{"id":"https://openalex.org/W2136007367","doi":"https://doi.org/10.1165/rcmb.2010-0473oc","title":"Structure\u2013Function Relations in an Elastase-Induced Mouse Model of Emphysema","display_name":"Structure\u2013Function Relations in an Elastase-Induced Mouse Model of Emphysema","publication_year":2010,"publication_date":"2010-12-17","ids":{"openalex":"https://openalex.org/W2136007367","doi":"https://doi.org/10.1165/rcmb.2010-0473oc","mag":"2136007367","pmid":"https://pubmed.ncbi.nlm.nih.gov/21169554","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3175584"},"language":"en","primary_location":{"id":"doi:10.1165/rcmb.2010-0473oc","doi":"https://doi.org/10.1165/rcmb.2010-0473oc","is_oa":false,"landing_page_url":"https://doi.org/10.1165/rcmb.2010-0473oc","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3175584","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065886084","display_name":"Hiroshi Hamakawa","orcid":"https://orcid.org/0000-0001-5850-2407","observed_orcids":["https://orcid.org/0000-0001-5850-2407"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroshi Hamakawa","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University, Boston","Dept. of Biomedical Engineering, Boston University, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Dept. of Biomedical Engineering, Boston University, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046278095","display_name":"Erzs\u00e9bet Bartol\u00e1k\u2010Suki","orcid":"https://orcid.org/0000-0003-1007-6394","observed_orcids":["https://orcid.org/0000-0003-1007-6394"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erzs\u00e9bet Bartol\u00e1k-Suki","raw_affiliation_strings":["Cellutraf Scientific Inc., Boston, Massachusetts","Department of Biomedical Engineering, Boston University, Boston","Cellutraf Scientific Inc., Boston, Massachusetts; Department of Biomedical Engineering, Boston University, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellutraf Scientific Inc., Boston, Massachusetts","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Cellutraf Scientific Inc., Boston, Massachusetts; Department of Biomedical Engineering, Boston University, Boston","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056906438","display_name":"Harikrishnan Parameswaran","orcid":"https://orcid.org/0000-0002-5324-5517","observed_orcids":["https://orcid.org/0000-0002-5324-5517"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harikrishnan Parameswaran","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048942846","display_name":"Arnab Majumdar","orcid":"https://orcid.org/0000-0003-1868-6154","observed_orcids":["https://orcid.org/0000-0003-1868-6154"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnab Majumdar","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058910452","display_name":"Kenneth R. Lutchen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth R. Lutchen","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045629242","display_name":"B\u00e9l\u00e2 Suki","orcid":"https://orcid.org/0000-0002-9720-1006","observed_orcids":["https://orcid.org/0000-0002-9720-1006"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B\u00e9la Suki","raw_affiliation_strings":["Department of Biomedical Engineering, Boston University, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Boston University, Boston","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045629242"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":null,"apc_paid":null,"fwci":2.2494,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.87957438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"45","issue":"3","first_page":"517","last_page":"524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.9980000257492065},{"id":"https://openalex.org/keywords/porcine-pancreatic-elastase","display_name":"porcine pancreatic elastase","score":0.8610000014305115},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.7519999742507935},{"id":"https://openalex.org/keywords/respiratory-system-compliance","display_name":"respiratory compliance","score":0.7749999761581421},{"id":"https://openalex.org/keywords/respiratory-impedance","display_name":"respiratory impedance","score":0.9509999752044678},{"id":"https://openalex.org/keywords/lung-extracellular-matrix","display_name":"lung extracellular matrix","score":0.7129999995231628},{"id":"https://openalex.org/keywords/elastin","display_name":"elastin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lung-remodeling","display_name":"lung remodeling","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mechanical-forces","display_name":"mechanical forces","score":0.6579999923706055},{"id":"https://openalex.org/keywords/positive-end-expiratory-pressure","display_name":"positive end-expiratory pressure","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.8134996891021729},{"id":"https://openalex.org/C2776326425","wikidata":"https://www.wikidata.org/wiki/Q976747","display_name":"Pancreatic elastase","level":4,"score":0.6703084111213684},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.6547787189483643},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.636976957321167},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6288155317306519},{"id":"https://openalex.org/C136936797","wikidata":"https://www.wikidata.org/wiki/Q2990558","display_name":"Pulmonary compliance","level":3,"score":0.6114406585693359},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5862889885902405},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4890066385269165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.450683057308197},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.40708041191101074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4005851745605469},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3994405269622803},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37689968943595886},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.328849732875824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08222004771232605},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07846599817276001}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011175","descriptor_name":"Positive-Pressure Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1165/rcmb.2010-0473oc","doi":"https://doi.org/10.1165/rcmb.2010-0473oc","is_oa":false,"landing_page_url":"https://doi.org/10.1165/rcmb.2010-0473oc","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2434516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3175584","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3175584","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3175584","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Respir Cell Mol Biol","raw_type":"Text"},{"id":"pmid:21169554","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21169554","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2434516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3175584","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6162501974","display_name":"Effects of mechanical forces on lung injury and repair","funder_award_id":"R01HL090757","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W22038449","https://openalex.org/W47757837","https://openalex.org/W105565469","https://openalex.org/W188669458","https://openalex.org/W326957580","https://openalex.org/W384590641","https://openalex.org/W1556356032","https://openalex.org/W1713255618","https://openalex.org/W1780521007","https://openalex.org/W1850182854","https://openalex.org/W1870141733","https://openalex.org/W1911795667","https://openalex.org/W1915025757","https://openalex.org/W1915103654","https://openalex.org/W1966580785","https://openalex.org/W1966871331","https://openalex.org/W1981681632","https://openalex.org/W1985675398","https://openalex.org/W2005804802","https://openalex.org/W2007657450","https://openalex.org/W2008683652","https://openalex.org/W2012219485","https://openalex.org/W2023018801","https://openalex.org/W2026019427","https://openalex.org/W2027787431","https://openalex.org/W2031033693","https://openalex.org/W2031679199","https://openalex.org/W2042364910","https://openalex.org/W2047193340","https://openalex.org/W2047456677","https://openalex.org/W2059646444","https://openalex.org/W2062822035","https://openalex.org/W2071392303","https://openalex.org/W2083289760","https://openalex.org/W2085021685","https://openalex.org/W2100192859","https://openalex.org/W2109676248","https://openalex.org/W2116569033","https://openalex.org/W2119946727","https://openalex.org/W2132011458","https://openalex.org/W2139507936","https://openalex.org/W2142401382","https://openalex.org/W2143645698","https://openalex.org/W2144541431","https://openalex.org/W2151551276","https://openalex.org/W2158025722","https://openalex.org/W2159804238","https://openalex.org/W2166821532","https://openalex.org/W4292166591"],"related_works":["https://openalex.org/W1524764594","https://openalex.org/W1975207518","https://openalex.org/W1515804562","https://openalex.org/W2151551276","https://openalex.org/W1938414558","https://openalex.org/W2091651497","https://openalex.org/W2026019427","https://openalex.org/W2315281750","https://openalex.org/W2117223781","https://openalex.org/W2122910171"],"abstract_inverted_index":{"Emphysema":[0],"is":[1,28,230],"a":[2,150,194,220],"progressive":[3,225],"disease":[4,26],"characterized":[5],"by":[6,113,163,239],"the":[7,19,40,44,51,72,82,87,95,102,105,120,140,198,206,233],"destruction":[8,202],"of":[9,34,43,50,74,81,132,143,182,197,223,235,244],"peripheral":[10],"airspaces":[11],"and":[12,23,47,61,78,108,119,145,176,180],"subsequent":[13],"decline":[14,226],"in":[15,53,94,101,122,170,193,200,219,227],"lung":[16,52,75,83,228],"function.":[17],"However,":[18],"relation":[20],"between":[21,173],"structure":[22,134,184],"function":[24,229],"during":[25],"progression":[27],"not":[29],"well":[30],"understood.":[31],"The":[32,130],"objective":[33],"this":[35],"study":[36],"was":[37,203],"to":[38,160,212,232],"assess":[39],"time":[41],"course":[42],"structural,":[45],"mechanical,":[46,241],"remodeling":[48],"properties":[49],"mice":[54],"after":[55,64],"elastolytic":[56],"injury.":[57],"At":[58],"2,":[59,157],"7,":[60],"21":[62,115],"days":[63],"treatment":[65,103],"with":[66,125],"porcine":[67],"pancreatic":[68],"elastase,":[69],"respiratory":[70,106],"impedance,":[71],"constituents":[73],"extracellular":[76],"matrix,":[77],"histological":[79],"sections":[80],"were":[84,92,190],"evaluated.":[85],"In":[86],"control":[88],"group,":[89,104],"no":[90],"changes":[91],"observed":[93],"structural":[96],"or":[97],"functional":[98],"properties,":[99],"whereas,":[100],"compliance":[107,174],"its":[109],"variability":[110],"significantly":[111],"increased":[112,136],"Day":[114,156,164],"(P":[116,152],"<":[117,153],"0.001),":[118],"difference":[121],"parameters":[123,175],"decreased":[124],"increasing":[126],"positive":[127],"end-expiratory":[128],"pressure.":[129],"heterogeneity":[131,181,237],"airspace":[133,183,236],"gradually":[135],"over":[137],"time.":[138],"Conversely,":[139],"relative":[141],"amounts":[142],"elastin":[144],"type":[146],"I":[147],"collagen":[148],"exhibited":[149],"peak":[151],"0.01)":[154],"at":[155],"but":[158],"returned":[159],"baseline":[161],"levels":[162],"21.":[165],"Structure-function":[166],"relations":[167,189],"manifested":[168],"themselves":[169],"strong":[171],"correlations":[172],"both":[177],"mean":[178],"size":[179],"(r(2)":[185],">":[186],"0.9).":[187],"Similar":[188],"also":[191],"obtained":[192],"network":[195],"model":[196,222],"parenchyma":[199],"which":[201],"based":[204],"on":[205],"notion":[207],"that":[208],"mechanical":[209],"forces":[210],"contribute":[211],"alveolar":[213],"wall":[214],"rupture.":[215],"We":[216],"conclude":[217],"that,":[218],"mouse":[221],"emphysema,":[224],"sensitive":[231],"development":[234],"governed":[238],"local,":[240],"force-induced":[242],"failure":[243],"remodeled":[245],"collagen.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
