{"id":"https://openalex.org/W2136185341","doi":"https://doi.org/10.1074/jbc.m502567200","title":"A Novel Form of Neurotensin Post-translationally Modified by Arginylation","display_name":"A Novel Form of Neurotensin Post-translationally Modified by Arginylation","publication_year":2005,"publication_date":"2005-08-09","ids":{"openalex":"https://openalex.org/W2136185341","doi":"https://doi.org/10.1074/jbc.m502567200","mag":"2136185341","pmid":"https://pubmed.ncbi.nlm.nih.gov/16087676"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m502567200","doi":"https://doi.org/10.1074/jbc.m502567200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m502567200","pdf_url":"http://www.jbc.org/article/S0021925819481799/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819481799/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021817865","display_name":"Elo Eriste","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Elo Eriste","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042028544","display_name":"\u00c5ke Norberg","orcid":"https://orcid.org/0000-0002-3776-1570","observed_orcids":["https://orcid.org/0000-0002-3776-1570"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"\u00c5ke Norberg","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103754065","display_name":"Diane H. Nepomuceno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Nepomuceno","raw_affiliation_strings":["Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080690112","display_name":"Chester Kuei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chester Kuei","raw_affiliation_strings":["Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065127539","display_name":"Fredrik Kamme","orcid":"https://orcid.org/0000-0003-2877-6954","observed_orcids":["https://orcid.org/0000-0003-2877-6954"]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fredrik Kamme","raw_affiliation_strings":["Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003605253","display_name":"Da\u2010Thao Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Da-Thao Tran","raw_affiliation_strings":["Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026349053","display_name":"Kerstin Strupat","orcid":"https://orcid.org/0009-0007-2001-8768","observed_orcids":["https://orcid.org/0009-0007-2001-8768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kerstin Strupat","raw_affiliation_strings":["Thermo Electron (Bremen) GmbH, D-28197 Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thermo Electron (Bremen) GmbH, D-28197 Bremen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113570579","display_name":"Hans J\u00f6rnvall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hans J\u00f6rnvall","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics Karolinska Institutet S\u2010171 77 Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics Karolinska Institutet S\u2010171 77 Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069483895","display_name":"Changlu Liu","orcid":"https://orcid.org/0000-0001-6878-9384","observed_orcids":["https://orcid.org/0000-0001-6878-9384","https://orcid.org/0000-0003-4603-9325"]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changlu Liu","raw_affiliation_strings":["Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113741633","display_name":"Timothy W. Lovenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy W. Lovenberg","raw_affiliation_strings":["Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Pharmaceutical Research and Development, San Diego, California 92121, and","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036064391","display_name":"Rannar Sillard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Rannar Sillard","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden,","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036064391"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.4143,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.52983888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"280","issue":"42","first_page":"35089","last_page":"35097"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotensin","display_name":"neurotensin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/arginylation","display_name":"arginylation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.9399999976158142},{"id":"https://openalex.org/keywords/isopeptide-bonds","display_name":"isopeptide bonds","score":0.8539999723434448},{"id":"https://openalex.org/keywords/porcine-intestine","display_name":"porcine intestine","score":0.8019999861717224},{"id":"https://openalex.org/keywords/neurotensin-receptor","display_name":"neurotensin receptor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neurotensin-receptor-1","display_name":"neurotensin receptor 1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.625},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.8519999980926514},{"id":"https://openalex.org/keywords/sk-n-sh-cells","display_name":"SK-N-SH cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/peptide-purification","display_name":"peptide purification","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2778976297","wikidata":"https://www.wikidata.org/wiki/Q419576","display_name":"Neurotensin","level":4,"score":0.6991623640060425},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3887270390987396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3200807571411133},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14822745323181152},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.1435309648513794},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13347294926643372}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009496","descriptor_name":"Neurotensin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009496","descriptor_name":"Neurotensin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018028","descriptor_name":"Receptors, Neurotensin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m502567200","doi":"https://doi.org/10.1074/jbc.m502567200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m502567200","pdf_url":"http://www.jbc.org/article/S0021925819481799/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16087676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16087676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m502567200","doi":"https://doi.org/10.1074/jbc.m502567200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m502567200","pdf_url":"http://www.jbc.org/article/S0021925819481799/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136185341.pdf","grobid_xml":"https://content.openalex.org/works/W2136185341.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1490542744","https://openalex.org/W1494884367","https://openalex.org/W1501407324","https://openalex.org/W1502578883","https://openalex.org/W1595171027","https://openalex.org/W1607957872","https://openalex.org/W1682371140","https://openalex.org/W1968908922","https://openalex.org/W1970425577","https://openalex.org/W1971865087","https://openalex.org/W1976694824","https://openalex.org/W1978378468","https://openalex.org/W1981123238","https://openalex.org/W1986276041","https://openalex.org/W1986370149","https://openalex.org/W1986637251","https://openalex.org/W1994342023","https://openalex.org/W1998858772","https://openalex.org/W2015109789","https://openalex.org/W2021363994","https://openalex.org/W2024482529","https://openalex.org/W2024858596","https://openalex.org/W2034457885","https://openalex.org/W2035596770","https://openalex.org/W2038225888","https://openalex.org/W2043465968","https://openalex.org/W2046344792","https://openalex.org/W2049520149","https://openalex.org/W2052519819","https://openalex.org/W2052969077","https://openalex.org/W2053807193","https://openalex.org/W2053865250","https://openalex.org/W2058130105","https://openalex.org/W2062636887","https://openalex.org/W2070020792","https://openalex.org/W2075330831","https://openalex.org/W2079042881","https://openalex.org/W2084877711","https://openalex.org/W2086793204","https://openalex.org/W2087321541","https://openalex.org/W2088433975","https://openalex.org/W2089146019","https://openalex.org/W2092592666","https://openalex.org/W2095236562","https://openalex.org/W2097039450","https://openalex.org/W2136714025","https://openalex.org/W2165768410","https://openalex.org/W2168145001","https://openalex.org/W2288497293","https://openalex.org/W2339181741"],"related_works":["https://openalex.org/W2043465968","https://openalex.org/W1970894679","https://openalex.org/W6931565256","https://openalex.org/W2066059449","https://openalex.org/W2063217677","https://openalex.org/W1542870268","https://openalex.org/W2613530633","https://openalex.org/W2944313366","https://openalex.org/W1991849045","https://openalex.org/W2944136210"],"abstract_inverted_index":{"A":[0],"novel":[1],"bioactive":[2],"form":[3],"of":[4,18,25,58,81,142,173,182],"neurotensin":[5,99,126,177,192],"post-translationally":[6,110],"modified":[7,111],"at":[8,89],"a":[9,78,90,146,161,187],"Glu":[10,59,91],"residue":[11],"was":[12,21,50],"isolated":[13],"from":[14],"porcine":[15],"intestine.":[16],"Purification":[17],"the":[19,47,56,67,101,156,166,215],"peptide":[20,70],"guided":[22],"by":[23,219],"detection":[24],"intracellular":[26,157],"Ca2+":[27,216],"release":[28],"in":[29,85,109,194,197],"SK-N-SH":[30,203],"neuroblastoma":[31,204],"cells.":[32],"Using":[33],"high":[34],"resolution":[35],"accurate":[36],"mass":[37,45],"analysis":[38],"on":[39,123],"an":[40,61],"ion":[41],"trap":[42],"Fourier":[43],"transform":[44],"spectrometer,":[46],"post-translational":[48],"modification":[49,80],"identified":[51,69],"as":[52,160],"arginine":[53],"linked":[54],"to":[55,140,150],"gamma-carboxyl":[57],"via":[60,222],"isopeptide":[62],"bond,":[63],"and":[64,112,130,132,176,196,208],"we":[65,116],"named":[66],"newly":[68],"\"arginylated":[71],"neurotensin\"":[72],"(R-NT,":[73],"N-(neurotensin-C5-4-yl)arginine).":[74],"Although":[75],"arginylation":[76],"is":[77,94,221],"known":[79,125],"N-terminal":[82],"amino":[83],"groups":[84],"proteins,":[86],"its":[87,120,174],"presence":[88],"side":[92],"chain":[93],"unique.":[95],"The":[96,180],"finding":[97],"places":[98],"among":[100],"few":[102],"physiologically":[103],"active":[104],"peptides":[105],"that":[106,134,202,214],"occur":[107],"both":[108],"unmodified":[113],"forms.":[114],"Pharmacologically,":[115],"characterized":[117],"R-NT":[118,135,175,220],"for":[119,190],"ligand":[121],"activity":[122],"three":[124,152],"receptors,":[127],"NTR1,":[128],"-2,":[129],"-3,":[131],"found":[133],"has":[136],"similar":[137],"pharmacological":[138],"properties":[139],"those":[141],"neurotensin,":[143],"however,":[144],"with":[145],"slightly":[147],"higher":[148],"affinity":[149],"all":[151],"receptors.":[153],"We":[154,199],"expressed":[155],"receptor":[158],"NTR3":[159,184,209],"soluble":[162,183],"protein":[163],"secreted":[164],"into":[165],"cell":[167],"culture":[168],"medium,":[169],"which":[170],"allowed":[171],"characterization":[172],"binding":[178],"properties.":[179],"creation":[181],"also":[185],"provides":[186],"potential":[188],"tool":[189],"neutralizing":[191],"action":[193],"vivo":[195],"vitro.":[198],"have":[200],"shown":[201],"cells":[205],"express":[206],"NTR1":[207],"but":[210],"not":[211],"NTR2,":[212],"suggesting":[213],"mobilization":[217],"elicited":[218],"NTR1.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
