilance (Kusuri-no-Check), Ueshio 5-1-20, Tennouji-ku, Osaka 543-0002, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Non-Profit Organization Japan Institute of Pharmacovigilance (Kusuri-no-Check), Ueshio 5-1-20, Tennouji-ku, Osaka 543-0002, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038568954","display_name":"Tetsuyuki Kobayashi","orcid":"https://orcid.org/0000-0002-9285-0859","observed_orcids":["https://orcid.org/0000-0002-9285-0859"]},"institutions":[{"id":"https://openalex.org/I26120043","display_name":"Ochanomizu University","ror":"https://ror.org/03599d813","country_code":"JP","type":"education","lineage":["https://openalex.org/I26120043"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuyuki Kobayashi","raw_affiliation_strings":["Graduate School of Humanities and Sciences, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo 112-8610, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Humanities and Sciences, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo 112-8610, Japan","institution_ids":["https://openalex.org/I26120043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073835966","display_name":"Hajime Uchino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hajime Uchino","raw_affiliation_strings":["Medical Corp. Uchino-kai, 5-10-12 Yahata, Minami-ku, Kumamoto 861-4113, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Corp. Uchino-kai, 5-10-12 Yahata, Minami-ku, Kumamoto 861-4113, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5070116875"],"corresponding_institution_ids":["https://openalex.org/I158048120","https://openalex.org/I33858575"],"apc_list":null,"apc_paid":null,"fwci":8.17,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.98216059,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"8","issue":"2","first_page":"189","last_page":"199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.16590000689029694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8190000057220459},{"id":"https://openalex.org/keywords/coronary-artery-calcification","display_name":"coronary artery calcification","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mitochondrial-toxicity","display_name":"mitochondrial toxicity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.9399999976158142},{"id":"https://openalex.org/keywords/heme-a","display_name":"heme a","score":0.9470000267028809},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.7900000214576721},{"id":"https://openalex.org/keywords/vitamin-k2","display_name":"vitamin K2","score":0.875},{"id":"https://openalex.org/keywords/matrix-gla-protein","display_name":"matrix Gla protein","score":0.9539999961853027},{"id":"https://openalex.org/keywords/selenoprotein-synthesis","display_name":"selenoprotein biosynthesis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.996999979019165},{"id":"https://openalex.org/keywords/selenium-deficiency","display_name":"selenium deficiency","score":0.7599999904632568},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/peroxidative-stress","display_name":"peroxidative stress","score":0.777999997138977},{"id":"https://openalex.org/keywords/statin-adverse-effects","display_name":"statin adverse effects","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2779384338","wikidata":"https://www.wikidata.org/wiki/Q321285","display_name":"Coenzyme Q10","level":2,"score":0.8967517614364624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8267115354537964},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7746013402938843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5136427283287048},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.4556674063205719},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.413699209690094},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3537946343421936},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3528628945350647},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3478732705116272}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012643","descriptor_name":"Selenium","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D012643","descriptor_name":"Selenium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1586/17512433.2015.1011125","doi":"https://doi.org/10.1586/17512433.2015.1011125","is_oa":false,"landing_page_url":"https://doi.org/10.1586/17512433.2015.1011125","pdf_url":null,"source":{"id":"https://openalex.org/S102962966","display_name":"Expert Review of Clinical Pharmacology","issn_l":"1751-2433","issn":["1751-2433","1751-2441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:25655639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25655639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of clinical pharmacology","raw_type":"Journal Article"},{"id":"mag:2188777938","doi":null,"is_oa":false,"landing_page_url":"https://www.sefofcouncil.net/wp-content/uploads/2015/08/news150825_2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316136","display_name":"Groupe Lipides et Nutrition","ror":"https://ror.org/04mwfbr44"},{"id":"https://openalex.org/F4320322170","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86"},{"id":"https://openalex.org/F4320322942","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1552474357","https://openalex.org/W1963492252","https://openalex.org/W1971714188","https://openalex.org/W1974187375","https://openalex.org/W1983419107","https://openalex.org/W1984124570","https://openalex.org/W1995481782","https://openalex.org/W2000949542","https://openalex.org/W2001615105","https://openalex.org/W2004878568","https://openalex.org/W2005267038","https://openalex.org/W2008182187","https://openalex.org/W2015814654","https://openalex.org/W2019193819","https://openalex.org/W2033867558","https://openalex.org/W2039149257","https://openalex.org/W2039364749","https://openalex.org/W2040122368","https://openalex.org/W2041402659","https://openalex.org/W2048760408","https://openalex.org/W2054019381","https://openalex.org/W2057235392","https://openalex.org/W2059930169","https://openalex.org/W2060028537","https://openalex.org/W2067047758","https://openalex.org/W2068276476","https://openalex.org/W2069430698","https://openalex.org/W2078205785","https://openalex.org/W2096878914","https://openalex.org/W2103636227","https://openalex.org/W2103946550","https://openalex.org/W2110601215","https://openalex.org/W2113985697","https://openalex.org/W2115142426","https://openalex.org/W2116045728","https://openalex.org/W2118057359","https://openalex.org/W2120649473","https://openalex.org/W2126452437","https://openalex.org/W2126563293","https://openalex.org/W2130779718","https://openalex.org/W2149378542","https://openalex.org/W2149622957","https://openalex.org/W2155496611","https://openalex.org/W2157125602","https://openalex.org/W2157624452","https://openalex.org/W2157775932","https://openalex.org/W2170078866","https://openalex.org/W2216733834","https://openalex.org/W2329069409","https://openalex.org/W2338977280","https://openalex.org/W2397420192","https://openalex.org/W3140388327","https://openalex.org/W4233158352","https://openalex.org/W4248245260"],"related_works":["https://openalex.org/W2188777938","https://openalex.org/W3172686342","https://openalex.org/W6981301348","https://openalex.org/W2061573089","https://openalex.org/W2265469053","https://openalex.org/W2069635468","https://openalex.org/W2351878715","https://openalex.org/W1965243930","https://openalex.org/W1976069407","https://openalex.org/W2168344988"],"abstract_inverted_index":{"In":[0],"contrast":[1],"to":[2,90],"the":[3,37,43,57,62,77,109,117,126,134],"current":[4,143],"belief":[5],"that":[6,17,32,124,142],"cholesterol":[7],"reduction":[8],"with":[9,113],"statins":[10,18],"decreases":[11],"atherosclerosis,":[12],"we":[13],"present":[14],"a":[15,101],"perspective":[16],"may":[19,99,129],"be":[20,100,131,147],"causative":[21],"in":[22,36,69,103],"coronary":[23],"artery":[24],"calcification":[25],"and":[26,39,48,51,122],"can":[27],"function":[28,35],"as":[29],"mitochondrial":[30],"toxins":[31],"impair":[33],"muscle":[34],"heart":[38,105,120],"blood":[40],"vessels":[41],"through":[42],"depletion":[44],"of":[45,59,79,84,96,108,119,137],"coenzyme":[46],"Q10":[47],"'heme":[49],"A',":[50],"thereby":[52],"ATP":[53],"generation.":[54],"Statins":[55,75],"inhibit":[56,76],"synthesis":[58],"vitamin":[60],"K2,":[61],"cofactor":[63],"for":[64],"matrix":[65],"Gla-protein":[66],"activation,":[67],"which":[68,85],"turn":[70],"protects":[71],"arteries":[72],"from":[73],"calcification.":[74],"biosynthesis":[78,98],"selenium":[80,114],"containing":[81],"proteins,":[82],"one":[83],"is":[86],"glutathione":[87],"peroxidase":[88],"serving":[89],"suppress":[91],"peroxidative":[92],"stress.":[93],"An":[94],"impairment":[95],"selenoprotein":[97],"factor":[102],"congestive":[104],"failure,":[106],"reminiscent":[107],"dilated":[110],"cardiomyopathies":[111],"seen":[112],"deficiency.":[115],"Thus,":[116],"epidemic":[118],"failure":[121],"atherosclerosis":[123],"plagues":[125],"modern":[127],"world":[128],"paradoxically":[130],"aggravated":[132],"by":[133],"pervasive":[135],"use":[136],"statin":[138,144],"drugs.":[139],"We":[140],"propose":[141],"treatment":[145],"guidelines":[146],"critically":[148],"reevaluated.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
