{"id":"https://openalex.org/W2136160261","doi":"https://doi.org/10.1002/mnfr.201100440","title":"Long\u2010term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism","display_name":"Long\u2010term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism","publication_year":2011,"publication_date":"2011-11-07","ids":{"openalex":"https://openalex.org/W2136160261","doi":"https://doi.org/10.1002/mnfr.201100440","mag":"2136160261","pmid":"https://pubmed.ncbi.nlm.nih.gov/22058071"},"language":"en","primary_location":{"id":"doi:10.1002/mnfr.201100440","doi":"https://doi.org/10.1002/mnfr.201100440","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mnfr.201100440","pdf_url":null,"source":{"id":"https://openalex.org/S27638457","display_name":"Molecular Nutrition & Food Research","issn_l":"1613-4125","issn":["1613-4125","1613-4133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-3","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Nutrition & Food Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2136160261"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025045839","display_name":"Su\u2010Kyung Shin","orcid":"https://orcid.org/0000-0002-8918-3995","observed_orcids":["https://orcid.org/0000-0002-8918-3995"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Su\u2010Kyung Shin","raw_affiliation_strings":["Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea","Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tae\u2010Youl Ha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114577","display_name":"Korea Food Research Institute","ror":"https://ror.org/028jp5z02","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210114577","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae\u2010Youl Ha","raw_affiliation_strings":["Korea Food Research Institute, Seongnam, Gyeonggi-Do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Food Research Institute, Seongnam, Gyeonggi-Do, Republic of Korea","institution_ids":["https://openalex.org/I4210114577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030500129","display_name":"Robin A. McGregor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Robin A. McGregor","raw_affiliation_strings":["Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031004025","display_name":"Myung\u2010Sook Choi","orcid":"https://orcid.org/0000-0002-6399-6787","observed_orcids":["https://orcid.org/0000-0002-6399-6787"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Myung\u2010Sook Choi","raw_affiliation_strings":["Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea","Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I31419693"]},{"raw_affiliation_string":"Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I31419693"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031004025"],"corresponding_institution_ids":["https://openalex.org/I31419693"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":4.7082,"has_fulltext":false,"cited_by_count":257,"citation_normalized_percentile":{"value":0.96463932,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"55","issue":"12","first_page":"1829","last_page":"1840"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.08169999718666077,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":1.0},{"id":"https://openalex.org/keywords/ldlr-knockout-mice","display_name":"Ldlr knockout mice","score":0.6669999957084656},{"id":"https://openalex.org/keywords/high-cholesterol-diet","display_name":"high-cholesterol diet","score":0.9670000076293945},{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hepatic-cholesterol-metabolism","display_name":"hepatic cholesterol metabolism","score":0.7540000081062317},{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hmg-coa-reductase-inhibition","display_name":"HMG-CoA reductase inhibition","score":0.8539999723434448},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/lxralpha","display_name":"liver X receptor alpha","score":0.9940000176429749},{"id":"https://openalex.org/keywords/complement-factor-d","display_name":"complement factor D","score":0.828000009059906},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9039999842643738},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.7699999809265137},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cholesteryl-ester-transfer-protein","display_name":"cholesteryl ester transfer protein","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dietary-phytochemicals","display_name":"dietary phytochemicals","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.9099711775779724},{"id":"https://openalex.org/C2780940807","wikidata":"https://www.wikidata.org/wiki/Q417740","display_name":"Lovastatin","level":3,"score":0.8071795105934143},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6404373645782471},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6131996512413025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6075858473777771},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4973125755786896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4831344783306122},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.4407806992530823},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4268527626991272},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.3340781331062317},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3304676413536072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28119468688964844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24831071496009827},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17315733432769775},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07524842023849487}],"mesh":[{"descriptor_ui":"D000071518","descriptor_name":"Liver X Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000101","descriptor_name":"Acetyl-CoA C-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000101","descriptor_name":"Acetyl-CoA C-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002791","descriptor_name":"Cholesterol, Dietary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057093","descriptor_name":"Orphan Nuclear Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057093","descriptor_name":"Orphan Nuclear Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mnfr.201100440","doi":"https://doi.org/10.1002/mnfr.201100440","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mnfr.201100440","pdf_url":null,"source":{"id":"https://openalex.org/S27638457","display_name":"Molecular Nutrition & Food Research","issn_l":"1613-4125","issn":["1613-4125","1613-4133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-3","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Nutrition & Food Research","raw_type":"journal-article"},{"id":"pmid:22058071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22058071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular nutrition & food research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1500847299","https://openalex.org/W1552485473","https://openalex.org/W1561233673","https://openalex.org/W1897938514","https://openalex.org/W1912658063","https://openalex.org/W1961712310","https://openalex.org/W1965195541","https://openalex.org/W1978848772","https://openalex.org/W1980455616","https://openalex.org/W2000152750","https://openalex.org/W2010285587","https://openalex.org/W2013453081","https://openalex.org/W2015136867","https://openalex.org/W2016211755","https://openalex.org/W2019222155","https://openalex.org/W2028743301","https://openalex.org/W2030007406","https://openalex.org/W2038653055","https://openalex.org/W2044204097","https://openalex.org/W2050823452","https://openalex.org/W2052187514","https://openalex.org/W2053633351","https://openalex.org/W2056539295","https://openalex.org/W2058538833","https://openalex.org/W2061558567","https://openalex.org/W2062019500","https://openalex.org/W2064338048","https://openalex.org/W2081147939","https://openalex.org/W2082570992","https://openalex.org/W2105405913","https://openalex.org/W2106182413","https://openalex.org/W2109674113","https://openalex.org/W2110855516","https://openalex.org/W2114570899","https://openalex.org/W2114704077","https://openalex.org/W2126039851","https://openalex.org/W2128009708","https://openalex.org/W2128635872","https://openalex.org/W2146832978","https://openalex.org/W2150579866","https://openalex.org/W2150667463","https://openalex.org/W2154998675","https://openalex.org/W2155671521","https://openalex.org/W2157627492","https://openalex.org/W2159332620","https://openalex.org/W2159780921","https://openalex.org/W2160770872","https://openalex.org/W2172297158","https://openalex.org/W2186512751","https://openalex.org/W2477872031","https://openalex.org/W4230870013","https://openalex.org/W4249825849","https://openalex.org/W4256475235","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3174948840","https://openalex.org/W2073365457","https://openalex.org/W4206257090","https://openalex.org/W2075071747","https://openalex.org/W2349434239","https://openalex.org/W2082570992","https://openalex.org/W2146832978","https://openalex.org/W1847452548","https://openalex.org/W1997888481","https://openalex.org/W2589294590"],"abstract_inverted_index":{"SCOPE:":[0],"Atherosclerosis":[1],"is":[2,197],"a":[3,60],"major":[4],"cause":[5],"of":[6,34,131,135,160,190,195],"cardiovascular":[7],"disease":[8],"caused":[9,128],"by":[10,147,168],"high":[11],"cholesterol.":[12],"Stains":[13],"are":[14],"widely":[15],"prescribed":[16],"to":[17,92,124,186],"lower":[18],"cholesterol":[19,102,117,179,205],"levels,":[20,158],"but":[21],"natural":[22,36],"dietary":[23,37],"compounds":[24],"may":[25],"also":[26],"be":[27],"effective.":[28],"Therefore,":[29],"we":[30],"studied":[31],"the":[32,35,187],"effect":[33,194],"compound":[38],"curcumin":[39,80,96,113,148,169,173,196],"on":[40,47],"atherosclerosis":[41],"and":[42,49,63,88,103,118,137,142,155,177,180,206],"its":[43],"underlying":[44],"mechanisms":[45,201],"based":[46],"plasma":[48,98,115,176],"hepatic":[50,178],"lipid":[51,85],"metabolism.":[52],"METHODS":[53],"AND":[54],"RESULTS:":[55],"LDLR(-/-)":[56],"mice":[57],"were":[58,165],"fed":[59],"high-cholesterol":[61],"diet":[62],"treated":[64],"with":[65],"curcumin,":[66],"lovastatin":[67,93,125],"or":[68],"control":[69],"(n=10":[70],"per":[71],"group)":[72],"for":[73],"18":[74],"wk.":[75],"Aortic":[76],"arch":[77],"sections":[78],"revealed":[79],"ameliorated":[81],"early":[82,182],"atherosclerotic":[83,183],"lesions,":[84],"infiltration,":[86],"ICAM-1":[87],"VCAM-1":[89],"localization,":[90],"similar":[91,123],"treatment.":[94,126,149,170],"Furthermore,":[95],"lowered":[97],"cholesterol,":[99],"triglycerides,":[100],"LDL":[101],"Apo":[104,120],"B":[105],"levels":[106],"as":[107,109],"well":[108],"CETP":[110],"activity,":[111],"while":[112],"increased":[114],"HDL":[116],"liver":[119],"A-I":[121],"expression,":[122],"Curcumin":[127],"transcriptional":[129],"inhibition":[130],"HMG-CoA":[132],"reductase,":[133],"independent":[134],"ACAT1":[136],"ACAT2":[138],"expression.":[139,209],"Hepatic":[140,150],"PPAR\u03b1":[141],"LXR\u03b1":[143],"expression":[144],"was":[145],"upregulated":[146],"complement":[151,162],"factor":[152],"D":[153],"(Cfd)":[154],"systemic":[156],"CRP":[157],"markers":[159],"immune":[161,207],"pathway":[163],"activation,":[164],"significantly":[166],"reduced":[167],"CONCLUSION:":[171],"Long-term":[172],"treatment":[174],"lowers":[175],"suppresses":[181],"lesions":[184],"comparable":[185],"protective":[188],"effects":[189],"lovastatin.":[191],"The":[192],"anti-atherogenic":[193],"mediated":[198],"via":[199],"multiple":[200],"including":[202],"altered":[203],"lipid,":[204],"gene":[208]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}