{"id":"https://openalex.org/W2136195069","doi":"https://doi.org/10.1371/journal.pone.0048311","title":"Dose-Related Estrogen Effects on Gene Expression in Fetal Mouse Prostate Mesenchymal Cells","display_name":"Dose-Related Estrogen Effects on Gene Expression in Fetal Mouse Prostate Mesenchymal Cells","publication_year":2012,"publication_date":"2012-10-29","ids":{"openalex":"https://openalex.org/W2136195069","doi":"https://doi.org/10.1371/journal.pone.0048311","mag":"2136195069","pmid":"https://pubmed.ncbi.nlm.nih.gov/23144751","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3483223"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0048311","doi":"https://doi.org/10.1371/journal.pone.0048311","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048311","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048311&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048311&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051514888","display_name":"Julia A. Taylor","orcid":"https://orcid.org/0000-0003-1811-1844","observed_orcids":["https://orcid.org/0000-0003-1811-1844"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Julia A. Taylor","raw_affiliation_strings":["Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of America. taylorja@missouri.edu","Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of America. taylorja@missouri.edu","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028994823","display_name":"Catherine A. Richter","orcid":"https://orcid.org/0000-0001-7322-4206","observed_orcids":["https://orcid.org/0000-0001-7322-4206"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine A. Richter","raw_affiliation_strings":["Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100766663","display_name":"Atsuko Suzuki","orcid":"https://orcid.org/0000-0003-2662-2177","observed_orcids":["https://orcid.org/0000-0003-2662-2177"]},"institutions":[{"id":"https://openalex.org/I138804964","display_name":"National Institute for Basic Biology","ror":"https://ror.org/05q8wtt20","country_code":"JP","type":"education","lineage":["https://openalex.org/I1319490839","https://openalex.org/I138804964","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I199525922","display_name":"National Institutes of Natural Sciences","ror":"https://ror.org/055n47h92","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I200475212","display_name":"The Graduate University for Advanced Studies, SOKENDAI","ror":"https://ror.org/0516ah480","country_code":"JP","type":"education","lineage":["https://openalex.org/I200475212"]},{"id":"https://openalex.org/I4210097088","display_name":"Okazaki Institute for Integrative Bioscience","ror":"https://ror.org/00v3cq569","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210097088"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuko Suzuki","raw_affiliation_strings":["Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, and Department of Basic Biology, Graduate University for Advanced Studies (SOKENDAI), Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, and Department of Basic Biology, Graduate University for Advanced Studies (SOKENDAI), Aichi, Japan","institution_ids":["https://openalex.org/I138804964","https://openalex.org/I199525922","https://openalex.org/I200475212","https://openalex.org/I4210097088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005879454","display_name":"Hajime Watanabe","orcid":"https://orcid.org/0000-0001-9657-6554","observed_orcids":["https://orcid.org/0000-0001-9657-6554","https://orcid.org/0000-0001-9089-8122"]},"institutions":[{"id":"https://openalex.org/I138804964","display_name":"National Institute for Basic Biology","ror":"https://ror.org/05q8wtt20","country_code":"JP","type":"education","lineage":["https://openalex.org/I1319490839","https://openalex.org/I138804964","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I199525922","display_name":"National Institutes of Natural Sciences","ror":"https://ror.org/055n47h92","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I200475212","display_name":"The Graduate University for Advanced Studies, SOKENDAI","ror":"https://ror.org/0516ah480","country_code":"JP","type":"education","lineage":["https://openalex.org/I200475212"]},{"id":"https://openalex.org/I4210097088","display_name":"Okazaki Institute for Integrative Bioscience","ror":"https://ror.org/00v3cq569","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210097088"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Watanabe","raw_affiliation_strings":["Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, and Department of Basic Biology, Graduate University for Advanced Studies (SOKENDAI), Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, and Department of Basic Biology, Graduate University for Advanced Studies (SOKENDAI), Aichi, Japan","institution_ids":["https://openalex.org/I138804964","https://openalex.org/I199525922","https://openalex.org/I200475212","https://openalex.org/I4210097088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005360431","display_name":"Taisen Iguchi","orcid":"https://orcid.org/0000-0002-6020-0704","observed_orcids":["https://orcid.org/0000-0002-6020-0704"]},"institutions":[{"id":"https://openalex.org/I138804964","display_name":"National Institute for Basic Biology","ror":"https://ror.org/05q8wtt20","country_code":"JP","type":"education","lineage":["https://openalex.org/I1319490839","https://openalex.org/I138804964","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I199525922","display_name":"National Institutes of Natural Sciences","ror":"https://ror.org/055n47h92","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I200475212","display_name":"The Graduate University for Advanced Studies, SOKENDAI","ror":"https://ror.org/0516ah480","country_code":"JP","type":"education","lineage":["https://openalex.org/I200475212"]},{"id":"https://openalex.org/I4210097088","display_name":"Okazaki Institute for Integrative Bioscience","ror":"https://ror.org/00v3cq569","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210097088"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taisen Iguchi","raw_affiliation_strings":["Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, and Department of Basic Biology, Graduate University for Advanced Studies (SOKENDAI), Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, and Department of Basic Biology, Graduate University for Advanced Studies (SOKENDAI), Aichi, Japan","institution_ids":["https://openalex.org/I138804964","https://openalex.org/I199525922","https://openalex.org/I200475212","https://openalex.org/I4210097088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069082145","display_name":"Kathryn R. Coser","orcid":"https://orcid.org/0000-0003-0377-7897","observed_orcids":["https://orcid.org/0000-0003-0377-7897"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn R. Coser","raw_affiliation_strings":["Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002131310","display_name":"Toshi Shioda","orcid":"https://orcid.org/0000-0002-9434-7835","observed_orcids":["https://orcid.org/0000-0002-9434-7835"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshihiro Shioda","raw_affiliation_strings":["Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Profiling Laboratory, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111413501","display_name":"Frederick S. vom Saal","orcid":"https://orcid.org/0000-0002-0488-3264","observed_orcids":["https://orcid.org/0000-0002-0488-3264"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick S. vom Saal","raw_affiliation_strings":["Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5051514888"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.8834,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.72389991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"10","first_page":"e48311","last_page":"e48311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.33889999985694885,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.11810000240802765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.3370000123977661},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mesenchymal-cells","display_name":"mesenchymal cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.628000020980835},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.753000020980835},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5910000205039978},{"id":"https://openalex.org/keywords/urogenital-sinus","display_name":"urogenital sinus","score":0.656000018119812},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.9120000004768372},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7269999980926514},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9670000076293945},{"id":"https://openalex.org/keywords/steroid-hormone-metabolism","display_name":"steroid hormone metabolism","score":0.7239999771118164},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/early-life-exposure","display_name":"early life exposure","score":0.4000000059604645},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6799757480621338},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.6520386934280396},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5918248295783997},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5868808031082153},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5808947086334229},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5419164896011353},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4892268180847168},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4838765859603882},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.4810612201690674},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.4237886965274811},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.411774605512619},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3470725417137146},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32809537649154663},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.17288854718208313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11384865641593933},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013196","descriptor_name":"Dihydrotestosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0048311","doi":"https://doi.org/10.1371/journal.pone.0048311","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048311","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048311&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2491885","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3483223","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3483223","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3483223","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1018.2743","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1018.2743","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"https://dash.harvard.edu/bitstream/handle/1/10579403/3483223.pdf?sequence%3D1","raw_type":"text"},{"id":"pmid:23144751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23144751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1020.4269","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1020.4269","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Taisen_Iguchi2/publication/233396880_Dose-Related_Estrogen_Effects_on_Gene_Expression_in_Fetal_Mouse_Prostate_Mesenchymal_Cells/links/0c96052267b34b1e23000000.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.816.352","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.816.352","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/be/3f/pone.0048311.PMC3483223.pdf","raw_type":"text"},{"id":"pmh:oai:dash.harvard.edu:1/10579403","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10579403","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:da10a256580b4c17b38c270ae6258f20","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/da10a256580b4c17b38c270ae6258f20","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 10, p e48311 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0048311","doi":"https://doi.org/10.1371/journal.pone.0048311","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048311","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048311&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4395216395","display_name":null,"funder_award_id":"KG090515","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G4609303048","display_name":null,"funder_award_id":"ES-11283","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5943548310","display_name":null,"funder_award_id":"ES 018764","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8091748765","display_name":"Developmental toxicity of environmental chemicals","funder_award_id":"R01ES011283","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8134166032","display_name":"Mechanisms of dioxin effects on prostate development","funder_award_id":"F32ES011549","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8915351695","display_name":"Bisphenol A:  Urine flow disorder and prostate pathology","funder_award_id":"RC2ES018764","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136195069.pdf","grobid_xml":"https://content.openalex.org/works/W2136195069.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W141389621","https://openalex.org/W315726089","https://openalex.org/W1562974583","https://openalex.org/W1566675931","https://openalex.org/W1867714524","https://openalex.org/W1968449473","https://openalex.org/W1968614586","https://openalex.org/W1972022922","https://openalex.org/W1973374297","https://openalex.org/W1973717291","https://openalex.org/W1974667009","https://openalex.org/W1975674531","https://openalex.org/W1978152488","https://openalex.org/W1990110300","https://openalex.org/W1990173431","https://openalex.org/W1992203600","https://openalex.org/W1994048261","https://openalex.org/W2008183439","https://openalex.org/W2021064276","https://openalex.org/W2022056262","https://openalex.org/W2024842895","https://openalex.org/W2025226724","https://openalex.org/W2026180592","https://openalex.org/W2028787260","https://openalex.org/W2031146912","https://openalex.org/W2037308071","https://openalex.org/W2041554939","https://openalex.org/W2044104475","https://openalex.org/W2049533157","https://openalex.org/W2061912939","https://openalex.org/W2066000490","https://openalex.org/W2072451938","https://openalex.org/W2080581227","https://openalex.org/W2092787533","https://openalex.org/W2094929131","https://openalex.org/W2095628944","https://openalex.org/W2108727531","https://openalex.org/W2114756433","https://openalex.org/W2115763257","https://openalex.org/W2124954099","https://openalex.org/W2128841974","https://openalex.org/W2130525612","https://openalex.org/W2131801187","https://openalex.org/W2133465414","https://openalex.org/W2133850570","https://openalex.org/W2135762870","https://openalex.org/W2143146123","https://openalex.org/W2151322467","https://openalex.org/W2153346478","https://openalex.org/W2155363874","https://openalex.org/W2158217645","https://openalex.org/W2164676422","https://openalex.org/W2165471176","https://openalex.org/W2171277427","https://openalex.org/W2394996993","https://openalex.org/W2414522840","https://openalex.org/W2419506035","https://openalex.org/W2479519786","https://openalex.org/W2529424654","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1968614586","https://openalex.org/W2115763257","https://openalex.org/W1994286831","https://openalex.org/W4243683627","https://openalex.org/W2133850570","https://openalex.org/W2069237251","https://openalex.org/W4212904874","https://openalex.org/W2164676422","https://openalex.org/W4231513949","https://openalex.org/W2085556797"],"abstract_inverted_index":{"Developmental":[0],"exposure":[1],"of":[2,54,57,72,106,110,124],"mouse":[3,74,86],"fetuses":[4,87],"to":[5,40,94],"estrogens":[6,34],"results":[7,216],"in":[8,60,69,103,134,145,151,181],"dose-dependent":[9],"permanent":[10],"effects":[11],"on":[12],"prostate":[13,75,219],"morphology":[14],"and":[15,26,29,35,45,92,128,138,159,201,204,211,239],"function.":[16],"Fetal":[17],"prostatic":[18],"mesenchyme":[19,80],"cells":[20,81,221,225],"express":[21],"estrogen":[22,231,246],"receptor":[23],"alpha":[24],"(ER\u03b1)":[25],"androgen":[27],"receptors":[28],"convert":[30],"stimuli":[31],"from":[32,84],"circulating":[33],"androgens":[36],"into":[37,51],"paracrine":[38],"signaling":[39,200],"regulate":[41,223],"epithelial":[42,224],"cell":[43,152,196,228],"proliferation":[44],"differentiation.":[46],"To":[47],"obtain":[48],"mechanistic":[49],"insight":[50],"the":[52,104,182,186],"role":[53],"different":[55],"doses":[56,123],"estradiol":[58],"(E2)":[59],"regulating":[61],"mesenchymal":[62,76,220],"cells,":[63],"we":[64],"examined":[65],"E2-induced":[66],"transcriptomal":[67],"changes":[68],"primary":[70],"cultures":[71],"fetal":[73],"cells.":[77],"Urogenital":[78],"sinus":[79],"were":[82,154,179],"obtained":[83],"male":[85],"at":[88,170,176],"gestation":[89],"day":[90],"17":[91],"exposed":[93],"10":[95,171],"pM,":[96],"100":[97,100,129,177],"pM":[98,127,172],"or":[99],"nM":[101],"E2":[102,125,169,173,191],"presence":[105],"a":[107],"physiological":[108],"concentration":[109],"dihydrotestosterone":[111],"(0.69":[112],"nM)":[113],"for":[114,195],"four":[115],"days.":[116],"Gene":[117],"ontology":[118],"studies":[119],"suggested":[120],"that":[121,218],"low":[122,234],"(10":[126],"pM)":[130,178],"induce":[131],"genes":[132,143,193],"involved":[133,144,150],"morphological":[135],"tissue":[136],"development":[137],"sterol":[139],"biosynthesis":[140],"but":[141,174],"suppress":[142],"growth":[146,237],"factor":[147],"signaling.":[148,214],"Genes":[149,162],"adhesion":[153],"enriched":[155,180,194],"among":[156],"both":[157],"up-regulated":[158],"down-regulated":[160],"genes.":[161],"showing":[163],"inverted-U-shape":[164],"dose":[165,188],"responses":[166],"(enhanced":[167],"by":[168],"suppressed":[175],"glycolytic":[183],"pathway.":[184],"At":[185],"highest":[187],"(100":[189],"nM),":[190],"induced":[192],"adhesion,":[197],"steroid":[198],"hormone":[199],"metabolism,":[202],"cytokines":[203,240],"their":[205],"receptors,":[206],"cell-to-cell":[207],"communication,":[208],"Wnt":[209],"signaling,":[210],"TGF-":[212],"\u03b2":[213],"These":[215],"suggest":[217],"may":[222],"through":[226],"direct":[227],"contacts":[229],"when":[230,245],"level":[232,247],"is":[233,248],"whereas":[235],"secreted":[236],"factors":[238],"might":[241],"play":[242],"significant":[243],"roles":[244],"high.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
