{"id":"https://openalex.org/W2135989730","doi":null,"title":"Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production.","display_name":"Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production.","publication_year":1981,"publication_date":"1981-07-01","ids":{"openalex":"https://openalex.org/W2135989730","mag":"2135989730","pmid":"https://pubmed.ncbi.nlm.nih.gov/7018671"},"language":"en","primary_location":{"id":"pmid:7018671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7018671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008224218","display_name":"Walter M. Lewko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W M Lewko","raw_affiliation_strings":["National Cancer Institute United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute United States","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086886026","display_name":"Lance A. Liotta","orcid":"https://orcid.org/0000-0001-5155-7907","observed_orcids":["https://orcid.org/0000-0001-5155-7907"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L A Liotta","raw_affiliation_strings":["National Cancer Institute United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute United States","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059956218","display_name":"Max S. Wicha","orcid":"https://orcid.org/0000-0003-4180-7727","observed_orcids":["https://orcid.org/0000-0003-4180-7727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M S Wicha","raw_affiliation_strings":["Internal Medicine - Hematology/Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine - Hematology/Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072058527","display_name":"Barbara K. Vonderhaar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B K Vonderhaar","raw_affiliation_strings":["National Cancer Institute United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute United States","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070148572","display_name":"William R. Kidwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W R Kidwell","raw_affiliation_strings":["National Cancer Institute United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute United States","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3102,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.88783166,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"41","issue":"7","first_page":"2855","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.23549999296665192,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.23549999296665192,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.2305999994277954,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.20520000159740448,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-nitrosomethylurea","display_name":"N-nitrosomethylurea","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mammary-tumors","display_name":"mammary tumors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.921999990940094},{"id":"https://openalex.org/keywords/basement-membrane-collagen","display_name":"basement membrane collagen","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8539999723434448},{"id":"https://openalex.org/keywords/collagen-synthesis-inhibition","display_name":"collagen synthesis inhibition","score":0.7179999947547913},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7720000147819519},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.8489999771118164},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.79011470079422},{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.7722057104110718},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.6248684525489807},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5660056471824646},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5637818574905396},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.5397994518280029},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5228431820869446},{"id":"https://openalex.org/C2777107211","wikidata":"https://www.wikidata.org/wiki/Q7860610","display_name":"Type IV collagen","level":4,"score":0.5105301141738892},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5013868808746338},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43990853428840637},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3855483829975128},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36335939168930054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3328578472137451},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2892622947692871},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27784082293510437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25693994760513306},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17212945222854614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10819962620735168},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.07879573106765747},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07848262786865234},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006909","descriptor_name":"Hydroxyproline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008770","descriptor_name":"Methylnitrosourea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009607","descriptor_name":"Nitrosourea Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7018671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7018671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2135989730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7018671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W596195193","https://openalex.org/W1024766135","https://openalex.org/W1528211880","https://openalex.org/W1579646597","https://openalex.org/W1595366583","https://openalex.org/W1629391151","https://openalex.org/W1920678776","https://openalex.org/W1959168549","https://openalex.org/W1974744101","https://openalex.org/W1979987943","https://openalex.org/W1990440707","https://openalex.org/W1994150598","https://openalex.org/W1995493762","https://openalex.org/W1996302033","https://openalex.org/W2010421901","https://openalex.org/W2013749636","https://openalex.org/W2014043577","https://openalex.org/W2035574132","https://openalex.org/W2039202061","https://openalex.org/W2050088183","https://openalex.org/W2062510144","https://openalex.org/W2094915902","https://openalex.org/W2103885797","https://openalex.org/W2110216040","https://openalex.org/W2128893725","https://openalex.org/W2151860884","https://openalex.org/W2153935830","https://openalex.org/W2167450010","https://openalex.org/W2240833240","https://openalex.org/W2413497969","https://openalex.org/W2479047683"],"related_works":["https://openalex.org/W2411116805","https://openalex.org/W2017595528","https://openalex.org/W2435892240","https://openalex.org/W1990440707","https://openalex.org/W2035574132","https://openalex.org/W2052630590","https://openalex.org/W1965339729","https://openalex.org/W2914768657","https://openalex.org/W2149163982","https://openalex.org/W2413493585"],"abstract_inverted_index":{"The":[0,104,160],"growth":[1,14,66,105,142],"of":[2,23,29,63,106,143,171,176],"primary":[3,144],"N-nitrosomethylurea-induced":[4,86,145],"rat":[5,87],"mammary":[6,88,118,146],"tumors":[7],"was":[8,67,109,130,163],"depressed":[9],"by":[10,69,97,112,133],"cis-hydroxyproline":[11],"(CHP).":[12],"This":[13],"arrest":[15],"appeared":[16],"to":[17,20,25,167],"be":[18],"related":[19],"the":[21,27,36,51,61,136,141,168,174],"ability":[22],"CHP":[24,148,172],"inhibit":[26],"deposition":[28],"basement":[30,56],"membrane":[31],"collagen":[32,52,74,94,128,177,184],"as":[33,95],"based":[34],"on":[35,79],"following":[37],"observations:":[38],"(a)":[39],"in":[40,43,55,59,73,178],"vitro":[41],"and":[42,101,129,149,153],"vivo,":[44],"tumor":[45,64,89,108,119],"cells":[46,179],"synthesized":[47],"type":[48,92,126,182],"IV":[49,93,127,183],"collagen,":[50],"uniquely":[53],"localized":[54],"membranes;":[57],"(b)":[58],"vitro,":[60],"inhibition":[62],"cell":[65,120],"preceded":[68],"a":[70,84],"specific":[71],"decrease":[72],"accumulation":[75,175],"with":[76],"no":[77,91,150],"effect":[78,162],"non-collagen":[80],"protein":[81],"synthesis;":[82],"(c)":[83],"transplantable":[85],"accumulated":[90],"determined":[96],"polyacrylamide":[98],"gel":[99],"electrophoresis":[100],"indirect":[102],"immunofluorescence.":[103],"this":[107],"not":[110,124,131,158],"influenced":[111],"CHP;":[113],"(d)":[114],"an":[115],"established":[116],"human":[117],"line,":[121],"MCF-7,":[122],"did":[123],"accumulate":[125],"inhibited":[132],"CHP.":[134],"At":[135],"doses":[137],"which":[138,180],"effectively":[139],"blocked":[140],"tumors,":[147],"toxic":[151],"effects,":[152],"serum":[154],"prolactin":[155],"levels":[156],"were":[157],"altered.":[159],"inhibitory":[161],"thus":[164],"apparently":[165],"due":[166],"direct":[169],"action":[170],"upon":[173],"required":[181],"production":[185],"for":[186],"continued":[187],"growth.":[188]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}