{"id":"https://openalex.org/W2136185762","doi":"https://doi.org/10.1210/en.2013-1694","title":"Synergistic Activation of Steroidogenic Acute Regulatory Protein Expression and Steroid Biosynthesis by Retinoids: Involvement of cAMP/PKA Signaling","display_name":"Synergistic Activation of Steroidogenic Acute Regulatory Protein Expression and Steroid Biosynthesis by Retinoids: Involvement of cAMP/PKA Signaling","publication_year":2013,"publication_date":"2013-11-22","ids":{"openalex":"https://openalex.org/W2136185762","doi":"https://doi.org/10.1210/en.2013-1694","mag":"2136185762","pmid":"https://pubmed.ncbi.nlm.nih.gov/24265455","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3891939"},"language":"en","primary_location":{"id":"doi:10.1210/en.2013-1694","doi":"https://doi.org/10.1210/en.2013-1694","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2013-1694","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3891939","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030460457","display_name":"Pulak R. Manna","orcid":"https://orcid.org/0000-0003-4292-4001","observed_orcids":["https://orcid.org/0000-0003-4292-4001"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pulak R. Manna","raw_affiliation_strings":["Department of Cell Biology and Biochemistry (P.R.M., S.R.K., D.M.S.), Texas Tech University Health Sciences Center, Lubbock, Texas 79430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Biochemistry (P.R.M., S.R.K., D.M.S.), Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050860545","display_name":"Andrzej T. Slominski","orcid":"https://orcid.org/0000-0001-8963-3995","observed_orcids":["https://orcid.org/0000-0001-8963-3995"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrzej T. Slominski","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee 38163","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108538936","display_name":"Steven R. King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. King","raw_affiliation_strings":["Department of Cell Biology and Biochemistry (P.R.M., S.R.K., D.M.S.), Texas Tech University Health Sciences Center, Lubbock, Texas 79430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Biochemistry (P.R.M., S.R.K., D.M.S.), Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072356743","display_name":"Cloyce L. Stetson","orcid":"https://orcid.org/0000-0002-1117-2313","observed_orcids":["https://orcid.org/0000-0002-1117-2313"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cloyce L. Stetson","raw_affiliation_strings":["Department of Dermatology and Pathology (C.L.S.), Texas Tech University Health Sciences Center, Lubbock, Texas 79430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Pathology (C.L.S.), Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111668367","display_name":"Douglas M. Stocco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas M. Stocco","raw_affiliation_strings":["Department of Cell Biology and Biochemistry (P.R.M., S.R.K., D.M.S.), Texas Tech University Health Sciences Center, Lubbock, Texas 79430"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Biochemistry (P.R.M., S.R.K., D.M.S.), Texas Tech University Health Sciences Center, Lubbock, Texas 79430","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111668367"],"corresponding_institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.9848,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.92030171,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"155","issue":"2","first_page":"576","last_page":"591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/steroidogenic-acute-regulatory-protein","display_name":"steroidogenic acute regulatory protein","score":0.9100000262260437},{"id":"https://openalex.org/keywords/retinoids","display_name":"retinoids","score":0.8619999885559082},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.902999997138977},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/camp-pka-signaling","display_name":"cAMP/PKA signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/retinoic-acid-receptor-alpha","display_name":"retinoic acid receptor alpha","score":0.878000020980835},{"id":"https://openalex.org/keywords/retinoid-x-receptor-alpha","display_name":"retinoid X receptor alpha","score":0.9919999837875366},{"id":"https://openalex.org/keywords/liver-x-receptor","display_name":"liver X receptor","score":0.8949999809265137},{"id":"https://openalex.org/keywords/creb-phosphorylation","display_name":"CREB phosphorylation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/creb-binding-protein","display_name":"CREB-binding protein","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hormone-sensitive-lipase","display_name":"hormone-sensitive lipase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/progesterone-synthesis","display_name":"progesterone secretion","score":0.7799999713897705},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ma-10-cells","display_name":"MA-10 cells","score":0.7110000252723694},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.7142223715782166},{"id":"https://openalex.org/C2779670467","wikidata":"https://www.wikidata.org/wiki/Q24727595","display_name":"Steroidogenic acute regulatory protein","level":4,"score":0.7006974220275879},{"id":"https://openalex.org/C128821507","wikidata":"https://www.wikidata.org/wiki/Q3454518","display_name":"Retinoid X receptor","level":5,"score":0.6886154413223267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6394863128662109},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5568737983703613},{"id":"https://openalex.org/C2775954498","wikidata":"https://www.wikidata.org/wiki/Q420418","display_name":"Retinoid","level":4,"score":0.5079408288002014},{"id":"https://openalex.org/C68484354","wikidata":"https://www.wikidata.org/wiki/Q17516011","display_name":"Retinoid X receptor alpha","level":5,"score":0.5034806132316589},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5002932548522949},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.4847697615623474},{"id":"https://openalex.org/C120197328","wikidata":"https://www.wikidata.org/wiki/Q2838685","display_name":"Retinoic acid receptor","level":4,"score":0.4224678874015808},{"id":"https://openalex.org/C162253465","wikidata":"https://www.wikidata.org/wiki/Q18031338","display_name":"Retinoid X receptor gamma","level":5,"score":0.42074739933013916},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42028263211250305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39982035756111145},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3925069272518158},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.39240413904190063},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3797188699245453},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33504313230514526},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.252798855304718},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.24862396717071533},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2475356161594391},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1601787805557251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06496724486351013}],"mesh":[{"descriptor_ui":"D000098682","descriptor_name":"Steroidogenic Acute Regulatory Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047488","descriptor_name":"Retinoid X Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047488","descriptor_name":"Retinoid X Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.2013-1694","doi":"https://doi.org/10.1210/en.2013-1694","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2013-1694","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3891939","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3891939","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Text"},{"id":"pmid:24265455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24265455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3891939","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3891939","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3497248051","display_name":"Mitochondrial Proteins and Leydig Cell Steroidogenesis","funder_award_id":"R01HD017481","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4147771997","display_name":null,"funder_award_id":"HD17481","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4546544336","display_name":"MITOCHONDRIAL PROTEINS AND LEYDIG CELL STEROIDOGENESIS","funder_award_id":"R37HD017481","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1564211606","https://openalex.org/W1610204701","https://openalex.org/W1643056575","https://openalex.org/W1963827257","https://openalex.org/W1976159941","https://openalex.org/W1979037868","https://openalex.org/W1981234399","https://openalex.org/W1982378312","https://openalex.org/W1982420603","https://openalex.org/W1985621145","https://openalex.org/W1986248731","https://openalex.org/W1987040411","https://openalex.org/W1988495226","https://openalex.org/W1989796804","https://openalex.org/W1990807902","https://openalex.org/W1995754186","https://openalex.org/W2000577172","https://openalex.org/W2000609399","https://openalex.org/W2009171847","https://openalex.org/W2009229814","https://openalex.org/W2010885000","https://openalex.org/W2011908174","https://openalex.org/W2012718702","https://openalex.org/W2019611093","https://openalex.org/W2020510672","https://openalex.org/W2021994993","https://openalex.org/W2024461862","https://openalex.org/W2026755394","https://openalex.org/W2030621682","https://openalex.org/W2032558948","https://openalex.org/W2035362985","https://openalex.org/W2036638367","https://openalex.org/W2041511626","https://openalex.org/W2042052859","https://openalex.org/W2044804886","https://openalex.org/W2046478225","https://openalex.org/W2047814115","https://openalex.org/W2051663421","https://openalex.org/W2052962370","https://openalex.org/W2055314203","https://openalex.org/W2056752882","https://openalex.org/W2064579441","https://openalex.org/W2067207360","https://openalex.org/W2068902736","https://openalex.org/W2069601913","https://openalex.org/W2070840393","https://openalex.org/W2077861288","https://openalex.org/W2089390194","https://openalex.org/W2091544680","https://openalex.org/W2093472525","https://openalex.org/W2097852397","https://openalex.org/W2103962971","https://openalex.org/W2106317671","https://openalex.org/W2107782059","https://openalex.org/W2110561492","https://openalex.org/W2112632255","https://openalex.org/W2117198713","https://openalex.org/W2117297645","https://openalex.org/W2119168427","https://openalex.org/W2120015244","https://openalex.org/W2121278592","https://openalex.org/W2124092999","https://openalex.org/W2127288848","https://openalex.org/W2128296469","https://openalex.org/W2133210300","https://openalex.org/W2134876608","https://openalex.org/W2140549508","https://openalex.org/W2143459579","https://openalex.org/W2146885393","https://openalex.org/W2150657249","https://openalex.org/W2154213419","https://openalex.org/W2157892593","https://openalex.org/W2163762391","https://openalex.org/W2164954416","https://openalex.org/W2165840006","https://openalex.org/W2172256092"],"related_works":["https://openalex.org/W2093472525","https://openalex.org/W7208595607","https://openalex.org/W2128296469","https://openalex.org/W2127288848","https://openalex.org/W2081500836","https://openalex.org/W2011908174","https://openalex.org/W1168062050","https://openalex.org/W7138046161","https://openalex.org/W2164286214","https://openalex.org/W2086785259"],"abstract_inverted_index":{"Both":[0],"retinoic":[1,63],"acid":[2,64],"receptors":[3,8],"(RARs)":[4],"and":[5,22,74,102,110,123,128,169,174,187,220,261,264,273],"retinoid":[6,147],"X":[7,155,246],"(RXRs)":[9],"mediate":[10],"the":[11,36,43,50,84,132,136,140,143,161,180,210,223,240,252,268],"action":[12,46],"of":[13,29,45,47,52,83,107,127,135,142,179,200,212,214,239,270],"retinoids":[14,48,257],"that":[15,61,229,243],"play":[16],"important":[17,234],"roles":[18],"in":[19,49,77,117,119,131,146,170,176,183,236,275],"reproductive":[20],"development":[21],"function,":[23],"as":[24,26],"well":[25],"steroidogenesis.":[27],"Regulation":[28],"steroid":[30,103],"biosynthesis":[31],"is":[32],"principally":[33],"mediated":[34],"by":[35,90,191,255],"steroidogenic":[37,241],"acute":[38],"regulatory":[39],"protein":[40,85,204],"(StAR);":[41],"however,":[42],"modes":[44],"regulation":[51,238,269],"steroidogenesis":[53,274],"remain":[54],"obscure.":[55],"In":[56],"this":[57],"study":[58],"we":[59],"demonstrate":[60],"all-trans":[62],"(atRA)":[65],"enhances":[66],"StAR":[67,122,137,181,224,271],"expression,":[68],"but":[69],"not":[70],"its":[71,194],"phosphorylation":[72,199,213],"(P-StAR),":[73],"progesterone":[75,124],"production":[76],"MA-10":[78,166],"mouse":[79,276],"Leydig":[80,277],"cells.":[81,278],"Activation":[82],"kinase":[86],"A":[87],"(PKA)":[88],"cascade,":[89],"dibutyrl-cAMP":[91,188],"or":[92],"type":[93],"I/II":[94],"PKA":[95],"analogs,":[96],"markedly":[97],"increased":[98],"retinoid-responsive":[99],"StAR,":[100],"P-StAR,":[101],"levels.":[104,125],"Targeted":[105],"silencing":[106],"endogenous":[108],"RAR\u03b1":[109,175,221],"RXR\u03b1,":[111,219],"with":[112],"small":[113],"interfering":[114],"RNAs,":[115],"resulted":[116],"decreases":[118],"9-cis":[120],"RA-stimulated":[121],"Truncation":[126],"mutational":[129],"alterations":[130],"5'-flanking":[133],"region":[134,145],"gene":[138,182],"demonstrated":[139],"importance":[141],"-254/-1-bp":[144,162],"responsiveness.":[148],"An":[149],"oligonucleotide":[150],"probe":[151],"encompassing":[152],"an":[153,233],"RXR/liver":[154],"receptor":[156,247],"recognition":[157],"motif,":[158],"located":[159],"within":[160],"region,":[163],"specifically":[164],"bound":[165],"nuclear":[167],"proteins":[168],"vitro":[171],"transcribed/translated":[172],"RXR\u03b1":[173],"EMSAs.":[177],"Transcription":[178],"response":[184,242],"to":[185,222],"atRA":[186],"was":[189],"influenced":[190],"several":[192],"factors,":[193],"up-regulation":[195],"being":[196],"dependent":[197],"on":[198],"cAMP":[201],"response-element":[202],"binding":[203,217],"(CREB).":[205],"Chromatin":[206],"immunoprecipitation":[207],"studies":[208,227],"revealed":[209],"association":[211],"CREB,":[215],"CREB":[216],"protein,":[218],"promoter.":[225],"Further":[226],"elucidated":[228],"hormone-sensitive":[230],"lipase":[231],"plays":[232],"role":[235],"atRA-mediated":[237],"involves":[244],"liver":[245],"signaling.":[248],"These":[249],"findings":[250],"delineate":[251],"molecular":[253],"events":[254],"which":[256],"influence":[258],"cAMP/PKA":[259],"signaling":[260],"provide":[262],"additional":[263],"novel":[265],"insight":[266],"into":[267],"expression":[272]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}