{"id":"https://openalex.org/W2136073863","doi":"https://doi.org/10.1038/sj.emboj.7600969","title":"Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer","display_name":"Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer","publication_year":2006,"publication_date":"2006-02-09","ids":{"openalex":"https://openalex.org/W2136073863","doi":"https://doi.org/10.1038/sj.emboj.7600969","mag":"2136073863","pmid":"https://pubmed.ncbi.nlm.nih.gov/16467855","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1422165"},"language":"en","primary_location":{"id":"doi:10.1038/sj.emboj.7600969","doi":"https://doi.org/10.1038/sj.emboj.7600969","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.emboj.7600969","pdf_url":"https://link.springer.com/content/pdf/10.1038/sj.emboj.7600969.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1038/sj.emboj.7600969.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048806381","display_name":"J.R. Mesters","orcid":"https://orcid.org/0000-0001-8532-6699","observed_orcids":["https://orcid.org/0000-0001-8532-6699"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jeroen R Mesters","raw_affiliation_strings":["Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066069524","display_name":"Cyril Ba\u0159inka","orcid":"https://orcid.org/0000-0003-2751-3060","observed_orcids":["https://orcid.org/0000-0003-2751-3060"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Cyril Barinka","raw_affiliation_strings":["Institute of Organic Chemistry and Biochemistry, Academy of Science of the Czech Republic, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Organic Chemistry and Biochemistry, Academy of Science of the Czech Republic, Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100771710","display_name":"Weixing Li","orcid":"https://orcid.org/0000-0002-1697-7444","observed_orcids":["https://orcid.org/0000-0002-1697-7444"]},"institutions":[{"id":"https://openalex.org/I4210155340","display_name":"MedPharm (United Kingdom)","ror":"https://ror.org/04yrw5p64","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210155340"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Weixing Li","raw_affiliation_strings":["Guilford Pharmaceuticals Inc., Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guilford Pharmaceuticals Inc., Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210155340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017074842","display_name":"Takashi Tsukamoto","orcid":"https://orcid.org/0000-0002-0216-7520","observed_orcids":["https://orcid.org/0000-0002-0216-7520"]},"institutions":[{"id":"https://openalex.org/I4210155340","display_name":"MedPharm (United Kingdom)","ror":"https://ror.org/04yrw5p64","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210155340"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Takashi Tsukamoto","raw_affiliation_strings":["Guilford Pharmaceuticals Inc., Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guilford Pharmaceuticals Inc., Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210155340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041296571","display_name":"Pavel Majer","orcid":"https://orcid.org/0000-0002-1804-6934","observed_orcids":["https://orcid.org/0000-0002-1804-6934"]},"institutions":[{"id":"https://openalex.org/I4210155340","display_name":"MedPharm (United Kingdom)","ror":"https://ror.org/04yrw5p64","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210155340"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pavel Majer","raw_affiliation_strings":["Guilford Pharmaceuticals Inc., Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guilford Pharmaceuticals Inc., Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210155340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023686004","display_name":"Barbara Stauch Slusher","orcid":"https://orcid.org/0000-0001-9814-4157","observed_orcids":["https://orcid.org/0000-0001-9814-4157"]},"institutions":[{"id":"https://openalex.org/I4210155340","display_name":"MedPharm (United Kingdom)","ror":"https://ror.org/04yrw5p64","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210155340"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barbara S Slusher","raw_affiliation_strings":["Guilford Pharmaceuticals Inc., Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guilford Pharmaceuticals Inc., Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210155340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003007213","display_name":"Jan Konvalinka","orcid":"https://orcid.org/0000-0003-0695-9266","observed_orcids":["https://orcid.org/0000-0003-0695-9266"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jan Konvalinka","raw_affiliation_strings":["Institute of Organic Chemistry and Biochemistry, Academy of Science of the Czech Republic, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Organic Chemistry and Biochemistry, Academy of Science of the Czech Republic, Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109132411","display_name":"Rolf Hilgenfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Rolf Hilgenfeld","raw_affiliation_strings":["Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of L\u00fcbeck, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109132411"],"corresponding_institution_ids":["https://openalex.org/I9341345"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":8.2115,"has_fulltext":true,"cited_by_count":287,"citation_normalized_percentile":{"value":0.98813803,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"25","issue":"6","first_page":"1375","last_page":"1384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.20080000162124634,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0689999982714653,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":1.0},{"id":"https://openalex.org/keywords/zinc-enzymes","display_name":"zinc metalloenzyme","score":0.7960000038146973},{"id":"https://openalex.org/keywords/n-acetylaspartate","display_name":"N-acetylaspartate","score":0.8989999890327454},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.48500001430511475},{"id":"https://openalex.org/keywords/enzyme-inhibitors","display_name":"enzyme inhibitors","score":0.7080000042915344},{"id":"https://openalex.org/keywords/homodimerization","display_name":"homodimerization","score":0.7419999837875366},{"id":"https://openalex.org/keywords/carbohydrate-moiety","display_name":"carbohydrate moiety","score":0.7329999804496765},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8389999866485596},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7590000033378601},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C20417620","wikidata":"https://www.wikidata.org/wiki/Q4140229","display_name":"Glutamate carboxypeptidase II","level":4,"score":0.9603846073150635},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.7205311059951782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6307322382926941},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.5410585999488831},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5382750630378723},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4277557134628296},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3760073781013489},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33038365840911865},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32557958364486694},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.2102404236793518},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19930145144462585},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.139611154794693},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043425","descriptor_name":"Glutamate Carboxypeptidase II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043425","descriptor_name":"Glutamate Carboxypeptidase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043425","descriptor_name":"Glutamate Carboxypeptidase II","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/sj.emboj.7600969","doi":"https://doi.org/10.1038/sj.emboj.7600969","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.emboj.7600969","pdf_url":"https://link.springer.com/content/pdf/10.1038/sj.emboj.7600969.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:408497","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1422165","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:16467855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16467855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1422165","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1422165/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/sj.emboj.7600969","doi":"https://doi.org/10.1038/sj.emboj.7600969","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.emboj.7600969","pdf_url":"https://link.springer.com/content/pdf/10.1038/sj.emboj.7600969.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7120284430","display_name":"Membrane-bound carboxypeptidases: stricture, activity and their role in prostate cancer and neurotoxicity","funder_award_id":"GA301/03/0784","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"}],"funders":[{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"},{"id":"https://openalex.org/F4320323051","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136073863.pdf","grobid_xml":"https://content.openalex.org/works/W2136073863.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W4793426","https://openalex.org/W111663151","https://openalex.org/W1483485226","https://openalex.org/W1543959669","https://openalex.org/W1592020922","https://openalex.org/W1819158969","https://openalex.org/W1849365998","https://openalex.org/W1964608935","https://openalex.org/W1968405341","https://openalex.org/W1969074641","https://openalex.org/W1975310412","https://openalex.org/W1977545099","https://openalex.org/W1980612042","https://openalex.org/W1981207136","https://openalex.org/W1985307249","https://openalex.org/W1986755460","https://openalex.org/W1987535606","https://openalex.org/W1992868992","https://openalex.org/W1994912497","https://openalex.org/W1995830387","https://openalex.org/W1996259599","https://openalex.org/W2001151163","https://openalex.org/W2001641653","https://openalex.org/W2002222551","https://openalex.org/W2004736778","https://openalex.org/W2004803702","https://openalex.org/W2006664751","https://openalex.org/W2019728652","https://openalex.org/W2021029707","https://openalex.org/W2021814641","https://openalex.org/W2032118712","https://openalex.org/W2033090934","https://openalex.org/W2033240631","https://openalex.org/W2035750459","https://openalex.org/W2036574824","https://openalex.org/W2038840577","https://openalex.org/W2041373139","https://openalex.org/W2044157217","https://openalex.org/W2049125285","https://openalex.org/W2050886880","https://openalex.org/W2063649715","https://openalex.org/W2072465507","https://openalex.org/W2077294102","https://openalex.org/W2081758723","https://openalex.org/W2081818708","https://openalex.org/W2083311095","https://openalex.org/W2083991080","https://openalex.org/W2086130715","https://openalex.org/W2097629605","https://openalex.org/W2097817417","https://openalex.org/W2107870182","https://openalex.org/W2109353776","https://openalex.org/W2114155688","https://openalex.org/W2120191312","https://openalex.org/W2122300808","https://openalex.org/W2123932686","https://openalex.org/W2132784998","https://openalex.org/W2135839939","https://openalex.org/W2137726937","https://openalex.org/W2150083064","https://openalex.org/W2153905340","https://openalex.org/W2155060077","https://openalex.org/W2155421560","https://openalex.org/W2157788428","https://openalex.org/W2160069559","https://openalex.org/W2161715331","https://openalex.org/W2167563458","https://openalex.org/W2263916383","https://openalex.org/W2312569573","https://openalex.org/W4238052567"],"related_works":["https://openalex.org/W2110010918","https://openalex.org/W2346910920","https://openalex.org/W1981161260","https://openalex.org/W2171637628","https://openalex.org/W2086130715","https://openalex.org/W3008550356","https://openalex.org/W2004736778","https://openalex.org/W1580481741","https://openalex.org/W1963529616","https://openalex.org/W1987567565"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}