{"id":"https://openalex.org/W2136072416","doi":"https://doi.org/10.1002/ana.410360402","title":"The ischemic penumbra, injury thresholds, and the therapeutic window for acute stroke","display_name":"The ischemic penumbra, injury thresholds, and the therapeutic window for acute stroke","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W2136072416","doi":"https://doi.org/10.1002/ana.410360402","mag":"2136072416","pmid":"https://pubmed.ncbi.nlm.nih.gov/7944286"},"language":"en","primary_location":{"id":"doi:10.1002/ana.410360402","doi":"https://doi.org/10.1002/ana.410360402","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410360402","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2136072416"],"child_works_count":0,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109242926","display_name":"Myron D. Ginsberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myron D. Ginsberg","raw_affiliation_strings":["Department of Neurology, University of Miami, School of Medicine, Miami, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Miami, School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111456112","display_name":"William A. Pulsinelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Pulsinelli","raw_affiliation_strings":["Department of Neurology, University of Tennessee, Mempbis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Tennessee, Mempbis, TN","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":209,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"4","first_page":"553","last_page":"554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-penumbra","display_name":"ischemic penumbra","score":0.9940000176429749},{"id":"https://openalex.org/keywords/injury-threshold","display_name":"injury threshold","score":0.7749999761581421},{"id":"https://openalex.org/keywords/therapeutic-window","display_name":"therapeutic window","score":0.8759999871253967},{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.6570000052452087},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2780577055","wikidata":"https://www.wikidata.org/wiki/Q2069532","display_name":"Penumbra","level":3,"score":0.877890408039093},{"id":"https://openalex.org/C2606647","wikidata":"https://www.wikidata.org/wiki/Q6827257","display_name":"Miami","level":2,"score":0.7698303461074829},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.6613940596580505},{"id":"https://openalex.org/C46622094","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic window","level":2,"score":0.6287758946418762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48578837513923645},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.41902098059654236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2598823308944702},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.23928964138031006},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16387686133384705},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11625421047210693},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.08004090189933777},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.0},{"id":"https://openalex.org/C159390177","wikidata":"https://www.wikidata.org/wiki/Q9161265","display_name":"Soil science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ana.410360402","doi":"https://doi.org/10.1002/ana.410360402","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410360402","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:7944286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7944286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1992026104","https://openalex.org/W2010758846","https://openalex.org/W2015084201","https://openalex.org/W2027712267","https://openalex.org/W2046731614","https://openalex.org/W2082870893","https://openalex.org/W2123894485","https://openalex.org/W2141827300","https://openalex.org/W2143773297","https://openalex.org/W2149542102","https://openalex.org/W2744146769","https://openalex.org/W2772047362"],"related_works":["https://openalex.org/W2123351961","https://openalex.org/W3010488578","https://openalex.org/W2063211382","https://openalex.org/W567582583","https://openalex.org/W2021029773","https://openalex.org/W193245259","https://openalex.org/W2128659230","https://openalex.org/W2011535752","https://openalex.org/W757512121","https://openalex.org/W4205768837"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}