{"id":"https://openalex.org/W2135592811","doi":"https://doi.org/10.2174/156802611797633429","title":"Neutralization of Local Toxicity Induced by Vipera russelli Phospholipase A2 by Lipophilic Derivative of Ascorbic Acid","display_name":"Neutralization of Local Toxicity Induced by Vipera russelli Phospholipase A2 by Lipophilic Derivative of Ascorbic Acid","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W2135592811","doi":"https://doi.org/10.2174/156802611797633429","mag":"2135592811","pmid":"https://pubmed.ncbi.nlm.nih.gov/21682683"},"language":"en","primary_location":{"id":"doi:10.2174/156802611797633429","doi":"https://doi.org/10.2174/156802611797633429","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156802611797633429","pdf_url":null,"source":{"id":"https://openalex.org/S107732428","display_name":"Current Topics in Medicinal Chemistry","issn_l":"1568-0266","issn":["1568-0266","1873-4294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046095127","display_name":"Riyaz Mohamed","orcid":"https://orcid.org/0000-0003-2398-3057","observed_orcids":["https://orcid.org/0000-0003-2398-3057","https://orcid.org/0000-0002-8659-2048"]},"institutions":[{"id":"https://openalex.org/I204743663","display_name":"University of Mysore","ror":"https://ror.org/012bxv356","country_code":"IN","type":"education","lineage":["https://openalex.org/I204743663"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Riyaz Mohamed","raw_affiliation_strings":["Department of Studies in Biochemistry, University of Mysore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Studies in Biochemistry, University of Mysore, India","institution_ids":["https://openalex.org/I204743663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048603971","display_name":"Holenarasipura V. Shivaprasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holenarasipura V Shivaprasad","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024833493","display_name":"Noor Mohamed Jameel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noor M Jameel","raw_affiliation_strings":["Centre for Diabetes Care and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Diabetes Care and Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110237064","display_name":"Mysore A. Shekar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132256","display_name":"Mysore Medical College","ror":"https://ror.org/03yz7v531","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210132256"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mysore A Shekar","raw_affiliation_strings":["Mysore Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mysore Medical College","institution_ids":["https://openalex.org/I4210132256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000500649","display_name":"Bannikuppe Sannanaik Vishwanath","orcid":"https://orcid.org/0000-0003-3284-4163","observed_orcids":["https://orcid.org/0000-0003-3284-4163"]},"institutions":[{"id":"https://openalex.org/I204743663","display_name":"University of Mysore","ror":"https://ror.org/012bxv356","country_code":"IN","type":"education","lineage":["https://openalex.org/I204743663"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bannikuppe S Vishwanath","raw_affiliation_strings":["Department of Studies in Biochemistry, University of Mysore, Mysore, India.,India","University of Mysore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Studies in Biochemistry, University of Mysore, Mysore, India.,India","institution_ids":["https://openalex.org/I204743663"]},{"raw_affiliation_string":"University of Mysore,","institution_ids":["https://openalex.org/I204743663"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6879,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76183206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"20","first_page":"2531","last_page":"2539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10332","display_name":"Amphibian and Reptile Biology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.625},{"id":"https://openalex.org/keywords/myotoxicity","display_name":"myotoxicity","score":0.800000011920929},{"id":"https://openalex.org/keywords/edema","display_name":"edema","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pulmonary-hemorrhage","display_name":"pulmonary hemorrhage","score":0.8989999890327454},{"id":"https://openalex.org/keywords/snake-venom-neutralization","display_name":"snake venom neutralization","score":0.6949999928474426},{"id":"https://openalex.org/keywords/enzyme-inhibitor-interaction","display_name":"enzyme-inhibitor binding","score":0.5619999766349792},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.5379999876022339},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"circular dichroism","score":0.7900000214576721},{"id":"https://openalex.org/keywords/intrinsic-fluorescence","display_name":"intrinsic fluorescence","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.7934761047363281},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7551624774932861},{"id":"https://openalex.org/C97664909","wikidata":"https://www.wikidata.org/wiki/Q24723833","display_name":"Myotoxin","level":4,"score":0.6699879765510559},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.568744957447052},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4823133945465088},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.46993666887283325},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4551023542881012},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44981884956359863},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.4286927878856659},{"id":"https://openalex.org/C2776725428","wikidata":"https://www.wikidata.org/wiki/Q424200","display_name":"Snake venom","level":3,"score":0.3779881000518799},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09729880094528198},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.07586026191711426},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000997","descriptor_name":"Antivenins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000997","descriptor_name":"Antivenins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000997","descriptor_name":"Antivenins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010168","descriptor_name":"Palmitates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010168","descriptor_name":"Palmitates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012909","descriptor_name":"Snake Bites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017840","descriptor_name":"Daboia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054501","descriptor_name":"Group II Phospholipases A2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054501","descriptor_name":"Group II Phospholipases A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054501","descriptor_name":"Group II Phospholipases A2","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2174/156802611797633429","doi":"https://doi.org/10.2174/156802611797633429","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156802611797633429","pdf_url":null,"source":{"id":"https://openalex.org/S107732428","display_name":"Current Topics in Medicinal Chemistry","issn_l":"1568-0266","issn":["1568-0266","1873-4294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Topics in Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:21682683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21682683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current topics in medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.uni-mysore.ac.in:2394","doi":null,"is_oa":false,"landing_page_url":"http://eprints.uni-mysore.ac.in/2394/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400737","display_name":"MyPrints@UOM (Mysore University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204743663","host_organization_name":"University of Mysore","host_organization_lineage":["https://openalex.org/I204743663"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320328621","display_name":"University of Mysore","ror":"https://ror.org/012bxv356"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1977307953","https://openalex.org/W2074152861","https://openalex.org/W2025524883","https://openalex.org/W2076392690","https://openalex.org/W1786216498","https://openalex.org/W2209335552","https://openalex.org/W2065852009","https://openalex.org/W2296277099","https://openalex.org/W2038976295","https://openalex.org/W1923442746"],"abstract_inverted_index":{"L-ascorbic":[0,15,21],"acid":[1,6,12,22],"upon":[2],"condensation":[3],"with":[4,42,58,106,124,143,176,200,210,227,233],"palmitic":[5],"in":[7,14,43,53,80,97,151,193],"the":[8,26,65,79,111,177,181,194,206,225],"presence":[9],"of":[10,20,29,61,72,104,116,127,139,198,208,236,243,249],"sulphuric":[11],"results":[13,214],"acid-6-palmitate":[16],"(AP).":[17],"The":[18,167],"effect":[19],"derivative,":[23],"AP":[24,48,89,105,144,173,209,217],"on":[25],"pharmacological":[27,82,165,221],"activities":[28,45,222],"purified":[30],"basic":[31],"multi-toxic":[32],"PLA2":[33],"enzyme,":[34],"VRV-PL-VIIIa":[35,50,91,107,112,140,147,199,219],"from":[36],"Vipera":[37],"russelli":[38,251],"snake":[39,237],"venom":[40,238,252],"along":[41,142,232],"vitro":[44],"is":[46,67,157],"described.":[47],"inhibited":[49,90,146],"enzyme":[51,155,178,211,226],"activity":[52,96,156],"a":[54,98],"concentration":[55],"dependent":[56],"manner":[57],"IC50":[59],"value":[60],"48.85":[62],"\u03bcM":[63],"and":[64,74,131,164,179],"inhibition":[66],"found":[68,87],"to":[69,245],"be":[70,242],"independent":[71],"substrate":[73],"calcium":[75],"concentration.":[76],"Upon":[77],"investigating":[78],"vivo":[81],"activities,":[83],"it":[84],"has":[85],"been":[86],"that":[88,137,154,172,216],"induced":[92,113,148,220],"mouse":[93,117,152],"paw":[94],"edematogenic":[95],"dose":[99],"dependant":[100],"manner.":[101],"Intramuscular":[102],"co-injection":[103],"(1:10":[108],"w:w)":[109],"neutralized":[110],"myotoxocity.":[114],"Sections":[115],"thigh":[118],"muscle":[119],"showed":[120,136,171,189],"normal":[121,125],"intact":[122],"musculature":[123],"levels":[126],"serum":[128],"creatine":[129],"kinase":[130],"lactate":[132],"dehydrogenase.":[133],"Histopathological":[134],"studies":[135,170],"administration":[138],"(i.p)":[141],"mixture":[145],"lung":[149],"haemorrhage":[150],"indicated":[153],"responsible":[158],"for":[159],"all":[160],"these":[161],"observed":[162],"pathological":[163],"activities.":[166],"biophysical":[168],"interaction":[169,207],"interacted":[174],"directly":[175],"decreased":[180],"relative":[182],"intrinsic":[183],"fluorescence":[184],"intensity.":[185],"CD":[186],"spectral":[187],"analysis":[188],"an":[190],"apparent":[191],"shift":[192],"far":[195],"UV-CD":[196],"spectra":[197],"AP.":[201],"Docking":[202],"study":[203],"also":[204],"confirmed":[205],"directly.":[212],"These":[213],"demonstrate":[215],"neutralizes":[218],"by":[223],"inhibiting":[224],"direct":[228],"interactions.":[229],"This":[230],"compound":[231],"other":[234],"inhibitors":[235],"hydrolytic":[239],"enzymes":[240],"might":[241],"use":[244],"neutralize":[246],"local":[247],"toxicity":[248],"V.":[250],"where":[253],"antivenoms":[254],"have":[255],"failed.":[256]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
