{"id":"https://openalex.org/W2135929048","doi":null,"title":"Helicobacter pylori - Multitalented Adaptation of Binding Properties","display_name":"Helicobacter pylori - Multitalented Adaptation of Binding Properties","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2135929048","mag":"2135929048"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-60751","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60751","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059300499","display_name":"Sara Henriksson","orcid":"https://orcid.org/0000-0003-1615-0583","observed_orcids":["https://orcid.org/0000-0003-1615-0583"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sara Henriksson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1615-0583","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059300499"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":1.0},{"id":"https://openalex.org/keywords/baba","display_name":"BabA","score":0.9200000166893005},{"id":"https://openalex.org/keywords/saba","display_name":"Saba","score":0.9789999723434448},{"id":"https://openalex.org/keywords/bacterial-adhesins","display_name":"bacterial adhesins","score":0.7059999704360962},{"id":"https://openalex.org/keywords/abo-blood-group-antigens","display_name":"ABO blood group antigens","score":0.9200000166893005},{"id":"https://openalex.org/keywords/leb-antigen","display_name":"Leb antigen","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sialylated-glycoconjugates","display_name":"sialylated glycoconjugates","score":0.8270000219345093},{"id":"https://openalex.org/keywords/bacterial-detachment","display_name":"bacterial detachment","score":0.47999998927116394},{"id":"https://openalex.org/keywords/epithelial-cell-turnover","display_name":"epithelial cell turnover","score":0.6200000047683716},{"id":"https://openalex.org/keywords/caga","display_name":"CagA","score":0.609000027179718},{"id":"https://openalex.org/keywords/vaca-toxin","display_name":"VacA toxin","score":0.8560000061988831},{"id":"https://openalex.org/keywords/secretor-phenotype","display_name":"secretor phenotype","score":0.9139999747276306},{"id":"https://openalex.org/keywords/gastric-colonization","display_name":"gastric colonization","score":0.6489999890327454},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6589999794960022},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.6141117811203003},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.556148886680603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23733985424041748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23434075713157654},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.11616650223731995},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09918662905693054}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-60751","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2135929048","doi":null,"is_oa":false,"landing_page_url":"https://diva-portal.org/smash/get/diva2:562583/fulltext01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-60751","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":164,"referenced_works":["https://openalex.org/W170249857","https://openalex.org/W603314494","https://openalex.org/W1488299617","https://openalex.org/W1503537507","https://openalex.org/W1511963303","https://openalex.org/W1533711237","https://openalex.org/W1560230717","https://openalex.org/W1763272466","https://openalex.org/W1797236837","https://openalex.org/W1861674145","https://openalex.org/W1894773512","https://openalex.org/W1910666671","https://openalex.org/W1918961492","https://openalex.org/W1922826048","https://openalex.org/W1954454178","https://openalex.org/W1966588173","https://openalex.org/W1966591261","https://openalex.org/W1967134059","https://openalex.org/W1969080858","https://openalex.org/W1969435936","https://openalex.org/W1970012260","https://openalex.org/W1971355633","https://openalex.org/W1971976758","https://openalex.org/W1972722248","https://openalex.org/W1973867838","https://openalex.org/W1974893818","https://openalex.org/W1978950267","https://openalex.org/W1979390293","https://openalex.org/W1983208716","https://openalex.org/W1985403135","https://openalex.org/W1985936207","https://openalex.org/W1986432599","https://openalex.org/W1986908298","https://openalex.org/W1989393999","https://openalex.org/W1989586375","https://openalex.org/W1989877147","https://openalex.org/W1990616611","https://openalex.org/W1990666278","https://openalex.org/W1990896685","https://openalex.org/W1991447989","https://openalex.org/W1992102272","https://openalex.org/W1992322620","https://openalex.org/W1994975655","https://openalex.org/W1996405559","https://openalex.org/W1997993215","https://openalex.org/W2000476027","https://openalex.org/W2003035812","https://openalex.org/W2004125187","https://openalex.org/W2005421819","https://openalex.org/W2008414196","https://openalex.org/W2012428428","https://openalex.org/W2012750529","https://openalex.org/W2013765874","https://openalex.org/W2015449706","https://openalex.org/W2016299826","https://openalex.org/W2017020122","https://openalex.org/W2018707425","https://openalex.org/W2023491512","https://openalex.org/W2023510054","https://openalex.org/W2024152313","https://openalex.org/W2024703363","https://openalex.org/W2024946285","https://openalex.org/W2026407856","https://openalex.org/W2027653803","https://openalex.org/W2029946169","https://openalex.org/W2030068202","https://openalex.org/W2030336958","https://openalex.org/W2032383132","https://openalex.org/W2035489371","https://openalex.org/W2038471507","https://openalex.org/W2040627002","https://openalex.org/W2042165840","https://openalex.org/W2042398310","https://openalex.org/W2045209229","https://openalex.org/W2047043794","https://openalex.org/W2047440121","https://openalex.org/W2050548181","https://openalex.org/W2052419566","https://openalex.org/W2052541899","https://openalex.org/W2058849414","https://openalex.org/W2059529313","https://openalex.org/W2062503200","https://openalex.org/W2062779633","https://openalex.org/W2065624359","https://openalex.org/W2068768225","https://openalex.org/W2071186106","https://openalex.org/W2072926262","https://openalex.org/W2073924276","https://openalex.org/W2075476726","https://openalex.org/W2078102780","https://openalex.org/W2079130007","https://openalex.org/W2080246516","https://openalex.org/W2080419167","https://openalex.org/W2080796863","https://openalex.org/W2084677920","https://openalex.org/W2087530874","https://openalex.org/W2088902653","https://openalex.org/W2092569336","https://openalex.org/W2092876860","https://openalex.org/W2093513798","https://openalex.org/W2096883568","https://openalex.org/W2097634699","https://openalex.org/W2097734621","https://openalex.org/W2098788436","https://openalex.org/W2101058428","https://openalex.org/W2104560884","https://openalex.org/W2104736539","https://openalex.org/W2105955080","https://openalex.org/W2106818699","https://openalex.org/W2107711908","https://openalex.org/W2108018752","https://openalex.org/W2108717988","https://openalex.org/W2110132014","https://openalex.org/W2112383415","https://openalex.org/W2114798556","https://openalex.org/W2116142734","https://openalex.org/W2118215527","https://openalex.org/W2120316582","https://openalex.org/W2121426096","https://openalex.org/W2121811021","https://openalex.org/W2123509518","https://openalex.org/W2124539321","https://openalex.org/W2126308420","https://openalex.org/W2126952238","https://openalex.org/W2128730778","https://openalex.org/W2129012692","https://openalex.org/W2130520416","https://openalex.org/W2130622312","https://openalex.org/W2130665827","https://openalex.org/W2131492616","https://openalex.org/W2131584531","https://openalex.org/W2131695415","https://openalex.org/W2135576809","https://openalex.org/W2140627067","https://openalex.org/W2141336798","https://openalex.org/W2143107875","https://openalex.org/W2144554336","https://openalex.org/W2145804286","https://openalex.org/W2146087394","https://openalex.org/W2148718613","https://openalex.org/W2149239043","https://openalex.org/W2149522348","https://openalex.org/W2152634089","https://openalex.org/W2152667563","https://openalex.org/W2154940764","https://openalex.org/W2156053656","https://openalex.org/W2156114650","https://openalex.org/W2156554634","https://openalex.org/W2157231599","https://openalex.org/W2158112812","https://openalex.org/W2158717508","https://openalex.org/W2159436483","https://openalex.org/W2160178352","https://openalex.org/W2161254070","https://openalex.org/W2162034701","https://openalex.org/W2162888767","https://openalex.org/W2164590051","https://openalex.org/W2164939868","https://openalex.org/W2166801001","https://openalex.org/W2169812063","https://openalex.org/W2170208356","https://openalex.org/W2171523728","https://openalex.org/W2171841656","https://openalex.org/W2320937221"],"related_works":["https://openalex.org/W2141579779","https://openalex.org/W158090181","https://openalex.org/W2886496308","https://openalex.org/W2593029724","https://openalex.org/W159507826","https://openalex.org/W141772285","https://openalex.org/W167233581","https://openalex.org/W1510180387","https://openalex.org/W2035065013","https://openalex.org/W2168155923"],"abstract_inverted_index":{"Helicobacter":[0],"pylori":[1,25,68,102,182,315,336],"infects":[2],"and":[3,12,44,53,77,80,138,242,248,310],"persistently":[4],"colonizes":[5],"the":[6,27,41,48,78,89,94,142,151,194,239,244,271,288,291],"stomach,":[7],"which":[8],"results":[9],"in":[10,13,93,207,223,232,255,262,295,316,322],"gastritis":[11],"some":[14],"individuals":[15],"peptic":[16],"ulcer":[17],"disease":[18,276,299],"or":[19],"gastric":[20,91,282],"cancer.":[21],"Adherence":[22],"of":[23,35,64,117,150,156,178,197,273,281,313],"H.":[24,67,101,181,314,335],"to":[26,62,88,104,106,129,141,188,220,259,297],"epithelium":[28,145],"is":[29,38],"an":[30,279],"important":[31],"factor":[32],"for":[33,66,134,146,168,217,275],"development":[34],"disease.":[36],"Attachment":[37],"mediated":[39,334],"by":[40,111,202,278],"adhesins":[42],"BabA":[43,157,229,274,284,304,333],"SabA":[45],"that":[46,100,122,214,227,331],"binds":[47],"ABO/Leb":[49],"blood":[50,245],"group":[51,246],"antigens":[52,222,261],"sialylated":[54],"glycoconjugates":[55],"respectively.":[56],"High-affinity":[57],"attachment":[58],"could":[59,199],"be":[60,63,200],"anticipated":[61],"disadvantage":[65],"because":[69],"epithelial":[70,82],"cells":[71,83,133],"have":[72],"a":[73,147,203,326],"fast":[74],"turnover":[75],"rate":[76],"dislocated":[79],"shed":[81],"would":[84],"carry":[85],"attached":[86],"bacteria":[87,128],"acidic":[90],"juice":[92],"lumen.":[95],"However,":[96],"here":[97],"we":[98,162,191,211,225,269,324],"describe":[99],"manage":[103],"adapt":[105],"this":[107],"innate":[108],"clearance":[109],"mechanism":[110],"unique":[112],"acid":[113,165,169],"regulatory":[114],"binding":[115,125,171,205,219,235,258],"properties":[116,126],"its":[118,233],"adhesins.":[119],"We":[120,301],"propose":[121],"pH":[123],"regulated":[124,170],"enable":[127],"detachment":[130],"from":[131,158,184,238],"host":[132],"chemotactic":[135],"guided":[136],"motility":[137],"successful":[139],"return":[140],"more":[143],"neutral":[144],"fresh":[148],"restart":[149],"infectious":[152],"cycle.":[153],"By":[154],"comparison":[155],"different":[159],"stomach":[160],"loci":[161],"identified":[163,212],"amino":[164],"key":[166],"position":[167],"activity.":[172],"Previous":[173],"studies":[174,321],"found":[175,226],"lower":[176],"prevalence":[177,196],"Leb-binding":[179,198],"among":[180,208],"isolates":[183],"southern":[185],"Europe":[186],"compared":[187],"Sweden.":[189],"Here":[190],"tested":[192],"if":[193],"reduced":[195],"explained":[201],"novel":[204],"mode;":[206],"Spanish":[209],"strains,":[210],"S812":[213],"demonstrates":[215],"preference":[216],"multivalent":[218],"ABO":[221,260],"glycolipids;":[224],"812":[228],"had":[230],"drifted":[231],"preferred":[234],"epitope":[236,252],"away":[237],"consensus":[240],"a1,2fucosylation":[241],"towards":[243],"A":[247],"B":[249],"derivatives.":[250],"Such":[251],"drift":[253],"might":[254],"particular":[256],"optimize":[257],"densely":[263],"packed":[264],"lipid":[265],"rafts.":[266],"In":[267],"parallel,":[268],"studied":[270],"influence":[272],"progression":[277],"inventory":[280],"biopsies.":[283],"correlated":[285],"both":[286],"with":[287,306],"oncoprotein":[289],"CagA,":[290],"VacAs1":[292],"toxin":[293],"and,":[294],"addition,":[296],"severe":[298],"progression.":[300],"further":[302],"correlate":[303],"expression":[305],"positive":[307],"secretor":[308],"phenotype":[309],"stronger":[311],"adhesion":[312],"vitro.":[317],"For":[318],"functional":[319],"adherence":[320],"vitro,":[323],"constructed":[325],"recombinant":[327],"Leb-expressing":[328],"cell":[329],"lineage":[330],"supports":[332],"attachment.":[337]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-04T10:56:28.161419","created_date":"2016-06-24T00:00:00"}