{"id":"https://openalex.org/W2136052079","doi":"https://doi.org/10.1371/journal.pone.0064078","title":"Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury","display_name":"Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury","publication_year":2013,"publication_date":"2013-05-14","ids":{"openalex":"https://openalex.org/W2136052079","doi":"https://doi.org/10.1371/journal.pone.0064078","mag":"2136052079","pmid":"https://pubmed.ncbi.nlm.nih.gov/23691153","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3653881"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0064078","doi":"https://doi.org/10.1371/journal.pone.0064078","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0064078","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0064078&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0064078&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102031946","display_name":"Dongjun Guo","orcid":"https://orcid.org/0000-0003-2645-218X","observed_orcids":["https://orcid.org/0000-0003-2645-218X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongjun Guo","raw_affiliation_strings":["Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023541354","display_name":"Linghui Zeng","orcid":"https://orcid.org/0000-0002-5924-4419","observed_orcids":["https://orcid.org/0000-0002-5924-4419"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linghui Zeng","raw_affiliation_strings":["Department of Pharmacy, Zhejiang University City College, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Zhejiang University City College, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065549626","display_name":"David L. Brody","orcid":"https://orcid.org/0000-0002-4864-3262","observed_orcids":["https://orcid.org/0000-0002-4864-3262"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Brody","raw_affiliation_strings":["Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058587345","display_name":"Michael Wong","orcid":"https://orcid.org/0000-0002-3796-743X","observed_orcids":["https://orcid.org/0000-0002-3796-743X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Wong","raw_affiliation_strings":["Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058587345"],"corresponding_institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":12.2621,"has_fulltext":true,"cited_by_count":206,"citation_normalized_percentile":{"value":0.99254757,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"8","issue":"5","first_page":"e64078","last_page":"e64078"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.11890000104904175,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/post-traumatic-epilepsy","display_name":"post-traumatic epilepsy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mtorc1-signaling","display_name":"mTORC1 signaling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/controlled-cortical-impact","display_name":"controlled cortical impact","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mossy-fiber-sprouting","display_name":"mossy fiber sprouting","score":0.9729999899864197},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9729999899864197},{"id":"https://openalex.org/keywords/seizure-frequency","display_name":"seizure frequency","score":0.8100000023841858},{"id":"https://openalex.org/keywords/video-eeg-monitoring","display_name":"video-EEG monitoring","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.9237916469573975},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.8391181230545044},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.7569572329521179},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.6311053037643433},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5956450700759888},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4967847168445587},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.45809394121170044},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39467865228652954},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33871638774871826},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3294123709201813},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.18895378708839417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1853582262992859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1182851791381836},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09157496690750122},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.06519916653633118},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004834","descriptor_name":"Epilepsy, Post-Traumatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004834","descriptor_name":"Epilepsy, Post-Traumatic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004834","descriptor_name":"Epilepsy, Post-Traumatic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019599","descriptor_name":"Mossy Fibers, Hippocampal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019599","descriptor_name":"Mossy Fibers, Hippocampal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0064078","doi":"https://doi.org/10.1371/journal.pone.0064078","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0064078","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0064078&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2655054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3653881","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3653881","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3653881","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23691153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23691153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-2495","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/1493","pdf_url":"https://digitalcommons.wustl.edu/open_access_pubs/1493","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.809.2122","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.809.2122","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/16/6e/pone.0064078.PMC3653881.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.819.4860","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.819.4860","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article%3D2495%26context%3Dopen_access_pubs","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9148b105b8f44b3d9b0bb8a2b0783f67","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9148b105b8f44b3d9b0bb8a2b0783f67","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 5, p e64078 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/703204","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/_Rapamycin_Attenuates_the_Development_of_Posttraumatic_Epilepsy_in_a_Mouse_Model_of_Traumatic_Brain_Injury_/703204","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0064078","doi":"https://doi.org/10.1371/journal.pone.0064078","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0064078","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0064078&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3591310947","display_name":"Washington University Center for Translational Neuroscience","funder_award_id":"P30NS057105","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8570133905","display_name":"Mechanisms of Brain Dysfunction in Tuberous Sclerosis","funder_award_id":"R01NS056872","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136052079.pdf","grobid_xml":"https://content.openalex.org/works/W2136052079.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1546826175","https://openalex.org/W1548531944","https://openalex.org/W1557124033","https://openalex.org/W1574757902","https://openalex.org/W1964044359","https://openalex.org/W1969029940","https://openalex.org/W1971424270","https://openalex.org/W1983635597","https://openalex.org/W1986442348","https://openalex.org/W1987735289","https://openalex.org/W1992597927","https://openalex.org/W1998406619","https://openalex.org/W2000828660","https://openalex.org/W2003643542","https://openalex.org/W2005311714","https://openalex.org/W2007898025","https://openalex.org/W2013796884","https://openalex.org/W2014362456","https://openalex.org/W2019518209","https://openalex.org/W2019723714","https://openalex.org/W2020209656","https://openalex.org/W2022598099","https://openalex.org/W2027044444","https://openalex.org/W2029038733","https://openalex.org/W2035495486","https://openalex.org/W2040534171","https://openalex.org/W2056111473","https://openalex.org/W2059181607","https://openalex.org/W2063759247","https://openalex.org/W2087441158","https://openalex.org/W2088889090","https://openalex.org/W2091406481","https://openalex.org/W2092491756","https://openalex.org/W2098216863","https://openalex.org/W2119856985","https://openalex.org/W2123977622","https://openalex.org/W2132711653","https://openalex.org/W2154289778","https://openalex.org/W2167665957","https://openalex.org/W2325851205","https://openalex.org/W2383259826","https://openalex.org/W2620344835"],"related_works":["https://openalex.org/W7096156004","https://openalex.org/W2173271778","https://openalex.org/W2346523550","https://openalex.org/W2794919472","https://openalex.org/W7098983916","https://openalex.org/W2027044444","https://openalex.org/W2277113332","https://openalex.org/W2082460264","https://openalex.org/W3045327421","https://openalex.org/W2061247854"],"abstract_inverted_index":{"Posttraumatic":[0],"epilepsy":[1,28,91,103,201,222],"is":[2],"a":[3,14,216],"major":[4],"source":[5],"of":[6,17,26,41,52,70,89,96,101,130,172,198],"disability":[7],"following":[8,33,121],"traumatic":[9],"brain":[10],"injury":[11,126],"(TBI)":[12],"and":[13,54,149,165,184,196],"common":[15],"cause":[16],"medically-intractable":[18],"epilepsy.":[19,71],"Previous":[20],"attempts":[21],"to":[22,62],"prevent":[23],"the":[24,38,55,78,87,105,131,154,193,203],"development":[25,88],"posttraumatic":[27,90,102,175,200,221],"with":[29,170,225],"treatments":[30],"administered":[31],"immediately":[32],"TBI":[34,191],"have":[35,63,76],"failed.":[36],"Recently,":[37],"mammalian":[39],"target":[40],"rapamycin":[42,81,143,164,185,213],"complex":[43],"1":[44],"(mTORC1)":[45],"pathway":[46,133],"has":[47,59,82],"been":[48,60],"implicated":[49],"in":[50,66,85,92,104,223],"mechanisms":[51],"epileptogenesis":[53],"mTORC1":[56,132],"inhibitor,":[57],"rapamycin,":[58],"proposed":[61],"antiepileptogenic":[64,83],"effects":[65],"preventing":[67,86,220],"some":[68],"types":[69],"In":[72],"this":[73],"study,":[74],"we":[75],"tested":[77],"hypothesis":[79],"that":[80,212],"actions":[84],"an":[93],"animal":[94],"model":[95,110],"TBI.":[97,122,226],"A":[98],"detailed":[99],"characterization":[100],"mouse":[106],"controlled":[107],"cortical":[108,124],"impact":[109,125],"was":[111,140,160],"first":[112],"performed":[113],"using":[114],"continuous":[115],"video-EEG":[116],"monitoring":[117,207],"for":[118,187,219],"16":[119,205],"weeks":[120,181],"Controlled":[123],"caused":[127],"immediate":[128],"hyperactivation":[129],"lasting":[134],"at":[135],"least":[136],"one":[137,188],"week,":[138],"which":[139],"reversed":[141],"by":[142],"treatment.":[144],"Rapamycin":[145],"decreased":[146,192],"neuronal":[147],"degeneration":[148],"mossy":[150,157],"fiber":[151,158],"sprouting,":[152],"although":[153],"effect":[155],"on":[156],"sprouting":[159],"reversible":[161],"after":[162,182,190],"stopping":[163],"did":[166],"not":[167],"directly":[168],"correlate":[169],"inhibition":[171],"epileptogenesis.":[173],"Most":[174],"seizures":[176],"occurred":[177],"greater":[178],"than":[179],"10":[180],"TBI,":[183],"treatment":[186,218],"month":[189],"seizure":[194],"frequency":[195],"rate":[197],"developing":[199],"during":[202],"entire":[204],"week":[206],"session.":[208],"These":[209],"results":[210],"suggest":[211],"may":[214],"represent":[215],"rational":[217],"patients":[224]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
