{"id":"https://openalex.org/W2136198939","doi":"https://doi.org/10.1271/bbb.110234","title":"Achillinin A, a Cytotoxic Guaianolide from the Flower of Yarrow,Achillea millefolium","display_name":"Achillinin A, a Cytotoxic Guaianolide from the Flower of Yarrow,Achillea millefolium","publication_year":2011,"publication_date":"2011-08-08","ids":{"openalex":"https://openalex.org/W2136198939","doi":"https://doi.org/10.1271/bbb.110234","mag":"2136198939","pmid":"https://pubmed.ncbi.nlm.nih.gov/21821943"},"language":"en","primary_location":{"id":"doi:10.1271/bbb.110234","doi":"https://doi.org/10.1271/bbb.110234","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.110234","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100676864","display_name":"Yong Li","orcid":"https://orcid.org/0000-0002-3595-6673","observed_orcids":["https://orcid.org/0000-0002-3595-6673"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong LI","raw_affiliation_strings":["School of Basic Medicine, Hebei Medical University, Hebei Province, PR China","School of Basic Medicine, Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Hebei Medical University, Hebei Province, PR China","institution_ids":["https://openalex.org/I111381250"]},{"raw_affiliation_string":"School of Basic Medicine, Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113689652","display_name":"Man\u2010Li Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Man-Li ZHANG","raw_affiliation_strings":["School of Pharmaceutical Sciences,Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences,Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022654613","display_name":"Bin Cong","orcid":"https://orcid.org/0000-0003-3325-371X","observed_orcids":["https://orcid.org/0000-0003-3325-371X"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin CONG","raw_affiliation_strings":["School of Basic Medicine, Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088571648","display_name":"Si-Ming Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Ming WANG","raw_affiliation_strings":["School of Pharmaceutical Sciences,Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences,Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100618886","display_name":"Mei Dong","orcid":"https://orcid.org/0000-0003-1735-5361","observed_orcids":["https://orcid.org/0000-0003-1735-5361"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei DONG","raw_affiliation_strings":["School of Basic Medicine, Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111746049","display_name":"Fran\u00e7oise Sauriol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise SAURIOL","raw_affiliation_strings":["Department of Chemistry, Queen's University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Queen's University","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109077229","display_name":"Chang\u2010Hong Huo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang-Hong HUO","raw_affiliation_strings":["School of Pharmaceutical Sciences,Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences,Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101517854","display_name":"Qing\u2010Wen Shi","orcid":"https://orcid.org/0000-0001-5653-7657","observed_orcids":["https://orcid.org/0000-0001-5653-7657"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing-Wen SHI","raw_affiliation_strings":["School of Pharmaceutical Sciences,Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences,Hebei Medical University","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008346603","display_name":"Yu\u2010Cheng Gu","orcid":"https://orcid.org/0000-0002-6400-6167","observed_orcids":["https://orcid.org/0000-0002-6400-6167"]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yu-Cheng GU","raw_affiliation_strings":["Syngenta, Jealott\u2019s Hill International Research Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta, Jealott\u2019s Hill International Research Centre","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012767350","display_name":"Hiromasa Kiyota","orcid":"https://orcid.org/0000-0002-1330-6522","observed_orcids":["https://orcid.org/0000-0002-1330-6522"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromasa KIYOTA","raw_affiliation_strings":["Graduate school of Agricultural Science, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate school of Agricultural Science, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3272,"currency":"USD","value_usd":3272},"apc_paid":null,"fwci":0.9818,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.72302946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"75","issue":"8","first_page":"1554","last_page":"1556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/guaianolides","display_name":"guaianolides","score":0.9200000166893005},{"id":"https://openalex.org/keywords/yarrow","display_name":"yarrow","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.996999979019165},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2781145515","wikidata":"https://www.wikidata.org/wiki/Q25408","display_name":"Achillea millefolium","level":2,"score":0.9858449697494507},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4751743674278259},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.46700724959373474},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.4575783610343933},{"id":"https://openalex.org/C2779878721","wikidata":"https://www.wikidata.org/wiki/Q25400","display_name":"Asteraceae","level":2,"score":0.44678887724876404},{"id":"https://openalex.org/C2776211264","wikidata":"https://www.wikidata.org/wiki/Q80218","display_name":"Sesquiterpene","level":2,"score":0.41404759883880615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36457276344299316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0652894377708435}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031162","descriptor_name":"Achillea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D035264","descriptor_name":"Flowers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1271/bbb.110234","doi":"https://doi.org/10.1271/bbb.110234","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.110234","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:21821943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21821943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1032387977","display_name":"Total synthesis and investigation of biologically active natural compounds with novel and complex structures and its application to the development of agricultural and pharmaceutical lead compounds","funder_award_id":"22580112","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1970077223","https://openalex.org/W1972743221","https://openalex.org/W1986486669","https://openalex.org/W1987824176","https://openalex.org/W1996107761","https://openalex.org/W1999134086","https://openalex.org/W2010968176","https://openalex.org/W2019648889","https://openalex.org/W2036863762","https://openalex.org/W2039436684","https://openalex.org/W2050311525","https://openalex.org/W2055438060","https://openalex.org/W2057833305","https://openalex.org/W2065670947","https://openalex.org/W2068830413","https://openalex.org/W2071855324","https://openalex.org/W2079416918","https://openalex.org/W2079796760","https://openalex.org/W2087692995","https://openalex.org/W2087944770","https://openalex.org/W2151885603","https://openalex.org/W2161921046","https://openalex.org/W2591195476"],"related_works":["https://openalex.org/W1967031500","https://openalex.org/W2014367025","https://openalex.org/W2023600916","https://openalex.org/W1978717690","https://openalex.org/W2171827476","https://openalex.org/W4387641530","https://openalex.org/W4405612793","https://openalex.org/W4353049683","https://openalex.org/W2765183342","https://openalex.org/W1469267021"],"abstract_inverted_index":{"Achillinin":[0],"A":[1],"(2\u03b2,3\u03b2-epoxy-1\u03b1,4\u03b2,10\u03b1-trihydroxyguai-11(13)-en-12,6\u03b1-olide,":[2],"1),":[3],"a":[4],"new":[5],"guaianolide":[6],"isolated":[7],"from":[8],"the":[9],"flower":[10],"of":[11,30],"Achillea":[12],"millefolium,":[13],"exhibited":[14],"potential":[15],"antiproliferative":[16],"activity":[17],"to":[18],"A549,":[19],"RERF-LC-kj":[20],"and":[21,33],"QG-90":[22],"cells":[23],"with":[24],"50%":[25],"inhibitory":[26],"concentration":[27],"(IC(50))":[28],"values":[29],"5.8,":[31],"10":[32],"0.31":[34],"\u00b5M,":[35],"respectively.":[36]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
