{"id":"https://openalex.org/W2136155663","doi":"https://doi.org/10.1182/blood.v97.5.1343","title":"SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation","display_name":"SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2136155663","doi":"https://doi.org/10.1182/blood.v97.5.1343","mag":"2136155663","pmid":"https://pubmed.ncbi.nlm.nih.gov/11222379"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v97.5.1343","doi":"https://doi.org/10.1182/blood.v97.5.1343","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v97.5.1343","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111490174","display_name":"Jacqueline E. Damen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jacqueline E. Damen","raw_affiliation_strings":["From the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108484551","display_name":"Mark D. Ware","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark D. Ware","raw_affiliation_strings":["From the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045149595","display_name":"Janet Kalesnikoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Janet Kalesnikoff","raw_affiliation_strings":["From the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106479385","display_name":"Michael R. Hughes","orcid":"https://orcid.org/0000-0002-7925-6070","observed_orcids":["https://orcid.org/0000-0002-7925-6070"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael R. Hughes","raw_affiliation_strings":["From the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017180599","display_name":"Gerald Krystal","orcid":"https://orcid.org/0000-0002-1961-6281","observed_orcids":["https://orcid.org/0000-0002-1961-6281"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gerald Krystal","raw_affiliation_strings":["From the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I1289530486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1289530486"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.6731,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.83737177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"97","issue":"5","first_page":"1343","last_page":"1351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ships","display_name":"ships","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bone-marrow-derived-mast-cells","display_name":"bone marrow-derived mast cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.578000009059906},{"id":"https://openalex.org/keywords/npxy-motif","display_name":"NPXY motif","score":0.718999981880188},{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.5099999904632568},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.6399999856948853},{"id":"https://openalex.org/keywords/mapk-phosphorylation","display_name":"MAPK phosphorylation","score":0.878000020980835},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.7319999933242798},{"id":"https://openalex.org/keywords/retroviral-gene-transfer","display_name":"retroviral gene transfer","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.8722826242446899},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.628108024597168},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5694909691810608},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5115633606910706},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4201643764972687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39943206310272217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38097304105758667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3686178922653198},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17217060923576355},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.061050236225128174}],"mesh":[{"descriptor_ui":"D000072183","descriptor_name":"Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018129","descriptor_name":"Phosphatidylinositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019089","descriptor_name":"Stem Cell Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v97.5.1343","doi":"https://doi.org/10.1182/blood.v97.5.1343","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v97.5.1343","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:11222379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11222379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W133636034","https://openalex.org/W146374089","https://openalex.org/W199729741","https://openalex.org/W1480698884","https://openalex.org/W1561838770","https://openalex.org/W1599249369","https://openalex.org/W1608613084","https://openalex.org/W1809259025","https://openalex.org/W1965616500","https://openalex.org/W1976755134","https://openalex.org/W1977797021","https://openalex.org/W1982833418","https://openalex.org/W1985782864","https://openalex.org/W1989954297","https://openalex.org/W2002999573","https://openalex.org/W2004756723","https://openalex.org/W2005131087","https://openalex.org/W2011870840","https://openalex.org/W2018587071","https://openalex.org/W2020892036","https://openalex.org/W2052414943","https://openalex.org/W2056462157","https://openalex.org/W2056909872","https://openalex.org/W2056911198","https://openalex.org/W2058872987","https://openalex.org/W2058924545","https://openalex.org/W2062241862","https://openalex.org/W2069097227","https://openalex.org/W2069545269","https://openalex.org/W2071981946","https://openalex.org/W2079270029","https://openalex.org/W2091545748","https://openalex.org/W2123685527","https://openalex.org/W2129770769","https://openalex.org/W2132630188","https://openalex.org/W2146670169","https://openalex.org/W2148144033","https://openalex.org/W2151313755","https://openalex.org/W2154161087","https://openalex.org/W2154230667","https://openalex.org/W2160922815","https://openalex.org/W2162332365","https://openalex.org/W2212341047","https://openalex.org/W2346213975","https://openalex.org/W2406581284","https://openalex.org/W4313333705"],"related_works":["https://openalex.org/W2048165608","https://openalex.org/W2058872987","https://openalex.org/W2015380315","https://openalex.org/W2154161087","https://openalex.org/W7096554677","https://openalex.org/W4241880997","https://openalex.org/W1965616500","https://openalex.org/W2051141212","https://openalex.org/W2790695271","https://openalex.org/W2053667827"],"abstract_inverted_index":{"The":[0],"SH2-containing":[1],"inositol-5'-phosphatase,":[2],"SHIP,":[3,76,142],"restrains":[4],"bone":[5,36],"marrow-derived":[6],"mast":[7],"cell":[8],"(BMMC)":[9],"degranulation,":[10],"at":[11,157],"least":[12],"in":[13,61,70,88,131,169],"part,":[14],"by":[15],"hydrolyzing":[16],"phosphatidylinositol":[17],"(PI)-3-kinase":[18],"generated":[19],"PI-3,4,5-P(3)":[20],"(PIP3)":[21],"to":[22,33,67,96,118,172],"PI-3,4-P(2).":[23],"To":[24],"determine":[25],"which":[26,89,112],"domains":[27],"within":[28],"SHIP":[29,46,51,86,171],"influence":[30],"its":[31],"ability":[32],"hydrolyze":[34,173],"PIP3,":[35,62],"marrow":[37],"from":[38],"SHIP(-/-)":[39,53,82,103,155],"mice":[40],"was":[41],"retrovirally":[42],"infected":[43],"with":[44],"various":[45],"constructs.":[47,136],"Introduction":[48],"of":[49,107,122,141,146],"wild-type":[50],"into":[52],"BMMCs":[54,108,132],"reverted":[55],"the":[56,81,90,102,110,119,134,147,154,163],"Steel":[57],"factor":[58],"(SF)-induced":[59],"increases":[60],"calcium":[63],"entry,":[64],"and":[65,175],"degranulation":[66],"those":[68],"observed":[69],"SHIP(+/+)":[71],"BMMCs.":[72],"A":[73],"5'-phosphatase":[74],"dead":[75],"however,":[77],"could":[78,99,113,151],"not":[79,114,152],"revert":[80,101,153],"response,":[83],"whereas":[84],"a":[85,166],"mutant":[87],"2":[91],"NPXY":[92],"motifs":[93],"were":[94],"converted":[95],"NPXFs":[97],"(2NPXF)":[98],"partially":[100],"response.":[104],"SF":[105],"stimulation":[106],"expressing":[109,133],"2NPXF,":[111],"bind":[115],"Shc,":[116],"led":[117],"same":[120],"level":[121],"mitogen-activated":[123],"protein":[124],"kinase":[125],"(MAPK)":[126],"phosphorylation":[127],"as":[128],"that":[129,162],"seen":[130],"other":[135],"Surprisingly,":[137],"C-terminally":[138],"truncated":[139],"forms":[140],"lacking":[143],"different":[144],"amounts":[145],"proline":[148],"rich":[149],"C-terminus,":[150],"response":[156],"all.":[158],"These":[159],"results":[160],"suggest":[161],"C-terminus":[164],"plays":[165],"critical":[167],"role":[168],"enabling":[170],"PIP(3)":[174],"inhibit":[176],"BMMC":[177],"degranulation.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
