{"id":"https://openalex.org/W2136181849","doi":"https://doi.org/10.1017/cbo9780511976117.027","title":"Neuroblastoma","display_name":"Neuroblastoma","publication_year":2011,"publication_date":"2011-04-25","ids":{"openalex":"https://openalex.org/W2136181849","doi":"https://doi.org/10.1017/cbo9780511976117.027","mag":"2136181849"},"language":"en","primary_location":{"id":"doi:10.1017/cbo9780511976117.027","doi":"https://doi.org/10.1017/cbo9780511976117.027","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9780511976117.027","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Metastasis","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1812248371","display_name":"Cancer Metastasis"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034081882","display_name":"Nai\u2010Kong V. Cheung","orcid":"https://orcid.org/0000-0001-6323-5171","observed_orcids":["https://orcid.org/0000-0001-6323-5171"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nai-Kong Cheung","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, United States","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043729995","display_name":"Brian H. Kushner","orcid":"https://orcid.org/0000-0002-8916-0697","observed_orcids":["https://orcid.org/0000-0002-8916-0697"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian H. Kushner","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, United States","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18338658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"264","last_page":"277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":1.0},{"id":"https://openalex.org/keywords/pediatric-solid-tumors","display_name":"pediatric solid tumors","score":0.875},{"id":"https://openalex.org/keywords/adrenal-medulla","display_name":"adrenal medulla","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-staging","display_name":"tumor staging","score":0.4970000088214874},{"id":"https://openalex.org/keywords/low-dose-chemotherapy","display_name":"low-dose chemotherapy","score":0.777999997138977},{"id":"https://openalex.org/keywords/spontaneous-regression","display_name":"spontaneous regression","score":0.6420000195503235},{"id":"https://openalex.org/keywords/ganglioneuroma","display_name":"ganglioneuroma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/survival-rate","display_name":"survival rate","score":0.5360000133514404},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.8734689950942993},{"id":"https://openalex.org/C2779126056","wikidata":"https://www.wikidata.org/wiki/Q337247","display_name":"Mediastinum","level":2,"score":0.7049645185470581},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5777277946472168},{"id":"https://openalex.org/C2779102060","wikidata":"https://www.wikidata.org/wiki/Q1124606","display_name":"Ganglioneuroma","level":4,"score":0.5517968535423279},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.5378450751304626},{"id":"https://openalex.org/C2778357063","wikidata":"https://www.wikidata.org/wiki/Q713102","display_name":"Pelvis","level":2,"score":0.5328640937805176},{"id":"https://openalex.org/C2777597313","wikidata":"https://www.wikidata.org/wiki/Q934888","display_name":"Adrenal medulla","level":3,"score":0.47365009784698486},{"id":"https://openalex.org/C17291353","wikidata":"https://www.wikidata.org/wiki/Q6807308","display_name":"Medulla","level":2,"score":0.41751915216445923},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3752042055130005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20694255828857422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.138208270072937},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.053255438804626465},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.04499650001525879},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1017/cbo9780511976117.027","doi":"https://doi.org/10.1017/cbo9780511976117.027","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9780511976117.027","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Metastasis","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":189,"referenced_works":["https://openalex.org/W40765902","https://openalex.org/W100836827","https://openalex.org/W164824509","https://openalex.org/W316863601","https://openalex.org/W323673244","https://openalex.org/W1535107443","https://openalex.org/W1535614393","https://openalex.org/W1538160646","https://openalex.org/W1538933790","https://openalex.org/W1555211613","https://openalex.org/W1570123945","https://openalex.org/W1575002436","https://openalex.org/W1576365704","https://openalex.org/W1591281137","https://openalex.org/W1606519347","https://openalex.org/W1606834485","https://openalex.org/W1607276234","https://openalex.org/W1614553858","https://openalex.org/W1802071582","https://openalex.org/W1815678056","https://openalex.org/W1823129171","https://openalex.org/W1878957336","https://openalex.org/W1894683927","https://openalex.org/W1901831739","https://openalex.org/W1915590218","https://openalex.org/W1936567301","https://openalex.org/W1940650862","https://openalex.org/W1951179504","https://openalex.org/W1959188680","https://openalex.org/W1960710326","https://openalex.org/W1964892825","https://openalex.org/W1965605868","https://openalex.org/W1965962344","https://openalex.org/W1966020001","https://openalex.org/W1966151215","https://openalex.org/W1966474027","https://openalex.org/W1966861659","https://openalex.org/W1967988534","https://openalex.org/W1970865970","https://openalex.org/W1975686452","https://openalex.org/W1976261697","https://openalex.org/W1978351983","https://openalex.org/W1982294823","https://openalex.org/W1982719013","https://openalex.org/W1985136204","https://openalex.org/W1986399662","https://openalex.org/W1989989994","https://openalex.org/W1991861013","https://openalex.org/W1993954120","https://openalex.org/W1994229890","https://openalex.org/W1994940008","https://openalex.org/W1995041534","https://openalex.org/W1995294036","https://openalex.org/W1997391175","https://openalex.org/W1997581613","https://openalex.org/W1998076925","https://openalex.org/W2000308064","https://openalex.org/W2003549188","https://openalex.org/W2005324578","https://openalex.org/W2005753828","https://openalex.org/W2007084896","https://openalex.org/W2008438533","https://openalex.org/W2010978319","https://openalex.org/W2011284024","https://openalex.org/W2012053348","https://openalex.org/W2013039182","https://openalex.org/W2017331095","https://openalex.org/W2022354436","https://openalex.org/W2023032576","https://openalex.org/W2023762732","https://openalex.org/W2026002143","https://openalex.org/W2026724934","https://openalex.org/W2028210102","https://openalex.org/W2029107944","https://openalex.org/W2035282066","https://openalex.org/W2039362801","https://openalex.org/W2039638023","https://openalex.org/W2044360617","https://openalex.org/W2046555621","https://openalex.org/W2048065547","https://openalex.org/W2049102738","https://openalex.org/W2053748622","https://openalex.org/W2054524692","https://openalex.org/W2054803078","https://openalex.org/W2057359246","https://openalex.org/W2060275730","https://openalex.org/W2061004887","https://openalex.org/W2061278019","https://openalex.org/W2063407256","https://openalex.org/W2063647772","https://openalex.org/W2064350486","https://openalex.org/W2064428081","https://openalex.org/W2065372463","https://openalex.org/W2067601106","https://openalex.org/W2067606868","https://openalex.org/W2068890283","https://openalex.org/W2071422257","https://openalex.org/W2072328760","https://openalex.org/W2075428230","https://openalex.org/W2081513802","https://openalex.org/W2085786448","https://openalex.org/W2087055812","https://openalex.org/W2087693524","https://openalex.org/W2091158789","https://openalex.org/W2091270752","https://openalex.org/W2093213870","https://openalex.org/W2093708841","https://openalex.org/W2094990097","https://openalex.org/W2096398040","https://openalex.org/W2098104239","https://openalex.org/W2101042741","https://openalex.org/W2101511312","https://openalex.org/W2101782429","https://openalex.org/W2102739282","https://openalex.org/W2103238639","https://openalex.org/W2103558670","https://openalex.org/W2104684902","https://openalex.org/W2106568960","https://openalex.org/W2107504931","https://openalex.org/W2109325347","https://openalex.org/W2111567736","https://openalex.org/W2111733282","https://openalex.org/W2113695682","https://openalex.org/W2114964602","https://openalex.org/W2118171008","https://openalex.org/W2121955260","https://openalex.org/W2122414959","https://openalex.org/W2123002505","https://openalex.org/W2124514001","https://openalex.org/W2125123324","https://openalex.org/W2125481027","https://openalex.org/W2125726411","https://openalex.org/W2128352319","https://openalex.org/W2130465135","https://openalex.org/W2130667403","https://openalex.org/W2131189233","https://openalex.org/W2132154679","https://openalex.org/W2134607826","https://openalex.org/W2136574608","https://openalex.org/W2138216545","https://openalex.org/W2143252790","https://openalex.org/W2143634092","https://openalex.org/W2144152847","https://openalex.org/W2144209664","https://openalex.org/W2144463537","https://openalex.org/W2147068163","https://openalex.org/W2148461908","https://openalex.org/W2149768039","https://openalex.org/W2150437482","https://openalex.org/W2150636854","https://openalex.org/W2154653852","https://openalex.org/W2155254558","https://openalex.org/W2155483480","https://openalex.org/W2155917076","https://openalex.org/W2156367667","https://openalex.org/W2157124382","https://openalex.org/W2157272402","https://openalex.org/W2159103399","https://openalex.org/W2162186771","https://openalex.org/W2162216424","https://openalex.org/W2164097016","https://openalex.org/W2164296311","https://openalex.org/W2164588772","https://openalex.org/W2164756216","https://openalex.org/W2168240861","https://openalex.org/W2168659791","https://openalex.org/W2171445183","https://openalex.org/W2257281028","https://openalex.org/W2317690033","https://openalex.org/W2322738006","https://openalex.org/W2323995621","https://openalex.org/W2327522594","https://openalex.org/W2335316179","https://openalex.org/W2400817683","https://openalex.org/W4210847313","https://openalex.org/W4296289652","https://openalex.org/W6632160541","https://openalex.org/W6633046316","https://openalex.org/W6636259470","https://openalex.org/W6636450797","https://openalex.org/W6638544398","https://openalex.org/W6642703874","https://openalex.org/W6649618143","https://openalex.org/W6675208333","https://openalex.org/W6678804789","https://openalex.org/W6678853435","https://openalex.org/W6681313144","https://openalex.org/W6682136467","https://openalex.org/W6682602230"],"related_works":["https://openalex.org/W2055203463","https://openalex.org/W2941647711","https://openalex.org/W2155917076","https://openalex.org/W7100660767","https://openalex.org/W324778424","https://openalex.org/W7072999881","https://openalex.org/W4401338817","https://openalex.org/W4240044119","https://openalex.org/W4241745424","https://openalex.org/W2280797192"],"abstract_inverted_index":{"Neuroblastoma":[0],"(NB)":[1],"originates":[2],"from":[3],"neural":[4],"crest":[5],"precursors":[6],"in":[7,14,49,54,139,150,159,196],"the":[8,11,15,23,31,42,50,88,96,189,209,216,220,223],"adrenal":[9],"medulla,":[10],"sympathetic":[12,89],"ganglia":[13],"neck,":[16],"mediastinum,":[17],"retroperitoneum,":[18],"or":[19,127,181,248],"pelvis.":[20],"It":[21],"is":[22],"most":[24,32,97],"common":[25,33],"extracranial":[26],"pediatric":[27,99,170],"solid":[28,68,100,171],"tumor":[29,78],"and":[30,76,146,222],"neoplasm":[34,86],"among":[35,67],"infants.":[36,197],"More":[37],"than":[38,44,57,105,161,208],"90":[39,106,137],"percent":[40,107,138,149,164,202,205],"of":[41,60,70,73,87,95,108,133,166,191,219,225],"more":[43,104,206],"700":[45],"cases":[46,178,207],"diagnosed":[47],"yearly":[48],"United":[51],"States":[52],"are":[53],"children":[55],"younger":[56],"five":[58],"years":[59],"age.":[61],"NB":[62,135,240],"has":[63,92,239],"a":[64,162],"notorious":[65],"reputation":[66],"tumors":[69,116],"childhood":[71],"because":[72],"its":[74],"massive":[75],"widespread":[77],"burden.":[79],"Stage":[80],"for":[81,168],"stage,":[82],"however,":[83],"this":[84],"embryonal":[85],"nervous":[90],"system":[91],"become":[93],"one":[94],"curable":[98],"tumors.":[101,172],"In":[102,152],"fact,":[103],"patients":[109,213],"with":[110,115,125,143,244],"localized":[111],"NBs,":[112],"including":[113],"those":[114],"spreading":[117],"to":[118,154,203],"regional":[119],"lymph":[120],"nodes,":[121],"will":[122],"survive,":[123],"often":[124],"little":[126],"no":[128],"cytotoxic":[129],"therapy.":[130],"Cure":[131],"rates":[132],"metastatic":[134],"exceed":[136],"infants":[140],"(usually":[141],"treated":[142],"low-dose":[144],"chemotherapy)":[145],"approximately":[147],"25":[148],"toddlers.":[151],"contrast":[153],"NB,":[155],"osteomedullary":[156],"metastases":[157],"result":[158],"less":[160],"5":[163],"chance":[165],"cure":[167],"other":[169,246],"The":[173],"long-held":[174],"view":[175],"that":[176],"many":[177],"spontaneously":[179],"regress":[180],"mature":[182],"into":[183],"asymptomatic":[184],"ganglioneuromas":[185],"was":[186,228],"confirmed":[187],"by":[188],"findings":[190],"urine":[192],"catecholamine":[193],"screening":[194],"programs":[195,199],"These":[198],"yielded":[200],"50":[201],"100":[204],"unscreened":[210],"population.":[211],"Most":[212],"identified":[214],"had":[215],"low-risk":[217],"forms":[218],"disease,":[221],"incidence":[224],"high-risk":[226],"disease":[227,247],"not":[229,235],"reduced.":[230],"Environmental":[231],"causative":[232],"factors":[233],"have":[234],"been":[236,241],"identified,":[237],"nor":[238],"significantly":[242],"associated":[243],"any":[245],"condition.":[249]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
