{"id":"https://openalex.org/W2135864545","doi":null,"title":"Comparative study of enalapril vs. losartan on residual renal function preservation in automated peritoneal dialysis. A randomized controlled study.","display_name":"Comparative study of enalapril vs. losartan on residual renal function preservation in automated peritoneal dialysis. A randomized controlled study.","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2135864545","mag":"2135864545","pmid":"https://pubmed.ncbi.nlm.nih.gov/23227581"},"language":"en","primary_location":{"id":"pmid:23227581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23227581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000260158","display_name":"Fernando Arturo Reyes-Mar\u00edn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405261060","display_name":"Instituto de Seguridad Social del Estado de M\u00e9xico y Municipios","ror":"https://ror.org/04pvd4f07","country_code":"MX","type":"government","lineage":["https://openalex.org/I4405261060"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Fernando Arturo Reyes-Mar\u00edn","raw_affiliation_strings":["Hospital de Concentraci\u00f3n, Instituto de Seguridad Social del Estado de M\u00e9xico y Municipios (ISSEMYM) de Sat\u00e9lite, Naucalpan. artmar@prodigy.net.mx"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Concentraci\u00f3n, Instituto de Seguridad Social del Estado de M\u00e9xico y Municipios (ISSEMYM) de Sat\u00e9lite, Naucalpan. artmar@prodigy.net.mx","institution_ids":["https://openalex.org/I4405261060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017147113","display_name":"Claudia Calzada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284955","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico, Facultad de Estudios Superiores Iztacala","ror":"https://ror.org/04h0jke78","country_code":"MX","type":"education","lineage":["https://openalex.org/I4405284955","https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Claudia Calzada","raw_affiliation_strings":["Universidad Nacional Autonoma de Mexico Facultad de Estudios Superiores Iztacala, Tlalnepantla, Estado de M\u00e9xico, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional Autonoma de Mexico Facultad de Estudios Superiores Iztacala, Tlalnepantla, Estado de M\u00e9xico, Mexico","institution_ids":["https://openalex.org/I4405284955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021495337","display_name":"Araceli Ballesteros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405261060","display_name":"Instituto de Seguridad Social del Estado de M\u00e9xico y Municipios","ror":"https://ror.org/04pvd4f07","country_code":"MX","type":"government","lineage":["https://openalex.org/I4405261060"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Araceli Ballesteros","raw_affiliation_strings":["Instituto de Seguridad Social del Estado de M\u00e9xico y Municipios, Hospital de Concentraci\u00f3n, Naucalpan, Estado de M\u00e9xico, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Seguridad Social del Estado de M\u00e9xico y Municipios, Hospital de Concentraci\u00f3n, Naucalpan, Estado de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I4405261060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049316790","display_name":"Dante Amato","orcid":"https://orcid.org/0000-0002-4849-1027","observed_orcids":["https://orcid.org/0000-0002-4849-1027","https://orcid.org/0009-0006-9563-0751"]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Dante Amato","raw_affiliation_strings":["Instituto Polit\u00e9cnico Nacional, Escuela Superior de Medicina, M\u00e9xico, Distrito Federal, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Polit\u00e9cnico Nacional, Escuela Superior de Medicina, M\u00e9xico, Distrito Federal, M\u00e9xico","institution_ids":["https://openalex.org/I59361560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2229,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79019584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"64","issue":"4","first_page":"315","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enalapril","display_name":"enalapril","score":0.9290000200271606},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":1.0},{"id":"https://openalex.org/keywords/residual-renal-function","display_name":"residual renal function","score":0.9789999723434448},{"id":"https://openalex.org/keywords/automated-peritoneal-dialysis","display_name":"automated peritoneal dialysis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.890999972820282},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-function-preservation","display_name":"renal function preservation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.931594967842102},{"id":"https://openalex.org/C2775940317","wikidata":"https://www.wikidata.org/wiki/Q422185","display_name":"Enalapril","level":4,"score":0.8257548809051514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8145582675933838},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.7455888986587524},{"id":"https://openalex.org/C2779056158","wikidata":"https://www.wikidata.org/wiki/Q1756474","display_name":"Peritoneal dialysis","level":2,"score":0.6901627779006958},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.49432992935180664},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4856647253036499},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.4466686546802521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3576163947582245},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.2994117736816406},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.24098336696624756},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.07776907086372375}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004656","descriptor_name":"Enalapril","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004656","descriptor_name":"Enalapril","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010530","descriptor_name":"Peritoneal Dialysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23227581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23227581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion","raw_type":"Comparative Study"},{"id":"mag:2135864545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23227581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1963849118","https://openalex.org/W1967058721","https://openalex.org/W1977552622","https://openalex.org/W1984261234","https://openalex.org/W1997310530","https://openalex.org/W2022897447","https://openalex.org/W2023181433","https://openalex.org/W2031252012","https://openalex.org/W2044773944","https://openalex.org/W2052110501","https://openalex.org/W2056976690","https://openalex.org/W2090330461","https://openalex.org/W2110330847","https://openalex.org/W2112221881","https://openalex.org/W2129731251","https://openalex.org/W2137273994","https://openalex.org/W2138670606","https://openalex.org/W2148103781","https://openalex.org/W2151214135","https://openalex.org/W2160644724","https://openalex.org/W2167485579","https://openalex.org/W2169987602","https://openalex.org/W2277966459","https://openalex.org/W2297164013","https://openalex.org/W2568019769","https://openalex.org/W3027612129","https://openalex.org/W4300987630"],"related_works":["https://openalex.org/W1546495058","https://openalex.org/W3088617859","https://openalex.org/W1739842983","https://openalex.org/W1963849118","https://openalex.org/W7097178285","https://openalex.org/W3011381079","https://openalex.org/W1972247183","https://openalex.org/W2052110501","https://openalex.org/W7100333703","https://openalex.org/W2972593923"],"abstract_inverted_index":{"BACKGROUND:":[0],"Residual":[1],"renal":[2],"function":[3],"(RRF)":[4],"is":[5,247],"an":[6],"important":[7],"determinant":[8],"of":[9,26,80,97,121,235,244],"mortality":[10],"and":[11,32,47,104,227],"morbidity":[12],"in":[13,40,52,87,126,197,205,249],"patients":[14],"receiving":[15],"peritoneal":[16,54],"dialysis":[17,55],"(PD).":[18],"Recent":[19],"studies":[20],"have":[21],"shown":[22],"a":[23,69],"positive":[24],"effect":[25,79],"angiotensin":[27,33],"converting":[28],"enzyme":[29],"inhibitors":[30],"(ACEi)":[31],"II":[34],"receptor":[35],"blockers":[36],"(ARBs)":[37],"on":[38,84,222],"RRF":[39,50,85,122,125,148,174,181,196,204,223],"PD":[41],"patients.":[42,57,90],"OBJECTIVE:":[43],"To":[44],"compare":[45,77],"enalapril":[46,81,128,226],"losartan":[48,83,146,228],"for":[49],"preservation":[51,86,224],"automated":[53],"(APD)":[56],"MATERIAL":[58],"AND":[59],"METHODS:":[60],"An":[61],"open":[62],"label":[63],"randomized":[64],"controlled":[65],"trial":[66],"(RCT)":[67],"with":[68,242],"12":[70,105,176,211],"month":[71],"follow-up":[72],"period":[73],"was":[74,114,149,200,218],"conducted":[75],"to":[76,116,136,155,187,233],"the":[78,95,98,118,127,145,170,179,198,206,236,240,245],"vs.":[82],"60":[88],"APD":[89],"Measurements":[91],"were":[92,165],"done":[93],"at":[94,175,210],"start":[96],"study":[99],"(baseline),":[100],"3,":[101],"6,":[102],"9,":[103],"months.":[106,177],"A":[107],"historical":[108],"control":[109],"group":[110,129,147],"(HCG)":[111],"without":[112],"treatment":[113,241],"included":[115],"assess":[117],"natural":[119],"history":[120],"loss.":[123],"RESULTS:":[124],"dropped":[130],"from":[131,151,183],"3.65":[132],"+/-":[133,138,157,185,189],"1.6":[134],"(baseline)":[135,154],"2.36":[137],"0.38":[139],"mL/min/1.73":[140],"m2":[141,161,193],"(12":[142,162,194],"months).":[143,163,195],"In":[144,178],"reduced":[150],"4.1+/-":[152],"2.01":[153],"2.54":[156],"0.47":[158],"mL/min/":[159,191],"1.73":[160,192],"There":[164,217],"not":[166,219],"significant":[167,220],"differences":[168],"between":[169,225],"two":[171,207],"groups":[172,209],"regarding":[173],"HCG,":[180],"declined":[182],"3.68":[184],"0.48":[186],"1.4":[188],"0.29":[190],"HCG":[199,237],"significantly":[201],"lower":[202],"than":[203],"treated":[208],"months":[212],"(P":[213],"<":[214],"0.05).":[215],"CONCLUSIONS:":[216],"difference":[221],"groups.":[229],"Comparing":[230],"these":[231],"results":[232],"those":[234],"suggests":[238],"that":[239],"any":[243],"drugs":[246],"useful":[248],"preserving":[250],"RRF.":[251]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}