{"id":"https://openalex.org/W2136072575","doi":"https://doi.org/10.1196/annals.1333.061","title":"Cross\u2010Linking of the Extracellular Matrix by the Maillard Reaction in Aging and Diabetes: An Update on \u201ca Puzzle Nearing Resolution\u201d","display_name":"Cross\u2010Linking of the Extracellular Matrix by the Maillard Reaction in Aging and Diabetes: An Update on \u201ca Puzzle Nearing Resolution\u201d","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2136072575","doi":"https://doi.org/10.1196/annals.1333.061","mag":"2136072575","pmid":"https://pubmed.ncbi.nlm.nih.gov/16037276"},"language":"en","primary_location":{"id":"doi:10.1196/annals.1333.061","doi":"https://doi.org/10.1196/annals.1333.061","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1333.061","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048439423","display_name":"Vincent M. Monnier","orcid":"https://orcid.org/0000-0002-4894-3142","observed_orcids":["https://orcid.org/0000-0002-4894-3142"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"VINCENT M. MONNIER","raw_affiliation_strings":["Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. vmm3@cwru.edu","Departments of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA","Departments of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. vmm3@cwru.edu","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Departments of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Departments of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048356082","display_name":"Georgian T. Mustata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GEORGIAN T. MUSTATA","raw_affiliation_strings":["Departments of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062074967","display_name":"Klaus M. Biemel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110079840","display_name":"University of Hohenheim","ror":"https://ror.org/00b1c9541","country_code":"DE","type":"education","lineage":["https://openalex.org/I110079840"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"KLAUS L. BIEMEL","raw_affiliation_strings":["Institute of Food Chemistry, University of Hohenheim, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food Chemistry, University of Hohenheim, Stuttgart, Germany","institution_ids":["https://openalex.org/I110079840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013801660","display_name":"Oliver Reihl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110079840","display_name":"University of Hohenheim","ror":"https://ror.org/00b1c9541","country_code":"DE","type":"education","lineage":["https://openalex.org/I110079840"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"OLIVER REIHL","raw_affiliation_strings":["Institute of Food Chemistry, University of Hohenheim, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food Chemistry, University of Hohenheim, Stuttgart, Germany","institution_ids":["https://openalex.org/I110079840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017983745","display_name":"MARCUS O. LEDERER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARCUS O. LEDERER","raw_affiliation_strings":["Deceased","Departments of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deceased","institution_ids":[]},{"raw_affiliation_string":"Departments of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"DAI ZHENYU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAI ZHENYU","raw_affiliation_strings":["Departments of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029026718","display_name":"David R. Sell","orcid":"https://orcid.org/0000-0001-7510-5745","observed_orcids":["https://orcid.org/0000-0001-7510-5745"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID R. SELL","raw_affiliation_strings":["Departments of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048439423"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":5.8958,"has_fulltext":false,"cited_by_count":243,"citation_normalized_percentile":{"value":0.97536946,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"1043","issue":"1","first_page":"533","last_page":"544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-matrix-cross-linking","display_name":"extracellular matrix cross-linking","score":0.8240000009536743},{"id":"https://openalex.org/keywords/maillard-reaction","display_name":"Maillard reaction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.800000011920929},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glucosepane","display_name":"glucosepane","score":0.8700000047683716},{"id":"https://openalex.org/keywords/strecker-degradation","display_name":"Strecker degradation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/oxidative-cross-linking","display_name":"oxidative cross-linking","score":0.9049999713897705},{"id":"https://openalex.org/keywords/glycation","display_name":"glycation","score":0.5540000200271606},{"id":"https://openalex.org/keywords/collagen-cross-links","display_name":"collagen cross-links","score":0.7960000038146973},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8820000290870667},{"id":"https://openalex.org/keywords/matrix-stiffening","display_name":"matrix stiffening","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C35378473","wikidata":"https://www.wikidata.org/wiki/Q647574","display_name":"Maillard reaction","level":2,"score":0.9492824077606201},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.8863708972930908},{"id":"https://openalex.org/C2780758796","wikidata":"https://www.wikidata.org/wiki/Q7165277","display_name":"Pentosidine","level":4,"score":0.783060610294342},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7161957025527954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6325727701187134},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5738929510116577},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46522992849349976},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34313687682151794},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.257712721824646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19344091415405273}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015416","descriptor_name":"Maillard Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015416","descriptor_name":"Maillard Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015416","descriptor_name":"Maillard Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1196/annals.1333.061","doi":"https://doi.org/10.1196/annals.1333.061","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1333.061","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:16037276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16037276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6899999976158142}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W820854987","https://openalex.org/W1540824953","https://openalex.org/W1550739028","https://openalex.org/W1553609829","https://openalex.org/W1600358206","https://openalex.org/W1609735481","https://openalex.org/W1843398852","https://openalex.org/W1964200421","https://openalex.org/W1978485557","https://openalex.org/W1978968920","https://openalex.org/W1981718074","https://openalex.org/W1982698379","https://openalex.org/W1983725247","https://openalex.org/W1990511592","https://openalex.org/W1994636910","https://openalex.org/W1996652514","https://openalex.org/W1996757319","https://openalex.org/W1998850358","https://openalex.org/W1999921913","https://openalex.org/W2001864263","https://openalex.org/W2003104765","https://openalex.org/W2004659869","https://openalex.org/W2011991245","https://openalex.org/W2015105035","https://openalex.org/W2017712161","https://openalex.org/W2025748287","https://openalex.org/W2029457074","https://openalex.org/W2032980322","https://openalex.org/W2034335685","https://openalex.org/W2044130121","https://openalex.org/W2046812261","https://openalex.org/W2047716315","https://openalex.org/W2050731020","https://openalex.org/W2054221638","https://openalex.org/W2061898896","https://openalex.org/W2063165518","https://openalex.org/W2065994422","https://openalex.org/W2066625772","https://openalex.org/W2074863648","https://openalex.org/W2074966603","https://openalex.org/W2075897888","https://openalex.org/W2077034296","https://openalex.org/W2082865005","https://openalex.org/W2084126217","https://openalex.org/W2089701069","https://openalex.org/W2090205376","https://openalex.org/W2096596085","https://openalex.org/W2097841537","https://openalex.org/W2108655405","https://openalex.org/W2114837987","https://openalex.org/W2116566080","https://openalex.org/W2121043731","https://openalex.org/W2140011142","https://openalex.org/W2150844478","https://openalex.org/W2151825309","https://openalex.org/W2160295947","https://openalex.org/W2166734122","https://openalex.org/W2257999693","https://openalex.org/W2279479268","https://openalex.org/W2321904325","https://openalex.org/W3024383408","https://openalex.org/W6673078142","https://openalex.org/W7037878373"],"related_works":["https://openalex.org/W2039842631","https://openalex.org/W3021933146","https://openalex.org/W2410509351","https://openalex.org/W2580979447","https://openalex.org/W2610212358","https://openalex.org/W2025420631","https://openalex.org/W2071464139","https://openalex.org/W2068405110","https://openalex.org/W2007375276","https://openalex.org/W2140812099"],"abstract_inverted_index":{"The":[0,75],"aging":[1,47,145],"extracellular":[2],"matrix":[3],"is":[4,146],"characterized":[5],"by":[6,21],"an":[7,107],"age-related":[8],"increase":[9],"in":[10,25,31,43,67,80,142],"insolubilization,":[11],"yellowing,":[12],"and":[13,37,54,90,130,144],"stiffening,":[14],"all":[15],"of":[16,50,77,109],"which":[17,41],"can":[18],"be":[19,121],"mimicked":[20],"the":[22,48,62,110,115,133],"Maillard":[23,124],"reaction":[24],"vitro.":[26],"These":[27],"phenomena":[28],"are":[29],"accelerated":[30],"metabolic":[32],"diseases":[33],"such":[34],"as":[35],"diabetes":[36,69,143],"end-stage":[38],"renal":[39],"disease,":[40],"have":[42],"common":[44],"with":[45],"physiological":[46],"accumulation":[49],"various":[51],"glycation":[52],"products":[53],"cross-links.":[55],"Eight":[56],"years":[57],"ago":[58],"we":[59,105],"concluded":[60],"that":[61,112,151],"evidence":[63],"favored":[64],"oxidative":[65],"cross-linking":[66,79,126],"experimental":[68],"[Monnier,":[70],"V.M.":[71],"et":[72],"al.":[73],"1996.":[74],"mechanism":[76],"collagen":[78,137],"diabetes:":[81],"a":[82,92,96,148],"puzzle":[83],"nearing":[84],"completion.":[85],"Diabetes":[86],"45(Suppl.":[87],"3):":[88],"67-72]":[89],"proposed":[91],"major":[93],"role":[94],"for":[95,123],"putative":[97],"non-UV":[98],"active":[99],"cross-link":[100,138,150],"derived":[101],"from":[102],"glucose.":[103],"Below,":[104],"provide":[106],"update":[108],"field":[111],"leads":[113],"to":[114,140],"conclusion":[116],"that,":[117],"while":[118],"oxidation":[119],"might":[120],"important":[122,136],"reaction-mediated":[125],"via":[127],"Strecker":[128],"degradation":[129],"allysine":[131],"formation,":[132],"single":[134],"most":[135],"known":[139],"date":[141],"glucosepane,":[147],"lysyl-arginine":[149],"forms":[152],"under":[153],"nonoxidative":[154],"conditions.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}