{"id":"https://openalex.org/W2136145106","doi":null,"title":"Isozyme profiles of oval cells, parenchymal cells, and biliary cells isolated by centrifugal elutriation from normal and preneoplastic livers.","display_name":"Isozyme profiles of oval cells, parenchymal cells, and biliary cells isolated by centrifugal elutriation from normal and preneoplastic livers.","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2136145106","mag":"2136145106","pmid":"https://pubmed.ncbi.nlm.nih.gov/6690044"},"language":"en","primary_location":{"id":"pmid:6690044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6690044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027083590","display_name":"Nancy Thompson Hayner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N T Hayner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111868828","display_name":"Lundy Braun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Braun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054902187","display_name":"Paul Yaswen","orcid":"https://orcid.org/0000-0001-6603-640X","observed_orcids":["https://orcid.org/0000-0001-6603-640X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Yaswen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Brooks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Brooks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112188919","display_name":"Nelson Fausto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Fausto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.369,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.96318811,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"44","issue":"1","first_page":"332","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-isozymes","display_name":"liver isozymes","score":0.7289999723434448},{"id":"https://openalex.org/keywords/oval-cells","display_name":"oval cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/choline-deficient-diet","display_name":"choline-deficient diet","score":0.7490000128746033},{"id":"https://openalex.org/keywords/ethionine","display_name":"ethionine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/aldolase-a","display_name":"aldolase A","score":0.8199999928474426},{"id":"https://openalex.org/keywords/aldolase-b","display_name":"aldolase B","score":0.9020000100135803},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cholangiocytes","display_name":"cholangiocytes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hepatocyte-dedifferentiation","display_name":"hepatocyte dedifferentiation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/liver-stem-cells","display_name":"liver stem cells","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.4729999899864197},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.7175949215888977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6954362392425537},{"id":"https://openalex.org/C2780854706","wikidata":"https://www.wikidata.org/wiki/Q900970","display_name":"Pyruvate kinase","level":4,"score":0.6267497539520264},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.5876415371894836},{"id":"https://openalex.org/C28165981","wikidata":"https://www.wikidata.org/wiki/Q5255119","display_name":"Aldolase A","level":3,"score":0.5874273180961609},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.5795365571975708},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5587801337242126},{"id":"https://openalex.org/C2780802856","wikidata":"https://www.wikidata.org/wiki/Q3025059","display_name":"Elutriation","level":2,"score":0.45672422647476196},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4208308458328247},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36628443002700806},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32822132110595703},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2786896824836731},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19690915942192078},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18921500444412231},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.166457861661911},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.13884487748146057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08668899536132812},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002796","descriptor_name":"Choline Deficiency","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005634","descriptor_name":"Fructose-Bisphosphate Aldolase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005634","descriptor_name":"Fructose-Bisphosphate Aldolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:6690044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6690044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.325.932","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.932","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/44/1/332.full.pdf","raw_type":"text"},{"id":"mag:2136145106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6690044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W81874192","https://openalex.org/W115454878","https://openalex.org/W129461181","https://openalex.org/W148208038","https://openalex.org/W1522083632","https://openalex.org/W1536739130","https://openalex.org/W1553883948","https://openalex.org/W1558211614","https://openalex.org/W1751595276","https://openalex.org/W1779296866","https://openalex.org/W1911914287","https://openalex.org/W1969845782","https://openalex.org/W1980195885","https://openalex.org/W1989763144","https://openalex.org/W1991501430","https://openalex.org/W1994374831","https://openalex.org/W2003521627","https://openalex.org/W2015735321","https://openalex.org/W2020901455","https://openalex.org/W2028154967","https://openalex.org/W2031359213","https://openalex.org/W2035084993","https://openalex.org/W2044748534","https://openalex.org/W2051028361","https://openalex.org/W2060462017","https://openalex.org/W2060918407","https://openalex.org/W2081669424","https://openalex.org/W2088394579","https://openalex.org/W2095109914","https://openalex.org/W2102795882","https://openalex.org/W2116492029","https://openalex.org/W2116985853","https://openalex.org/W2132767444","https://openalex.org/W2165956314","https://openalex.org/W2335442973","https://openalex.org/W2339004739","https://openalex.org/W2345132165","https://openalex.org/W2465068277"],"related_works":["https://openalex.org/W7099766860","https://openalex.org/W2044748534","https://openalex.org/W2037153882","https://openalex.org/W2097649993","https://openalex.org/W1522083632","https://openalex.org/W2048409670","https://openalex.org/W823664738","https://openalex.org/W1751595276","https://openalex.org/W7098305560","https://openalex.org/W2164498029"],"abstract_inverted_index":{"The":[0,172],"fetal":[1,40],"liver":[2,111,219],"isozymes":[3,69,166],"aldolase":[4,61,156],"A":[5,157],"and":[6,63,93,101,117,128,144,158,200],"pyruvate":[7,64,159],"kinase":[8,65,160],"K":[9],"increase":[10],"in":[11,71,96,109,122,129,138,168,176,225],"livers":[12,31,55,127,153],"of":[13,32,56,74,125,133,148,191,204,228],"adult":[14,76],"rats":[15,81],"fed":[16],"a":[17,192,218],"choline":[18],"deficient-diet":[19],"containing":[20,223],"0.1%":[21],"ethionine.":[22],"Oval":[23],"cells":[24,51,73,124,132,140,224],"isolated":[25,52,141],"by":[26],"centrifugal":[27],"elutriation":[28],"from":[29,53,80,142,151,188,202],"preneoplastic":[30,126,145],"animals":[33,58,177],"receiving":[34,82,178],"the":[35,54,67,83,106,164,189,208],"carcinogenic":[36,84,180],"diet":[37,85],"contained":[38],"these":[39,57,198],"forms":[41,107],"as":[42,44],"well":[43],"fetal-adult":[45,165],"isozyme":[46,182],"hybrids.":[47],"In":[48],"contrast,":[49],"parenchymal":[50,72,139],"had":[59],"only":[60],"B":[62],"L,":[66],"same":[68],"present":[70,121,167],"normal":[75,110,134,143,152],"rats.":[77],"Liver":[78],"homogenates":[79],"contain":[86,155],"lactate":[87],"dehydrogenase":[88],"(LDH)":[89],"1,":[90,114],"LDH":[91,94,99,102,113,115,118],"2,":[92,116],"3":[95,119],"addition":[97],"to":[98],"4":[100],"5,":[103],"which":[104,196],"are":[105,120],"detected":[108],"homogenates.":[112],"oval":[123,169],"biliary":[130,149],"epithelial":[131],"livers,":[135],"but":[136,162],"not":[137,163,201],"livers.":[146],"Cells":[147],"epithelium":[150],"also":[154],"K,":[161],"cell":[170,194,214,221],"populations.":[171],"results":[173],"indicate":[174],"that,":[175],"this":[179,212],"diet,":[181],"alterations":[183],"associated":[184],"with":[185],"neoplasia":[186],"result":[187],"proliferation":[190],"new":[193,213],"population":[195,215],"contains":[197],"enzymes":[199],"\"dedifferentiation\"":[203],"mature":[205],"hepatocytes.":[206],"Furthermore,":[207],"data":[209],"suggest":[210],"that":[211],"may":[216],"include":[217],"stem":[220],"compartment":[222],"transitional":[226],"states":[227],"differentiation.":[229]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
