{"id":"https://openalex.org/W2135510653","doi":null,"title":"Examining the Role of DAX-1 in Regulation of Cell Proliferation in Human Breast Cells","display_name":"Examining the Role of DAX-1 in Regulation of Cell Proliferation in Human Breast Cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2135510653","mag":"2135510653"},"language":"en","primary_location":{"id":"pmh:oai:repository.usfca.edu:thes-1128","doi":null,"is_oa":true,"landing_page_url":"https://repository.usfca.edu/thes/112","pdf_url":"https://repository.usfca.edu/thes/112","source":{"id":"https://openalex.org/S4377196440","display_name":"USF Scholarship Repository (University of San Francisco)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I76766440","host_organization_name":"University of San Francisco","host_organization_lineage":["https://openalex.org/I76766440"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.usfca.edu/thes/112","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059003622","display_name":"Amy E Scandurra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amy E Scandurra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059003622"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1664,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42331288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dax-1","display_name":"DAX-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nuclear-receptors","display_name":"nuclear receptors","score":0.5009999871253967},{"id":"https://openalex.org/keywords/transcriptional-repressor","display_name":"transcriptional repressor","score":0.8149999976158142},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.996999979019165},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8510000109672546},{"id":"https://openalex.org/keywords/sumoylation-sites","display_name":"SUMOylation sites","score":0.8119999766349792},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6029999852180481},{"id":"https://openalex.org/keywords/breast-cells","display_name":"breast cells","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4982271194458008},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.428976833820343},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35645806789398193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3196326196193695},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16384083032608032}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.usfca.edu:thes-1128","doi":null,"is_oa":true,"landing_page_url":"https://repository.usfca.edu/thes/112","pdf_url":"https://repository.usfca.edu/thes/112","source":{"id":"https://openalex.org/S4377196440","display_name":"USF Scholarship Repository (University of San Francisco)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I76766440","host_organization_name":"University of San Francisco","host_organization_lineage":["https://openalex.org/I76766440"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},{"id":"mag:2135510653","doi":null,"is_oa":false,"landing_page_url":"https://repository.usfca.edu/cgi/viewcontent.cgi?article=1128&context=thes","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.usfca.edu:thes-1128","doi":null,"is_oa":true,"landing_page_url":"https://repository.usfca.edu/thes/112","pdf_url":"https://repository.usfca.edu/thes/112","source":{"id":"https://openalex.org/S4377196440","display_name":"USF Scholarship Repository (University of San Francisco)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I76766440","host_organization_name":"University of San Francisco","host_organization_lineage":["https://openalex.org/I76766440"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2135510653.pdf","grobid_xml":"https://content.openalex.org/works/W2135510653.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W18457490","https://openalex.org/W1520109974","https://openalex.org/W1578641183","https://openalex.org/W1600888450","https://openalex.org/W1615606566","https://openalex.org/W1660177314","https://openalex.org/W1798563091","https://openalex.org/W1850383434","https://openalex.org/W1964247670","https://openalex.org/W1965493433","https://openalex.org/W1965536937","https://openalex.org/W1966433403","https://openalex.org/W1968086690","https://openalex.org/W1981243923","https://openalex.org/W1982849988","https://openalex.org/W1985313012","https://openalex.org/W1991326375","https://openalex.org/W1999054610","https://openalex.org/W2003235634","https://openalex.org/W2005842420","https://openalex.org/W2005856772","https://openalex.org/W2011935366","https://openalex.org/W2013108773","https://openalex.org/W2034927648","https://openalex.org/W2035843765","https://openalex.org/W2037614468","https://openalex.org/W2043880865","https://openalex.org/W2044568134","https://openalex.org/W2049802303","https://openalex.org/W2050895547","https://openalex.org/W2051813305","https://openalex.org/W2054339472","https://openalex.org/W2056526146","https://openalex.org/W2060692611","https://openalex.org/W2061485338","https://openalex.org/W2062703739","https://openalex.org/W2064593166","https://openalex.org/W2064686852","https://openalex.org/W2067371211","https://openalex.org/W2067795450","https://openalex.org/W2072386144","https://openalex.org/W2076244912","https://openalex.org/W2076298841","https://openalex.org/W2077655442","https://openalex.org/W2078595516","https://openalex.org/W2082153133","https://openalex.org/W2082486840","https://openalex.org/W2089539660","https://openalex.org/W2093742476","https://openalex.org/W2094209629","https://openalex.org/W2095341088","https://openalex.org/W2096388785","https://openalex.org/W2099435096","https://openalex.org/W2104108365","https://openalex.org/W2109915223","https://openalex.org/W2111369086","https://openalex.org/W2113613354","https://openalex.org/W2116755431","https://openalex.org/W2118205303","https://openalex.org/W2121416807","https://openalex.org/W2122044343","https://openalex.org/W2131079238","https://openalex.org/W2138346779","https://openalex.org/W2139013669","https://openalex.org/W2153683027","https://openalex.org/W2161029930","https://openalex.org/W2162355648","https://openalex.org/W2167523718","https://openalex.org/W2169375901","https://openalex.org/W2169670265","https://openalex.org/W2171226274","https://openalex.org/W2172198114","https://openalex.org/W2172256092","https://openalex.org/W2172298521","https://openalex.org/W2726651211"],"related_works":["https://openalex.org/W7095439827","https://openalex.org/W42982663","https://openalex.org/W2282753788","https://openalex.org/W1981700185","https://openalex.org/W2965027567","https://openalex.org/W2886541840","https://openalex.org/W2033184490","https://openalex.org/W2785929089","https://openalex.org/W7070927732","https://openalex.org/W2005353027"],"abstract_inverted_index":{"DAX-1":[0,16,40,59,73,76,87,91,103,119,204,215,236,267],"is":[1,216],"a":[2,13,75,108,154,264],"member":[3],"of":[4,24,49,58,62,132,140,156,175,180,195,203,257,266],"the":[5,22,47,56,138,141,176,193,199,235],"Nuclear":[6],"Hormone":[7],"Receptor":[8],"superfamily":[9],"and":[10,26,38,106,124,170,224,242,249],"acts":[11],"as":[12,82,84],"transcriptional":[14],"repressor.":[15],"plays":[17],"an":[18,114],"important":[19],"role":[20,33,57],"in":[21,34,60,64,74,89,110,122,163,171,205,218,230,246],"development":[23,37],"adrenal":[25],"gonadal":[27],"tissues.":[28],"In":[29,67,113],"addition":[30,139],"to":[31,42,54,101,116,149,263,272],"its":[32],"normal":[35,90,123,223],"cell":[36,80,207,220],"differentiation,":[39],"appears":[41],"have":[43,71,153,185],"some":[44,172],"influence":[45],"on":[46,158,188,197],"progression":[48],"cancer.":[50,66],"This":[51],"work":[52],"aims":[53],"examine":[55],"regulation":[61],"proliferation":[63,111],"breast":[65,78,93],"our":[68],"study,":[69],"we":[70,98,127],"expressed":[72],"deficient":[77],"cancer":[79],"line":[81],"well":[83],"knocked":[85],"down":[86],"expression":[88,248],"positive":[92],"cells.":[94,226],"Through":[95],"these":[96],"experiments,":[97],"were":[99,228,239],"able":[100],"identify":[102],"target":[104,159,177],"genes":[105],"effect":[107],"change":[109],"rate.":[112],"effort":[115],"better":[117],"understand":[118],"function":[120,269],"both":[121,222],"disease":[125],"states":[126],"also":[128],"examined":[129],"one":[130],"type":[131],"posttranslational":[133],"modification,":[134],"SUMOylation.":[135],"SUMOylation":[136,151,179,196,201,232,260],"involves":[137],"small":[142],"polypeptide":[143],"conjugate":[144],"SUMO":[145],"(Small":[146],"Ubiquitin-like":[147],"Modifier)":[148],"proteins.":[150],"can":[152,184],"variety":[155],"effects":[157,187,194],"proteins":[160],"including":[161],"changes":[162,245],"localization,":[164],"protein-protein":[165],"interaction,":[166],"interaction":[167],"with":[168],"DNA,":[169],"cases":[173],"stabilization":[174],"protein.":[178],"nuclear":[181],"hormone":[182],"receptors":[183],"profound":[186],"their":[189],"function.":[190],"To":[191],"study":[192],"DAX-1,":[198],"overall":[200],"status":[202],"mammalian":[206],"lines":[208],"was":[209,212,252],"determined.":[210],"It":[211,251],"found":[213],"that":[214,254],"SUMOylated":[217],"several":[219],"lines,":[221],"carcinoma":[225],"Mutations":[227],"made":[229],"putative":[231,259],"sites":[233,261],"within":[234],"gene.":[237],"Mutants":[238],"then":[240],"transfected":[241],"assayed":[243],"for":[244],"gene":[247],"activity.":[250],"determined":[253],"mutating":[255],"either":[256],"two":[258],"led":[262],"loss":[265],"repressive":[268],"when":[270],"compared":[271],"wild-type":[273],"DAX-1.":[274]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}
