{"id":"https://openalex.org/W2136144181","doi":null,"title":"Castration-induced apoptosis of androgen-dependent shionogi carcinoma is associated with increased expression of genes encoding insulin-like growth factor-binding proteins.","display_name":"Castration-induced apoptosis of androgen-dependent shionogi carcinoma is associated with increased expression of genes encoding insulin-like growth factor-binding proteins.","publication_year":1999,"publication_date":"1999-07-15","ids":{"openalex":"https://openalex.org/W2136144181","mag":"2136144181","pmid":"https://pubmed.ncbi.nlm.nih.gov/10416600"},"language":"en","primary_location":{"id":"pmid:10416600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10416600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089927607","display_name":"Tara Nickerson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"T Nickerson","raw_affiliation_strings":["Lady Davis Research Institute of the Sir Mortimer B. Davis Jewish General Hospital and Department of Oncology, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lady Davis Research Institute of the Sir Mortimer B. Davis Jewish General Hospital and Department of Oncology, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109167309","display_name":"Hideaki Miyake","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Miyake","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062125605","display_name":"Martin Edwin Gleave","orcid":"https://orcid.org/0000-0003-4235-0167","observed_orcids":["https://orcid.org/0000-0003-4235-0167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Gleave","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005616347","display_name":"Micha\u00ebl Pollak","orcid":"https://orcid.org/0000-0003-3047-0604","observed_orcids":["https://orcid.org/0000-0003-3047-0604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Pollak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.3452,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.9735868,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"59","issue":"14","first_page":"3392","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.36469998955726624,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration","display_name":"castration","score":0.7570000290870667},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/androgen-dependent-prostate-cancer","display_name":"androgen-dependent prostate cancer","score":0.6859999895095825},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-proteins","display_name":"IGF binding proteins","score":0.8970000147819519},{"id":"https://openalex.org/keywords/igfbp-5","display_name":"IGFBP-5","score":0.9919999837875366},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.9819999933242798},{"id":"https://openalex.org/keywords/igfbp-4","display_name":"IGFBP-4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.9240000247955322},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7631552219390869},{"id":"https://openalex.org/C2779256933","wikidata":"https://www.wikidata.org/wiki/Q58929","display_name":"Castration","level":3,"score":0.7520767450332642},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7466691732406616},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6634172797203064},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5962409973144531},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5289908647537231},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.49703291058540344},{"id":"https://openalex.org/C2780378035","wikidata":"https://www.wikidata.org/wiki/Q17143674","display_name":"Insulin-like growth factor-binding protein","level":5,"score":0.48417311906814575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4767388105392456},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4600219130516052},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4361013174057007},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32326120138168335},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27420786023139954},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.17623686790466309},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15023580193519592},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009919","descriptor_name":"Orchiectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018975","descriptor_name":"Insulin-Like Growth Factor Binding Protein 5","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018975","descriptor_name":"Insulin-Like Growth Factor Binding Protein 5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10416600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10416600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2136144181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10416600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6800000071525574,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1535604717","https://openalex.org/W1568528806","https://openalex.org/W1584184269","https://openalex.org/W1672583421","https://openalex.org/W1973408614","https://openalex.org/W1973530448","https://openalex.org/W1993685571","https://openalex.org/W2002599993","https://openalex.org/W2004899570","https://openalex.org/W2007006137","https://openalex.org/W2014418366","https://openalex.org/W2020636054","https://openalex.org/W2021163920","https://openalex.org/W2032490803","https://openalex.org/W2042268825","https://openalex.org/W2048106517","https://openalex.org/W2060548721","https://openalex.org/W2070769230","https://openalex.org/W2077956417","https://openalex.org/W2081197593","https://openalex.org/W2085813665","https://openalex.org/W2086949115","https://openalex.org/W2101581671","https://openalex.org/W2126484796","https://openalex.org/W2127526484","https://openalex.org/W2133732525","https://openalex.org/W2140491527","https://openalex.org/W2163557440","https://openalex.org/W2329683094","https://openalex.org/W2335179754"],"related_works":["https://openalex.org/W1602137524","https://openalex.org/W7162089048","https://openalex.org/W2004899570","https://openalex.org/W6980463592","https://openalex.org/W1603546883","https://openalex.org/W1981231164","https://openalex.org/W2031346969","https://openalex.org/W2077388974","https://openalex.org/W4254037116","https://openalex.org/W2021117030"],"abstract_inverted_index":{"Insulin-like":[0],"growth":[1],"factor":[2],"(IGF)-I":[3],"has":[4],"well-characterized":[5],"mitogenic":[6],"and":[7,19,134,144,148,169,172],"antiapoptotic":[8],"effects":[9],"that":[10],"are":[11],"essential":[12],"for":[13,36,132,186],"maintenance":[14],"of":[15,25,54,78,92,98,105,150,177,190],"the":[16,26,195],"normal":[17,27],"prostate":[18,28,30,37],"may":[20],"be":[21],"important":[22],"during":[23,52],"regression":[24,53,97,171],"and/or":[29],"tumors":[31,58,71,81,116,125,140],"induced":[32,197],"by":[33,43,72,102,198],"androgen-targeting":[34],"therapies":[35],"cancer.":[38],"IGF-I":[39],"activity":[40],"is":[41],"modulated":[42],"IGF-binding":[44],"proteins":[45],"(IGFBPs).":[46],"Here":[47],"we":[48,64],"examine":[49],"IGFBP":[50],"expression":[51,192],"androgen-dependent":[55,202],"Shionogi":[56,70,139],"carcinoma":[57],"after":[59,86,108,128,179],"castration.":[60,109,129,180],"In":[61],"this":[62],"model,":[63],"observe":[65],"a":[66,89,187],"90%":[67],"reduction":[68],"in":[69,115,124,138,193,201],"10":[73],"days":[74,127],"postcastration.":[75],"Northern":[76],"blotting":[77],"RNA":[79],"from":[80,117,141],"collected":[82],"at":[83],"various":[84],"times":[85],"castration":[87],"indicates":[88],"rapid":[90],"induction":[91],"IGFBP-5":[93,110,178,191],"concomitant":[94],"with":[95,162],"apoptotic":[96],"tumors,":[99],"as":[100],"detected":[101],"Apoptag":[103],"staining":[104],"tumor":[106,170],"sections":[107],"mRNA":[111],"was":[112],"not":[113],"detectable":[114],"control":[118],"animals,":[119],"but":[120],"levels":[121],"increased":[122],"120-fold":[123],"3":[126],"The":[130],"mRNAs":[131],"IGFBP-3":[133],"4":[135],"were":[136],"abundant":[137],"intact":[142],"mice":[143],"decreased":[145],"to":[146],"-33%":[147],"-20%":[149],"control,":[151],"respectively.":[152],"Castration":[153],"had":[154],"no":[155],"significant":[156],"effect":[157],"on":[158],"IGFBP-2":[159],"expression.":[160],"Treatment":[161],"calcium":[163],"channel":[164],"blockers":[165],"inhibited":[166,175],"castration-induced":[167],"apoptosis":[168,196],"also":[173],"significantly":[174],"up-regulation":[176],"These":[181],"data":[182],"provide":[183],"strong":[184],"evidence":[185],"functional":[188],"role":[189],"mediating":[194],"androgen":[199],"deprivation":[200],"neoplasia.":[203]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
