{"id":"https://openalex.org/W2135539775","doi":null,"title":"Association between ACE Gene I/D Polymorphism and Unstable Angina in Uzbek Patients with Family History of Coronary Heart Disease","display_name":"Association between ACE Gene I/D Polymorphism and Unstable Angina in Uzbek Patients with Family History of Coronary Heart Disease","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2135539775","mag":"2135539775"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:d08759e565554a74b450050e8c71a763","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d08759e565554a74b450050e8c71a763","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Biomedicine, Vol 2, Iss 4, Pp 275-278 (2012)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/d08759e565554a74b450050e8c71a763","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070140754","display_name":"\u0411\u0435\u043a\u043c\u0435\u0442\u043e\u0432\u0430 \u0424\u0435\u0440\u0443\u0437\u0430 \u041c\u0430\u0442\u0441\u0430\u043f\u0430\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-0619-4729","observed_orcids":["https://orcid.org/0000-0002-0619-4729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0424. \u041c. \u0411\u0435\u043a\u043c\u0435\u0442\u043e\u0432\u0430","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040143603","display_name":"R. D. Kurbanov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. D. Kurbanov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088355861","display_name":"Liliya E. Kan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liliya E. Kan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103559111","display_name":"Alexander B. Shek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander B. Shek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"2","issue":"4","first_page":"275","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.036400001496076584,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ace-gene","display_name":"ACE gene","score":0.6759999990463257},{"id":"https://openalex.org/keywords/insertion-deletion-polymorphism","display_name":"insertion/deletion polymorphism","score":0.9879999756813049},{"id":"https://openalex.org/keywords/unstable-angina","display_name":"unstable angina","score":0.9929999709129333},{"id":"https://openalex.org/keywords/family-history-of-coronary-heart-disease","display_name":"family history of coronary heart disease","score":0.9079999923706055},{"id":"https://openalex.org/keywords/d-allele","display_name":"D allele","score":0.5879999995231628},{"id":"https://openalex.org/keywords/carotid-intima-media-thickness","display_name":"carotid intima-media thickness","score":0.9639999866485596},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.9909999966621399},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.7375987768173218},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6753482222557068},{"id":"https://openalex.org/C2778718127","wikidata":"https://www.wikidata.org/wiki/Q9264","display_name":"Uzbek","level":2,"score":0.654263973236084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6330281496047974},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5113222599029541},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.46897372603416443},{"id":"https://openalex.org/C2777785093","wikidata":"https://www.wikidata.org/wiki/Q2032041","display_name":"Unstable angina","level":3,"score":0.4633072018623352},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4311266541481018},{"id":"https://openalex.org/C76252995","wikidata":"https://www.wikidata.org/wiki/Q3395645","display_name":"Gene polymorphism","level":4,"score":0.4297628402709961},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4267069697380066},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4171425700187683},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.3112005293369293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2088795006275177},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1616426706314087},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.15121141076087952},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1082715094089508},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:d08759e565554a74b450050e8c71a763","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d08759e565554a74b450050e8c71a763","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Biomedicine, Vol 2, Iss 4, Pp 275-278 (2012)","raw_type":"article"},{"id":"mag:2135539775","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d08759e565554a74b450050e8c71a763","pdf_url":null,"source":{"id":"https://openalex.org/S2736370905","display_name":"International Journal of Biomedicine","issn_l":"2158-0510","issn":["2158-0510","2158-0529"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315865","host_organization_name":"International Medical Research and Development Corporation","host_organization_lineage":["https://openalex.org/P4310315865"],"host_organization_lineage_names":["International Medical Research and Development Corporation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Biomedicine","raw_type":null}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:d08759e565554a74b450050e8c71a763","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d08759e565554a74b450050e8c71a763","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Biomedicine, Vol 2, Iss 4, Pp 275-278 (2012)","raw_type":"article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1968214872","https://openalex.org/W1970544224","https://openalex.org/W2031564429","https://openalex.org/W2043600435","https://openalex.org/W2120549911","https://openalex.org/W2414944327","https://openalex.org/W2433357808"],"related_works":["https://openalex.org/W51364697","https://openalex.org/W2162821813","https://openalex.org/W2291440986","https://openalex.org/W2375233525","https://openalex.org/W1977846909","https://openalex.org/W2354037955","https://openalex.org/W1030252450","https://openalex.org/W2373913592","https://openalex.org/W2373616040","https://openalex.org/W1647563862"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"study":[2],"the":[3,10,21,96,104,118,142,150,159,175,189,215,228,232,236,246,249,253],"distribution":[4],"of":[5,9,23,26,74,88,117,135,158,171,178,188,210,214,231,235,248,252,258],"I/D":[6,115,238],"polymorphic":[7],"marker":[8],"ACE":[11,119,237],"gene":[12,120,239],"in":[13,141,245],"Uzbek":[14,39,81,220],"patients":[15,40,53,58,65,138,166,221],"with":[16,29,41,54,167,174,222,227],"unstable":[17,42,55,223],"angina,":[18],"depending":[19],"on":[20],"presence":[22,209],"family":[24,72,86,169,212],"history":[25,73,87,170,213],"CHD":[27,84],"compared":[28,173],"healthy":[30,80,176],"individuals.":[31],"Materials":[32],"and":[33,63,85,146,162,198,256],"methods:":[34],"There":[35],"were":[36,180],"examined":[37],"125":[38],"angina":[43,56,224],"(class":[44],"IIB":[45],"by":[46,111,242],"E.":[47],"Braunwald":[48],"et":[49,127],"al.,":[50],"1989).":[51],"In":[52,131],"63":[57],"(the":[59,66],"1st":[60,151],"group)":[61,68],"had":[62,69,153],"62":[64],"2nd":[67],"no":[70],"a":[71,132,168,184,211],"CHD.":[75,89],"Control":[76],"group":[77,152,177],"included":[78],"45":[79],"subjects":[82],"without":[83],"The":[90,208],"genomic":[91],"DNA":[92,106],"was":[93,121,225],"isolated":[94],"from":[95],"peripheral":[97],"blood":[98],"lymphocytes":[99],"following":[100],"standard":[101],"protocol":[102],"using":[103],"DiatomTM":[105],"Prep":[107],"200":[108],"kit":[109],"(produced":[110],"LLC":[112],"\"Laboratory":[113],"IsoGene\").":[114],"polymorphism":[116],"detected":[122],"according":[123],"to":[124,182],"Cambian":[125],"F.":[126],"al.":[128],"(1992).":[129],"Results:":[130],"comparative":[133],"analysis":[134],"both":[136],"groups,":[137],"showed":[139],"similarity":[140],"baseline":[143],"clinical,":[144],"hemodynamic":[145],"biochemical":[147],"parameters;":[148],"however,":[149],"significant":[154],"higher":[155,186,229],"IMC":[156],"thickness":[157,247],"carotid":[160,254],"arteries":[161,255],"hsCRP":[163],"levels.":[164],"Simultaneously,":[165],"CHD,":[172],"individuals,":[179],"noted":[181],"have":[183],"significantly":[185],"prevalence":[187],"D/D":[190],"genotype":[191],"[OR:":[192,201],"3.46":[193],"(95%":[194,203],"CI:":[195,204],"1.18-8.11;":[196],"P=0.035)]":[197],"\"damaging\"":[199],"D-allele":[200,234],"2.47":[202],"1.40-4.34;":[205],"P=0.002)].":[206],"Conclusion:":[207],"coronary":[216],"heart":[217],"disease":[218],"among":[219],"associated":[226],"frequency":[230],"\"damaging\u201d":[233],"polymorphism,":[240],"accompanied":[241],"an":[243],"increase":[244],"intima-media":[250],"complex":[251],"level":[257],"high-sensitivity":[259],"C-reactive":[260],"protein.":[261]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}