{"id":"https://openalex.org/W2135486341","doi":"https://doi.org/10.1021/jm970096g","title":"Synthesis and Biological Activity of Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2-Aryl-Substituted Benzimidazoles","display_name":"Synthesis and Biological Activity of Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2-Aryl-Substituted Benzimidazoles","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W2135486341","doi":"https://doi.org/10.1021/jm970096g","mag":"2135486341","pmid":"https://pubmed.ncbi.nlm.nih.gov/9435891"},"language":"en","primary_location":{"id":"doi:10.1021/jm970096g","doi":"https://doi.org/10.1021/jm970096g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm970096g","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086812053","display_name":"Thomas F. Roth","orcid":"https://orcid.org/0000-0002-4688-4433","observed_orcids":["https://orcid.org/0000-0002-4688-4433"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Roth","raw_affiliation_strings":["Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087926024","display_name":"Marshall Morningstar","orcid":"https://orcid.org/0000-0002-2163-7452","observed_orcids":["https://orcid.org/0000-0002-2163-7452"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marshall L. Morningstar","raw_affiliation_strings":["Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053352871","display_name":"Paul L. Boyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul L. Boyer","raw_affiliation_strings":["Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063432648","display_name":"Stephen H. Hughes","orcid":"https://orcid.org/0000-0002-9176-4377","observed_orcids":["https://orcid.org/0000-0002-9176-4377"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen H. Hughes","raw_affiliation_strings":["Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert W. Buckheit,","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Buckheit,","raw_affiliation_strings":["Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063314566","display_name":"Christopher J. Michejda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Michejda","raw_affiliation_strings":["Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Aspects of Drug Design Section and Gene Expression in Eukaryotes Section, ABL-Basic Research and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, P.O. Box B, Frederick, Maryland 21702, and Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.0391,"has_fulltext":false,"cited_by_count":371,"citation_normalized_percentile":{"value":0.8759994,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"40","issue":"26","first_page":"4199","last_page":"4207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-reverse-transcriptase","display_name":"HIV-1 reverse transcriptase","score":0.8889999985694885},{"id":"https://openalex.org/keywords/benzimidazole","display_name":"benzimidazole","score":0.8880000114440918},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.4580000042915344},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hiv-1-resistance","display_name":"HIV-1 resistance","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9436044692993164},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.8153051733970642},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.7313504219055176},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.6225792169570923},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5190765857696533},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.4926338791847229},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.44206884503364563},{"id":"https://openalex.org/C2778484023","wikidata":"https://www.wikidata.org/wiki/Q415190","display_name":"Benzimidazole","level":2,"score":0.4368270933628082},{"id":"https://openalex.org/C153574943","wikidata":"https://www.wikidata.org/wiki/Q408939","display_name":"Nucleotidyltransferase","level":4,"score":0.4338512420654297},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.4274858832359314},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4232999384403229},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2951987683773041},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2638232707977295},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2535944879055023},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24559196829795837},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.10699599981307983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm970096g","doi":"https://doi.org/10.1021/jm970096g","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm970096g","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:9435891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9435891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1576999979","https://openalex.org/W1895373002","https://openalex.org/W1970106134","https://openalex.org/W1976683819","https://openalex.org/W1982561792","https://openalex.org/W1989791734","https://openalex.org/W2002403041","https://openalex.org/W2015559549","https://openalex.org/W2020331839","https://openalex.org/W2038311079","https://openalex.org/W2039927490","https://openalex.org/W2065577535","https://openalex.org/W2068998304","https://openalex.org/W2080291668","https://openalex.org/W2095725835","https://openalex.org/W2115853658","https://openalex.org/W2180476901"],"related_works":["https://openalex.org/W2080043305","https://openalex.org/W2953328635","https://openalex.org/W2048005189","https://openalex.org/W2059778013","https://openalex.org/W2333586345","https://openalex.org/W2002156139","https://openalex.org/W2615250591","https://openalex.org/W2908808086","https://openalex.org/W7132663318","https://openalex.org/W2776418222"],"abstract_inverted_index":{"The":[0,115],"development":[1],"of":[2,6,29,37,52,66,96,105,174,193,200,209,221],"new":[3],"nonnucleoside":[4,169,202],"inhibitors":[5,56,203],"human":[7],"immunodeficiency":[8],"virus":[9,156],"type-1":[10],"(HIV-1)":[11],"reverse":[12],"transcriptase":[13],"(RT)":[14],"active":[15],"against":[16,57,127,154,161,176],"the":[17,43,50,94,100,106,110,172,214,218,222],"drug-induced":[18],"mutations":[19],"in":[20,80,131,133,185],"RT":[21,130,186],"continues":[22],"to":[23,78,98,168,198,216],"be":[24],"a":[25,34],"very":[26],"important":[27],"goal":[28],"AIDS":[30],"research.":[31],"We":[32],"used":[33],"known":[35],"inhibitor":[36],"HIV-1":[38,84,128,165],"RT,":[39],"1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-alpha]benzimidazole":[40],"(TZB),":[41],"as":[42],"lead":[44],"structure":[45],"for":[46,75,93,103],"drug":[47],"design":[48],"with":[49,181],"objective":[51],"making":[53],"more":[54],"potent":[55],"both":[58],"wild-type":[59,155,177],"(WT)":[60],"and":[61,73,112,178,195],"variant":[62,219],"RTs.":[63],"A":[64,87],"series":[65,95],"structurally":[67],"related":[68],"1,2-substituted":[69],"benzimidazoles":[70],"was":[71,90],"synthesized":[72],"evaluated":[74],"their":[76],"ability":[77],"inhibit":[79,217],"vitro":[81,134],"polymerization":[82],"by":[83],"WT":[85,129],"RT.":[86],"structure-activity":[88],"study":[89],"carried":[91],"out":[92],"compounds":[97],"determine":[99],"optimum":[101],"groups":[102],"substitution":[104,184],"benzimidazole":[107],"ring":[108],"at":[109],"N1":[111],"C2":[113],"positions.":[114],"best":[116],"inhibitor,":[117],"1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methylbenzimida":[118],"zole":[119],"(35),":[120],"has":[121],"an":[122,132],"IC50":[123],"=":[124,151],"200":[125],"nM":[126],"enzyme":[135],"assay.":[136],"Cytoprotection":[137],"assays":[138],"utilizing":[139],"HIV-infected":[140],"MT-4":[141],"cells":[142],"revealed":[143],"that":[144,192,199],"35":[145,175],"had":[146],"strong":[147],"antiviral":[148],"activity":[149,160,173],"(EC50":[150],"440":[152],"nM)":[153],"while":[157],"retaining":[158],"broad":[159],"many":[162],"clinically":[163],"observed":[164],"strains":[166,180],"resistant":[167,179],"inhibitors.":[170],"Overall,":[171],"amino":[182],"acid":[183],"is":[187,196],"4-fold":[188],"or":[189],"greater":[190],"than":[191],"TZB":[194],"comparable":[197],"other":[201],"currently":[204],"undergoing":[205],"clinical":[206],"trials,":[207],"most":[208],"which":[210],"do":[211],"not":[212],"have":[213],"capacity":[215],"forms":[220],"enzyme.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":29},{"year":2012,"cited_by_count":26}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
