{"id":"https://openalex.org/W2135860607","doi":"https://doi.org/10.1002/ijc.2910440613","title":"Transforming activity of nasopharyngeal carcinoma DNA detectable in mouse JB6 cells","display_name":"Transforming activity of nasopharyngeal carcinoma DNA detectable in mouse JB6 cells","publication_year":1989,"publication_date":"1989-12-15","ids":{"openalex":"https://openalex.org/W2135860607","doi":"https://doi.org/10.1002/ijc.2910440613","mag":"2135860607","pmid":"https://pubmed.ncbi.nlm.nih.gov/2558076"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910440613","doi":"https://doi.org/10.1002/ijc.2910440613","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910440613","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048962207","display_name":"Nancy H. Colburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"N. H. Colburn","raw_affiliation_strings":["Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21701","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022059483","display_name":"Nancy Raab\u2010Traub","orcid":"https://orcid.org/0000-0002-7709-1014","observed_orcids":["https://orcid.org/0000-0002-7709-1014"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Raab\u2010Traub","raw_affiliation_strings":["Department of Microbiology, University of North Carolina, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of North Carolina, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079747950","display_name":"Dorothea Becker","orcid":"https://orcid.org/0000-0003-1924-0736","observed_orcids":["https://orcid.org/0000-0003-1924-0736"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Becker","raw_affiliation_strings":["Department of Tumor Biology, M.D. Anderson Institute, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Biology, M.D. Anderson Institute, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100641609","display_name":"Ya Cao","orcid":"https://orcid.org/0000-0002-3558-3336","observed_orcids":["https://orcid.org/0000-0002-3558-3336"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Cao","raw_affiliation_strings":["Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21701","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023517577","display_name":"Dolores Winterstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Winterstein","raw_affiliation_strings":["Program Resources, Frederick Cancer Research Facility, Frederick, MD 21701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program Resources, Frederick Cancer Research Facility, Frederick, MD 21701, USA","institution_ids":["https://openalex.org/I4210130649"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5048962207"],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":2.5285,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.89084065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"6","first_page":"1012","last_page":"1016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.20679999887943268,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-activity","display_name":"transforming activity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.5529999732971191},{"id":"https://openalex.org/keywords/ebv-dna","display_name":"EBV DNA","score":0.5979999899864197},{"id":"https://openalex.org/keywords/oncogenic-activity","display_name":"oncogenic activity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.7309222221374512},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5682709813117981},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5513845682144165},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43827447295188904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4209422171115875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2914334237575531},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1878906786441803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1579541265964508},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.07000967860221863}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.2910440613","doi":"https://doi.org/10.1002/ijc.2910440613","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910440613","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:2558076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2558076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306149","display_name":"Rockefeller Foundation","ror":"https://ror.org/03sfkwk85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W159156145","https://openalex.org/W271542888","https://openalex.org/W1604455297","https://openalex.org/W1769951129","https://openalex.org/W1774370734","https://openalex.org/W1807851304","https://openalex.org/W1979947204","https://openalex.org/W1980314954","https://openalex.org/W1989842486","https://openalex.org/W1992870468","https://openalex.org/W1993328555","https://openalex.org/W1996224662","https://openalex.org/W1998342643","https://openalex.org/W1998701295","https://openalex.org/W2004151481","https://openalex.org/W2020411245","https://openalex.org/W2045367517","https://openalex.org/W2046983903","https://openalex.org/W2055620164","https://openalex.org/W2059833979","https://openalex.org/W2064567786","https://openalex.org/W2080069870","https://openalex.org/W2088516814","https://openalex.org/W2106495814","https://openalex.org/W2126779118","https://openalex.org/W2134749755","https://openalex.org/W2153393494","https://openalex.org/W2260045613","https://openalex.org/W4211191038"],"related_works":["https://openalex.org/W33271375","https://openalex.org/W1807851304","https://openalex.org/W2092035492","https://openalex.org/W2265818006","https://openalex.org/W2016668165","https://openalex.org/W1998701295","https://openalex.org/W7097025324","https://openalex.org/W6889588125","https://openalex.org/W2050684646","https://openalex.org/W29523598"],"abstract_inverted_index":{"A":[0],"JB6":[1,50],"mouse":[2,49],"epidermal":[3],"recipient":[4],"cell":[5],"line":[6],"has":[7],"been":[8],"used":[9],"to":[10,39],"detect":[11],"nasopharyngeal":[12],"carcinoma":[13],"(NPC)":[14],"DNA-associated":[15,89],"transforming":[16,32,76],"activity":[17,33,35,95],"that":[18,59,68],"is":[19],"not":[20,63],"detectable":[21],"in":[22,44,70],"the":[23],"NIH":[24],"3T3":[25],"focus":[26],"assay.":[27],"NPC":[28,57,88],"DNA":[29,66],"showed":[30,74],"both":[31,86],"and":[34,67,78,92],"for":[36,81],"transferring":[37,82],"sensitivity":[38,91],"tumor-promoter-induced":[40],"neoplastic":[41],"transformation,":[42],"assayed":[43],"2":[45],"different":[46],"variants":[47],"of":[48,53,72,98],"cells.":[51],"Comparison":[52],"DNAs":[54],"from":[55],"various":[56],"sources":[58],"did":[60,62],"or":[61],"harbor":[64],"EBV":[65,100],"varied":[69],"degree":[71],"differentiation":[73],"similar":[75,79],"activities":[77,80],"promotion":[83,90],"sensitivity.":[84],"Thus":[85],"a":[87],"an":[93],"oncogenic":[94],"function":[96],"independently":[97],"concurrent":[99],"gene":[101],"expression.":[102]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}